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Conserved domains on  [gi|18859749|ref|NP_572664|]
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uncharacterized protein Dmel_CG15208, isoform A [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-132 2.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  44 LEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFDELKYLVNA-KSLTSLWLLDNPcsIAAGSNYRASVLRMLPNLKK 122
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNP--VCKKPKYRDKIILASKSLEV 199

                        90
                ....*....|
gi 18859749 123 LDNVDVAEEE 132
Cdd:cd21340 200 LDGKEITDTE 209
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-132 2.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  44 LEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFDELKYLVNA-KSLTSLWLLDNPcsIAAGSNYRASVLRMLPNLKK 122
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNP--VCKKPKYRDKIILASKSLEV 199

                        90
                ....*....|
gi 18859749 123 LDNVDVAEEE 132
Cdd:cd21340 200 LDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-102 1.57e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  24 KLNFCNCGLNDISLCL-KMPYLEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFDELKYLvnaKSLTSLWLLDNPCS 102
Cdd:COG4886 209 ELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLT 285
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 44-83 1.95e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 1.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18859749    44 LEVLSLSMNKITSLKSLVRCTRLKELYLRQN-EIADFDELK 83
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-132 2.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  44 LEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFDELKYLVNA-KSLTSLWLLDNPcsIAAGSNYRASVLRMLPNLKK 122
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNP--VCKKPKYRDKIILASKSLEV 199

                        90
                ....*....|
gi 18859749 123 LDNVDVAEEE 132
Cdd:cd21340 200 LDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-102 1.57e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  24 KLNFCNCGLNDISLCL-KMPYLEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFDELKYLvnaKSLTSLWLLDNPCS 102
Cdd:COG4886 209 ELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-124 1.77e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  24 KLNFCNCGLNDISLCL-KMPYLEVLSLSMNKITSL-KSLVRCTRLKELYLRQNEIADFDELkyLVNAKSLTSLWLLDNPC 101
Cdd:COG4886 117 SLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQI 194

                        90       100
                ....*....|....*....|...
gi 18859749 102 SIAAGSnyrasvLRMLPNLKKLD 124
Cdd:COG4886 195 TDLPEP------LGNLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-124 1.05e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 1.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  24 KLNFCNCGLNDISLCL-KMPYLEVLSLSMNKITSL-KSLVRCTRLKELYLRQNEIADFDElkYLVNAKSLTSLWLLDNPC 101
Cdd:COG4886 163 SLDLSNNQLTDLPEELgNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQL 240

                        90       100
                ....*....|....*....|...
gi 18859749 102 SiaagsnyRASVLRMLPNLKKLD 124
Cdd:COG4886 241 T-------DLPELGNLTNLEELD 256
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 44-83 1.95e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 1.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18859749    44 LEVLSLSMNKITSLKSLVRCTRLKELYLRQN-EIADFDELK 83
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_9 pfam14580
Leucine-rich repeat;
41-139 3.13e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.98  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749    41 MPYLEVLSLSMNKIT----SLKSLVRCtrLKELYLRQNEIADFDELKYLVNAKSLTSLWLLDNPcsIAAGSNYRASVLRM 116
Cdd:pfam14580  63 LRRLKTLLLNNNRICrigeGLGEALPN--LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNP--VTNKPHYRLYVIYK 138

                          90       100
                  ....*....|....*....|...
gi 18859749   117 LPNLKKLDNVDVAEEELESALRY 139
Cdd:pfam14580 139 VPQLRLLDFRKVKQKERQAAEKM 161
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-124 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859749  40 KMPYLEVLSLSMNKITSL-KSLVRCTRLKELYLRQNEIADFDElkYLVNAKSLTSLWLLDN-----PCSIAAgsnyrasv 113
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNqltdlPEELGN-------- 180

                        90
                ....*....|.
gi 18859749 114 lrmLPNLKKLD 124
Cdd:COG4886 181 ---LTNLKELD 188
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-123 2.42e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.42e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859749  47 LSLSMNKITSLKSLVRCTRLKELYLRQNEIadfDELKYLVNAKSLTSLWLLDNPCSiaagsnyRASVLRMLPNLKKL 123
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKI---TKIENLEFLTNLTHLYLQNNQIE-------KIENLENLVNLKKL 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-94 4.06e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 4.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18859749  24 KLNFCNCGLNDISLCLKMPYLEVLSLSMNKITSLKSLVRCTRLKELYLRQNEIADFdELKYLVNAKSLTSL 94
Cdd:COG4886 232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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