|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
310-720 |
6.24e-69 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 236.21 E-value: 6.24e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 310 RKRHNITLTSWnmRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGI 389
Cdd:PTZ00110 112 RKEKEITIIAG--ENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAI 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 390 MKMhNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGN-----SQWQGHAECDLLVASAGRLLQMI 464
Cdd:PTZ00110 190 VHI-NAQPLLRYGDGPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGvpkrgQIYALRRGVEILIACPGRLIDFL 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 465 DnkKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTA-IRVGEINNIG 543
Cdd:PTZ00110 269 E--SNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEEPVhVNVGSLDLTA 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 544 VRlqNIRQRVEVVNGLSKVERLMKELTAIYDTSDipgKVVIYVKRQKVVEELVDLIR-NCVPCEGIHGGRTAQENQGIIH 622
Cdd:PTZ00110 347 CH--NIKQEVFVVEEHEKRGKLKMLLQRIMRDGD---KILIFVETKKGADFLTKELRlDGWPALCIHGDKKQEERTWVLN 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 623 DFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGcLSYNRNCEvISFFTMANYKLVTEVVDFLKIC 702
Cdd:PTZ00110 422 EFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTG-RAGAKGAS-YTFLTPDKYRLARDLVKVLREA 499
|
410
....*....|....*...
gi 386763933 703 KQEIGPHLLQLAEEKMFG 720
Cdd:PTZ00110 500 KQPVPPELEKLSNERSNG 517
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
331-670 |
9.13e-54 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 191.13 E-value: 9.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 331 SFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRglmqhKKGPIVLIL 410
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSR-----PRAPQALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 411 VDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNID 485
Cdd:COG0513 78 APTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRalkrgVDIVVATPGRLLDLIERGA--LDLSGVETLVLDEAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 486 RMIDVGLEGNICRLLCRLRPHAQ-LIVSSTsWSSNLKRMANKFLGQYTAIRVGEINNIgvrLQNIRQRVEVVNGLSKVEr 564
Cdd:COG0513 156 RMLDMGFIEDIERILKLLPKERQtLLFSAT-MPPEIRKLAKRYLKNPVRIEVAPENAT---AETIEQRYYLVDKRDKLE- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 565 LMKELTAIYDtsdiPGKVVIYVKRQKVVEELVD-LIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLD 643
Cdd:COG0513 231 LLRRLLRDED----PERAIVFCNTKRGADRLAEkLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGID 306
|
330 340
....*....|....*....|....*..
gi 386763933 644 VPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:COG0513 307 IDDVSHVINYDLPEDPEDYVHRIGRTG 333
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
308-537 |
1.77e-48 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 170.96 E-value: 1.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 308 NYRKRHNITLTSwnmRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLP 387
Cdd:cd18049 5 QYRRSKEITVRG---HNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 388 GIMKMhNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQwQGHAECDL------LVASAGRLL 461
Cdd:cd18049 82 AIVHI-NHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAP-KGPQIRDLergveiCIATPGRLI 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763933 462 QMIDNKKhvVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVG 537
Cdd:cd18049 160 DFLEAGK--TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
341-534 |
3.10e-46 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 163.31 E-value: 3.10e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRgLMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQP-PLERGDGPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVGLEGN 495
Cdd:cd17966 80 QQEANKFGGSSRLRNTCVYGGAPKGPQIRdlrrgVEICIATPGRLIDFLDQGK--TNLRRVTYLVLDEADRMLDMGFEPQ 157
|
170 180 190
....*....|....*....|....*....|....*....
gi 386763933 496 ICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAI 534
Cdd:cd17966 158 IRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
341-528 |
6.43e-43 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 153.75 E-value: 6.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRglMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEP--KKKGRGPQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVGLEGN 495
Cdd:cd00268 79 AEVARKLGKGTGLKVAAIYGGAPIKKQIEalkkgPDIVVGTPGRLLDLIERGK--LDLSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190
....*....|....*....|....*....|...
gi 386763933 496 ICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd00268 157 VEKILSALPKDRQTLLFSATLPEEVKELAKKFL 189
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
309-537 |
2.62e-41 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 152.09 E-value: 2.62e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 309 YRKRHNITLTSwnmRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPG 388
Cdd:cd18050 44 LRRKKEITIRG---VGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 389 IMKMhNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQwQGHAECDL------LVASAGRLLQ 462
Cdd:cd18050 121 IVHI-NHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAP-KGPQIRDLergveiCIATPGRLID 198
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763933 463 MIDNKKhvVELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVG 537
Cdd:cd18050 199 FLEAGK--TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
323-528 |
2.78e-39 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 144.83 E-value: 2.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 323 RNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLmQHK 402
Cdd:cd17953 5 KDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV-KPG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 403 KGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGH-AE----CDLLVASAGRllqMID----NKKHVVEL 473
Cdd:cd17953 84 EGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQiAElkrgAEIVVCTPGR---MIDiltaNNGRVTNL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 386763933 474 ERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17953 161 RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVL 215
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
330-706 |
4.61e-39 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 150.73 E-value: 4.61e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 330 LSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPgIMKMHNQRGlmQHKKG--PI- 406
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLP-LLQHLITRQ--PHAKGrrPVr 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 407 VLILVDCREAAVMVQREVLYYTNPLELRTHCLLG----NSQWQG-HAECDLLVASAGRLLQMidNKKHVVELERCTYLVL 481
Cdd:PRK10590 78 ALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGgvsiNPQMMKlRGGVDVLVATPGRLLDL--EHQNAVKLDQVEILVL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 482 DNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGvrlQNIRQRVEVVNGLSK 561
Cdd:PRK10590 156 DEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTAS---EQVTQHVHFVDKKRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 562 VERLmkeltaiydtSDIPGK-----VVIYVKRQKVVEELVD-LIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVAT 635
Cdd:PRK10590 233 RELL----------SQMIGKgnwqqVLVFTRTKHGANHLAEqLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVAT 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386763933 636 QMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGclSYNRNCEVISFFTMANYKLVTevvDFLKICKQEI 706
Cdd:PRK10590 303 DIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTG--RAAATGEALSLVCVDEHKLLR---DIEKLLKKEI 368
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
341-528 |
9.14e-37 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 136.78 E-value: 9.14e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLmQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQREL-EKGEGPIAVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVLYYTNPLELRTHCLLGN-SQWQGHAE----CDLLVASAGRLLQMIdnKKHVVELERCTYLVLDNIDRMIDVGLEGN 495
Cdd:cd17952 80 YLEAKKFGKAYNLRVVAVYGGgSKWEQAKAlqegAEIVVATPGRLIDMV--KKKATNLQRVTYLVLDEADRMFDMGFEYQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 386763933 496 ICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17952 158 VRSIVGHVRPDRQTLLFSATFKKKIEQLARDIL 190
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
549-684 |
2.94e-36 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 132.63 E-value: 2.94e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 549 IRQRVEVVNGLSKVERLMKELtaiyDTSDIPGKVVIYVKRQKVVEELVDLIRNC-VPCEGIHGGRTAQENQGIIHDFGTG 627
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLL----LEKLKPGKAIIFVNTKKRVDRLAELLEELgIKVAALHGDLSQEERERALKKFRSG 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 386763933 628 AYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLsyNRNCEVISFF 684
Cdd:cd18787 77 KVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRA--GRKGTAITFV 131
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
341-528 |
2.26e-35 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 132.59 E-value: 2.26e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVLYYTNPlELRTHCLLGNSQWQGHAE-----CDLLVASAGRL--LQMIDnkkhVVELERCTYLVLDNIDRMIDVGLE 493
Cdd:cd17958 81 EAECSKYSYK-GLKSVCVYGGGNRNEQIEdlskgVDIIIATPGRLndLQMNN----VINLKSITYLVLDEADRMLDMGFE 155
|
170 180 190
....*....|....*....|....*....|....*
gi 386763933 494 GNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17958 156 PQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYL 190
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
326-700 |
6.79e-33 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 133.76 E-value: 6.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 326 PEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQR-GLMQHKKG 404
Cdd:PLN00206 117 PPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRsGHPSEQRN 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 405 PIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIdnKKHVVELERCTYL 479
Cdd:PLN00206 197 PLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYriqqgVELIVGTPGRLIDLL--SKHDIELDNVSVL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 480 VLDNIDRMIDVGLEGNICRLLcRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVEVVNGL 559
Cdd:PLN00206 275 VLDEVDCMLERGFRDQVMQIF-QALSQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKK 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 560 SKVERLMKEltaiydTSDIPGKVVIYVKRQKVVEELVDLIRNC--VPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQM 637
Cdd:PLN00206 354 QKLFDILKS------KQHFKPPAVVFVSSRLGADLLANAITVVtgLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGV 427
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386763933 638 TSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSynRNCEVISFFTMANYKLVTEVVDFLK 700
Cdd:PLN00206 428 LGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMG--EKGTAIVFVNEEDRNLFPELVALLK 488
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
342-670 |
1.92e-31 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 127.75 E-value: 1.92e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 342 LQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGImkmhnqrglmQH-------KKGPI-VLILVDC 413
Cdd:PRK11192 13 LEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPAL----------QHlldfprrKSGPPrILILTPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 414 REAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAEC-----DLLVASAGRLLQMIDNKK---HVVELerctyLVLDNID 485
Cdd:PRK11192 83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVfsenqDIVVATPGRLLQYIKEENfdcRAVET-----LILDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 486 RMIDVGLEGNICRLL--CRLRPHAqLIVSSTSWSSNLKRMANKFLgqytairvgeinnigvrlqniRQRVEVVNGLSKVE 563
Cdd:PRK11192 158 RMLDMGFAQDIETIAaeTRWRKQT-LLFSATLEGDAVQDFAERLL---------------------NDPVEVEAEPSRRE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 564 RlMKELTAIYDTSDIPGKV---------------VIYVKRQKVVEELVDLIRNcvpcEGIHG----GRTAQE--NQGIIH 622
Cdd:PRK11192 216 R-KKIHQWYYRADDLEHKTallchllkqpevtrsIVFVRTRERVHELAGWLRK----AGINCcyleGEMVQAkrNEAIKR 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 386763933 623 dFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:PRK11192 291 -LTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTG 337
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
341-493 |
1.35e-29 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 117.04 E-value: 1.35e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKK--GPIVLILVDCREAAV 418
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKddGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 419 MVQREVLYYTNPLELRTHCLLGnsqwqGHAE----------CDLLVASAGRLLQMIDNkkHVVELERCTYLVLDNIDRMI 488
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVG-----GHSIeeqafslrngCEILIATPGRLLDCLER--RLLVLNQCTYVVLDEADRMI 153
|
....*
gi 386763933 489 DVGLE 493
Cdd:cd17945 154 DMGFE 158
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
322-683 |
1.71e-29 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 123.91 E-value: 1.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 322 MRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQH 401
Cdd:PRK04537 1 MSDKPLTDLTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 402 K-KGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIdnKKH-VVELE 474
Cdd:PRK04537 81 KpEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQREllqqgVDVIIATPGRLIDYV--KQHkVVSLH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 475 RCTYLVLDNIDRMIDVGLEGNICRLLCRL--RPHAQLIVSSTSWSSNLKRMANKFLGQYTAIrVGEINNIGVrlQNIRQR 552
Cdd:PRK04537 159 ACEICVLDEADRMFDLGFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKL-VVETETITA--ARVRQR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 553 VEVVNGLSKVERLMKELtaiydtSDIPG-KVVIYVKRQKVVEELVDLIRNCVPCEGIHGGRTAQEN-QGIIHDFGTGAYN 630
Cdd:PRK04537 236 IYFPADEEKQTLLLGLL------SRSEGaRTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKrESLLNRFQKGQLE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 386763933 631 IIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSynRNCEVISF 683
Cdd:PRK04537 310 ILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLG--EEGDAISF 360
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
341-670 |
8.76e-28 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 117.71 E-value: 8.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKG-PIVLILVDCREAAVM 419
Cdd:PRK01297 98 LMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGePRALIIAPTRELVVQ 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 420 VQREVLYYTNPLELRTHCLLGNSQWQGHAE------CDLLVASAGRLLQMidNKKHVVELERCTYLVLDNIDRMIDVGLE 493
Cdd:PRK01297 178 IAKDAAALTKYTGLNVMTFVGGMDFDKQLKqlearfCDILVATPGRLLDF--NQRGEVHLDMVEVMVLDEADRMLDMGFI 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 494 GNIcRLLCRLRPHA---QLIVSSTSWSSNLKRMANKFLgqyTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVeRLMKELT 570
Cdd:PRK01297 256 PQV-RQIIRQTPRKeerQTLLFSATFTDDVMNLAKQWT---TDPAIVEIEPENVASDTVEQHVYAVAGSDKY-KLLYNLV 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 571 aiydTSDIPGKVVIYVKRQKVVEELVD-LIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRY 649
Cdd:PRK01297 331 ----TQNPWERVMVFANRKDEVRRIEErLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISH 406
|
330 340
....*....|....*....|.
gi 386763933 650 VINYDFPDNIDKYVQRMSRTG 670
Cdd:PRK01297 407 VINFTLPEDPDDYVHRIGRTG 427
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
331-539 |
3.30e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 110.27 E-value: 3.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 331 SFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKM----HNQRGLMQHKKGPI 406
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgPPSVGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 407 VLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDnkKHVVELERCTYLVL 481
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLqllrgCDILVATPGRLVDFIE--RGRISLSSIKFLVL 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386763933 482 DNIDRMIDVGLEGNICRLL--CRLRPHAQ---LIVSSTsWSSNLKRMANKFLGQYTAIRVGEI 539
Cdd:cd17967 159 DEADRMLDMGFEPQIRKIVehPDMPPKGErqtLMFSAT-FPREIQRLAADFLKNYIFLTVGRV 220
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
354-522 |
9.65e-26 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 104.25 E-value: 9.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 354 TPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGImkmhnqRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLEL 433
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPAL------EALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 434 RTHCLLGNS----QWQGHAECDLLVASAGRLLQMIDNKKhvvELERCTYLVLDNIDRMIDVGLEGNICRLLCRLRPHAQL 509
Cdd:pfam00270 75 KVASLLGGDsrkeQLEKLKGPDILVGTPGRLLDLLQERK---LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQI 151
|
170
....*....|...
gi 386763933 510 IVSSTSWSSNLKR 522
Cdd:pfam00270 152 LLLSATLPRNLED 164
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
323-539 |
8.58e-25 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 104.28 E-value: 8.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 323 RNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHK 402
Cdd:cd18052 36 RNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSF 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 403 KG---PIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELE 474
Cdd:cd18052 116 SEvqePQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRqiekgCHILVATPGRLLDFIGRGK--ISLS 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 475 RCTYLVLDNIDRMIDVGLEGNICRLLCRL----RPHAQLIVSSTSWSSNLKRMANKFLGQ-YTAIRVGEI 539
Cdd:cd18052 194 KLKYLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLKEdYLFLTVGRV 263
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
324-685 |
1.32e-24 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 106.83 E-value: 1.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 324 NLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQhkk 403
Cdd:PTZ00424 22 NYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ--- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 404 gpiVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDnKKHVvELERCTY 478
Cdd:PTZ00424 99 ---ALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINklkagVHMVVGTPGRVYDMID-KRHL-RVDDLKL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 479 LVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVgeiNNIGVRLQNIRQRVEVVNg 558
Cdd:PTZ00424 174 FILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILV---KKDELTLEGIRQFYVAVE- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 559 lsKVERLMKELTAIYDTSDIPgKVVIYVKRQKVVEELVDLIRNC-VPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQM 637
Cdd:PTZ00424 250 --KEEWKFDTLCDLYETLTIT-QAIIYCNTRRKVDYLTKKMHERdFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 386763933 638 TSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGclSYNRNCEVISFFT 685
Cdd:PTZ00424 327 LARGIDVQQVSLVINYDLPASPENYIHRIGRSG--RFGRKGVAINFVT 372
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
345-544 |
5.40e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 100.26 E-value: 5.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 345 LEDQGYDGPTPIQAQTWSIAKEGKNIVMISGK-GTGKTLGYLLPGIMKMHNQrglmqhkKGPIVLILVDCREAAVMVQRE 423
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPtGSGKTLAALLPALEALKRG-------KGGRVLVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 424 VLYYTNPLELRTHCLLGNSQWQGHAE------CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVGLEGNIC 497
Cdd:smart00487 74 LKKLGPSLGLKVVGLYGGDSKREQLRklesgkTDILVTTPGRLLDLLENDK--LSLSNVDLVILDEAHRLLDGGFGDQLE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 386763933 498 RLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGV 544
Cdd:smart00487 152 KLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
331-670 |
1.28e-22 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 103.00 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 331 SFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPgimKMHNqrgLMQHKKGPIVLIL 410
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLP---LLHN---LDPELKAPQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 411 VDCREAAVMVQREVLYYTNPLE-LRTHCLLGNSQW--------QGHaecDLLVASAGRLLQMIdnKKHVVELERCTYLVL 481
Cdd:PRK11634 81 APTRELAVQVAEAMTDFSKHMRgVNVVALYGGQRYdvqlralrQGP---QIVVGTPGRLLDHL--KRGTLDLSKLSGLVL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 482 DNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGeiNNIGVRlQNIRQRVEVVNGLSK 561
Cdd:PRK11634 156 DEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQ--SSVTTR-PDISQSYWTVWGMRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 562 VERLMKELTA-IYDTSdipgkvVIYVKRQKVVEELVD-LIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTS 639
Cdd:PRK11634 233 NEALVRFLEAeDFDAA------IIFVRTKNATLEVAEaLERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAA 306
|
330 340 350
....*....|....*....|....*....|.
gi 386763933 640 NCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:PRK11634 307 RGLDVERISLVVNYDIPMDSESYVHRIGRTG 337
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
560-670 |
4.35e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 91.50 E-value: 4.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 560 SKVERLMKELTaiydtSDIPGKVVIYVKRQKVVEELVDLIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTS 639
Cdd:pfam00271 1 EKLEALLELLK-----KERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|.
gi 386763933 640 NCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAG 106
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
341-496 |
9.81e-22 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 93.94 E-value: 9.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLM--QHKKGPIVLILVDCREAAV 418
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLpfIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 419 MVQREVLYYTNPLE------LRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRM 487
Cdd:cd17951 81 QTHEVIEYYCKALQeggypqLRCLLCIGGMSVKEQLEvirkgVHIVVATPGRLMDMLNKKK--INLDICRYLCLDEADRM 158
|
....*....
gi 386763933 488 IDVGLEGNI 496
Cdd:cd17951 159 IDMGFEEDI 167
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
324-539 |
4.72e-21 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 93.18 E-value: 4.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 324 NLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLP----------GIMKMH 393
Cdd:cd18051 15 NCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPilsqiyeqgpGESLPS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 394 NQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKK 468
Cdd:cd18051 95 ESGYYGRRKQYPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRdlergCHLLVATPGRLVDMLERGK 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763933 469 hvVELERCTYLVLDNIDRMIDVGLEGNICRLL--CRLRPHA--QLIVSSTSWSSNLKRMANKFLGQYTAIRVGEI 539
Cdd:cd18051 175 --IGLDYCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPTGerQTLMFSATFPKEIQMLARDFLDNYIFLAVGRV 247
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
341-528 |
1.03e-20 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 90.69 E-value: 1.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMhnqrglMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRC------LTEHRNPSALILTPTRELAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREV-LYYTNPLELRTHCLLGN-------SQWQGHAEcdLLVASAGRLLQMIdnKKHVVELERCTYLVLDNIDRMIDVGL 492
Cdd:cd17962 75 EDQAkELMKGLPPMKTALLVGGlplppqlYRLQQGVK--VIIATPGRLLDIL--KQSSVELDNIKIVVVDEADTMLKMGF 150
|
170 180 190
....*....|....*....|....*....|....*.
gi 386763933 493 EGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17962 151 QQQVLDILENISHDHQTILVSATIPRGIEQLAGQLL 186
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
331-514 |
6.67e-20 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 88.52 E-value: 6.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 331 SFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQrglmQHKKGPIVLIL 410
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAH----SPTVGARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 411 VDCREAAVM---VQREVLYYTNpleLRTHCLLG----NSQWQGHAEC-DLLVASAGRLLQmidnkkHVVE----LERCTY 478
Cdd:cd17959 78 SPTRELALQtlkVTKELGKFTD---LRTALLVGgdslEEQFEALASNpDIIIATPGRLLH------LLVEmnlkLSSVEY 148
|
170 180 190
....*....|....*....|....*....|....*..
gi 386763933 479 LVLDNIDRMIDVGLEGNICRLLCRLRPHAQ-LIVSST 514
Cdd:cd17959 149 VVFDEADRLFEMGFAEQLHEILSRLPENRQtLLFSAT 185
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
341-491 |
7.26e-20 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 89.22 E-value: 7.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTW-SIAKEGKNIVMISGKGTGKTLGYLLP---GIMKMHNQRGLMQHKKGPIVLILVDCREA 416
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALpAAIRDGKDVIGAAETGSGKTLAFGIPileRLLSQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 417 AVMVQR---EVLYYTNpleLRTHCLLGN--SQWQG---HAECDLLVASAGRLLQMIDNK-KHVVELERCTYLVLDNIDRM 487
Cdd:cd17946 81 AVQVKDhlkAIAKYTN---IKIASIVGGlaVQKQErllKKRPEIVVATPGRLWELIQEGnEHLANLKSLRFLVLDEADRM 157
|
....
gi 386763933 488 IDVG 491
Cdd:cd17946 158 LEKG 161
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
341-492 |
1.31e-19 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 87.64 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRglmqHKKGPIVLILVDCREAAVMV 420
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPR----KKKGLRALILAPTRELASQI 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386763933 421 QREVLYYTNPLELRThCLLGNSQWQGHAE-------CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVGL 492
Cdd:cd17957 77 YRELLKLSKGTGLRI-VLLSKSLEAKAKDgpksitkYDILVSTPLRLVFLLKQGP--IDLSSVEYLVLDEADKLFEPGF 152
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
341-514 |
2.55e-19 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 86.54 E-value: 2.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGImkmhnQRGLMQHKKGPI--VLILVDCREAAV 418
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-----ERLLYRPKKKAAtrVLVLVPTRELAM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 419 MVQ---REVLYYTNPlelrTHCLL--GNSQWQGHAEC----DLLVASAGRLLQMIDNKKHvVELERCTYLVLDNIDRMID 489
Cdd:cd17947 76 QCFsvlQQLAQFTDI----TFALAvgGLSLKAQEAALrarpDIVIATPGRLIDHLRNSPS-FDLDSIEILVLDEADRMLE 150
|
170 180
....*....|....*....|....*..
gi 386763933 490 VGLEGNICRLLcRLRPHAQ--LIVSST 514
Cdd:cd17947 151 EGFADELKEIL-RLCPRTRqtMLFSAT 176
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
341-503 |
2.94e-19 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 86.48 E-value: 2.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMhnQRGLMQHKKGPIV-LILVDCREAAVM 419
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL--LKRKANLKKGQVGaLIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 420 VQREVLYYTNPLELRTHCLL---GNSQWQGHAE-----CDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVG 491
Cdd:cd17960 79 IYEVLQSFLEHHLPKLKCQLligGTNVEEDVKKfkrngPNILVGTPGRLEELLSRKADKVKVKSLEVLVLDEADRLLDLG 158
|
170
....*....|..
gi 386763933 492 LEGNICRLLCRL 503
Cdd:cd17960 159 FEADLNRILSKL 170
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
332-530 |
1.92e-18 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 84.27 E-value: 1.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 332 FERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQhkkgpiVLILV 411
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQ------ALILV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 412 DCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQG-----HAECDLLVASAGRLLQMIDnkKHVVELERCTYLVLDNIDR 486
Cdd:cd17940 75 PTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDdimrlYQTVHVLVGTPGRILDLAK--KGVADLSHCKTLVLDEADK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 386763933 487 MIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQ 530
Cdd:cd17940 153 LLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHN 196
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
341-526 |
1.19e-17 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 82.80 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHK-KGPIVLILVDCREAAVM 419
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPfNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 420 VQREVLYYTNPLELRTHCLLGnsqwqGH----------AECDLLVASAGRLLQMIdnKKHVVELERCTYLVLDNIDRMID 489
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITG-----GRtkrqirnphfEEVDILVATPGALSKLL--TSRIYSLEQLRHLVLDEADTLLD 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 386763933 490 VGLEGNICRLLCR-------------LRPHAQLIVSSTSWSSNLKRMANK 526
Cdd:cd17948 154 DSFNEKLSHFLRRfplasrrsentdgLDPGTQLVLVSATMPSGVGEVLSK 203
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
349-523 |
2.09e-17 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 81.48 E-value: 2.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 349 GYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMV----QREV 424
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQIyevlEKLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 425 LYYTNpleLRTHCLLGNSqwQGHAE-------CDLLVASAGRLLQMIDNKKhVVELERCTYLVLDNIDRMIDVGLEGNIC 497
Cdd:cd17949 90 KPFHW---IVPGYLIGGE--KRKSEkarlrkgVNILIATPGRLLDHLKNTQ-SFDVSNLRWLVLDEADRLLDMGFEKDIT 163
|
170 180
....*....|....*....|....*.
gi 386763933 498 RLLCRLRPHAQLIVSSTSWSSNLKRM 523
Cdd:cd17949 164 KILELLDDKRSKAGGEKSKPSRRQTV 189
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
337-530 |
2.99e-17 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 81.09 E-value: 2.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 337 FNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGK-GTGKTLGYLLPGIMKMhnQRGLMQHKKGPI-VLILVDCR 414
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKtGTGKTLAFLLPAIQSL--LNTKPAGRRSGVsALIISPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 415 EAAVMVQRE---VLYYtnPLELRTHCLLG----NSQWQGH--AECDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNID 485
Cdd:cd17964 79 ELALQIAAEakkLLQG--LRKLRVQSAVGgtsrRAELNRLrrGRPDILVATPGRLIDHLENPGVAKAFTDLDYLVLDEAD 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 386763933 486 RMIDVGLEGNICRLLCRLRPHAQ-----LIVSSTSwSSNLKRMANKFLGQ 530
Cdd:cd17964 157 RLLDMGFRPDLEQILRHLPEKNAdprqtLLFSATV-PDEVQQIARLTLKK 205
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
341-528 |
2.37e-16 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 78.39 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTRELAQQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVlyytnpLELRTHC--------------------LLGNSQwqghaecDLLVASAGRLLQMIDNKKHVVeLERCTYLV 480
Cdd:cd17961 85 SKVL------EQLTAYCrkdvrvvnlsasssdsvqraLLAEKP-------DIVVSTPARLLSHLESGSLLL-LSTLKYLV 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 386763933 481 LDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17961 151 IDEADLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVL 198
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
331-500 |
2.58e-16 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 78.13 E-value: 2.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 331 SFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPgIMkmhnQRgLMQHKKGPIVLIL 410
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALP-IL----QA-LLENPQRFFALVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 411 VDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAeCDL------LVASAGRLLQMIDNKKHvVELERCTYLVLDNI 484
Cdd:cd17954 75 APTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQA-IALakkphvIVATPGRLVDHLENTKG-FSLKSLKFLVMDEA 152
|
170
....*....|....*.
gi 386763933 485 DRMIDVGLEGNICRLL 500
Cdd:cd17954 153 DRLLNMDFEPEIDKIL 168
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
336-670 |
3.03e-16 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 81.56 E-value: 3.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 336 GFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPgimKMHNqrgLMQH-------KKGPIVL 408
Cdd:PRK04837 14 ALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTA---TFHY---LLSHpapedrkVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 409 ILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLlqmID-NKKHVVELERCTYLVLD 482
Cdd:PRK04837 88 IMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKvlesgVDILIGTTGRL---IDyAKQNHINLGAIQVVVLD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 483 NIDRMIDVGLEGNIcRLLCRLRPHAQ----LIVSSTsWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQnirqrvEVVNG 558
Cdd:PRK04837 165 EADRMFDLGFIKDI-RWLFRRMPPANqrlnMLFSAT-LSYRVRELAFEHMNNPEYVEVEPEQKTGHRIK------EELFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 559 LSKVERLMKELTAIYDtsDIPGKVVIYVKRQKVveelvdlirncvpCEGIHG-------------GRTAQENQ-GIIHDF 624
Cdd:PRK04837 237 PSNEEKMRLLQTLIEE--EWPDRAIIFANTKHR-------------CEEIWGhlaadghrvglltGDVAQKKRlRILEEF 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 386763933 625 GTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:PRK04837 302 TRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTG 347
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
342-491 |
3.76e-16 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 77.58 E-value: 3.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 342 LQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQ 421
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVT 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763933 422 REVLYYTNplELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVG 491
Cdd:cd17944 82 KDFKDITR--KLSVACFYGGTPYQQQIFairngIDILVGTPGRIKDHLQNGR--LDLTKLKHVVLDEVDQMLDMG 152
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
341-535 |
7.82e-16 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 76.53 E-value: 7.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMkmhnqrGLMQHKKGPIVLILVDCREAAVMV 420
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALE------SLDLERRHPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QrEVLYYTNPL--ELRTHCLLGNSQWQGH----AECDLLVASAGRLLQMIdnKKHVVELERCTYLVLDNIDRMIDVGLEG 494
Cdd:cd17943 75 H-DVFKKIGKKleGLKCEVFIGGTPVKEDkkklKGCHIAVGTPGRIKQLI--ELGALNVSHVRLFVLDEADKLMEGSFQK 151
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 386763933 495 NICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIR 535
Cdd:cd17943 152 DVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
593-670 |
5.43e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 70.32 E-value: 5.43e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386763933 593 EELVDLIRNC-VPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:smart00490 1 EELAELLKELgIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
332-528 |
2.22e-14 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 72.64 E-value: 2.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 332 FERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGImkmhnQRgLMQHKKGPIVLILV 411
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPIL-----QR-LSEDPYGIFALVLT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 412 DCREAAVMVQREVLYYTNPLELRTHCLLGN----SQWQGHAEC-DLLVASAGRLLQMIDNKKHVVE-LERCTYLVLDNID 485
Cdd:cd17955 75 PTRELAYQIAEQFRALGAPLGLRCCVIVGGmdmvKQALELSKRpHIVVATPGRLADHLRSSDDTTKvLSRVKFLVLDEAD 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 386763933 486 RMIDVGLEGNICRLLCRLRPHAQ-LIVSSTsWSSNLKRMANKFL 528
Cdd:cd17955 155 RLLTGSFEDDLATILSALPPKRQtLLFSAT-LTDALKALKELFG 197
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
341-524 |
6.12e-14 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 71.17 E-value: 6.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQR-----GLmqhkkGpiVLILVDCRE 415
Cdd:cd17941 1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERwtpedGL-----G--ALIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 416 AAV---MVQREVLYYTNpleLRTHCLLGNSQWQGHAE----CDLLVASAGRLLQMIDNKK--HVVELErctYLVLDNIDR 486
Cdd:cd17941 74 LAMqifEVLRKVGKYHS---FSAGLIIGGKDVKEEKErinrMNILVCTPGRLLQHMDETPgfDTSNLQ---MLVLDEADR 147
|
170 180 190
....*....|....*....|....*....|....*...
gi 386763933 487 MIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMA 524
Cdd:cd17941 148 ILDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLA 185
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
332-526 |
2.41e-13 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 69.66 E-value: 2.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 332 FERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPgimkmhnqrgLMQhkkgpIV--LI 409
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLP----------VLQ-----IVvaLI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 410 LVDCREAAVMVQREVL----YYTNPlELRTHCLLGNSQWQGH-----AECDLLVASAGRLLQMIdnKKHVVELERCTYLV 480
Cdd:cd17938 66 LEPSRELAEQTYNCIEnfkkYLDNP-KLRVALLIGGVKAREQlkrleSGVDIVVGTPGRLEDLI--KTGKLDLSSVRFFV 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 386763933 481 LDNIDRMIDVGLEGNICRLLCRLRPHA------QLIV-SSTSWSSNLKRMANK 526
Cdd:cd17938 143 LDEADRLLSQGNLETINRIYNRIPKITsdgkrlQVIVcSATLHSFEVKKLADK 195
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
341-493 |
4.18e-12 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 65.84 E-value: 4.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRglMQHKKGPIVLILVDCREAAVM- 419
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLK--FKPRNGTGVIIISPTRELALQi 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 420 --VQREVLYYTNplelRTH-CLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKH-VVELERCtyLVLDNIDRMIDV 490
Cdd:cd17942 79 ygVAKELLKYHS----QTFgIVIGGANRKAEAEklgkgVNILVATPGRLLDHLQNTKGfLYKNLQC--LIIDEADRILEI 152
|
...
gi 386763933 491 GLE 493
Cdd:cd17942 153 GFE 155
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
349-534 |
3.25e-09 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 57.33 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 349 GYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLpGIMkmhnQRGLMQHKKgPIVLILVDCREAAVMVQREVLYYT 428
Cdd:cd17939 16 GFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSI-GAL----QRIDTTVRE-TQALVLAPTRELAQQIQKVVKALG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 429 NPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMIDVGLEGNICRLLCRL 503
Cdd:cd17939 90 DYMGVKVHACIGGTSVREDRRklqygPHIVVGTPGRVFDMLQRRS--LRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFL 167
|
170 180 190
....*....|....*....|....*....|.
gi 386763933 504 RPHAQLIVSSTSWSSNLKRMANKFLGQYTAI 534
Cdd:cd17939 168 PPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
341-524 |
5.24e-09 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 57.26 E-value: 5.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNI--------VMISGK-GTGKTLGYLLPGIMKmhnqrglMQHKKGPIV--LI 409
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSKStppyrpgdLCVSAPtGSGKTLAYVLPIVQA-------LSKRVVPRLraLI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 410 LVDCREAAVMVQREVLYYTNPLELRTHCLLGNS-----------QWQGHAEC--DLLVASAGRLLQMIDNKKHvVELERC 476
Cdd:cd17956 74 VVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKsfkkeqklllvDTSGRYLSrvDILVATPGRLVDHLNSTPG-FTLKHL 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386763933 477 TYLVLDNIDRMID-------VGLEGNICR-------------LLCRLRPHAQLIVSSTSWSSNLKRMA 524
Cdd:cd17956 153 RFLVIDEADRLLNqsfqdwlETVMKALGRptapdlgsfgdanLLERSVRPLQKLLFSATLTRDPEKLS 220
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
342-670 |
6.11e-09 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 59.04 E-value: 6.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 342 LQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLpgimkmhnqrGLMQH--KKGPIVLILVDC--REAA 417
Cdd:PRK11776 16 LANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGL----------GLLQKldVKRFRVQALVLCptRELA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 418 VMVQREvlyytnpleLR------------THC-------LLGNSQWQGHaecdLLVASAGRLLQMIdnKKHVVELERCTY 478
Cdd:PRK11776 86 DQVAKE---------IRrlarfipnikvlTLCggvpmgpQIDSLEHGAH----IIVGTPGRILDHL--RKGTLDLDALNT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 479 LVLDNIDRMIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNigvrLQNIRQRV-EVVN 557
Cdd:PRK11776 151 LVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHD----LPAIEQRFyEVSP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 558 G--LSKVERLMKELTaiydtsdiPGKVVIYVKRQKVVEELVDLIRNcvpcEGI-----HGGRTAQE-NQGIIHdFGTGAY 629
Cdd:PRK11776 227 DerLPALQRLLLHHQ--------PESCVVFCNTKKECQEVADALNA----QGFsalalHGDLEQRDrDQVLVR-FANRSC 293
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 386763933 630 NIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:PRK11776 294 SVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTG 334
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
583-670 |
5.60e-08 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 52.21 E-value: 5.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 583 VIYVKRQKVVEEL-VDLIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDK 661
Cdd:cd18794 34 IIYCLSRKECEQVaARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
....*....
gi 386763933 662 YVQRMSRTG 670
Cdd:cd18794 114 YYQESGRAG 122
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
545-670 |
2.16e-07 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 54.35 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 545 RLQNIRQRVEVVNGL-SKVERLMKELTAIYDTSDIpGKVVIYVKRQKVVEELVD-LIRNCVPCEGIHG--------GRTA 614
Cdd:COG1111 319 RFRKAMRLAEEADIEhPKLSKLREILKEQLGTNPD-SRIIVFTQYRDTAEMIVEfLSEPGIKAGRFVGqaskegdkGLTQ 397
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 386763933 615 QENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYD-FPDNIdKYVQRMSRTG 670
Cdd:COG1111 398 KEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVPSEI-RSIQRKGRTG 453
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
349-528 |
4.29e-07 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 50.91 E-value: 4.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 349 GYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQrglmqhKKGPIVLILVDCREAAVMVQREVLYYT 428
Cdd:cd18046 18 GFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTS------LKATQALVLAPTRELAQQIQKVVMALG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 429 NPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDnkKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCRL 503
Cdd:cd18046 92 DYMGIKCHACIGGTSVRDDAQklqagPHIVVGTPGRVFDMIN--RRYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKL 169
|
170 180
....*....|....*....|....*
gi 386763933 504 RPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd18046 170 PPDTQVVLLSATMPNDVLEVTTKFM 194
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
341-528 |
5.06e-07 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 50.81 E-value: 5.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQRGLMQhkkgpiVLILVDCREAAVMV 420
Cdd:cd17950 13 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS------VLVICHTRELAFQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 421 QREVLYYTNPL-ELRTHCLLGNSQWQGHAE------CDLLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDRMI-DVGL 492
Cdd:cd17950 87 SNEYERFSKYMpNVKTAVFFGGVPIKKDIEvlknkcPHIVVGTPGRILALVREKK--LKLSHVKHFVLDECDKMLeQLDM 164
|
170 180 190
....*....|....*....|....*....|....*.
gi 386763933 493 EGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd17950 165 RRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFM 200
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
559-670 |
5.59e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 49.66 E-value: 5.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 559 LSKVERLMKE---LTAIYDTSdipgKVVIYVKRQKVVEELVDLIRNCVPceGIHG-------------GRTAQENQGIIH 622
Cdd:cd18801 11 LEKLEEIVKEhfkKKQEGSDT----RVIIFSEFRDSAEEIVNFLSKIRP--GIRAtrfigqasgksskGMSQKEQKEVIE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 386763933 623 DFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:cd18801 85 QFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTG 132
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
332-528 |
7.08e-07 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 50.54 E-value: 7.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 332 FERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLpGIMKMhnqrgLMQHKKGPIVLILV 411
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSI-SVLQC-----LDIQVRETQALILS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 412 DCREAAVMVQREVLYYTNPLELRTH-CLLGNSQWQGHAECD----LLVASAGRLLQMIDNKKhvVELERCTYLVLDNIDR 486
Cdd:cd18045 75 PTRELAVQIQKVLLALGDYMNVQCHaCIGGTSVGDDIRKLDygqhIVSGTPGRVFDMIRRRS--LRTRHIKMLVLDEADE 152
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 386763933 487 MIDVGLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd18045 153 MLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFM 194
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
323-670 |
1.59e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 51.76 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 323 RNLPEPVLSFE--RSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYLLPGImkmhnqRGLMQ 400
Cdd:COG1205 25 RTIPAREARYApwPDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVL------EALLE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 401 HKKGPIVLI----------------LVDCREAAVMV----------QREVLYY------TNPLELRTHCLLGNSQWQgha 448
Cdd:COG1205 99 DPGATALYLyptkalardqlrrlreLAEALGLGVRVatydgdtppeERRWIREhpdivlTNPDMLHYGLLPHHTRWA--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 449 ecdllvasagRLlqmidnkkhvveLERCTYLVLDN---------------IDRMidvglegnicRLLCR-LRPHAQLIVS 512
Cdd:COG1205 176 ----------RF------------FRNLRYVVIDEahtyrgvfgshvanvLRRL----------RRICRhYGSDPQFILA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 513 S-TswSSNLKRMANKFLGQ-YTAI-----RVGEIN----NIGVRLQNIRQ--RVE--------VVNGL---------SKV 562
Cdd:COG1205 224 SaT--IGNPAEHAERLTGRpVTVVdedgsPRGERTfvlwNPPLVDDGIRRsaLAEaarlladlVREGLrtlvftrsrRGA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 563 ERLMKELTAIYDTSDIPGKVVIYvkrqkvveelvdlirncvpcegiHGGRTAQENQGIIHDFGTGAYNIIVATqmtsNCL 642
Cdd:COG1205 302 ELLARYARRALREPDLADRVAAY-----------------------RAGYLPEERREIERGLRSGELLGVVST----NAL 354
|
410 420 430
....*....|....*....|....*....|..
gi 386763933 643 ----DVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:COG1205 355 elgiDIGGLDAVVLAGYPGTRASFWQQAGRAG 386
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
548-664 |
2.34e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 50.91 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 548 NIRQRVEVVNGLSKVERLMKELTAIYDTSDIpgkvvIYVKRQKVVEELVDLIRNcvpcEGI-----HGGRTAQENQGIIH 622
Cdd:COG0514 204 NLRLEVVPKPPDDKLAQLLDFLKEHPGGSGI-----VYCLSRKKVEELAEWLRE----AGIraaayHAGLDAEEREANQD 274
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 386763933 623 DFGTGAYNIIVATqmtsNCL----DVPGIRYVINYDFPDNIDKYVQ 664
Cdd:COG0514 275 RFLRDEVDVIVAT----IAFgmgiDKPDVRFVIHYDLPKSIEAYYQ 316
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
559-668 |
3.26e-06 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 47.20 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 559 LSKVERLMKELTAIYDTSDIPgKVVIYVKRQ---KVVEELVDLI---RNCVPCEGIHGGR----------TAQENQGIIH 622
Cdd:cd18802 6 IPKLQKLIEILREYFPKTPDF-RGIIFVERRataVVLSRLLKEHpstLAFIRCGFLIGRGnssqrkrslmTQRKQKETLD 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 386763933 623 DFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSR 668
Cdd:cd18802 85 KFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
341-535 |
2.45e-05 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 45.64 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 341 ILQQLEDQGYDGPTPIQAQTWSI--AKEGKNIVMISGKGTGKTLGYLLPGIMKMHNQrglmqhKKGPIVLILVDCREAAV 418
Cdd:cd17963 5 LLKGLYAMGFNKPSKIQETALPLilSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPT------LKSPQALCLAPTRELAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 419 MVQREVLYYTNPLELRTHCLL------GNSQWQGHaecdLLVASAGRLLQMIdnKKHVVELERCTYLVLDNIDRMIDVGL 492
Cdd:cd17963 79 QIGEVVEKMGKFTGVKVALAVpgndvpRGKKITAQ----IVIGTPGTVLDWL--KKRQLDLKKIKILVLDEADVMLDTQG 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 386763933 493 EGNICRLLCR-LRPHAQLIVSSTSWSSNLKRMANKFLGQYTAIR 535
Cdd:cd17963 153 HGDQSIRIKRmLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
629-670 |
2.27e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 2.27e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 386763933 629 YNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTG 670
Cdd:cd18785 23 LEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAG 64
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
563-651 |
1.13e-03 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 42.32 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 563 ERLMKELTAIYDTSDIPGKVVIYVKRQKVVEELVDLIRNC-VPCEGIHGGRTAQENQGIIHDFGTGAYNIIVatqmTSNC 641
Cdd:COG1061 289 ERKDKILRELLREHPDDRKTLVFCSSVDHAEALAELLNEAgIRAAVVTGDTPKKEREEILEAFRDGELRILV----TVDV 364
|
90
....*....|....
gi 386763933 642 L----DVPGIRYVI 651
Cdd:COG1061 365 LnegvDVPRLDVAI 378
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
329-528 |
1.26e-03 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 41.16 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 329 VLSFERSGFNATILQQLEDQGYDGPTPIQ--AQTWSIAKEGKNIVMISGKGTGKTLGYLLPGIMKMHnqrglmQHKKGPI 406
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQenALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLSRVD------ALKLYPQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763933 407 VLILVDCREAAVMVQR---EVLYYTNPLELrTHCLLGNSQWQG-HAECDLLVASAGRLLQMIdNKKHVVELERCTYLVLD 482
Cdd:cd18048 91 CLCLSPTFELALQTGKvveEMGKFCVGIQV-IYAIRGNRPGKGtDIEAQIVIGTPGTVLDWC-FKLRLIDVTNISVFVLD 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 386763933 483 NIDRMIDV-GLEGNICRLLCRLRPHAQLIVSSTSWSSNLKRMANKFL 528
Cdd:cd18048 169 EADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIV 215
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
570-645 |
3.79e-03 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 38.48 E-value: 3.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386763933 570 TAIYDTSDIPGKVVIYVKRQKVVEELVDLIRNCVPCEGI---HGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVP 645
Cdd:cd18810 16 EAIERELLRGGQVFYVHNRIESIEKLATQLRQLVPEARIaiaHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIP 94
|
|
| |
