NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18858819|ref|NP_571222|]
View 

homeobox protein Hox-A11b [Danio rerio]

Protein Classification

DUF3528 and homeodomain domain-containing protein( domain architecture ID 11191843)

DUF3528 and homeodomain domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-151 5.98e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


:

Pssm-ID: 432284  Cd Length: 127  Bit Score: 222.29  E-value: 5.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858819    26 TDFSSLPPFLPQTPSsCPMTYSYStSSLPQVQSVREVSFRDYAIDTSSKWHSRGNLPHCYATEDMVHRECLSNPGTLGDM 105
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYS-SNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTRGEM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 18858819   106 LSKNNSVLYHSNSSHT---SNVYGSVGRNGVLPQAFDQFFETAYGNVEN 151
Cdd:pfam12045  79 LFKNESVYGHHHHGSShpsSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
212-268 5.72e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 5.72e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819   212 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 268
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-151 5.98e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 222.29  E-value: 5.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858819    26 TDFSSLPPFLPQTPSsCPMTYSYStSSLPQVQSVREVSFRDYAIDTSSKWHSRGNLPHCYATEDMVHRECLSNPGTLGDM 105
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYS-SNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTRGEM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 18858819   106 LSKNNSVLYHSNSSHT---SNVYGSVGRNGVLPQAFDQFFETAYGNVEN 151
Cdd:pfam12045  79 LFKNESVYGHHHHGSShpsSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
212-268 5.72e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 5.72e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819   212 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 268
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 211-267 3.27e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 89.62  E-value: 3.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819    211 TRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 267
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 212-268 1.51e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 85.37  E-value: 1.51e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819 212 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 268
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
197-271 2.48e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 2.48e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18858819 197 NNEDKFSGSSNGQKTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNR 271
Cdd:COG5576  37 SEMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-151 5.98e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 222.29  E-value: 5.98e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858819    26 TDFSSLPPFLPQTPSsCPMTYSYStSSLPQVQSVREVSFRDYAIDTSSKWHSRGNLPHCYATEDMVHRECLSNPGTLGDM 105
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYS-SNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTRGEM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 18858819   106 LSKNNSVLYHSNSSHT---SNVYGSVGRNGVLPQAFDQFFETAYGNVEN 151
Cdd:pfam12045  79 LFKNESVYGHHHHGSShpsSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
212-268 5.72e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 5.72e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819   212 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 268
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 211-267 3.27e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 89.62  E-value: 3.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819    211 TRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 267
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 212-268 1.51e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 85.37  E-value: 1.51e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858819 212 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 268
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
197-271 2.48e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 2.48e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18858819 197 NNEDKFSGSSNGQKTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNR 271
Cdd:COG5576  37 SEMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH