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Conserved domains on  [gi|320461689|ref|NP_569059|]
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ankyrin repeat and SOCS box protein 12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 8.52e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 8.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 320461689 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 4.63e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


:

Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.92  E-value: 4.63e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320461689  276 TPRSLLSQVRLVVRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 8.52e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 8.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 320461689 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-168 2.61e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689   77 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAspGGSIYNNCSPVLTAARDGAVAILQ 156
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 320461689  157 ELLDHGAEANVK 168
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-229 6.07e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 69.51  E-value: 6.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE-AGAS---PGGSIynncspVLTAARDG 150
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISdphAAGDL------LCTAAKRN 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461689 151 AVAILQELLDHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLlarvpRPRTLLEI 229
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGADVDKANTDDDF-----SPTELREL 698
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 4.63e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.92  E-value: 4.63e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320461689  276 TPRSLLSQVRLVVRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 276-317 2.15e-04

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 38.22  E-value: 2.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320461689 276 TPRSLLSQVRLVVRRALCQAGqPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRR-LDLIDKLPLPPRLKDYLLYK 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 108-132 1.03e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|....*
gi 320461689   108 TPLFTAVSHGHLDCVRVLLEAGASP 132
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 278-317 2.09e-03

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 35.08  E-value: 2.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 320461689   278 RSLLSQVRLVVRRALCQagqpqaINQLDIPPMLISYLKHQ 317
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG------IDKLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 8.52e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 8.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 320461689 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
75-275 2.90e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 2.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAI 154
Cdd:COG0666   56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 155 LQELLDHGAEANVKAKlpvwasniaSCSGPLYLAAVYGHLDCFRLLLLHGADPDynctdqgllARVPRPRTLLEICLHHN 234
Cdd:COG0666  136 VKLLLEAGADVNAQDN---------DGNTPLHLAAANGNLEIVKLLLEAGADVN---------ARDNDGETPLHLAAENG 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 320461689 235 CePEYIQLLIDFGANIYLpslsldltsQDDKGIALLLQARA 275
Cdd:COG0666  198 H-LEIVKLLLEAGADVNA---------KDNDGKTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-210 6.35e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 6.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  64 INSRSGWGVpgTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPV 143
Cdd:COG0666  146 VNAQDNDGN--TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320461689 144 LTAARDGAVAILQELLDHGAEANVKAKlpvwasniaSCSGPLYLAAVYGHLDCFRLLLLHGADPDYN 210
Cdd:COG0666  224 DLAAENGNLEIVKLLLEAGADLNAKDK---------DGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-168 2.61e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689   77 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAspGGSIYNNCSPVLTAARDGAVAILQ 156
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 320461689  157 ELLDHGAEANVK 168
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-229 6.07e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 69.51  E-value: 6.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE-AGAS---PGGSIynncspVLTAARDG 150
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISdphAAGDL------LCTAAKRN 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461689 151 AVAILQELLDHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLlarvpRPRTLLEI 229
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGADVDKANTDDDF-----SPTELREL 698
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-170 1.03e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  64 INSRSGWGvpGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPV 143
Cdd:COG0666  179 VNARDNDG--ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256

                         90       100
                 ....*....|....*....|....*..
gi 320461689 144 LTAARDGAVAILQELLDHGAEANVKAK 170
Cdd:COG0666  257 LLAAAAGAALIVKLLLLALLLLAAALL 283
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-211 1.90e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  89 LQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVK 168
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 320461689 169 aklpvwASNIAScsgPLYLAAVYGHLDCFRLLLLHGADPDYNC 211
Cdd:PHA02874 187 ------DNNGES---PLHNAAEYGDYACIKLLIDHGNHIMNKC 220
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-258 4.55e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.00  E-value: 4.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  39 LNQAVYDNDSYTLDQLLRQERYKRFINSRSGwgvpGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 118
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDG----MTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 119 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPvwasniasCSGPLYLAAVYGHLDCFR 198
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG--------CVAALCYAIENNKIDIVR 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461689 199 LLLLHGADPDYNCTDQGllarvpRPRTLLEICLHH--NCEPEYIQLLI-DFGANIYLPSLSLD 258
Cdd:PHA02875 220 LFIKRGADCNIMFMIEG------EECTILDMICNMctNLESEAIDALIaDIAIRIHKKTIRRD 276
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-250 1.41e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGH-LSCLQVLLAHGADVDSLDVKAQTPLFTAVS-HGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAV 152
Cdd:PHA02876 309 TPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 153 AILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAvyghldcfRLLLLHGAdpDYNCTDQGLlarvprpRTLLEICLH 232
Cdd:PHA02876 389 VIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSV--------KTLIDRGA--NVNSKNKDL-------STPLHYACK 451

                        170
                 ....*....|....*...
gi 320461689 233 HNCEPEYIQLLIDFGANI 250
Cdd:PHA02876 452 KNCKLDVIEMLLDNGADV 469
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-251 3.19e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.37  E-value: 3.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  89 LQVLLAHGADVDSLDVKAQTPLFTAVSH--GHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAV--AILQELLDHGAE 164
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 165 ANVKAKL--------PVWASNIASCSgPLYLAAVYGHLDCFRLLLLHGADPDYnCTDQGLlarvprprTLLEICLhHNCE 236
Cdd:PHA03100 169 INAKNRVnyllsygvPINIKDVYGFT-PLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGD--------TPLHIAI-LNNN 237

                        170
                 ....*....|....*
gi 320461689 237 PEYIQLLIDFGANIY 251
Cdd:PHA03100 238 KEIFKLLLNNGPSIK 252
Ank_4 pfam13637
Ankyrin repeats (many copies);
75-126 4.23e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 4.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320461689   75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 126
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 79-223 5.23e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 5.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  79 LAASyGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQEL 158
Cdd:PTZ00322  89 LAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461689 159 LDHGAEanvkaklpvwASNIASCSGPLYLAAVYGHLDCFRLLLLHgadPDYnctdqgllARVPRP 223
Cdd:PTZ00322 168 SRHSQC----------HFELGANAKPDSFTGKPPSLEDSPISSHH---PDF--------SAVPQP 211
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 107-250 1.68e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.38  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 107 QTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKA----------------- 169
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpdieselhdaveegdvk 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 170 ------KLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGL---LARVPRPRTLLEICLHHN---- 234
Cdd:PHA02875  83 aveellDLGKFADDVFYKDGmtPLHLATILKKLDIMKLLIARGADPDIPNTDKFSplhLAVMMGDIKGIELLIDHKacld 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 320461689 235 ------CEP----------EYIQLLIDFGANI 250
Cdd:PHA02875 163 iedccgCTPliiamakgdiAICKMLLDSGANI 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-240 3.17e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG-SIYNNCSPVLTAARDGAVA 153
Cdd:PHA02878 170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHISVGYCKDYD 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 154 ILQELLDHGAEANVKaklpvwaSNIASCSgPLYLAavYGHLDCFRLLLLHGADPD-YNCTDQGLLARVPRPRTLLEIC-- 230
Cdd:PHA02878 250 ILKLLLEHGVDVNAK-------SYILGLT-ALHSS--IKSERKLKLLLEYGADINsLNSYKLTPLSSAVKQYLCINIGri 319

                        170
                 ....*....|.
gi 320461689 231 -LHHNCEPEYI 240
Cdd:PHA02878 320 lISNICLLKRI 330
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 75-170 4.30e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 4.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAI 154
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90
                 ....*....|....*.
gi 320461689 155 LQELLDHGAEANVKAK 170
Cdd:PHA02874 206 IKLLIDHGNHIMNKCK 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-249 1.35e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGA--DVDSLDVKaqTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN-CSPVLTAARDGA 151
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIE--SELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 152 VAILQELLDHGAEANVKAK-------LPVWA---------------SNIASCSG--PLYLAAVYGHLDCFRLLLLHGADP 207
Cdd:PHA02875 115 LDIMKLLIARGADPDIPNTdkfsplhLAVMMgdikgiellidhkacLDIEDCCGctPLIIAMAKGDIAICKMLLDSGANI 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 320461689 208 DYnctdqglLARvpRPRTLLEICLHHNCEPEYIQLLIDFGAN 249
Cdd:PHA02875 195 DY-------FGK--NGCVAALCYAIENNKIDIVRLFIKRGAD 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 89-250 1.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  89 LQVLLAHGADVDSLDV-KAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 167
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 168 KAKlpvwasniasC-SGPLYLAAVY-GHLDCFRLLLLHGADPDYNCTDQGLlarvprprTLLEICLHhncEPEYIQLLID 245
Cdd:PHA02878 230 RDK----------CgNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGL--------TALHSSIK---SERKLKLLLE 288


                 ....*
gi 320461689 246 FGANI 250
Cdd:PHA02878 289 YGADI 293
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-167 1.97e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.89  E-value: 1.97e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461689  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 167
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 4.63e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.92  E-value: 4.63e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320461689  276 TPRSLLSQVRLVVRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
108-159 1.98e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 1.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320461689  108 TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELL 159
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 75-126 2.61e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.61e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 126
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA03095 PHA03095
ankyrin-like protein; Provisional
 92-251 4.89e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDC---VRVLLEAGASPGGSIYNNCSPVLTAARDGAVA-ILQELLDHGAEANV 167
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 168 KAKLpvwASNIAScsgpLYLAAVYGHLDCFRLLLLHGADP----DYNCTDQGLLARvprprtlleiclHHNCEPEYIQLL 243
Cdd:PHA03095 113 KDKV---GRTPLH----VYLSGFNINPKVIRLLLRKGADVnaldLYGMTPLAVLLK------------SRNANVELLRLL 173


                 ....*...
gi 320461689 244 IDFGANIY 251
Cdd:PHA03095 174 IDAGADVY 181
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-266 5.73e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 5.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVA-----ILQELLDHGAEAN 166
Cdd:PHA03100  21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 167 VKaklpvwasNIASCSgPLYLAAVY--GHLDCFRLLLLHGADpdynctdqgLLARVPRPRTLLEICLHHNC-EPEYIQLL 243
Cdd:PHA03100 101 AP--------DNNGIT-PLLYAISKksNSYSIVEYLLDNGAN---------VNIKNSDGENLLHLYLESNKiDLKILKLL 162

                        170       180       190
                 ....*....|....*....|....*....|
gi 320461689 244 IDFGANI-------YLPSLSLDLTSQDDKG 266
Cdd:PHA03100 163 IDKGVDInaknrvnYLLSYGVPINIKDVYG 192
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 276-317 2.15e-04

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 38.22  E-value: 2.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320461689 276 TPRSLLSQVRLVVRRALCQAGqPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRR-LDLIDKLPLPPRLKDYLLYK 41
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 75-148 4.11e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.51  E-value: 4.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461689  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAAR 148
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
PHA03095 PHA03095
ankyrin-like protein; Provisional
 64-164 4.73e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 4.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  64 INSRSGWGVpgTPLRLAASYGH-LSCLQVLLAHGADVDSLDVKAQTPLftavsHGHL-------DCVRVLLEAGASPGGS 135
Cdd:PHA03095  76 VNAPERCGF--TPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPL-----HVYLsgfninpKVIRLLLRKGADVNAL 148

                         90       100       110
                 ....*....|....*....|....*....|.
gi 320461689 136 IYNNCSP--VLTAARDGAVAILQELLDHGAE 164
Cdd:PHA03095 149 DLYGMTPlaVLLKSRNANVELLRLLIDAGAD 179
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 275-317 4.80e-04

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 37.09  E-value: 4.80e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 320461689 275 ATPRSLLSQVRLVVRRALCQAgQPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRR-RLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-103 9.13e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 9.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461689   38 ALNQAVYDNDSYTLDQLLRQERYKRFINSRsgwgvpgTPLRLAASYGHLSCLQVLLAHGADVDSLD 103
Cdd:pfam12796  33 ALHLAAKNGHLEIVKLLLEHADVNLKDNGR-------TALHYAARSGHLEIVKLLLEKGADINVKD 91
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 108-132 1.03e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|....*
gi 320461689   108 TPLFTAVSHGHLDCVRVLLEAGASP 132
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADI 28
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-133 1.39e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 320461689   92 LLAHG-ADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 133
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN 43
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 184-209 1.56e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.56e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461689   184 PLYLAAVYGHLDCFRLLLLHGADPDY 209
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 278-317 2.09e-03

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 35.08  E-value: 2.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 320461689   278 RSLLSQVRLVVRRALCQagqpqaINQLDIPPMLISYLKHQ 317
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG------IDKLPLPPRLKDYLLYY 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 75-103 2.82e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.82e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 320461689   75 TPLRLAA-SYGHLSCLQVLLAHGADVDSLD 103
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 75-100 3.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.68e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461689    75 TPLRLAASYGHLSCLQVLLAHGADVD 100
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02946 PHA02946
ankyin-like protein; Provisional
 76-171 5.10e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.50  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  76 PLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLF--TAVSHGHLDCVRVLLEAGASPGGSI-YNNCSPVLtAARDGAV 152
Cdd:PHA02946  75 PLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYylSGTDDEVIERINLLVQYGAKINNSVdEEGCGPLL-ACTDPSE 153

                         90
                 ....*....|....*....
gi 320461689 153 AILQELLDHGAEANVKAKL 171
Cdd:PHA02946 154 RVFKKIMSIGFEARIVDKF 172
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 110-213 5.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.04  E-value: 5.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 110 LFTAVSHGHLDCVRVLLEAGASPG----GSIYNNCSPVLTAAR-DGAVAILQeLLDHGAEANVKAKLPVWAsniascsgP 184
Cdd:PHA02884  37 LYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDcDNDDAAKL-LIRYGADVNRYAEEAKIT--------P 107

                         90       100
                 ....*....|....*....|....*....
gi 320461689 185 LYLAAVYGHLDCFRLLLLHGADPDYNCTD 213
Cdd:PHA02884 108 LYISVLHGCLKCLEILLSYGADINIQTND 136
Ank_5 pfam13857
Ankyrin repeats (many copies);
64-110 6.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 6.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 320461689   64 INSRSGWGVpgTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPL 110
Cdd:pfam13857   9 LNRLDGEGY--TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 75-155 7.71e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 7.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  75 TPLRLAASYGHLSCLQV--LLAHGADVDSLDVKAQTPL-FTAVSHGHLDCVRvLLEAGASPGGSIYNNCSPVLTAARDGA 151
Cdd:PHA03095 224 TPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLhYAAVFNNPRACRR-LIALGADINAVSSDGNTPLSLMVRNNN 302


                 ....
gi 320461689 152 VAIL 155
Cdd:PHA03095 303 GRAV 306
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-206 8.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.64  E-value: 8.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689  39 LNQAVYDNDSYTLDQLLRqerYKRFINSRSGWGvpGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 118
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFE---YGADVNIEDDNG--CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGD 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461689 119 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAIlqELLDHGAEANVKAklpvwasniASCSGPLYLAAVYG-HLDCF 197
Cdd:PHA02874 203 YACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASINDQD---------IDGSTPLHHAINPPcDIDII 271


                 ....*....
gi 320461689 198 RLLLLHGAD 206
Cdd:PHA02874 272 DILLYHKAD 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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