BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799 145 LALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSN- 223
Cdd:cd14822   1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPDs 80

                        90       100
                ....*....|....*....|.
gi 18859799 224 -VDFKSVVSYVRLPLMNLEHL 243
Cdd:cd14822  81 kEDAKEILEAVRLPLMSLTEL 101

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799   299 DALLDGDVTTYdmengytRHCITDSKDAGIVVELGTFCMINHIRMLLWDRDSRAY--SYYVEVSGDQQHWDRVVDYS--- 373
Cdd:pfam00754  15 AAALDGDPNTA-------WSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYvtSYKIEYSLDGENWTTVKDEKipg 87

                          90       100
                  ....*....|....*....|....*...
gi 18859799   374 DYHCRSWQYLYFEaRPV--RFIRLVGTQ 399
Cdd:pfam00754  88 NNDNNTPVTNTFD-PPIkaRYVRIVPTS 114

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799 145 LALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSN- 223
Cdd:cd14822   1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPDs 80

                        90       100
                ....*....|....*....|.
gi 18859799 224 -VDFKSVVSYVRLPLMNLEHL 243
Cdd:cd14822  81 kEDAKEILEAVRLPLMSLTEL 101

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799    42 NEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLE-VPLEAFKVLLRYIYSGTLllstLDEDSTID 120
Cdd:pfam00651   7 QGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDdVSPEDFEALLEFMYTGKL----ISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 18859799   121 VLGMANQYGFQDLEMAISNYLRQYL 145
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799    150 VCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAP-EVQIFLAVWKWSRFNSNVDFKS 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 18859799    229 ---VVSYVRLPLMNLEHLLQV 246
Cdd:smart00875  81 lpeLLEHVRLPLLSPDYLLEV 101

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799   451 NALINGDYvrydwDSGYTCHQLGSGE-IVVRLGQPYYLGSMRLLLW--DCDDRTYSFYIEISTNRKEWQMVVDRR---ND 524
Cdd:pfam00754  15 AAALDGDP-----NTAWSAWSGDDPQwIQVDLGKPKKITGVVTQGRqdGSNGYVTSYKIEYSLDGENWTTVKDEKipgNN 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 18859799   525 RTRSWQNFHFtPRPVV--YIRIVGT-RNTANEI 554
Cdd:pfam00754  90 DNNTPVTNTF-DPPIKarYVRIVPTsWNGGNGI 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799 145 LALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSN- 223
Cdd:cd14822   1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPDs 80

                        90       100
                ....*....|....*....|.
gi 18859799 224 -VDFKSVVSYVRLPLMNLEHL 243
Cdd:cd14822  81 kEDAKEILEAVRLPLMSLTEL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  32 FSADMARLCMNEQYADVEFIVEEERIP--AHRVILAARSEYFRALLY-GGMAETTQRQIPL-EVPLEAFKVLLRYIYSGT 107
Cdd:cd18294   1 FAADMKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLtGPQKESTQSPLVLsDIEPEVFRAVLEFIYTNC 80

                        90       100
                ....*....|....*....|....*.
gi 18859799 108 LllsTLDEDSTIDVLGMANQYGFQDL 133
Cdd:cd18294  81 V---TLSNHTVIEVLAAAVEYGLDEL 103

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799    42 NEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLE-VPLEAFKVLLRYIYSGTLllstLDEDSTID 120
Cdd:pfam00651   7 QGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDdVSPEDFEALLEFMYTGKL----ISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 18859799   121 VLGMANQYGFQDLEMAISNYLRQYL 145
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  42 NEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSGTLLLSTLDEDSTID 120
Cdd:cd18297   9 NPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIpDIRYDIFQLMMQYLYTGGVESLDVAQDDALE 88

                        90       100
                ....*....|....*....|....*....
gi 18859799 121 VLGMANQYGFQDLEMAISNYLRQYLALDN 149
Cdd:cd18297  89 LLRAASFFQLDGLKRHCEILLSQQIDLDN 117

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799     47 DVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLE-VPLEAFKVLLRYIYSGTLLlstLDEDSTIDVLGMA 125
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDdVSPEDFRALLNFLYTGKLD---LPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 18859799    126 NQYGFQDLEMAISNYLRQYL 145
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  36 MARLCMNEQYADVEFIV----EEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLEVPLEAFKVLLRYIYSGTlllS 111
Cdd:cd18281  13 FAFLFNNETLSDVHFIVgkgdNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDE---V 89

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859799 112 TLDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDN 149
Cdd:cd18281  90 QIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799    150 VCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAP-EVQIFLAVWKWSRFNSNVDFKS 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 18859799    229 ---VVSYVRLPLMNLEHLLQV 246
Cdd:smart00875  81 lpeLLEHVRLPLLSPDYLLEV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  42 NEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSGTLLLSTldedstid 120
Cdd:cd18238  12 NGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIkDIDEEAVELLVDFAYTGKLTLTV-------- 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 18859799 121 vlgmanqygfqdlemaisnylrqylalDNVCMILDAARLYNLEELTEVCLMFM 173
Cdd:cd18238  84 ---------------------------DNVQSLLYAASLLQVEEVAKACCEFM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  35 DMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLE-VPLEAFKVLLRYIYSgtlllstl 113
Cdd:cd18280   4 HFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEdVEPPVFKALLHFIYK-------- 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859799 114 deDSTIDVLGMANQYGFQ-DLEMAisnylrQYLaldnvcmiLDAARLYNLEELTEVC 169
Cdd:cd18280  76 --DELPDDVEPAGSDSSSlDTTMA------QHL--------LAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  31 RFSADMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLEVpleaFKVLLRYIYSGTLLL 110
Cdd:cd18303   4 RLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSDISYEV----VLALLRWLYTDELDL 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859799 111 sTLDEDSTIDVLGMANQYGFQDL----EMAISNYLR 142
Cdd:cd18303  80 -TLDDEFLLELMKAAKRFQLTDLvercERALMSSVN 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  39 LCMN-----EQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSGTLllsT 112
Cdd:cd18237  10 GVMNnmrkqKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELkDAEPDIIELLVEFAYTARI---S 86

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859799 113 LDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDN 149
Cdd:cd18237  87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  42 NEQYADVEFIV----EEERIPAHRVILAARSEYFRALLYGGMAET-TQRQIPlEVPLEAFKVLLRYIYSGTLllsTLDED 116
Cdd:cd18349   5 NELMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFYGDLAEVkSEIHIP-DVEPAAFLILLKYMYSDEI---DLEAD 80

                        90       100
                ....*....|....*....|....*....
gi 18859799 117 STIDVLGMANQYGFQDLEMAISNYLRQYL 145
Cdd:cd18349  81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  35 DMARLCMNEQYADVEFIV--EEERIPAHRVILAARSEYFRALL---------------------YGGMAETTQRQIPLEV 91
Cdd:cd18308  13 DFGRLLESRQFCDVEFIVgeEEERIPAHIAFVAARSKWLRNKIlqarerqkqkaeqevedegseADSSSASKNDSPMLEV 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859799  92 PL-----EAFKVLLRYIYSGTLLLSTLDEDST--------IDVLGMANQYGFQDLEMAISNYL 141
Cdd:cd18308  93 RLpeadpEAFELILSFIYTDKIDPTRKGQDPGsnevvllmMDVYRLALQFQMSRLEQLCVQYL 155

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  42 NEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSGTLLLSTldeDSTID 120
Cdd:cd18352  10 NATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIpNIRWEVFELMMRFIYTGSVDITN---DIAKD 86

                        90       100       110
                ....*....|....*....|....*....|
gi 18859799 121 VLGMANQYGFQDLEMAISNYLRQYLALDNV 150
Cdd:cd18352  87 LLRAADQYLLEGLKRLCEYTIAQDLTLENI 116

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  45 YADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAE--TTQRQIPL----EVPLEAFKVLLRYIYSGtlllST-LDEDS 117
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseENNGSIPVvtlhDVSPEVFAIVLYYIYTD----DTdLPPEN 92

                        90
                ....*....|.
gi 18859799 118 TIDVLGMANQY 128
Cdd:cd18296  93 AYDVLYVADMY 103

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  45 YADVEFIVEEERIPAHRVILAARSEYFRALLyggmAETTQRQIPL----EVPLEAFKVLLRYIYSGTLLLSTLDEDSTID 120
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL----KETPPDEHPViilpDVPYSELKALLDFIYTGEVNVSQEQLESLLK 76

                ....
gi 18859799 121 VLGM 124
Cdd:cd18315  77 LAEL 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  47 DVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLE-VPLEAFKVLLRYIYSGTLllsTLDEDSTIDVLGMA 125
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQgIEPSALEALINFAYSGRI---AIDTSNVQSLLVGA 97

                        90
                ....*....|....*...
gi 18859799 126 NQYGFQDLEMAISNYLRQ 143
Cdd:cd18247  98 SFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  31 RFSADMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSGTll 109
Cdd:cd18279   4 RLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEInDVDPEVFKEMMRFIYTGK-- 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859799 110 lSTLDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDN 149
Cdd:cd18279  82 -APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  40 CMNE-----QYADVEFIVEEERIPAHRVILAARSEYFRALL-YG-GMAETTQRQIPLE-VPLEAFKVLLRYIYSGTLlls 111
Cdd:cd18245   4 ALNSfreepHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnYNpPKDDGSTYKIELEgISVEVMEEILDYIYTGQI--- 80

                        90       100       110
                ....*....|....*....|....*....|
gi 18859799 112 TLDEDSTIDVLGMANQYGFQDLEMAISNYL 141
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859799  36 MARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPL-EVPLEAFKVLLRYIYSgtlllstld 114
Cdd:cd18235  12 MNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLqDVDGKALLLLIDYVYT--------- 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18859799 115 edSTIDVlgmanqygfqdlemaisnylrqylALDNVCMILDAARLYNLEELTEVCLMFM 173
Cdd:cd18235  83 --AEIQV------------------------TEENVQVLLPAANLLQLTDVRDACCDFL 115