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Conserved domains on  [gi|18857975|ref|NP_572451|]
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uncharacterized protein Dmel_CG10959, isoform A [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-416 3.97e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 258 CQLCDKVFKSSRSLLRHVQG--HSG--ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREAL---- 329
Cdd:COG5048 292 SKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 330 ---IVHRRTHTGEKPFQC--QTCARRFASKSLLNEHQAMHSTEKPY--KCDKCDSAFSRPKALYHHKHLHLGIKKFKCKI 402
Cdd:COG5048 372 pqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                       170
                ....*....|....
gi 18857975 403 CGnAYAQAAGLSAH 416
Cdd:COG5048 452 LK-SFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-416 3.97e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 258 CQLCDKVFKSSRSLLRHVQG--HSG--ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREAL---- 329
Cdd:COG5048 292 SKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 330 ---IVHRRTHTGEKPFQC--QTCARRFASKSLLNEHQAMHSTEKPY--KCDKCDSAFSRPKALYHHKHLHLGIKKFKCKI 402
Cdd:COG5048 372 pqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                       170
                ....*....|....
gi 18857975 403 CGnAYAQAAGLSAH 416
Cdd:COG5048 452 LK-SFRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-438 1.85e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18857975 368 KPYkCDKCDSAFSRPKALYHH---KHlhlgikkFKCKICGNAYAQAAGLSAH-MRAHK--LQASVNATEGAEAEPIE 438
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHqkaKH-------FKCHICHKKLYTAGGLAVHcLQVHKetLTKVPNALPGRDDPEIE 69
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 5.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 18857975   328 ALIVHRRTHTGEKPFQCQTCARRFAS 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-416 3.97e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 258 CQLCDKVFKSSRSLLRHVQG--HSG--ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREAL---- 329
Cdd:COG5048 292 SKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 330 ---IVHRRTHTGEKPFQC--QTCARRFASKSLLNEHQAMHSTEKPY--KCDKCDSAFSRPKALYHHKHLHLGIKKFKCKI 402
Cdd:COG5048 372 pqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451

                       170
                ....*....|....
gi 18857975 403 CGnAYAQAAGLSAH 416
Cdd:COG5048 452 LK-SFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-393 7.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 7.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18857975 280 GARTFKCEHENCGKSFVNQHNLTSHRrvhseernyvceLCGYRSryrealivhRRTHTGEKPfqcqtcarrfasksllNE 359
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHM------------LHGHQN---------QKLHENPSP----------------EK 388

                        90       100       110
                ....*....|....*....|....*....|....*
gi 18857975 360 HQAMHSTEKPYKCDKCDSAFSRPKAL-YHHKHLHL 393
Cdd:COG5189 389 MNIFSAKDKPYRCEVCDKRYKNLNGLkYHRKHSHD 423
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-438 1.85e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18857975 368 KPYkCDKCDSAFSRPKALYHH---KHlhlgikkFKCKICGNAYAQAAGLSAH-MRAHK--LQASVNATEGAEAEPIE 438
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHqkaKH-------FKCHICHKKLYTAGGLAVHcLQVHKetLTKVPNALPGRDDPEIE 69
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 5.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 18857975   328 ALIVHRRTHTGEKPFQCQTCARRFAS 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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