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Conserved domains on  [gi|18543283|ref|NP_569993|]
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uncharacterized protein Dmel_CG3071 [Drosophila melanogaster]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-316 4.36e-55

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.51  E-value: 4.36e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   4 SFLPLNTRRFRQRAQVETPDTVYWDRLAKPELLKEHNTIDYLDFSPSDPDNFVVTCSVRVQIYNLVTMLVVKNLSRFQKT 83
Cdd:COG2319  43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  84 AYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYED 163
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 164 tHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcR 242
Cdd:COG2319 203 -HTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATG-E 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543283 243 LLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLT-YPNAVVSMAVADGDQAVVAGMVDGLV 316
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV 354
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 349-497 7.11e-47

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 160.34  E-value: 7.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   349 NNTQEVDHTIKDHVKGPGLKSYDVHLRQFNHKKALDDVMNaqKMQYQPELIVAVITDLLHRGSLGKALTGRHEAALVRFI 428
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLE--PGVKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18543283   429 DFICNHLGEVRFMRPLMMAASTVLDVFEQrLVAYSQKLMKALQRLSLAMQEEVRLTAELMRMKGAVDML 497
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGS-VLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-316 4.36e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.51  E-value: 4.36e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   4 SFLPLNTRRFRQRAQVETPDTVYWDRLAKPELLKEHNTIDYLDFSPSDPDNFVVTCSVRVQIYNLVTMLVVKNLSRFQKT 83
Cdd:COG2319  43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  84 AYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYED 163
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 164 tHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcR 242
Cdd:COG2319 203 -HTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATG-E 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543283 243 LLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLT-YPNAVVSMAVADGDQAVVAGMVDGLV 316
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-318 3.78e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.97  E-value: 3.78e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  89 FRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDY 168
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 169 VRAGAMHPqAGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSiFVSAGGS--QVRVWDLiSGCRLLTM 246
Cdd:cd00200  96 VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQdgTIKLWDL-RTGKCVAT 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18543283 247 MSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLTY-PNAVVSMAVADGDQAVVAGMVDGLVSI 318
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 349-497 7.11e-47

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 160.34  E-value: 7.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   349 NNTQEVDHTIKDHVKGPGLKSYDVHLRQFNHKKALDDVMNaqKMQYQPELIVAVITDLLHRGSLGKALTGRHEAALVRFI 428
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLE--PGVKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18543283   429 DFICNHLGEVRFMRPLMMAASTVLDVFEQrLVAYSQKLMKALQRLSLAMQEEVRLTAELMRMKGAVDML 497
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGS-VLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 pfam00400
WD domain, G-beta repeat;
242-279 1.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18543283   242 RLLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYD 279
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 2.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.17e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18543283    112 SRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWD 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 89-303 2.41e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   89 FRQDGRLLAAGDEEGHVKLFDTTS-----RNI---LRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQT 160
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFECESiikdgRDIhypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  161 YEDtHTDYVRAGAMHPQAGHMFVSGGYDGKIKLYDTRAETAVQrTLDHGAPVESMLFlPNGSIFVSAGGS---QVRVWDL 237
Cdd:PLN00181 571 MKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQF-PSESGRSLAFGSadhKVYYYDL 647

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543283  238 ISGCRLLTMMSQHHKTVTCLRLgSDGRRLLSGGLDRHVKIYDVSTYKT------VHTLTYPNAV---VSMAVADG 303
Cdd:PLN00181 648 RNPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVknfVGLSVSDG 721
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-316 4.36e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.51  E-value: 4.36e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   4 SFLPLNTRRFRQRAQVETPDTVYWDRLAKPELLKEHNTIDYLDFSPSDPDNFVVTCSVRVQIYNLVTMLVVKNLSRFQKT 83
Cdd:COG2319  43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  84 AYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYED 163
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 164 tHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcR 242
Cdd:COG2319 203 -HTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATG-E 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543283 243 LLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLT-YPNAVVSMAVADGDQAVVAGMVDGLV 316
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
27-318 5.84e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 5.84e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  27 WDRLAKPEL--LKEH-NTIDYLDFSPSDpdNFVVTCSV--RVQIYNLVTMLVVKNLSRFQKTAYGATFRQDGRLLAAGDE 101
Cdd:COG2319 105 WDLATGLLLrtLTGHtGAVRSVAFSPDG--KTLASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 102 EGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDYVRAGAMHPQaGHM 181
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPD-GRL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 182 FVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcRLLTMMSQHHKTVTCLRLG 260
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATG-KLLRTLTGHTGAVRSVAFS 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 261 SDGRRLLSGGLDRHVKIYDVSTYKTVHTLT-YPNAVVSMAV-ADGDQAVVAGMvDGLVSI 318
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFsPDGRTLASGSA-DGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
4-318 2.50e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.80  E-value: 2.50e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   4 SFLPLNTRRFRQRAQVETPDTVYWDRLAKPELLKEHNTIDYLDFSPSDPDNFVVTCSVRVQIYNLVTMLVVKNLSRFQKT 83
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  84 AYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYED 163
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 164 tHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcR 242
Cdd:COG2319 161 -HSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLATG-K 237

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18543283 243 LLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLT-YPNAVVSMAVADGDQAVVAGMVDGLVSI 318
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
27-282 6.58e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 6.58e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  27 WDRLAKPEL--LKEH-NTIDYLDFSPSDpdNFVVTCSV--RVQIYNLVTMLVVKNLSRFQKTAYGATFRQDGRLLAAGDE 101
Cdd:COG2319 147 WDLATGKLLrtLTGHsGAVTSVAFSPDG--KLLASGSDdgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 102 EGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDYVRAGAMHPQaGHM 181
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPD-GKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 182 FVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcRLLTMMSQHHKTVTCLRLG 260
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATG-ELLRTLTGHTGAVTSVAFS 381

                       250       260
                ....*....|....*....|..
gi 18543283 261 SDGRRLLSGGLDRHVKIYDVST 282
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-318 3.78e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.97  E-value: 3.78e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  89 FRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDY 168
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 169 VRAGAMHPqAGHMFVSGGYDGKIKLYDTRAETAVQRTLDHGAPVESMLFLPNGSiFVSAGGS--QVRVWDLiSGCRLLTM 246
Cdd:cd00200  96 VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQdgTIKLWDL-RTGKCVAT 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18543283 247 MSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLTY-PNAVVSMAVADGDQAVVAGMVDGLVSI 318
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 349-497 7.11e-47

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 160.34  E-value: 7.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   349 NNTQEVDHTIKDHVKGPGLKSYDVHLRQFNHKKALDDVMNaqKMQYQPELIVAVITDLLHRGSLGKALTGRHEAALVRFI 428
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLE--PGVKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18543283   429 DFICNHLGEVRFMRPLMMAASTVLDVFEQrLVAYSQKLMKALQRLSLAMQEEVRLTAELMRMKGAVDML 497
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGS-VLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-318 6.14e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.42  E-value: 6.14e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  45 LDFSPSDpdNFVVTCSV--RVQIYNLVTMLVVKNLSRFQKTAYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGH 122
Cdd:cd00200  15 VAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 123 TAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYDTRAETAV 202
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 203 QRTLDHGAPVESMLFLPNGSIFVSAGG-SQVRVWDLISGcRLLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVS 281
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18543283 282 TYKTVHTLT-YPNAVVSMAVADGDQAVVAGMVDGLVSI 318
Cdd:cd00200 250 TGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-279 3.23e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 3.23e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  36 LKEHnTIDYLDFSPSDPDNFVVTCSV--RVQIYNLVTMLVVKNLSRFQKTAYGATFRQDGRLLAAGDEEGHVKLFDTTSR 113
Cdd:cd00200  47 LKGH-TGPVRDVAASADGTYLASGSSdkTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 114 NILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQTYEDtHTDYVRAGAMHPQaGHMFVSGGYDGKIKL 193
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPD-GEKLLSSSSDGTIKL 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 194 YDTRAETAVQRTLDHGAPVESMLFLPNGSIFVSAGGSQ-VRVWDLISGcRLLTMMSQHHKTVTCLRLGSDGRRLLSGGLD 272
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGtIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 18543283 273 RHVKIYD 279
Cdd:cd00200 283 GTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-318 1.28e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.28e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18543283 250 HHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLTYPNAVVS--MAVADGDQAVVAGMvDGLVSI 318
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRdvAASADGTYLASGSS-DKTIRL 77
WD40 pfam00400
WD domain, G-beta repeat;
242-279 1.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18543283   242 RLLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYD 279
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 2.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.17e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18543283    112 SRNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWD 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 89-303 2.41e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   89 FRQDGRLLAAGDEEGHVKLFDTTS-----RNI---LRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWDVANEKVVQT 160
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFECESiikdgRDIhypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  161 YEDtHTDYVRAGAMHPQAGHMFVSGGYDGKIKLYDTRAETAVQrTLDHGAPVESMLFlPNGSIFVSAGGS---QVRVWDL 237
Cdd:PLN00181 571 MKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQF-PSESGRSLAFGSadhKVYYYDL 647

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18543283  238 ISGCRLLTMMSQHHKTVTCLRLgSDGRRLLSGGLDRHVKIYDVSTYKT------VHTLTYPNAV---VSMAVADG 303
Cdd:PLN00181 648 RNPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVknfVGLSVSDG 721
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-279 2.50e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 18543283    242 RLLTMMSQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYD 279
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 154-195 4.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 18543283    154 NEKVVQTYEDtHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYD 195
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
56-282 4.23e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 4.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  56 VVTCSVRVQIYNLVTMLVVKNLSRFQKTAYGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPVHRTFFTADK 135
Cdd:COG3391   1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 136 LQLASFGDDKSVRLWDVANEKVVQTYedTHTDYVRAGAMHPQAGHMFVSGGYDGKIKLYDTrAETAVQRTLDHGAPVESM 215
Cdd:COG3391  81 RLYVANSGSGRVSVIDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDT-ATGKVVATIPVGAGPHGI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 216 LFLPNGS-IFVSAGGSQ-----VRVWDLISGCRLLTMmsQHHKTVTCLRLGSDGRRLL--------SGGLDRHVKIYDVS 281
Cdd:COG3391 158 AVDPDGKrLYVANSGSNtvsviVSVIDTATGKVVATI--PVGGGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDLA 235


                .
gi 18543283 282 T 282
Cdd:COG3391 236 T 236
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 233-298 4.27e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18543283   233 RVWDlISGCrlltmmsQHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVSTYKTVHTLTYPNAVVSM 298
Cdd:pfam12894  28 RVWT-LSPD-------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITC 85
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 180-282 9.49e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 9.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 180 HMFVSGGYDGKIKLYDTRAetavQRTldhgaPVESMLFL----------PNGS-IFVSAGGSQVRVWDLISGCRLLTMMS 248
Cdd:cd22857 193 RKIVTGTGYHQVRLYDTRA----QRR-----PVVSVDFGetpikavaedPDGHtVYVGDTSGDLASIDLRTGKLLGCFKG 263

                        90       100       110
                ....*....|....*....|....*....|....
gi 18543283 249 QHHKTVTCLRLGSDGRRLLSGGLDRHVKIYDVST 282
Cdd:cd22857 264 KCGGSIRSIARHPELPLIASCGLDRYLRIWDTET 297
WD40 pfam00400
WD domain, G-beta repeat;
113-151 1.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18543283   113 RNILRLFKGHTAPVHRTFFTADKLQLASFGDDKSVRLWD 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
7-190 2.00e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 2.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283   7 PLNTRRFRQRAQVETPDTVYWDRLAKPELLKEHNTIDYLDFSPSDPDNFVVTCSV--RVQIYNLVTMLVVKNLSRFQKTA 84
Cdd:COG3391  34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGsgRVSVIDLATGKVVATIPVGGGPR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283  85 YGATFRQDGRLLAAGDEEGHVKLFDTTSRNILRLFKGHTAPvHRTFFTADKLQL--ASFGDDKS---VRLWDVANEKVVQ 159
Cdd:COG3391 114 GLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGKRLyvANSGSNTVsviVSVIDTATGKVVA 192

                       170       180       190
                ....*....|....*....|....*....|.
gi 18543283 160 TYEDthTDYVRAGAMHPQAGHMFVSGGYDGK 190
Cdd:COG3391 193 TIPV--GGGPVGVAVSPDGRRLYVANRGSNT 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 208-236 2.47e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.47e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 18543283    208 HGAPVESMLFLPNGSIFVSAGG-SQVRVWD 236
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDdGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
220-358 3.53e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 3.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 220 NGSIFVSAGGS-QVRVWDLISGCRLLTMMSQHHktVTCLRLGSDGRRLL-SGGLDRHVKIYDVSTYKTVHTLTYPNAVVS 297
Cdd:COG3391  79 GRRLYVANSGSgRVSVIDLATGKVVATIPVGGG--PRGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVATIPVGAGPHG 156

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18543283 298 MAV-ADGDQAVVAGMVDGLVS-------------IRRMMVDSKPSHlkkIRADRARKY-FVSTKRTNNTQEVDHTI 358
Cdd:COG3391 157 IAVdPDGKRLYVANSGSNTVSvivsvidtatgkvVATIPVGGGPVG---VAVSPDGRRlYVANRGSNTSNGGSNTV 229
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 176-287 5.70e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 39.15  E-value: 5.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18543283 176 PQAGHMFVSG-GYdGKIKLYDTRAEtavQRTLDHGAPVESMLFLPNG-SIFVSAGGSQVRVWDLISGCRLLTMMSQHHKT 253
Cdd:cd22850 202 DHRKFKFVTGtRY-GQVRLYDTSAG---RRPVFSEKPIKKPEEDLDGhTVYVGDTSGDLALIDIRTGKLLGRLLGKYGGS 277

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18543283 254 VTCLRLGSD--GRRLLSGGLDRHVKIYDVSTYKTVH 287
Cdd:cd22850 278 ITGAVRHPElfDPYLASGGLDRYLRVFDIETRELLA 313
WD40 pfam00400
WD domain, G-beta repeat;
156-195 6.51e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18543283   156 KVVQTYEDtHTDYVRAGAMHPQaGHMFVSGGYDGKIKLYD 195
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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