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Conserved domains on  [gi|45549358|ref|NP_572685|]
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uncharacterized protein Dmel_CG11122 [Drosophila melanogaster]

Protein Classification

DNA topoisomerase 2-like domain-containing protein( domain architecture ID 1000163)

DNA topoisomerase 2-like domain-containing protein; DNA topoisomerase 2 alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 3122-3462 2.62e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3122 MSHEEIEQLIDEGQRKSKRRcatnrpKKLVETWSSDEYeeflcTKDIIALIEQKEQQEQKRKRKTSEANtQPEPVAPPVA 3201
Cdd:PTZ00108 1099 LTKEKVEKLNAELEKKEKEL------EKLKNTTPKDMW-----LEDLDKFEEALEEQEEVEEKEIAKEQ-RLKSKTKGKA 1166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3202 SKKAQTPQATAGKRKNRASEKKAAPAEPEQPKPRARQRNQPPPPAPAHVPPVVQAPPAPAPEVLTPPARGKSKAAAKSKT 3281
Cdd:PTZ00108 1167 SKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSK 1246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3282 PVTKATNNRKKRFNEKSRVQESREDEEEEEEQEQAEVEVEPPDRTRSSRQQPKVKANETEKEpiaptppppaqpplpaaa 3361
Cdd:PTZ00108 1247 KNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKK------------------ 1308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3362 peaqrerskvrqhgNQQQTLppaphpRSSSVATPSSTTNNNNNSSSSNKNLKAKRKSQTSRQSPARRKRPASEkqlyywS 3441
Cdd:PTZ00108 1309 --------------KVKKRL------EGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKS------D 1362

                         330       340
                  ....*....|....*....|.
gi 45549358  3442 SSSDDEFGRLDDETEAADGES 3462
Cdd:PTZ00108 1363 SSSEDDDDSEVDDSEDEDDED 1383
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 3122-3462 2.62e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3122 MSHEEIEQLIDEGQRKSKRRcatnrpKKLVETWSSDEYeeflcTKDIIALIEQKEQQEQKRKRKTSEANtQPEPVAPPVA 3201
Cdd:PTZ00108 1099 LTKEKVEKLNAELEKKEKEL------EKLKNTTPKDMW-----LEDLDKFEEALEEQEEVEEKEIAKEQ-RLKSKTKGKA 1166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3202 SKKAQTPQATAGKRKNRASEKKAAPAEPEQPKPRARQRNQPPPPAPAHVPPVVQAPPAPAPEVLTPPARGKSKAAAKSKT 3281
Cdd:PTZ00108 1167 SKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSK 1246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3282 PVTKATNNRKKRFNEKSRVQESREDEEEEEEQEQAEVEVEPPDRTRSSRQQPKVKANETEKEpiaptppppaqpplpaaa 3361
Cdd:PTZ00108 1247 KNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKK------------------ 1308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3362 peaqrerskvrqhgNQQQTLppaphpRSSSVATPSSTTNNNNNSSSSNKNLKAKRKSQTSRQSPARRKRPASEkqlyywS 3441
Cdd:PTZ00108 1309 --------------KVKKRL------EGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKS------D 1362

                         330       340
                  ....*....|....*....|.
gi 45549358  3442 SSSDDEFGRLDDETEAADGES 3462
Cdd:PTZ00108 1363 SSSEDDDDSEVDDSEDEDDED 1383
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 3122-3462 2.62e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3122 MSHEEIEQLIDEGQRKSKRRcatnrpKKLVETWSSDEYeeflcTKDIIALIEQKEQQEQKRKRKTSEANtQPEPVAPPVA 3201
Cdd:PTZ00108 1099 LTKEKVEKLNAELEKKEKEL------EKLKNTTPKDMW-----LEDLDKFEEALEEQEEVEEKEIAKEQ-RLKSKTKGKA 1166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3202 SKKAQTPQATAGKRKNRASEKKAAPAEPEQPKPRARQRNQPPPPAPAHVPPVVQAPPAPAPEVLTPPARGKSKAAAKSKT 3281
Cdd:PTZ00108 1167 SKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSK 1246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3282 PVTKATNNRKKRFNEKSRVQESREDEEEEEEQEQAEVEVEPPDRTRSSRQQPKVKANETEKEpiaptppppaqpplpaaa 3361
Cdd:PTZ00108 1247 KNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKK------------------ 1308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549358  3362 peaqrerskvrqhgNQQQTLppaphpRSSSVATPSSTTNNNNNSSSSNKNLKAKRKSQTSRQSPARRKRPASEkqlyywS 3441
Cdd:PTZ00108 1309 --------------KVKKRL------EGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKS------D 1362

                         330       340
                  ....*....|....*....|.
gi 45549358  3442 SSSDDEFGRLDDETEAADGES 3462
Cdd:PTZ00108 1363 SSSEDDDDSEVDDSEDEDDED 1383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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