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Conserved domains on  [gi|24640523|ref|NP_572452|]
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Gbeta5 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-358 2.38e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.96  E-value: 2.38e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  62 PRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPI 141
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 142 TSDEEmaakKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetgNTFVSGS 221
Cdd:cd00200  81 ETGEC----VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 222 C-DRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVF-AKESiifGVNSVDFSVS 299
Cdd:cd00200 154 SqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHEN---GVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24640523 300 GRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVWA 358
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-358 2.38e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.96  E-value: 2.38e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  62 PRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPI 141
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 142 TSDEEmaakKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetgNTFVSGS 221
Cdd:cd00200  81 ETGEC----VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 222 C-DRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVF-AKESiifGVNSVDFSVS 299
Cdd:cd00200 154 SqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHEN---GVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24640523 300 GRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVWA 358
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
61-357 7.17e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 226.72  E-value: 7.17e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSY-MSCCIYPNSdQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVS 219
Cdd:COG2319 191 LATGKLL----RTLTGHTGAvRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 220 GSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVFAKESIifGVNSVDFSVS 299
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPD 341

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24640523 300 GRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-272 1.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24640523    233 SGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYD 272
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
234-272 7.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 7.71e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24640523   234 GHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYD 272
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 115-349 9.83e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 9.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  115 IMACAYAPSGNFVACGGLDNKVTVYP----ITSDEEMAAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESG 190
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  191 QLLQSFHGHSGDVMAIDLAPNETgNTFVSGSCDRMAFIWDMRSGHVVQSFEGhQSDVNSVKF-HPCGDAIATGSDDSSCR 269
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVY 643

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  270 LYDMRADR--EVAVFAKESIIFGVNSVDFSVsgrlLFAGYNDYTVNLWDT------LKSERVCLLYGHENKVSCVQVSPD 341
Cdd:PLN00181 644 YYDLRNPKlpLCTMIGHSKTVSYVRFVDSST----LVSSSTDNTLKLWDLsmsisgINETPLHSFMGHTNVKNFVGLSVS 719


                 ....*...
gi 24640523  342 GTALSTGS 349
Cdd:PLN00181 720 DGYIATGS 727
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-358 2.38e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.96  E-value: 2.38e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  62 PRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPI 141
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 142 TSDEEmaakKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetgNTFVSGS 221
Cdd:cd00200  81 ETGEC----VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 222 C-DRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVF-AKESiifGVNSVDFSVS 299
Cdd:cd00200 154 SqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHEN---GVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24640523 300 GRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVWA 358
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
61-357 7.17e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 226.72  E-value: 7.17e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSY-MSCCIYPNSdQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVS 219
Cdd:COG2319 191 LATGKLL----RTLTGHTGAvRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 220 GSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVFAKESIifGVNSVDFSVS 299
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPD 341

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24640523 300 GRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
61-357 4.22e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 4.22e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVSG 220
Cdd:COG2319 149 LATGKLL----RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 221 SCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVFAKESiiFGVNSVDFSVSG 300
Cdd:COG2319 223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDG 300

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24640523 301 RLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:COG2319 301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
61-317 3.91e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.60  E-value: 3.91e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVSG 220
Cdd:COG2319 233 LATGKLL----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD--GKLLASG 306

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 221 SCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVFAKESiiFGVNSVDFSVSG 300
Cdd:COG2319 307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT--GAVTSVAFSPDG 384

                       250
                ....*....|....*..
gi 24640523 301 RLLFAGYNDYTVNLWDT 317
Cdd:COG2319 385 RTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
77-357 5.42e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 5.42e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  77 DWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSdeemAAKKRTVGT 156
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA----GALLATLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 157 HTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVSGSCDRMAFIWDMRSGHV 236
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATGKL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 237 VQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVAVFAKESiiFGVNSVDFSVSGRLLFAGYNDYTVNLWD 316
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 24640523 317 TLKSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
61-274 1.02e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 1.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSY-MSCCIYPNSdQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVS 219
Cdd:COG2319 275 LATGELL----RTLTGHSGGvNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKTLAS 347

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24640523 220 GSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMR 274
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
61-233 4.91e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 4.91e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYP 140
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 141 ITSDEEMaakkRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFVSG 220
Cdd:COG2319 317 LATGKLL----RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD--GRTLASG 390

                       170
                ....*....|...
gi 24640523 221 SCDRMAFIWDMRS 233
Cdd:COG2319 391 SADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-272 2.24e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  59 NIKPRKVLKGHQAKVLCTDWSPDKRHIISSsqdgrliiwdafttnkehavtmpttwimacayapsgnfvacggldnkvtv 138
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSS-------------------------------------------------- 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 139 ypitsdeemaakkrtvgthtsymscciypnsdqqiltgSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNetGNTFV 218
Cdd:cd00200 196 --------------------------------------SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD--GYLLA 235

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 24640523 219 SGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYD 272
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-272 1.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24640523    233 SGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYD 272
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 61-98 3.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 3.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24640523     61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWD 98
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
234-272 7.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 7.71e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24640523   234 GHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYD 272
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 115-349 9.83e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 9.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  115 IMACAYAPSGNFVACGGLDNKVTVYP----ITSDEEMAAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESG 190
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  191 QLLQSFHGHSGDVMAIDLAPNETgNTFVSGSCDRMAFIWDMRSGHVVQSFEGhQSDVNSVKF-HPCGDAIATGSDDSSCR 269
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVY 643

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  270 LYDMRADR--EVAVFAKESIIFGVNSVDFSVsgrlLFAGYNDYTVNLWDT------LKSERVCLLYGHENKVSCVQVSPD 341
Cdd:PLN00181 644 YYDLRNPKlpLCTMIGHSKTVSYVRFVDSST----LVSSSTDNTLKLWDLsmsisgINETPLHSFMGHTNVKNFVGLSVS 719


                 ....*...
gi 24640523  342 GTALSTGS 349
Cdd:PLN00181 720 DGYIATGS 727
WD40 pfam00400
WD domain, G-beta repeat;
61-98 2.52e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24640523    61 KPRKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWD 98
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
326-357 1.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.02e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24640523   326 LYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-357 1.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24640523    319 KSERVCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-271 8.54e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 8.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523   82 KRHIISSSQDGRLIIWDA-----FTTNKEHAvtmPTTWIMACAYAPSgNFVACGGLDNKVTVYPITSDEEMAAKKrtvgt 156
Cdd:PLN00181 545 KSQVASSNFEGVVQVWDVarsqlVTEMKEHE---KRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIK----- 615

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  157 hTSYMSCCI-YPN-SDQQILTGSGDSTCALWDVESGQL-LQSFHGHSGDVMAIDLAPNetgNTFVSGSCDRMAFIWDMR- 232
Cdd:PLN00181 616 -TKANICCVqFPSeSGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDS---STLVSSSTDNTLKLWDLSm 691

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 24640523  233 --SG---HVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLY 271
Cdd:PLN00181 692 siSGineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-230 1.02e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24640523    189 SGQLLQSFHGHSGDVMAIDLAPNetGNTFVSGSCDRMAFIWD 230
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
190-230 1.80e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24640523   190 GQLLQSFHGHSGDVMAIDLAPNetGNTFVSGSCDRMAFIWD 230
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 329-357 6.40e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.29  E-value: 6.40e-05
                          10        20
                  ....*....|....*....|....*....
gi 24640523   329 HENKVSCVQVSPDGTALSTGSWDYTIRVW 357
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 83-284 1.28e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 43.37  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  83 RHIISSSQDGRLIIWDafTTNKEHAVTMPTTW------IMACAYAPSGNFVACGGLDNKVTVYPIT-SDEEM-AAKK--- 151
Cdd:cd22857  93 GTLLTCTSKGSLRSTK--LPDDSTASSSPTAWvclggnLLCMRVDPNENYFAFGGKEVELNVWDLEeKPGKIwRAKNvpn 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 152 -----RT---VgTHTSYMscciyPNSDQ-QILTGSGDSTCALWDVESGQ---LLQSFHGHSGDVMAIDLAPNETgntFVS 219
Cdd:cd22857 171 dslglRVpvwV-TDLTFL-----SKDDHrKIVTGTGYHQVRLYDTRAQRrpvVSVDFGETPIKAVAEDPDGHTV---YVG 241

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640523 220 -GSCDRMAFiwDMRSGHVVQSFEGHQS-DVNSVKFHPCGDAIATGSDDSSCRLYDMR-ADREVAVFAK 284
Cdd:cd22857 242 dTSGDLASI--DLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRYLRIWDTEtRQLLSKVYLK 307
PTZ00421 PTZ00421
coronin; Provisional
 167-280 5.97e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 5.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523  167 PNSDQQILTGSGDSTCALWDVESGQLLQS-------FHGHSGDVMAIDLAPNeTGNTFVSGSCDRMAFIWDMRSGHVVQS 239
Cdd:PTZ00421  85 PFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPS-AMNVLASAGADMVVNVWDVERGKAVEV 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 24640523  240 FEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADREVA 280
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
PTZ00421 PTZ00421
coronin; Provisional
 169-245 1.02e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640523  169 SDQQILTGSG-DSTCALWDVESGQLLQSFHGHSGDVMAIDLapNETGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQS 245
Cdd:PTZ00421 136 SAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEW--NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
PTZ00420 PTZ00420
coronin; Provisional
 62-111 1.58e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24640523   62 PRKVLKGHQAKVLCTDWSPDKRHIISSSQ-DGRLIIWDAFTTNKEHAVTMP 111
Cdd:PTZ00420 117 PQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDIENEKRAFQINMP 167
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 176-253 3.49e-03

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 36.99  E-value: 3.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640523 176 GSGDSTCALWDVESGQLLQSFHGHSGDVM-AIDLAPNETGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSD-VNSVKFH 253
Cdd:cd09614  46 GGGGNLSPTLNFSSGEYITEVTGRSGDRVdQVQFTTNYGGRTLPGGGGGGSAFTWTVPDNQKVIGFAGRSGSyLDQLQVY 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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