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Conserved domains on  [gi|24640773|ref|NP_572542|]
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uncharacterized protein Dmel_CG15369, isoform A [Drosophila melanogaster]

Protein Classification

cystatin family protein( domain architecture ID 10036424)

cystatin family protein may function as a cysteine protease inhibitor

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
PubMed:  1855589|9007972|3555466|14587292
SCOP:  4001013

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-110 8.33e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.70  E-value: 8.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640773  24 GAPKVLEGEDLAsAQQTLEASLTKLAAGE-GPHYRLSKILSATSQVVSGFKNDYSVELID------------------NQ 84
Cdd:cd00042   1 GGPSDIPANDPE-VQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGDtnckkssvpldcpdckllEE 79

                        90       100
                ....*....|....*....|....*.
gi 24640773  85 GATKVCQVDIWSQSWLPNGIQVTFRC 110
Cdd:cd00042  80 GKKKFCTAKVWEKPWENFKELLSFKC 105
 
Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-110 8.33e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.70  E-value: 8.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640773  24 GAPKVLEGEDLAsAQQTLEASLTKLAAGE-GPHYRLSKILSATSQVVSGFKNDYSVELID------------------NQ 84
Cdd:cd00042   1 GGPSDIPANDPE-VQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGDtnckkssvpldcpdckllEE 79

                        90       100
                ....*....|....*....|....*.
gi 24640773  85 GATKVCQVDIWSQSWLPNGIQVTFRC 110
Cdd:cd00042  80 GKKKFCTAKVWEKPWENFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-110 2.82e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 42.80  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640773     37 AQQTLEASLTKLAAGEGPHYRLS--KILSATSQVVSGFKNDYSVELID---------------NQGATKVCQVDIWSQSW 99
Cdd:smart00043  16 VQEAADFAVAEYNKKSNDKYELRviKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpfLDQGEKFCTAKVWEKPW 95

                           90
                   ....*....|.
gi 24640773    100 LPNGIQVTFRC 110
Cdd:smart00043  96 ENKIKLVEFKC 106
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 37-81 5.90e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.16  E-value: 5.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 24640773    37 AQQTLEASLTKLAAGE-GPHYRLSKILSATSQVVSGFKndYSVELI 81
Cdd:pfam00031  13 LQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTN--YFIKVE 56
 
Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-110 8.33e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.70  E-value: 8.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640773  24 GAPKVLEGEDLAsAQQTLEASLTKLAAGE-GPHYRLSKILSATSQVVSGFKNDYSVELID------------------NQ 84
Cdd:cd00042   1 GGPSDIPANDPE-VQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGDtnckkssvpldcpdckllEE 79

                        90       100
                ....*....|....*....|....*.
gi 24640773  85 GATKVCQVDIWSQSWLPNGIQVTFRC 110
Cdd:cd00042  80 GKKKFCTAKVWEKPWENFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-110 2.82e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 42.80  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640773     37 AQQTLEASLTKLAAGEGPHYRLS--KILSATSQVVSGFKNDYSVELID---------------NQGATKVCQVDIWSQSW 99
Cdd:smart00043  16 VQEAADFAVAEYNKKSNDKYELRviKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpfLDQGEKFCTAKVWEKPW 95

                           90
                   ....*....|.
gi 24640773    100 LPNGIQVTFRC 110
Cdd:smart00043  96 ENKIKLVEFKC 106
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 37-81 5.90e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.16  E-value: 5.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 24640773    37 AQQTLEASLTKLAAGE-GPHYRLSKILSATSQVVSGFKndYSVELI 81
Cdd:pfam00031  13 LQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTN--YFIKVE 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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