uncharacterized protein Dmel_CG3078, isoform A [Drosophila melanogaster]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| MFS super family | cl28910 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
496-731 | 4.37e-25 | |||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. The actual alignment was detected with superfamily member cd17406: Pssm-ID: 475125 [Multi-domain] Cd Length: 390 Bit Score: 108.11 E-value: 4.37e-25
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| bZIP super family | cl21462 | Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ... |
11-43 | 2.20e-03 | |||||
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. The actual alignment was detected with superfamily member cd14694: Pssm-ID: 473870 Cd Length: 60 Bit Score: 36.92 E-value: 2.20e-03
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| FucP super family | cl43255 | Fucose permease [Carbohydrate transport and metabolism]; |
294-358 | 7.50e-03 | |||||
Fucose permease [Carbohydrate transport and metabolism]; The actual alignment was detected with superfamily member COG0738: Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 7.50e-03
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| Name | Accession | Description | Interval | E-value | |||||
| MFS_unc93A_like | cd17406 | Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ... |
496-731 | 4.37e-25 | |||||
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340964 [Multi-domain] Cd Length: 390 Bit Score: 108.11 E-value: 4.37e-25
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| bZIP_NFIL3 | cd14694 | Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): ... |
11-43 | 2.20e-03 | |||||
Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain; NFIL3, also called E4 promoter-binding protein 4 (E4BP4), is a Basic leucine zipper (bZIP) transcription factor that was independently identified as a transactivator of the IL3 promoter in T-cells and as a transcriptional repressor that binds to a DNA sequence site in the adenovirus E4 promoter. Its expression levels are regulated by cytokines and it plays crucial functions in the immune system. It is required for the development of natural killer cells and CD8+ conventional dendritic cells. In B-cells, NFIL3 mediates immunoglobulin heavy chain class switching that is required for IgE production, thereby influencing allergic and pathogenic immune responses. It is also involved in the polarization of T helper responses. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. Pssm-ID: 269842 Cd Length: 60 Bit Score: 36.92 E-value: 2.20e-03
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| FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
294-358 | 7.50e-03 | |||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 7.50e-03
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| Name | Accession | Description | Interval | E-value | |||||
| MFS_unc93A_like | cd17406 | Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ... |
496-731 | 4.37e-25 | |||||
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340964 [Multi-domain] Cd Length: 390 Bit Score: 108.11 E-value: 4.37e-25
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| MFS_unc93_like | cd17338 | Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ... |
557-671 | 1.12e-09 | |||||
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340896 [Multi-domain] Cd Length: 388 Bit Score: 60.82 E-value: 1.12e-09
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| MFS_unc93B1 | cd17408 | Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 ... |
562-658 | 7.06e-06 | |||||
Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 homolog B1 (UNC93B1) controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. It regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity. UNC93B1 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340966 [Multi-domain] Cd Length: 456 Bit Score: 49.02 E-value: 7.06e-06
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| bZIP_NFIL3 | cd14694 | Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): ... |
11-43 | 2.20e-03 | |||||
Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain; NFIL3, also called E4 promoter-binding protein 4 (E4BP4), is a Basic leucine zipper (bZIP) transcription factor that was independently identified as a transactivator of the IL3 promoter in T-cells and as a transcriptional repressor that binds to a DNA sequence site in the adenovirus E4 promoter. Its expression levels are regulated by cytokines and it plays crucial functions in the immune system. It is required for the development of natural killer cells and CD8+ conventional dendritic cells. In B-cells, NFIL3 mediates immunoglobulin heavy chain class switching that is required for IgE production, thereby influencing allergic and pathogenic immune responses. It is also involved in the polarization of T helper responses. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. Pssm-ID: 269842 Cd Length: 60 Bit Score: 36.92 E-value: 2.20e-03
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| FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
294-358 | 7.50e-03 | |||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 7.50e-03
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| Blast search parameters | ||||
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