BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 28571112 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 28571112 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112     33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*.
gi 28571112    111 AVQGLT 116
Cdd:smart00225  81 QIPGLV 86

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 28571112   478 KCDMCNKNFKNKYSLREHIRIsH 500
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRT-H 23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 28571112 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112     33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*.
gi 28571112    111 AVQGLT 116
Cdd:smart00225  81 QIPGLV 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  14 YLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKEN--PHPHPVIIFKFIKFEDLNSIIEFMYQG 91
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100
                ....*....|....*....|....*..
gi 28571112  92 EVNVQQEALQSFLQTAELLAVQGLTAE 118
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIKLVLKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  17 HLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFMYQGE 92
Cdd:cd18265   9 RILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFgghlKES-RQAVVEIQK-VSAAAMEVLLDYMYGGG 86

                        90       100
                ....*....|....*....|...
gi 28571112  93 VNVQQEALQSFLQTAELLAVQGL 115
Cdd:cd18265  87 LRIQEDNVESVLEASDLLQVSKL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHP----VIIFKFIKFEDLNSIIEFMYQGEV 93
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQI 80

                        90
                ....*....|....*..
gi 28571112  94 NVQQEALQSFLQTAELL 110
Cdd:cd18245  81 KLSEDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  25 HRLNDD-FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFK--ENPHPHPVII-FKFIKFEDLNSIIEFMYQGEVNVQQEAL 100
Cdd:cd18293   8 RQQNSGvFCDVLLQAEGESVPAHCCVLSACSPYLTERLSsePPPAGQKVVLeLQGLKAHTLLKLVDFLYTSELEVSSEEA 87

                        90       100       110
                ....*....|....*....|....*....|
gi 28571112 101 QSFLQTAELLAVQGLTAEEKEKPQIPVAPL 130
Cdd:cd18293  88 QDVLAAARRLQISELESLCLEGGKLVKAPP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIfKFIKFEDLNSIIEFMYQGEV 93
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFcndlKEK-YEEKIII-KGVDAETMQILLDYTYTSKV 88

                        90
                ....*....|....*.
gi 28571112  94 NVQQEALQSFLQTAEL 109
Cdd:cd18236  89 LITKQNVQRVLEAASL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  22 LDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKeNPHPHP---VIIFKFIKFEDLNSIIEFMYQGEVNVQQE 98
Cdd:cd18253   9 FNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC-NDHRESremLVEINGILAEAMDCFLQYVYTGKVKITTE 87

                        90
                ....*....|....*..
gi 28571112  99 ALQSFLQTAELLAVQGL 115
Cdd:cd18253  88 NVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  22 LDNHRLND-DFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQGEV---NV 95
Cdd:cd18297   2 IDPHYVNNpEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSteAQTPVIEIPDIRYDIFQLMMQYLYTGGVeslDV 81

                        90       100
                ....*....|....*....|
gi 28571112  96 QQEALQSFLQTAELLAVQGL 115
Cdd:cd18297  82 AQDDALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENPHPHpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAE 108
Cdd:cd18235  23 DVILVADGVEIPAHRVVLASCSPYFHAMFtgdlSESRANR--VTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAAN 100

                ..
gi 28571112 109 LL 110
Cdd:cd18235 101 LL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  10 RWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFK---ENPHPHPVIIFKfIKFEDLNSIIE 86
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmREAHQKEVELVG-ASYIGLKAVID 82

                        90       100
                ....*....|....*....|....*.
gi 28571112  87 FMYQGEVNVQQEALQSFLQTAELLAV 112
Cdd:cd18266  83 FLYSSELPLDGGNIDYVLETAHLLQI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  17 HLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFMYQGE 92
Cdd:cd18250   7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFagelRES-RADRVVLHG-VSAEILGLLLDFSYTGR 84

                        90
                ....*....|....*...
gi 28571112  93 VNVQQEALQSFLQTAELL 110
Cdd:cd18250  85 VTVTQDNVEALLRAADLF 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF---------KEnphphpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSF 103
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFthdmveskqDE-------ITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

                        90
                ....*....|
gi 28571112 104 LQTAELLAVQ 113
Cdd:cd18247  94 LVGASFLQLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF-------KENPhphpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQ 105
Cdd:cd18234   3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFtndvreaTEEE-----IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLA 77

                ....*
gi 28571112 106 TAELL 110
Cdd:cd18234  78 TACLL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  13 NYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFM 88
Cdd:cd18256   2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggmSES-SKDVVQIHG-VEPDIFHILLDFI 79

                        90       100
                ....*....|....*....|..
gi 28571112  89 YQGEVNVQQEALQSFLQTAELL 110
Cdd:cd18256  80 YTGVVEVTVSNVQELLVAADML 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  21 SLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPH-PHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEA 99
Cdd:cd18212  13 NFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEvGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKS 92

                        90
                ....*....|....*.
gi 28571112 100 LQSFLQTAELLAVQGL 115
Cdd:cd18212  93 LEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  21 SLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYF-KEIFKENPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEA 99
Cdd:cd18277  17 SLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAELNITLPEEVTVKGFEPLIQFAYTAKLILSKDN 96

                        90
                ....*....|....*.
gi 28571112 100 LQSFLQTAELLAVQGL 115
Cdd:cd18277  97 VDEVCKCVEFLSVHNI 112

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112   31 FVDVSLCV--DGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIfkFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAE 108
Cdd:PHA03098   9 FCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINL--NIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                 ....
gi 28571112  109 LLAV 112
Cdd:PHA03098  87 YLII 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  14 YLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHpVIIFKFIKFEDLNSIIEFMYQGEV 93
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNC-LVLPSVIEAAAFENLLQLIYSGRL 79

                        90
                ....*....|....
gi 28571112  94 NVQQEALQSFLQTA 107
Cdd:cd18200  80 TLCMDALPSHLLVA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  17 HLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIFKFIK-FEDLNSIIEFMYQGEVNV 95
Cdd:cd18233   4 HLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKnVGGIGQILDFMYTSHLDL 83

                        90
                ....*....|....*...
gi 28571112  96 QQEALQSFLQTAELLAVQ 113
Cdd:cd18233  84 NQDNVQVMLDIAQCLQVQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  21 SLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIFK--FIKFEDLNSIIEFMYQGEVNVQQE 98
Cdd:cd18198  15 GLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEidFVSPEALTALLEFAYTATLTVSTA 94

                        90
                ....*....|....*....
gi 28571112  99 ALQSFLQTAELLAVQGLTA 117
Cdd:cd18198  95 NVGDILSAARLLEIPCVSH 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKEN--PHPHPVIIFKFIKFEDLNSIIEFMYQGEVNV 95
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfrESSQAKVDLKGIDSDVLDQIVDYVYTGEILI 89

                        90
                ....*....|....*
gi 28571112  96 QQEALQSFLQTAELL 110
Cdd:cd18268  90 TRDNVLPLMEAASML 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  13 NYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQ 90
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTlaDQPYVYEIDFVTPEALSAILEFAYT 86

                        90       100
                ....*....|....*....|...
gi 28571112  91 GEVNVQQEALQSFLQTAELLAVQ 113
Cdd:cd18328  87 STLTITTSNVKHILNAAQMLEIQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  12 NNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENPHPHPVIIFKFIKFEDLNSIIEF 87
Cdd:cd18201   2 NSYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcftnKESCDQTTVTHLDVVAVQGFSVILDF 81

                        90       100
                ....*....|....*....|....*....
gi 28571112  88 MYQGE-VNVQQEALQ-----SFLQTAELL 110
Cdd:cd18201  82 MYSGNlVLTSQNAIEvmsvaSYLQMTEVV 110

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28571112  29 DDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIFKFIKF----EDLNSIIEFMYQGEVNVQQE 98
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpsrQAFDSLLRYIYYGDVTMPPE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  26 RLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKEN--PHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSF 103
Cdd:cd18259  27 RSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEAL 106

                ....*..
gi 28571112 104 LQTAELL 110
Cdd:cd18259 107 IRTSNRL 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571112  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF-------KENPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSF 103
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfaesEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                        90
                ....*....|..
gi 28571112 104 LQTAELLAVQGL 115
Cdd:cd18296  97 LYVADMYLLPGL 108