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Conserved domains on  [gi|24640704|ref|NP_572516|]
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uncharacterized protein Dmel_CG15365, isoform A [Drosophila melanogaster]

Protein Classification

COG4913 and Fez1 superfamily-containing protein( domain architecture ID 709350)

COG4913 and Fez1 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fez1 super family cl25940
Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper ...
 728-805 2.51e-11

Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.


The actual alignment was detected with superfamily member pfam06818:

Pssm-ID: 462015 [Multi-domain]  Cd Length: 198  Bit Score: 63.48  E-value: 2.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640704   728 QRLQLDQGQGTQQTLDTLIEEsttyaedIAKLRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCL 805
Cdd:pfam06818 123 QRQEEADLGSLRREVERLRAE-------LREERQRRERQASSFEQERRTWQEEKEKVIRYQKQLQLNYVQMYRRNQAL 193
 
Name Accession Description Interval E-value
Fez1 pfam06818
Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper ...
 728-805 2.51e-11

Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.


Pssm-ID: 462015 [Multi-domain]  Cd Length: 198  Bit Score: 63.48  E-value: 2.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640704   728 QRLQLDQGQGTQQTLDTLIEEsttyaedIAKLRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCL 805
Cdd:pfam06818 123 QRQEEADLGSLRREVERLRAE-------LREERQRRERQASSFEQERRTWQEEKEKVIRYQKQLQLNYVQMYRRNQAL 193
 
Name Accession Description Interval E-value
Fez1 pfam06818
Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper ...
 728-805 2.51e-11

Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.


Pssm-ID: 462015 [Multi-domain]  Cd Length: 198  Bit Score: 63.48  E-value: 2.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640704   728 QRLQLDQGQGTQQTLDTLIEEsttyaedIAKLRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCL 805
Cdd:pfam06818 123 QRQEEADLGSLRREVERLRAE-------LREERQRRERQASSFEQERRTWQEEKEKVIRYQKQLQLNYVQMYRRNQAL 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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