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Conserved domains on  [gi|18543199|ref|NP_569872|]
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uncharacterized protein Dmel_CG3704 [Drosophila melanogaster]

Protein Classification

GPN-loop GTPase family protein( domain architecture ID 13027284)

GPN-loop GTPase family protein similar to human GPN-loop GTPase 1, a small GTPase which is required for proper nuclear import of RNA polymerase II (RNAPII), and may act at an RNAP assembly step prior to nuclear import

CATH:  3.40.50.300
EC:  3.6.5.-
Gene Ontology:  GO:0005525|GO:0003924
PubMed:  23324351|11916378

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 24-264 1.09e-144

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


:

Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 409.65  E-value: 1.09e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  24 VCILVLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFT 102
Cdd:cd17870   1 VVIIVVGMAGSGKTTFVQRLNAYLHDnKKPPYVINLDPAVKSLPYPPNIDIRDTVNYKEVMKQYGLGPNGAIVTSLNLFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 103 TKMAQFAELVRRAGERgHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILY 182
Cdd:cd17870  81 TKFDQVINLIEKRASE-LDYVIIDTPGQIEVFTWSASGSIITEALASSFPTVVVYVVDTPRCTSPITFMSNMLYACSILY 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 183 KTRLPFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKI 262
Cdd:cd17870 160 KTKLPFILVFNKTDVVSHDFAIEWMEDFESFQDALKEDSSYMSSLSRSMSLVLDEFYNNLRVVGVSAKTGEGFEELLEAI 239


                ..
gi 18543199 263 LE 264
Cdd:cd17870 240 DE 241
 
Name Accession Description Interval E-value
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 24-264 1.09e-144

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 409.65  E-value: 1.09e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  24 VCILVLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFT 102
Cdd:cd17870   1 VVIIVVGMAGSGKTTFVQRLNAYLHDnKKPPYVINLDPAVKSLPYPPNIDIRDTVNYKEVMKQYGLGPNGAIVTSLNLFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 103 TKMAQFAELVRRAGERgHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILY 182
Cdd:cd17870  81 TKFDQVINLIEKRASE-LDYVIIDTPGQIEVFTWSASGSIITEALASSFPTVVVYVVDTPRCTSPITFMSNMLYACSILY 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 183 KTRLPFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKI 262
Cdd:cd17870 160 KTKLPFILVFNKTDVVSHDFAIEWMEDFESFQDALKEDSSYMSSLSRSMSLVLDEFYNNLRVVGVSAKTGEGFEELLEAI 239


                ..
gi 18543199 263 LE 264
Cdd:cd17870 240 DE 241
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 28-268 3.36e-100

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 296.98  E-value: 3.36e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199    28 VLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTKMA 106
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLrGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   107 QFAELVrragERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKTRL 186
Cdd:pfam03029  81 WLDEEL----KREDDYYLFDTPGQIELFTHWDSLAIIVEALESRGALGAVYLVDTRRLTDPTDFFSGLLYALSIMLRLGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   187 PFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKILESV 266
Cdd:pfam03029 157 PFVVALNKFDLLSLEFALKWFTDPEDLQLLLELDDGKYRKLNEAIREALDLFYLVPVFLPDARERGESMEDLLTLIDEAL 236


                  ..
gi 18543199   267 DE 268
Cdd:pfam03029 237 QY 238
PRK13768 PRK13768
GTPase; Provisional
 26-264 3.04e-48

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 163.89  E-value: 3.04e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   26 ILVLGMAGSGKTTFTQKLIQHAQEK-FNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTK 104
Cdd:PRK13768   5 VFFLGTAGSGKTTLTKALSDWLEEQgYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLLLTK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  105 MaqfAELVRRAGERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKT 184
Cdd:PRK13768  85 A---DEIKEEIESLDADYVLVDTPGQMELFAFRESGRKLVERLSGSSKSVVVFLIDAVLAKTPSDFVSLLLLALSVQLRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  185 RLPFLVALNKIDL---KDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTK 261
Cdd:PRK13768 162 GLPQIPVLNKADLlseEELERILKWLEDPEYLLEELKLEKGLQGLLSLELLRALEETGLPVRVIPVSAKTGEGFDELYAA 241


                 ...
gi 18543199  262 ILE 264
Cdd:PRK13768 242 IQE 244
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
26-270 7.36e-11

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 60.38  E-value: 7.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  26 ILVLGMAGSGKTTFTQKLIqhaqekfnpyvvnldpacrevpyaahvdiRDTVNYREVmkqyqLGPNGgivtalnmfttkm 105
Cdd:COG1100   6 IVVVGTGGVGKTSLVNRLV-----------------------------GDIFSLEKY-----LSTNG------------- 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 106 AQFAELVRRAGERGHKWCVIDTPGQIEVfnwSASGSIITEGLATmfPTIVVYVMDVERsacPTTFMSNMLYACSIL-YKT 184
Cdd:COG1100  39 VTIDKKELKLDGLDVDLVIWDTPGQDEF---RETRQFYARQLTG--ASLYLFVVDGTR---EETLQSLYELLESLRrLGK 110

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 185 RLPFLVALNKIDLkdcgfvmdwmtdfeafqeaqeeehsfVSNLTRTMSLTLDTFYENLRTCG---VSAKTGVGFTQLLTK 261
Cdd:COG1100 111 KSPIILVLNKIDL--------------------------YDEEEIEDEERLKEALSEDNIVEvvaTSAKTGEGVEELFAA 164


                ....*....
gi 18543199 262 ILESVDEYE 270
Cdd:COG1100 165 LAEILRGEG 173
 
Name Accession Description Interval E-value
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 24-264 1.09e-144

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 409.65  E-value: 1.09e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  24 VCILVLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFT 102
Cdd:cd17870   1 VVIIVVGMAGSGKTTFVQRLNAYLHDnKKPPYVINLDPAVKSLPYPPNIDIRDTVNYKEVMKQYGLGPNGAIVTSLNLFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 103 TKMAQFAELVRRAGERgHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILY 182
Cdd:cd17870  81 TKFDQVINLIEKRASE-LDYVIIDTPGQIEVFTWSASGSIITEALASSFPTVVVYVVDTPRCTSPITFMSNMLYACSILY 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 183 KTRLPFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKI 262
Cdd:cd17870 160 KTKLPFILVFNKTDVVSHDFAIEWMEDFESFQDALKEDSSYMSSLSRSMSLVLDEFYNNLRVVGVSAKTGEGFEELLEAI 239


                ..
gi 18543199 263 LE 264
Cdd:cd17870 240 DE 241
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 28-268 3.36e-100

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 296.98  E-value: 3.36e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199    28 VLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTKMA 106
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLrGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   107 QFAELVrragERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKTRL 186
Cdd:pfam03029  81 WLDEEL----KREDDYYLFDTPGQIELFTHWDSLAIIVEALESRGALGAVYLVDTRRLTDPTDFFSGLLYALSIMLRLGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   187 PFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKILESV 266
Cdd:pfam03029 157 PFVVALNKFDLLSLEFALKWFTDPEDLQLLLELDDGKYRKLNEAIREALDLFYLVPVFLPDARERGESMEDLLTLIDEAL 236


                  ..
gi 18543199   267 DE 268
Cdd:pfam03029 237 QY 238
GPN cd17868
GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small ...
 25-199 3.26e-55

GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small GTPases, Gpn1, 2, and 3. They form heterodimers, interact with RNA polymerase II and may function in nuclear import of RNA polymerase II.


Pssm-ID: 349777 [Multi-domain]  Cd Length: 198  Bit Score: 180.21  E-value: 3.26e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  25 CILVLGMAGSGKTTFTQKLIQHAQ-EKFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTT 103
Cdd:cd17868   2 AILVIGPAGSGKTTFCKNMKEHLRaRKRNPYVINLDPGNINEPLDYDIDIRDLIKYDDIMEELDLGPNGSIVYSLEYFEK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 104 KMAQFAELVRRAGERGHkWCVIDTPGQIEVFNWSASGSIITEGLATMF-PTIVVYVMDVERSACPTTFMSNMLYACSILY 182
Cdd:cd17868  82 NFDWFEKKLENEDKNPH-YILFDCPGQIELFTHSDSLPKIIERFASWFiSVVIVNLIDSQFLSDKSKFLSNLLIALSSMF 160

                       170
                ....*....|....*..
gi 18543199 183 KTRLPFLVALNKIDLKD 199
Cdd:cd17868 161 RLELPQINVISKMDLLD 177
PRK13768 PRK13768
GTPase; Provisional
 26-264 3.04e-48

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 163.89  E-value: 3.04e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   26 ILVLGMAGSGKTTFTQKLIQHAQEK-FNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTK 104
Cdd:PRK13768   5 VFFLGTAGSGKTTLTKALSDWLEEQgYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLLLTK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  105 MaqfAELVRRAGERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKT 184
Cdd:PRK13768  85 A---DEIKEEIESLDADYVLVDTPGQMELFAFRESGRKLVERLSGSSKSVVVFLIDAVLAKTPSDFVSLLLLALSVQLRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  185 RLPFLVALNKIDL---KDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTK 261
Cdd:PRK13768 162 GLPQIPVLNKADLlseEELERILKWLEDPEYLLEELKLEKGLQGLLSLELLRALEETGLPVRVIPVSAKTGEGFDELYAA 241


                 ...
gi 18543199  262 ILE 264
Cdd:PRK13768 242 IQE 244
GPN3 cd17872
GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear ...
 25-197 2.49e-29

GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.


Pssm-ID: 349781 [Multi-domain]  Cd Length: 196  Bit Score: 112.24  E-value: 2.49e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  25 CILVLGMAGSGKTTFTQKLIQHAQE-KFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTT 103
Cdd:cd17872   2 AQLVMGPAGSGKSTYCSTLQEHCETlGRSVHVVNLDPAAEEFEYPVSIDIRDLISLEDVMEELGLGPNGGLVYCMEYLLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 104 KMAQFAELVrraGERGHKWCVIDTPGQIEVF-NWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILY 182
Cdd:cd17872  82 NLDWLEEQL---GDYEDDYLIFDCPGQIELYtHLPVMKRLVDALQRWGFRLCAVYLLDSQFISDASKFISGVLSALSAMI 158

                       170
                ....*....|....*
gi 18543199 183 KTRLPFLVALNKIDL 197
Cdd:cd17872 159 QLELPHVNVLTKMDL 173
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 27-197 3.98e-21

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 89.90  E-value: 3.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  27 LVLGMAGSGKTTFTQKLIQHAQEKFNPY-VVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTKM 105
Cdd:cd17871   4 VVIGPPGSGKTTYCKGMQQFLSALGRKVaVVNLDPANEFLPYPCDVDIRELITVEDVMEELKLGPNGGLLYCMEYLEKNI 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 106 AQFAELVRRAGERghkWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIV-VYVMDVERSACPTTFMSNMLYACSILYKT 184
Cdd:cd17871  84 DWLIDKLKKLKDS---YLIFDCPGQVELYTHHNSLRNILDKLQKWLYRLVaVHLVDSHYCSDPSKFISALLLSLSTMLRL 160

                       170
                ....*....|...
gi 18543199 185 RLPFLVALNKIDL 197
Cdd:cd17871 161 ELPHVNVLSKIDL 173
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
26-270 7.36e-11

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 60.38  E-value: 7.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  26 ILVLGMAGSGKTTFTQKLIqhaqekfnpyvvnldpacrevpyaahvdiRDTVNYREVmkqyqLGPNGgivtalnmfttkm 105
Cdd:COG1100   6 IVVVGTGGVGKTSLVNRLV-----------------------------GDIFSLEKY-----LSTNG------------- 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 106 AQFAELVRRAGERGHKWCVIDTPGQIEVfnwSASGSIITEGLATmfPTIVVYVMDVERsacPTTFMSNMLYACSIL-YKT 184
Cdd:COG1100  39 VTIDKKELKLDGLDVDLVIWDTPGQDEF---RETRQFYARQLTG--ASLYLFVVDGTR---EETLQSLYELLESLRrLGK 110

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 185 RLPFLVALNKIDLkdcgfvmdwmtdfeafqeaqeeehsfVSNLTRTMSLTLDTFYENLRTCG---VSAKTGVGFTQLLTK 261
Cdd:COG1100 111 KSPIILVLNKIDL--------------------------YDEEEIEDEERLKEALSEDNIVEvvaTSAKTGEGVEELFAA 164


                ....*....
gi 18543199 262 ILESVDEYE 270
Cdd:COG1100 165 LAEILRGEG 173
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 26-194 1.64e-10

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 57.83  E-value: 1.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  26 ILVLGM-AGSGKTTFTQKLIQH-AQEKFNPYVVNLDpacrevpyaahvdirdtvnyrevmkqyqlgpnggivtalnmftt 103
Cdd:cd01983   3 IAVTGGkGGVGKTTLAAALAVAlAAKGYKVLLIDLD-------------------------------------------- 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 104 kmaqfaelvrragerghKWCVIDTPGQIEVFNWSASgsiITEGLATMFPTIVVYVMDVERSACPTTFmsNMLYACSILYK 183
Cdd:cd01983  39 -----------------DYVLIDGGGGLETGLLLGT---IVALLALKKADEVIVVVDPELGSLLEAV--KLLLALLLLGI 96

                       170
                ....*....|.
gi 18543199 184 TRLPFLVALNK 194
Cdd:cd01983  97 GIRPDGIVLNK 107
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 27-264 1.20e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 42.06  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199  27 LVLGMAGSGKTTFTQKLIQhaqekfnpyvvnldpacrevpyaAHVDIRDTVnyrevmkqyqlgpnggivtalnMFTTKMA 106
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLG-----------------------GEVGEVSDV----------------------PGTTRDP 35

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 107 QFAELvrRAGERGHKWCVIDTPGQIEvfnwsaSGSIITEGLATMF---PTIVVYVMDVERsacPTTFMSNMLYACSILYK 183
Cdd:cd00882  36 DVYVK--ELDKGKVKLVLVDTPGLDE------FGGLGREELARLLlrgADLILLVVDSTD---RESEEDAKLLILRRLRK 104

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 184 TRLPFLVALNKIDLKDcgfvmdwmtdfeafqeaqeeehsfVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKIL 263
Cdd:cd00882 105 EGIPIILVGNKIDLLE------------------------EREVEELLRLEELAKILGVPVFEVSAKTGEGVDELFEKLI 160


                .
gi 18543199 264 E 264
Cdd:cd00882 161 E 161
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
25-77 2.10e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 43.64  E-value: 2.10e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18543199  25 CILVLGMAGSGKTTFTQKLIQHAQEKFN------PYVVNLdpacREvpYAAHVDIRDTV 77
Cdd:COG5635 182 RLLILGEPGSGKTTLLRYLALELAERYLdaedpiPILIEL----RD--LAEEASLEDLL 234
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
 26-60 1.12e-03

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 41.09  E-value: 1.12e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18543199  26 ILVLGMAGSGKTTFTQKLIQHAQeKFNPYVVNLDP 60
Cdd:COG3451 207 TLILGPSGSGKSFLLKLLLLQLL-RYGARIVIFDP 240
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 25-59 2.86e-03

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 38.44  E-value: 2.86e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 18543199  25 CILVLGMAGSGKTTFTQKLIQHAQEK-FNPYVVNLD 59
Cdd:cd02028   1 VVGIAGPSGSGKTTFAKKLSNQLRVNgIGPVVISLD 36
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 101-194 3.50e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 36.83  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   101 FTTKMAQFAELVRRagerGHKWCVIDTPGQIEvfnWSASGSIITEGLATMFPT-IVVYVMDVERSacpttFMSNMLYACS 179
Cdd:pfam01926  31 GTTRDPNEGRLELK----GKQIILVDTPGLIE---GASEGEGLGRAFLAIIEAdLILFVVDSEEG-----ITPLDEELLE 98

                          90
                  ....*....|....*
gi 18543199   180 ILYKTRLPFLVALNK 194
Cdd:pfam01926  99 LLRENKKPIILVLNK 113
PRK14845 PRK14845
translation initiation factor IF-2; Provisional
 124-262 4.11e-03

translation initiation factor IF-2; Provisional


Pssm-ID: 237833 [Multi-domain]  Cd Length: 1049  Bit Score: 39.48  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   124 VIDTPGQIEVFNWSASGSIITEglatmfptIVVYVMDVERSACPTTFMsnmlyACSILYKTRLPFLVALNKIDL------ 197
Cdd:PRK14845  530 FIDTPGHEAFTSLRKRGGSLAD--------LAVLVVDINEGFKPQTIE-----AINILRQYKTPFVVAANKIDLipgwni 596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   198 -KDCGFVMDWMTDFEAFQEAQEE----------EHSF-------VSNLTRTMSLTldtfyenlrtcGVSAKTGVGFTQLL 259
Cdd:PRK14845  597 sEDEPFLLNFNEQDQHALTELEIklyeligklyELGFdadrfdrVQDFTRTVAIV-----------PVSAKTGEGIPELL 665


                  ...
gi 18543199   260 TKI 262
Cdd:PRK14845  666 MMV 668
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 4-95 6.80e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 36.74  E-value: 6.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199   4 GVESIKLEALSLSEgiRESPVCILVLGMAGSGKTTFTQKLIQHAQEKFNPyVVNLDpaCREVPYAAHVDIRDTVNYREVM 83
Cdd:cd00009   2 GQEEAIEALREALE--LPPPKNLLLYGPPGTGKTTLARAIANELFRPGAP-FLYLN--ASDLLEGLVVAELFGHFLVRLL 76

                        90
                ....*....|..
gi 18543199  84 KQYQLGPNGGIV 95
Cdd:cd00009  77 FELAEKAKPGVL 88
IF2_eIF5B cd01887
Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; IF2/eIF5B ...
 124-264 6.91e-03

Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases, IF2/IF5B undergoes conformational changes between its GTP- and GDP-bound states. Eukaryotic IF2/eIF5Bs possess three characteristic segments, including a divergent N-terminal region followed by conserved central and C-terminal segments. This core region is conserved among all known eukaryotic and archaeal IF2/eIF5Bs and eubacterial IF2s.


Pssm-ID: 206674 [Multi-domain]  Cd Length: 169  Bit Score: 37.07  E-value: 6.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543199 124 VIDTPGQiEVF-NWSASGSIITEglatmfptIVVYVMDVERSacpttFMSNMLYACSILYKTRLPFLVALNKIDLkdcgf 202
Cdd:cd01887  53 FIDTPGH-EAFtNMRARGASVTD--------IAILVVAADDG-----VMPQTIEAINHAKAANVPIIVAINKIDK----- 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543199 203 vmdwmtdfeafqeaQEEEHSFVSNLTRTMSLTLDTFYENLRTCG---VSAKTGVGFTQLLTKILE 264
Cdd:cd01887 114 --------------PYGTEADPERVKNELSELGLVGEEWGGDVSivpISAKTGEGIDDLLEAILL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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