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Conserved domains on  [gi|18859825|ref|NP_572738|]
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valette, isoform B [Drosophila melanogaster]

Protein Classification

COMM domain-containing protein 10( domain architecture ID 10140838)

COMM domain-containing protein 10 (COMMD10) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
12-224 1.62e-67

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 206.08  E-value: 1.62e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  12 AREGIKIINALPYETFTTVLFYTHRQmspsvasasatsstvgtsvtttgrvDSSTEENPTSNTEPEYTLEELERLvgvpR 91
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQK-------------------------LHLKAERSFSEEEEEKLQEAFKLL----S 51
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  92 QDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRLWVRETTPIMNNLASKRYESNVIEDVAWKLNM 171
Cdd:cd04758  52 QDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNL 129
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859825 172 EISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFESIQGELDAM 224
Cdd:cd04758 130 QMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLESIQEQLDSL 186
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
12-224 1.62e-67

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 206.08  E-value: 1.62e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  12 AREGIKIINALPYETFTTVLFYTHRQmspsvasasatsstvgtsvtttgrvDSSTEENPTSNTEPEYTLEELERLvgvpR 91
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQK-------------------------LHLKAERSFSEEEEEKLQEAFKLL----S 51
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  92 QDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRLWVRETTPIMNNLASKRYESNVIEDVAWKLNM 171
Cdd:cd04758  52 QDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNL 129
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859825 172 EISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFESIQGELDAM 224
Cdd:cd04758 130 QMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLESIQEQLDSL 186
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
159-217 1.14e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 55.63  E-value: 1.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859825   159 SNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTA----VGEDINIEMTQPELMELYNQFESI 217
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSdgdgSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
12-224 1.62e-67

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 206.08  E-value: 1.62e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  12 AREGIKIINALPYETFTTVLFYTHRQmspsvasasatsstvgtsvtttgrvDSSTEENPTSNTEPEYTLEELERLvgvpR 91
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQK-------------------------LHLKAERSFSEEEEEKLQEAFKLL----S 51
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825  92 QDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRLWVRETTPIMNNLASKRYESNVIEDVAWKLNM 171
Cdd:cd04758  52 QDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNL 129
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859825 172 EISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFESIQGELDAM 224
Cdd:cd04758 130 QMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLESIQEQLDSL 186
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
159-217 1.14e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 55.63  E-value: 1.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859825   159 SNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTA----VGEDINIEMTQPELMELYNQFESI 217
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSdgdgSSEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
140-221 1.33e-09

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 53.47  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859825 140 LWVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVG-----EDINIEMTQPELMELYNQF 214
Cdd:cd04748   1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGdnnssEKICFEMTKEELQNFLNKL 80

                ....*..
gi 18859825 215 ESIQGEL 221
Cdd:cd04748  81 KKIKAQL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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