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Conserved domains on  [gi|18859807|ref|NP_572743|]
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transport and golgi organization 10, isoform A [Drosophila melanogaster]

Protein Classification

BTB/POZ domain-containing protein 17( domain architecture ID 13033514)

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (Pox virus and Zinc finger) domain-containing protein 17

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-239 9.75e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 189.03  E-value: 9.75e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
250-323 5.61e-24

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


:

Pssm-ID: 350568  Cd Length: 74  Bit Score: 95.34  E-value: 5.61e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859807 250 GYLVSWLQYTLSFTptHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWL 323
Cdd:cd18493   3 NHAVSWLQYAKMCG--HKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
 
Name Accession Description Interval E-value
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-239 9.75e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 189.03  E-value: 9.75e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
250-323 5.61e-24

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 95.34  E-value: 5.61e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859807 250 GYLVSWLQYTLSFTptHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWL 323
Cdd:cd18493   3 NHAVSWLQYAKMCG--HKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
135-242 5.21e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 88.08  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807   135 NLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLYVGQIeVTLQ 214
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSG---QESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78
                          90       100
                  ....*....|....*....|....*...
gi 18859807   215 TVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
144-242 1.37e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 78.12  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807    144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEacCSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSS-DFKESDKSEIYLDDV--SPEDFRALLNFLYTGKLDLPEENVEELLELA 77
                           90
                   ....*....|....*....
gi 18859807    224 DKYNIRDLIDLCVDYMNKH 242
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
258-359 6.90e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.45  E-value: 6.90e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807    258 YTLSFTPTHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQmeatgsgg 337
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEK-------- 76
                           90       100
                   ....*....|....*....|..
gi 18859807    338 FMELIEQTVSHIRFGMMTPRQL 359
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYL 98
PHA03098 PHA03098
kelch-like protein; Provisional
145-325 6.10e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.17  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  145 IVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEAccsaVFPQFIKYLYVGQIEVTLQTVMPMLALSD 224
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKN---NFKENEINLNIDYD----SFNEVIKYIYTGKINITSNNVKDILSIAN 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  225 KYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSftpthnDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQ 304
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCK------KLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160
                        170       180
                 ....*....|....*....|.
gi 18859807  305 NDLVVTSEYKLFDILQTWLLH 325
Cdd:PHA03098 161 DKLNVSSEDVVLEIIIKWLTS 181
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
260-363 8.21e-11

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 59.10  E-value: 8.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807   260 LSFTPTHN--DLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEatgsgg 337
Cdd:pfam07707   5 YRFADAYGctELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRK------ 78
                          90       100
                  ....*....|....*....|....*.
gi 18859807   338 fmELIEQTVSHIRFGMMTPRQLSHLL 363
Cdd:pfam07707  79 --KHLPELLSAVRLPLLSPQYLLNLV 102
 
Name Accession Description Interval E-value
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-239 9.75e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 189.03  E-value: 9.75e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
250-323 5.61e-24

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 95.34  E-value: 5.61e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859807 250 GYLVSWLQYTLSFTptHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWL 323
Cdd:cd18493   3 NHAVSWLQYAKMCG--HKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-226 1.33e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 89.15  E-value: 1.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSS-GMKESSSSEIELDD--VSPEAFEALLDYIYTGELELSEENVEELLA 77

                ....*
gi 18859807 222 LSDKY 226
Cdd:cd18186  78 AADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
135-242 5.21e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 88.08  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807   135 NLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLYVGQIeVTLQ 214
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSG---QESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78
                          90       100
                  ....*....|....*....|....*...
gi 18859807   215 TVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-238 1.30e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 78.82  E-value: 1.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVML---MnpewNECSKHVIELHEEAccSAVFPQFIKYLYVGQI 209
Cdd:cd18287  13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggM----RESQQSEIELKDTN--AEAFKALLKYIYTGRL 86
                        90       100       110
                ....*....|....*....|....*....|..
gi 18859807 210 EVTL---QTVMPMLALSDKYNIRDLIDLCVDY 238
Cdd:cd18287  87 TLTDlkeDVLLDVLGLAHQYGFEELEAAISDY 118
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
144-242 1.37e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 78.12  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807    144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEacCSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSS-DFKESDKSEIYLDDV--SPEDFRALLNFLYTGKLDLPEENVEELLELA 77
                           90
                   ....*....|....*....
gi 18859807    224 DKYNIRDLIDLCVDYMNKH 242
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
143-235 2.53e-17

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 77.38  E-value: 2.53e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMnPEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18314   7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLT-GSMIESNLKEVTLEDVE--PEIFETVLKYMYTGQVTLSEENVLDLLML 83
                        90
                ....*....|...
gi 18859807 223 SDKYNIRDLIDLC 235
Cdd:cd18314  84 ASKYQVPDLEKLC 96
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-242 9.46e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 76.60  E-value: 9.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18240  19 DVVIRVNGVEFPAHRNILCACSPYFRALFTN-GWNETEKKVYKIPGVS--PEMMELIIEYAYTRTVPITAENVEELLPAA 95
                        90
                ....*....|....*....
gi 18859807 224 DKYNIRDLIDLCVDYMNKH 242
Cdd:cd18240  96 DQFNIMGIVKACCDFLEDQ 114
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
258-359 6.90e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.45  E-value: 6.90e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807    258 YTLSFTPTHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQmeatgsgg 337
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEK-------- 76
                           90       100
                   ....*....|....*....|..
gi 18859807    338 FMELIEQTVSHIRFGMMTPRQL 359
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYL 98
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-220 1.83e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 70.16  E-value: 1.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIKYLY 205
Cdd:cd18242   5 AKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTS-EMSEKGKSEVELQG--LTASTMEILLDFVY 81
                        90
                ....*....|....*
gi 18859807 206 VGQIEVTLQTVMPML 220
Cdd:cd18242  82 TETVHVTVENVQELL 96
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
135-243 1.42e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 67.51  E-value: 1.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 135 NLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQ 214
Cdd:cd18237  14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS-NMTESKSSEVELKDAE--PDIIELLVEFAYTARISVNSN 90
                        90       100
                ....*....|....*....|....*....
gi 18859807 215 TVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18237  91 NVQSLLDAANQYQIEPVKKMCVDFLKEQL 119
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
138-239 2.19e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 66.59  E-value: 2.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 138 AEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVML-MNPEWNECSKHVIELheEACCSAVFPQFIKYLYVGQIEVTLQTV 216
Cdd:cd18245  10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnYNPPKDDGSTYKIEL--EGISVEVMEEILDYIYTGQIKLSEDNI 87
                        90       100
                ....*....|....*....|...
gi 18859807 217 MPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18245  88 QDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 4.81e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 66.56  E-value: 4.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVielHEEACCSAVFPQFIKYLY 205
Cdd:cd18270  10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV---HLRNVDAATLQIIITYAY 86
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18270  87 TGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKI 124
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
130-242 8.56e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 65.39  E-value: 8.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 130 LNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQI 209
Cdd:cd18238   3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTS-EMAESKQDSITIKDID--EEAVELLVDFAYTGKL 79
                        90       100       110
                ....*....|....*....|....*....|...
gi 18859807 210 EVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18238  80 TLTVDNVQSLLYAASLLQVEEVAKACCEFMKDH 112
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
136-239 9.37e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 64.96  E-value: 9.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 136 LYAEQLMSDIVLLV--DGKEFPAHRVILCASSDVFQVMLMNPEW--NECSKHVIELHEEAccsaVFPQFIKYLYVGQIEV 211
Cdd:cd18294   8 LINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQkeSTQSPLVLSDIEPE----VFRAVLEFIYTNCVTL 83
                        90       100
                ....*....|....*....|....*...
gi 18859807 212 TLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18294  84 SNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
129-244 1.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 65.19  E-value: 1.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 129 VLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLYVGQ 208
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCN---NFRESSQAKVDLKGIDSDVLDQIVDYVYTGE 86
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18268  87 ILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLT 122
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-239 1.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 64.79  E-value: 1.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18265  24 TDVVLLVDGKDFPCHRATLSANSAYFRAMF-GGHLKESRQAVVEIQKVS--AAAMEVLLDYMYGGGLRIQEDNVESVLEA 100
                        90
                ....*....|....*..
gi 18859807 223 SDKYNIRDLIDLCVDYM 239
Cdd:cd18265 101 SDLLQVSKLREACVRFL 117
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-244 3.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 63.70  E-value: 3.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVT 212
Cdd:cd18279   9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEH-EMEESKKNRVEINDVD--PEVFKEMMRFIYTGKAPNL 85
                        90       100       110
                ....*....|....*....|....*....|..
gi 18859807 213 LQTVMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18279  86 DKMADDLLAAADKYALERLKVMCEDALCSNLS 117
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
131-234 9.66e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 62.28  E-value: 9.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPeWNECSKHVIELHEEACcsAVFPQFIKYLYVGQIE 210
Cdd:cd18286   6 KDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGS-WAESNSSEITLTGVSH--AAVSFVLLFIYGGVLD 82
                        90       100
                ....*....|....*....|....*
gi 18859807 211 VTL-QTVMPMLALSDKYNIRDLIDL 234
Cdd:cd18286  83 LPDdVNLGELLSLADMYGLDGLKDV 107
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
117-241 2.92e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 61.39  E-value: 2.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 117 QDEASTMIDANSVLnkianlyaeqlmsDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKhviELHEEACCSAV 196
Cdd:cd18340  15 QDGLKDLLDHNKFV-------------DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKR---EIVLEDVDPDV 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 18859807 197 FPQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18340  79 MGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQK 123
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 4.74e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 60.55  E-value: 4.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18250   5 ALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAG-ELRESRADRVVLHGVS--AEILGLLLDFSY 81
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18250  82 TGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRL 119
PHA03098 PHA03098
kelch-like protein; Provisional
145-325 6.10e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.17  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  145 IVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEAccsaVFPQFIKYLYVGQIEVTLQTVMPMLALSD 224
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKN---NFKENEINLNIDYD----SFNEVIKYIYTGKINITSNNVKDILSIAN 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  225 KYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSftpthnDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQ 304
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCK------KLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160
                        170       180
                 ....*....|....*....|.
gi 18859807  305 NDLVVTSEYKLFDILQTWLLH 325
Cdd:PHA03098 161 DKLNVSSEDVVLEIIIKWLTS 181
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 6.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 60.11  E-value: 6.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18256   4 ASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQIHGVE--PDIFHILLDFIY 80
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18256  81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
260-363 8.21e-11

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 59.10  E-value: 8.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807   260 LSFTPTHN--DLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEatgsgg 337
Cdd:pfam07707   5 YRFADAYGctELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRK------ 78
                          90       100
                  ....*....|....*....|....*.
gi 18859807   338 fmELIEQTVSHIRFGMMTPRQLSHLL 363
Cdd:pfam07707  79 --KHLPELLSAVRLPLLSPQYLLNLV 102
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
129-244 9.46e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 59.81  E-value: 9.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 129 VLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEwNECSKHVIELHeeACCSAVFPQFIKYLYVGQ 208
Cdd:cd18264  15 VLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYT-QESKARVIHLP--VVSAAGLQRVLDFIYTSW 91
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18264  92 LSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLA 127
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
131-244 1.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 59.20  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIE 210
Cdd:cd18344  12 DDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEH-EMEERLKNPIEIHD--LDPQVFKEMMGFIYTGKAP 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859807 211 VTLQTVMP--MLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18344  89 HLHSHSMAcdVLAAADKYGLEGLKVLCEDALCRNLS 124
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
136-244 2.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 58.57  E-value: 2.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 136 LYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKhviELHEEACCSAVFPQFIKYLYVGQIEVTLQT 215
Cdd:cd18269  21 LLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKK---EVVLEDVDPDVMGMILKYLYTSEIDLNDQN 97
                        90       100
                ....*....|....*....|....*....
gi 18859807 216 VMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18269  98 VQDIFALASRFQIPSIFTVCVSYLQKRLS 126
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-242 2.52e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 58.22  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVdGKE-----FPAHRVILCASSDVFQVML---MNPEWNEcskhvIELHEEAccSAVFPQ 199
Cdd:cd18281   8 TVKERFAFLFNNETLSDVHFIV-GKGdneqrIPAHKFVLSIGSAVFDAMFnggMATTSAE-----IELPDVE--PAAFLA 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 18859807 200 FIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18281  80 LLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKN 122
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
133-240 2.52e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 57.61  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKE-FPAHRVILCASSDVFQVMLMnpewNECskhVIELHEEACCSAvFPQFIKYLYVGQIEV 211
Cdd:cd18299   3 LRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFL----MMT---VVTLDSDITPEA-FRRVLEFLYTGVLDE 74
                        90       100
                ....*....|....*....|....*....
gi 18859807 212 TLQTVMPMLALSDKYNIRDLIDLCVDYMN 240
Cdd:cd18299  75 NEDDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-242 4.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 57.40  E-value: 4.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheEACCSAVFPQFIKYLYVG 207
Cdd:cd18255   4 TLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG-GMRESSQDEIEL--KGVSAKGLKHILDFAYTS 80
                        90       100       110
                ....*....|....*....|....*....|....*
gi 18859807 208 QIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18255  81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSA 115
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-241 4.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 57.54  E-value: 4.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheeaccSAVFPQ----FI 201
Cdd:cd18253   2 SESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCN-DHRESREMLVEI------NGILAEamdcFL 74
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859807 202 KYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18253  75 QYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEE 114
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-235 6.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 56.90  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPeWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIE---VTLQTVMP 218
Cdd:cd18297  12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSG-STEAQTPVIEIPD--IRYDIFQLMMQYLYTGGVEsldVAQDDALE 88
                        90
                ....*....|....*..
gi 18859807 219 MLALSDKYNIRDLIDLC 235
Cdd:cd18297  89 LLRAASFFQLDGLKRHC 105
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
140-239 6.06e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 57.00  E-value: 6.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 140 QLMSDIVLLVDGK----EFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheEACCSAVFPQFIKYLYVGQIEVTLQT 215
Cdd:cd18248  19 QQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTS-GLRECGMEVVPI--EGVHPCVMSRLIEFAYTASISVGEKC 95
                        90       100
                ....*....|....*....|....
gi 18859807 216 VMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18248  96 VLHVLPGAVMYQMDSVVKACCDFL 119
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
144-235 7.19e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 56.92  E-value: 7.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNP----EWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIEVTLQTVMPM 219
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHfaesEENNGSIPVVTLHD--VSPEVFAIVLYYIYTDDTDLPPENAYDV 96
                        90
                ....*....|....*.
gi 18859807 220 LALSDKYNIRDLIDLC 235
Cdd:cd18296  97 LYVADMYLLPGLKRLC 112
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
139-243 1.07e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 56.09  E-value: 1.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEACcsAVFPQFIKYLYVGQIEVT-LQTVM 217
Cdd:cd18300   6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGG-NFRESSAKEVELPGVSK--ETFLALLEYLYTDQAPILeDGDCV 82
                        90       100
                ....*....|....*....|....*.
gi 18859807 218 PMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18300  83 GLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
142-235 1.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 56.33  E-value: 1.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEACcsAVFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18352  13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMF-DGGYREKEARDIEIPNIRW--EVFELMMRFIYTGSVDITNDIAKDLLR 89
                        90
                ....*....|....
gi 18859807 222 LSDKYNIRDLIDLC 235
Cdd:cd18352  90 AADQYLLEGLKRLC 103
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
139-243 1.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 56.83  E-value: 1.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMP 218
Cdd:cd18272  29 DGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTS-NLKEARNRVIELKDVS--ESVFQLLVDYIYHGTVKLRVEELQE 105
                        90       100
                ....*....|....*....|....*
gi 18859807 219 MLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18272 106 TYEVADMYQLTALFEECSRFLARTV 130
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-243 5.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 54.68  E-value: 5.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLV----------DGKEFPAHRVILCASSDVFQVMLMNPEWNECSKhvIELHEEAccSAVF 197
Cdd:cd18346   8 SLKERFAFLFNNELLSDVRFVVgkgrprgpgpGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE--IELPDVE--PAAF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 18859807 198 PQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18346  84 LALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 129
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 6.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 54.28  E-value: 6.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIElheeacCSAVFPQFIKYLY 205
Cdd:cd18222   9 SNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIK------NPTVFEQLLSFCY 82
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18222  83 TGRICLQLADIISYLTAASFLQMQHIIDKC 112
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-237 6.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 54.03  E-value: 6.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSavFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18293  17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQGLKAHT--LLKLVDFLYTSELEVSSEEAQDVLAAA 94
                        90
                ....*....|....
gi 18859807 224 DKYNIRDLIDLCVD 237
Cdd:cd18293  95 RRLQISELESLCLE 108
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-243 1.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 53.66  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVM----LMnpewnECSKHVIELHEEACCSAVFpqFIKY 203
Cdd:cd18276   7 TLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMftcgLM-----ECSQREVVLHDITAESVSI--ILNY 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18276  80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHM 119
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-235 1.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 53.47  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVT 212
Cdd:cd18343  12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEH-EMEESKKNRVEINDVD--PEVFKEMMRFIYTGKAPNL 88
                        90       100
                ....*....|....*....|...
gi 18859807 213 LQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18343  89 DKMADNLLAAADKYALERLKVMC 111
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
123-239 1.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 53.20  E-value: 1.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 123 MIDANSVLNKianLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIK 202
Cdd:cd18235   5 TQKAFDVMNE---LRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTG-DLSESRANRVTLQD--VDGKALLLLID 78
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859807 203 YLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18235  79 YVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
131-239 1.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 53.70  E-value: 1.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecskHVIELHEEACC-----SAVFPQFIKYLY 205
Cdd:cd18236  13 NGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCN--------DLKEKYEEKIIikgvdAETMQILLDYTY 84
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18236  85 TSKVLITKQNVQRVLEAASLFQFLRMVDACASFL 118
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
142-235 1.88e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 52.75  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLL-VDGKEFPAHRVILCASSDVFQVMLMN--PEWNECSKHVIELHeeaccSAVFPQFIKYLYVGQIEVTLQT--- 215
Cdd:cd18302   5 LYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSswIEASSCSALTMPIP-----SDILEIILDYLYTDEASAVKESqnv 79
                        90       100
                ....*....|....*....|..
gi 18859807 216 --VMPMLALSDKYNIRDLIDLC 235
Cdd:cd18302  80 efLCNVLVIADQLLITRLKEIC 101
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-235 2.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 52.54  E-value: 2.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIEL----HEeaccsaVFPQFIKYLYVGQ 208
Cdd:cd18345   9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEH-EMEERKQNRVEItdvdHE------VMREMLRFIYTGK 81
                        90       100
                ....*....|....*....|....*..
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18345  82 APNLDKMADDLLAAADKYALERLKVMC 108
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
123-243 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 52.80  E-value: 2.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 123 MIDANSVLNKianLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIK 202
Cdd:cd18339   5 MKKAFKVMNE---LRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTG-DMSESKAKKIEIKD--VDGQTLSKLID 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 18859807 203 YLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18339  79 YIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
133-233 2.30e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 52.64  E-value: 2.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNecSKHVIELHEEACCSAVFPQFIKYLYVGQIEVT 212
Cdd:cd18295  10 LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFET-KWK--DKREINLKHPLVNPDAFRALLQYLYTGRLEIH 86
                        90       100
                ....*....|....*....|.
gi 18859807 213 LQTVMPMLALSDKYNIRDLID 233
Cdd:cd18295  87 VDDVEDCKRLAKQCRLEELIE 107
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-243 2.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 52.65  E-value: 2.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVIL-CASSDVFQVMLMNPEWNECSKHVIE-LHEEAccsavFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18306  20 DVILQVGGHEIPAHRAVLaCASPYLFELFSSDSDGESILTVKLDgLDPDA-----VEVLVNYAYTSRLEVPADLVKSVYS 94
                        90       100
                ....*....|....*....|..
gi 18859807 222 LSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18306  95 AAKKLKMDRVKKACGDFLLEKL 116
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 2.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 52.74  E-value: 2.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheEACCSAVFPQFIKYLY 205
Cdd:cd18336   3 AEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTN-DVREAKQEEIKM--EGVDPDALKALVHYAY 79
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18336  80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQL 117
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-241 3.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 51.60  E-value: 3.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaccsaVFPQ----FIKYLYVGQIEVTLQTVM 217
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTN-DVREATEEEIKLKD------VDPDalwtLVQYCYTGRLELKEDNVE 73
                        90       100
                ....*....|....*....|....
gi 18859807 218 PMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18234  74 SLLATACLLQLSEVVEACCGFLMK 97
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 3.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 52.68  E-value: 3.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVM----LMNPEWNECSKHViELHEEaccsaVFPQFI 201
Cdd:cd18267  24 ADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMfsggLKESQDSEVNFHD-SIHPE-----VLELLL 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18859807 202 KYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18267  98 DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNL 139
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
136-239 4.71e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 51.24  E-value: 4.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 136 LYAEQLMSDIVLLVDGKE----FPAHRVILCASSDVFQVMLmnpeWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEV 211
Cdd:cd18282   1 MFNNELMADVHFIVGPPGgtqrIPAHKYVLATGSSVFYAMF----YGGLAENKNEIEIPDVEPAAFLNLLRYLYCDEIDL 76
                        90       100
                ....*....|....*....|....*...
gi 18859807 212 TLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18282  77 EPDTVLATLYAAKKYLVPHLARACVQFL 104
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-239 8.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 50.72  E-value: 8.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18298  13 SDLKFRVDGKYIYVHKAILKIRCEYFRSMFQS-HWNEDDKNVIEIDQYS--YPVYYAFLRYLYTDQVDLPPEDAIGLLDL 89
                        90
                ....*....|....*..
gi 18859807 223 SDKYNIRDLIDLCVDYM 239
Cdd:cd18298  90 ANSYCEERLKKLCEDII 106
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
121-239 8.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 51.50  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 121 STMIDANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIelHEEACCSAVFPQF 200
Cdd:cd18244   9 NSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMF-TADMRERDQDKI--HLKGLTATGFSHV 85
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 18859807 201 IKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18244  86 LQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFL 124
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-239 1.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 50.59  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELH---EEACCsavfpQFIKYL 204
Cdd:cd18251   9 ALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAG-GLREMQQTEVLIHgvsYNAMC-----KILDFI 82
                        90       100       110
                ....*....|....*....|....*....|....*
gi 18859807 205 YVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18251  83 YTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-241 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 50.36  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHE-EAccSAVfPQFIKYL 204
Cdd:cd18247   3 PSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTH-DMVESKQDEITMQGiEP--SAL-EALINFA 78
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859807 205 YVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18247  79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
136-239 1.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 49.98  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 136 LYAEQLMSDIVLLV----DGKEFPAHRVILCASSDVFQVMLmnpeWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEV 211
Cdd:cd18349   2 MFNNELMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMF----YGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDL 77
                        90       100
                ....*....|....*....|....*...
gi 18859807 212 TLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18349  78 EADTVLATLYAAKKYIVPALAKACVNFL 105
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-239 2.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 49.85  E-value: 2.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18257   2 SEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTG---NLSEKENSEVEFQCIDETALQAIVEYAY 78
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18257  79 TGTVFISQATVESLLPAANLLQIKLVLKECCDFL 112
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
136-246 2.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 50.23  E-value: 2.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 136 LYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIElheEACCSAVFPQFIKYLYVGQIEVTLQT 215
Cdd:cd18341  21 LLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVL---DNVDPNIMDMILKYLYSAEIDLNDGN 97
                        90       100       110
                ....*....|....*....|....*....|.
gi 18859807 216 VMPMLALSDKYNIRDLIDLCVDYMNKHVAKA 246
Cdd:cd18341  98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPA 128
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-241 2.81e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 49.86  E-value: 2.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLV---DGKEFPAHRVILCASSDVFQVMLMNPeWNECSKHVIELHEEACCSAVFPQ----FIKYLYVGQIEVTL 213
Cdd:cd18241  22 LFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQ-FSESRSGRVEMRKWSSEPGPDPDtveaVIQYMYTGRIRVST 100
                        90       100
                ....*....|....*....|....*...
gi 18859807 214 QTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18241 101 GNVHEVLELADRFLLIRLKEFCGEFLKK 128
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-235 2.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 49.63  E-value: 2.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMNP--EWNEcskHVIELHE-EAccsAVFPQFIKYLY----------VGQI 209
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPmrEENE---GEIVIEDvEP---PVFKALLHFIYkdelpddvepAGSD 88
                        90       100
                ....*....|....*....|....*...
gi 18859807 210 EVTLQTVMP--MLALSDKYNIRDLIDLC 235
Cdd:cd18280  89 SSSLDTTMAqhLLAAADRYALERLRLLC 116
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 4.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 49.22  E-value: 4.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVD-GKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEAccsAVFPQFIKYL 204
Cdd:cd18274   6 ACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA---ESMHLVLDYA 82
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 18859807 205 YVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18274  83 YTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRL 121
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-239 5.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 48.66  E-value: 5.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMnpewNECSKHVIELHEeacCSAV-FPQFIKYLYV 206
Cdd:cd18260   4 NLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK----KDPSLQRVELND---ISPLgLATVITYAYT 76
                        90       100       110
                ....*....|....*....|....*....|...
gi 18859807 207 GQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18260  77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFL 109
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
152-237 5.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 49.08  E-value: 5.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 152 KEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDL 231
Cdd:cd18211  39 EEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNE--IYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDL 116

                ....*.
gi 18859807 232 IDLCVD 237
Cdd:cd18211 117 SETCFQ 122
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-244 7.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 48.50  E-value: 7.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLmnpewnecskHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18243  16 SDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF----------SINNLVLQGCSSIGLRLVLEYLY 85
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18243  86 TANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQIS 124
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 8.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 48.29  E-value: 8.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELheeaCCSAVFPQFIKYLY 205
Cdd:cd18224  10 PNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF----ITPANFEKVLSFIY 85
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18224  86 TSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
116-239 8.92e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 48.42  E-value: 8.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 116 GQDEASTMIDANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVM----LMNPEWNECSKHVIElheea 191
Cdd:cd18261   2 GQRLCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNLHGVT----- 76
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 18859807 192 ccSAVFPQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18261  77 --SLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 1.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 48.29  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18259  16 PQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTG-DFVESISARVEIKDVD--PAVMESLIDFAY 92
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18259  93 TGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQI 130
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 1.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 47.93  E-value: 1.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVF------QVMLMNPEWNECSKHVIELHEeaCCSAVFPQ 199
Cdd:cd18228   3 SQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFrsklvgQASPRLVLVSPAGKCVLDLHH--VTVTGFAP 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 18859807 200 FIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18228  81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-238 1.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 47.11  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18307   3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGA 82
                        90
                ....*....|....*
gi 18859807 224 DKYNIRDLIDLCVDY 238
Cdd:cd18307  83 KYFNIPRLKDHCVDF 97
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-241 1.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 47.73  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18335   3 AEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTS---DVCEAKQEEIKMEGIDPNALWDLVQFAY 79
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18335  80 TGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMK 115
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-235 1.36e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 47.48  E-value: 1.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSD--IVLLVDGKE-----FPAHRVILCASSDVfQVMLMNPEWNecskhvIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18304   8 LGLLYDSQQGCDfnISVLTAGGEeeeltFCAHRVILMLSPEA-NFLHKTGSSN------ITLDVDEECLPHVPDFLRYFY 80
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18304  81 TRQIDITLTSVKCFHKLASIYGVRKLREYC 110
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
131-235 1.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 47.79  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIE 210
Cdd:cd18342  11 DELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEH-EMEESKKNRVEINDVE--PEVFKEMMCFIYTGKAP 87
                        90       100
                ....*....|....*....|....*
gi 18859807 211 VTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18342  88 NLDKMADDLLAAADKYALERLKVMC 112
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-235 1.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 47.65  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHeeACCSAVFPQFIKYLYVGQIEVTLQTvMPMLALS 223
Cdd:cd18207  29 DVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMH--TISSKVFGDILDFAYTSRIVVRLES-FPELMTA 105
                        90
                ....*....|...
gi 18859807 224 DKYNI-RDLIDLC 235
Cdd:cd18207 106 AKFLLmRSVIDIC 118
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
144-207 1.65e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 46.51  E-value: 1.65e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHV-IELHEEACCSAVFPQFIKYLYVG 207
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGcDVVHIEKVPPEIFEQLLQFIYTD 84
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-230 1.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 47.72  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEACcsAVFPQFIKYLYVGQI---EVTLQTVM 217
Cdd:cd18246  38 LLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTN-EMSESRQTHVTLHDIDP--QALEQLVQYAYTAEIvvgEGNVQTLL 114
                        90
                ....*....|...
gi 18859807 218 PMLALSDKYNIRD 230
Cdd:cd18246 115 PAASLLQLNGVRD 127
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-243 1.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 47.38  E-value: 1.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLV----DGKEFPAHRVILCASSDVFQVMLMNPEWNECSKhvIELHEEAccSAVFPQFIKY 203
Cdd:cd18347   8 TVQERFAFLFNNEVLSDVHFLVgkglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE--IELPDVE--PAAFLALLKF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18347  84 LYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 123
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
130-243 2.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 47.13  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 130 LNKIANLYAEQLMSDIVLL-VDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEACcsAVFPQFIKYLYVGQ 208
Cdd:cd18252   9 LDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMF-TADMKEKSNNVIKLSGIDH--DILEALVNYVYTSQ 85
                        90       100       110
                ....*....|....*....|....*....|....*
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18252  86 ICITERNVQSLLEAADLLQFISVKKACEQFLVRHL 120
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-239 2.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 46.89  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCaSSDVFQVMlMNPEWNECSKHVIELH-------EEACcSAVFPQfikyLYVGQIEVTLQT 215
Cdd:cd18305  16 SDITICALGREWKLHKIYLC-QSGYFASM-FSGSWKESKETVINLEipddnitVEAL-NVVFGS----LYRDEIEIKPSR 88
                        90       100
                ....*....|....*....|....
gi 18859807 216 VMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18305  89 VVSILAAATLLQLDGLIQQCSEVM 112
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
130-234 2.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 46.42  E-value: 2.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 130 LNKIANLYAEQLMSDIVL-LVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHvieLHEEACCSAVFPqFIKYLYVGQ 208
Cdd:cd18311   2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLI---MPNELQADAVVP-VINFMYTGQ 77
                        90       100
                ....*....|....*....|....*.
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDL 234
Cdd:cd18311  78 LEFEEKSYGKLLRTAKELNMTVLLKL 103
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
127-240 4.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 45.94  E-value: 4.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 127 NSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEwnECSKHVIELheEACCSAVFPQFIKYLYV 206
Cdd:cd18212   8 DTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEG--EVGQSIYML--EGMVAETFGALLEFIYT 83
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 207 GQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMN 240
Cdd:cd18212  84 GCLQVGEKSLEQILATAQFLKVNDLVKAYSDYQN 117
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-237 4.39e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 46.16  E-value: 4.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSkhVIELHEEACCSAvfpqfIKYLYVGQIEVT 212
Cdd:cd18303   9 VASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLA-STNELD--LSDISYEVVLAL-----LRWLYTDELDLT 80
                        90       100
                ....*....|....*....|....*..
gi 18859807 213 LQTV--MPMLALSDKYNIRDLIDLCVD 237
Cdd:cd18303  81 LDDEflLELMKAAKRFQLTDLVERCER 107
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-241 4.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 46.74  E-value: 4.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKE--------FPAHRVILCASSDVFQVMLMNPeWNECSKHVIELHEEACCSavF 197
Cdd:cd18273  10 ARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGG-LYESKQETVTIHDVDSES--M 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 18859807 198 PQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18273  87 ALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLAR 130
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-235 4.98e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 46.38  E-value: 4.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMN-PEWNECSKHVIELHEEAccSAVFPQFIKYLYVG---QIEVTLQTVM 217
Cdd:cd18350  24 MSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNkSEQESQGSKTIEISDIK--YHIFQMLMQYLYYGgteSMEIPIADVL 101
                        90
                ....*....|....*...
gi 18859807 218 PMLALSDKYNIRDLIDLC 235
Cdd:cd18350 102 ELLSAASLFQLDALQRHC 119
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-241 5.36e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 45.71  E-value: 5.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18353  21 SDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQS-HWNEDMKEVIEIDQFS--YPVYRAFLEYLYTDSVDLPPEDAIGLLDL 97
                        90
                ....*....|....*....
gi 18859807 223 SDKYNIRDLIDLCVDYMNK 241
Cdd:cd18353  98 ATSYCENRLKKLCQHIIKR 116
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
144-211 5.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 44.46  E-value: 5.88e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMnpEWNECSKHVIELHEeaccsavFPQF-----IKYLYVGQIEV 211
Cdd:cd18315   3 DVTLACEGGSLKAHKLVLAAASPYFAALLK--ETPPDEHPVIILPD-------VPYSelkalLDFIYTGEVNV 66
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 6.20e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 45.79  E-value: 6.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEeaccsaVFPQFIKYLY 205
Cdd:cd18220   9 SNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPN------VFEQLLSFCY 82
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18220  83 TGRMSLQLKDVVSFLTAASFLQMQCVIDKC 112
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-235 6.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 45.31  E-value: 6.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecSKHVIelHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPML 220
Cdd:cd18206  21 LLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD------QKDVV--HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVL 92
                        90
                ....*....|....*
gi 18859807 221 ALSDKYNIRDLIDLC 235
Cdd:cd18206  93 AVATFLQMQDIVTAC 107
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
129-235 1.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 44.36  E-value: 1.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 129 VLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMlmnpeWNECSKHVIELHEEacCSAVFPQFIKYLYVGQ 208
Cdd:cd18232   5 VLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSL-----YGDGTSGSVVLPES--FAEVFGLLLDFFYTGE 77
                        90       100
                ....*....|....*....|....*..
gi 18859807 209 IEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18232  78 LALTRENRDRVLLAAKELRVPEAVELC 104
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
129-243 1.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 44.82  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 129 VLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVM--LMNPEWNECSKHVIELHEEACCSavfpqFIKYLYV 206
Cdd:cd18271  11 ILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMfeVNMKERDDGSVTISNLSPKAVKA-----FLDYAYT 85
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859807 207 GQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18271  86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSI 122
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
132-239 1.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 44.68  E-value: 1.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 132 KIAN-LYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIE 210
Cdd:cd18338  10 KVMNeLRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTG-EMSESRAKRVRIKE--VDGWTLKMLIDYVYTAEIQ 86
                        90       100
                ....*....|....*....|....*....
gi 18859807 211 VTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18338  87 VTEENVQVLLPAAGLLQLQDVKKTCCEFL 115
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-235 1.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 44.54  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLmnpewNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18354  21 ADLKFLVDGKYIYVHKVLLKIRCEHFRSLL-----NENEEEIIEMSQFS--YPVYRAFLEYLYTDSISLSPEDAIGLLDL 93
                        90
                ....*....|...
gi 18859807 223 SDKYNIRDLIDLC 235
Cdd:cd18354  94 ATFYRENRLKKLC 106
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
139-235 1.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQvMLMNPEWNECSKHVIELHeEACCSAVFPQFIKYLYVGQIEVTLQTVMP 218
Cdd:cd18329  18 QELFCDCSILVEGQVFKAHRNVLFASSGYFK-MLLSQNAKETGQPTVATF-DVFSPDTFTIILDFVYSGKLSLTSQNVIE 95
                        90
                ....*....|....*..
gi 18859807 219 MLALSDKYNIRDLIDLC 235
Cdd:cd18329  96 VMSAASYLQMTDVISVC 112
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
130-235 2.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 43.77  E-value: 2.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 130 LNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHvielheEACCSAVFPQFIKYLYVGQI 209
Cdd:cd18218   6 LHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLG------EGISPSTFKQLLDFVYGESV 79
                        90       100
                ....*....|....*....|....*.
gi 18859807 210 EVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18218  80 EVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-235 4.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 43.43  E-value: 4.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSkhVIELHEEAccSAVFPQFIKYLYVGQIEVTL---QTVMP 218
Cdd:cd18351  24 MSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENT--CIEISYVK--YHIFQLVMQYLYCGGTESLLiknNEIME 99
                        90
                ....*....|....*..
gi 18859807 219 MLALSDKYNIRDLIDLC 235
Cdd:cd18351 100 LLSAAKFFQLEALQRHC 116
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-245 4.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 43.34  E-value: 4.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVielhEEACCSAV-FPQFIKYL 204
Cdd:cd18266   9 SNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEV----ELVGASYIgLKAVIDFL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 18859807 205 YVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVAK 245
Cdd:cd18266  85 YSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSE 125
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-235 5.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 42.72  E-value: 5.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSkhVIELheEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18204  20 DIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSS--VIEI--DFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSG 95
                        90
                ....*....|..
gi 18859807 224 DKYNIRDLIDLC 235
Cdd:cd18204  96 QILGIRFLDKLC 107
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 5.91e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 42.65  E-value: 5.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecsKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18334   5 AKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH-------DNLINLDTDMVNPTVFRQILDFIY 77
                        90       100       110
                ....*....|....*....|....*....|....
gi 18859807 206 VGQIEVTLQTVMP----MLALSDKYNIRDLIDLC 235
Cdd:cd18334  78 TGKLLTSDQPGEQnfnaLLTAASYLQLHDLAALC 111
BACK_LGALS3BP cd18496
BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding ...
269-323 5.98e-05

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.


Pssm-ID: 350571  Cd Length: 74  Bit Score: 41.61  E-value: 5.98e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859807 269 LTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWL 323
Cdd:cd18496  20 LRGLCLQYLAWNCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
130-246 6.63e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 42.49  E-value: 6.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 130 LNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHeeaccsAVFPQ----FIKYLY 205
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTS-GMKESTQSVVQLP------TIPAKdlrlLISFAY 73
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVAKA 246
Cdd:cd18263  74 SGILHLSWENLFEATCTALQLQISGALALCLDFLQREISPA 114
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
124-240 7.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 42.62  E-value: 7.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 124 IDANSVLNKIANlyaEQLMSDIVLLVDGKEFPAHRVILCASSDVFQvMLMNPEWNECSKHVIELheEACCSAVFPQFIKY 203
Cdd:cd18326  10 SDILSSLNEQRT---QGLLCDVVILVEGREFPTHRSVLAACSQYFK-KLFTSGAVVDQQNVYEI--DFVSAEALTALLDF 83
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMN 240
Cdd:cd18326  84 AYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
128-239 8.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 42.70  E-value: 8.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 128 SVLNKIANLYAEQLMSDIVLLVD----GKEFPAHRVILCASSDVFQVMLmnpeWNECSKHVIELHEEACCSAVFPQFIKY 203
Cdd:cd18348   7 TIRERNAVMFNNDLMADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMF----YGELAEDKDEIRIPDVEPAAFLAMLKY 82
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18348  83 IYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFL 118
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
127-243 8.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 42.69  E-value: 8.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 127 NSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHV---IELHEEaccsaVFPQFIKY 203
Cdd:cd18254   7 DCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVnfhDSLHPE-----VLELLLDF 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18254  82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 121
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-211 9.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 42.17  E-value: 9.03e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEwNEcSKHVIELheEACCSAVFPQFIKYLYVGQIEV 211
Cdd:cd18209  20 DVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKE-NE-SQSVFQL--DFCEPDAFENVLNYIYSSSLFV 83
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-239 1.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 41.84  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELheEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18330  20 DCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASL--DIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97
                        90
                ....*....|....*.
gi 18859807 224 DKYNIRDLIDLCVDYM 239
Cdd:cd18330  98 SYLQMTDVVNFCKGYI 113
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
139-239 1.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 42.24  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECskhVIELHEEACCSAVFPqFIKYLYVGQIEVTLQTVMP 218
Cdd:cd18278  28 QDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDL---VVSLPEEVTARGFGP-LLQFAYTAKLLLSRENIQE 103
                        90       100
                ....*....|....*....|.
gi 18859807 219 MLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18278 104 VIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-242 1.47e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 41.75  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecsKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18216   4 ATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLH-------DNLIHLDQDMVSPTVFQQILDFIY 76
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVM---PMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18216  77 TGKLLDSLFEEPnlsEVLAAANYLQLPDLAALCRSKLKRG 116
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
269-360 2.01e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 40.75  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 269 LTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEatgsggfmELIEQTVSH 348
Cdd:cd18457  21 LVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENRE--------EYLPELLSK 92
                        90
                ....*....|..
gi 18859807 349 IRFGMMTPRQLS 360
Cdd:cd18457  93 VRLPLLRPQFLT 104
PHA02713 PHA02713
hypothetical protein; Provisional
129-325 2.18e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 44.23  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  129 VLNKIANLYAEQLMSDIVLLV-DGKEFPAHRVILCASSDVFQVMLMNPEWneCSKHVIELHEEACCSAVFPQFIKYLYVG 207
Cdd:PHA02713  12 VVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMI--IRDLVTRVNLQMFDKDAVKNIVQYLYNR 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807  208 QIevTLQTVMPMLALSDKYNIRDLIDLCVDYMnKHVAKAATSGYLVSWLqYTLSFTPthndLTETLKRFLKWNLEMVAES 287
Cdd:PHA02713  90 HI--SSMNVIDVLKCADYLLIDDLVTDCESYI-KDYTNHDTCIYMYHRL-YEMSHIP----IVKYIKRMLMSNIPTLITT 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 18859807  288 RDFVEMDPAILILLLQQND--LVVTSEYKLfDILQTWLLH 325
Cdd:PHA02713 162 DAFKKTVFEILFDIISTNDnvYLYREGYKV-TILLKWLEY 200
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-243 2.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 41.20  E-value: 2.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheEACCSAVFPQFIKYLY 205
Cdd:cd18337   7 AEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTN-DVREAKQEEIKM--EGVEPNALWALVQYAY 83
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18337  84 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQL 121
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
141-239 2.82e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 40.60  E-value: 2.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHeeACCSAVFPQFIKYLYVGQ-IEVTLQTVMPM 219
Cdd:cd18360   9 LLADVVFKIQGTTVPAHRAVLVARCEVMAAMF-NGNYAEAKSFLVPIY--GVSKDTFLSFLEYLYTDScCPASILQAMAL 85
                        90       100
                ....*....|....*....|
gi 18859807 220 LALSDKYNIRDLIDLCVDYM 239
Cdd:cd18360  86 LICAEMYQVSRLQHICELYI 105
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
139-239 2.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 40.48  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQvMLMNPEWNECSKHVIELHeEACCSAVFPQFIKYLYVGQIEVTLQTVMP 218
Cdd:cd18199  15 QDFFCDCSIIVEGRIFKAHRNVLFASSGYFR-MLLSHYIQDTGRPSTASF-DVFSSDAFSIILDFVYSGKLSLTSQNVIE 92
                        90       100
                ....*....|....*....|.
gi 18859807 219 MLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18199  93 VMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-239 3.00e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 40.81  E-value: 3.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEwnECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPML 220
Cdd:cd18230  20 ILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQ--KTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVM 97
                        90
                ....*....|....*....
gi 18859807 221 ALSDKYNIRDLIDLCVDYM 239
Cdd:cd18230  98 SAASYLQMTDIVQACHNFI 116
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
143-209 4.25e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.45  E-value: 4.25e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMN--PEWNECSkhvIELHEEACCSAVFPQFIKYLYVGQI 209
Cdd:cd18309  21 CDITLLLDGHPIPAHKAILAARCSYFEAMFRSfmPEDNTVN---ISIGEMVPSRQAFDSLLRYIYYGDV 86
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-239 4.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 39.76  E-value: 4.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECskhVIELHEEACCSAVFPqFIKYLYVGQIEVTLQTVMPMLALS 223
Cdd:cd18955   3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDL---VITLPEEVTVKGFEP-LLQFAYTAKLLLSKENVLEVCRCA 78
                        90
                ....*....|....*.
gi 18859807 224 DKYNIRDLIDLCVDYM 239
Cdd:cd18955  79 EFLGVHNIEKACFDFL 94
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-236 4.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 39.77  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKE-FPAHRVILCASSDVFQVMLMNPEwNECSKHVIELHeEACCSAVFpQFIKYLYVGQIEV--TLQTVMPM 219
Cdd:cd18313   2 ADVEIETDNNShIPAHSNVLASASPVIAGMLKQPR-RKSSKKVIKIL-GVPCDAVR-VFIRFLYSSCYEEeeMEKFGIHL 78
                        90
                ....*....|....*..
gi 18859807 220 LALSDKYNIRDLIDLCV 236
Cdd:cd18313  79 LVLSHVYVVPQLKRVCE 95
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
127-241 5.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.40  E-value: 5.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 127 NSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMlmnpeWNECSKHVIELhEEACCSAVFPQFIKYLYV 206
Cdd:cd18289  14 NTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDL-----FSGNSKSAFEL-PATVPPACFQQILSFCYT 87
                        90       100       110
                ....*....|....*....|....*....|....*
gi 18859807 207 GQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18289  88 GKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFK 122
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
143-250 5.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 40.34  E-value: 5.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18258  18 TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEA 97
                        90       100
                ....*....|....*....|....*...
gi 18859807 223 SDKYNIRDLIDLCVDYMNKHVAKAATSG 250
Cdd:cd18258  98 ANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-235 7.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 39.80  E-value: 7.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18194  23 LCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRD---RLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLA 99
                        90
                ....*....|....
gi 18859807 222 LSDKYNIRDLIDLC 235
Cdd:cd18194 100 AASYLHMYDIVKVC 113
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 7.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 39.45  E-value: 7.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPewNECSKHVIELHEEACCSAvFPQFIKYLY 205
Cdd:cd18331   8 ASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQ--LKCNLSVINLDPEINPEG-FNILLDFMY 84
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18331  85 TSRLNLREGNIMAVMATAMYLQMEHVVDTC 114
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
127-213 8.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 39.63  E-value: 8.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 127 NSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMlmnpeWNECSKHVIELhEEACCSAVFPQFIKYLYV 206
Cdd:cd18290  12 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDL-----FNSSRSAVVEL-PAAVQPQSFQQILSFCYT 85

                ....*..
gi 18859807 207 GQIEVTL 213
Cdd:cd18290  86 GRLSMNV 92
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-235 1.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 39.09  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSkhVIELHEEACCSAVFPqFIKYLY 205
Cdd:cd18215   3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVS--VINLDPEIEPEGFRI-LLDFMY 79
                        90       100       110
                ....*....|....*....|....*....|
gi 18859807 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18215  80 TSRLNLREGNIMAVMATAMYLQMEHVVDTC 109
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
131-233 1.36e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 38.83  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELH-EEACCSAVfpqfIKYLYVGQ- 208
Cdd:cd18359   9 NRVKECLAKGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYtSRSSMRAV----LEYLYTGQf 84
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859807 209 -----------IEVTLQTVMPML-ALSDKYNIRDLID 233
Cdd:cd18359  85 ssspdlddmklIILANRLCLPHLvALTEQYTVTVLME 121
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-242 1.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 38.73  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecsKHVIELHEEACCSAVFPQFIKYLYVGQI----EVTLQTV 216
Cdd:cd18333  20 FLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH-------DNLINLDHEMVSPGIFRLILDYIYTGRLsegdPGSEQNL 92
                        90       100
                ....*....|....*....|....*.
gi 18859807 217 MPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18333  93 GAVLAAASYLQIPDLVALCKKKLKRN 118
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
127-211 1.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 38.62  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 127 NSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPE-WneCSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18223   3 DTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEiW--ISSHVLELPDLK--AEVFAEILNFIY 78

                ....*.
gi 18859807 206 VGQIEV 211
Cdd:cd18223  79 SSKVVV 84
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-242 1.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 38.36  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewnecSKHV--IELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18231  18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQ------NKQLqrVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLN 91
                        90       100
                ....*....|....*....|.
gi 18859807 222 LSDKYNIRDLIDLCVDYMNKH 242
Cdd:cd18231  92 AAAVLQMNDIAASCQELIDSR 112
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
129-235 2.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 38.25  E-value: 2.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 129 VLNKIANLYAEQLMSDIVLLV-DGKE-FPAHRVILCASSDVFQVML---MNPEWNECskhvIELHeeACCSAVFPQFIKY 203
Cdd:cd18239  10 VLQGFDQLRGEGLLCDVTLVPgDGDEtFPVHRAMMASASDYFKAMFtggMKEQELMC----IKLH--GVSKIGLKNIIDF 83
                        90       100       110
                ....*....|....*....|....*....|..
gi 18859807 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18239  84 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 115
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
269-356 2.62e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 37.83  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 269 LTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMeatgsggfMELIEQTVSH 348
Cdd:cd18446  21 LKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESER--------LPLLPRVLEN 92

                ....*...
gi 18859807 349 IRFGMMTP 356
Cdd:cd18446  93 VRLPLLDP 100
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
141-239 4.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 37.24  E-value: 4.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 141 LMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIElHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPML 220
Cdd:cd18201  20 ILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVT-HLDVVAVQGFSVILDFMYSGNLVLTSQNAIEVM 98
                        90
                ....*....|....*....
gi 18859807 221 ALSDKYNIRDLIDLCVDYM 239
Cdd:cd18201  99 SVASYLQMTEVVQSCRNFI 117
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
131-250 4.88e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 37.64  E-value: 4.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELH-EEACCSAVfpqfIKYLYVGQI 209
Cdd:cd18358   9 NRIKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNiSKVSMQAV----LDYLYTKQL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18859807 210 EVTLQ-TVMPMLALSDKYNIRDLIDLCVDYMNKHVAKAATSG 250
Cdd:cd18358  85 SPTADlDPLELIALANRFCLPHLVALTEQHAVQELTKASKSG 126
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
143-209 5.67e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 36.54  E-value: 5.67e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859807 143 SDIVLLVDGKEFPAHRVILCASSDVFQVmLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQI 209
Cdd:cd18283   3 TDVDLVFQGTCFPVHRAILSARCPFFRD-LLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEF 68
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-174 7.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 36.84  E-value: 7.42e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 18859807 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVF--QVMLMN 174
Cdd:cd18227   9 SSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKN 59
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
261-325 9.59e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 35.74  E-value: 9.59e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859807 261 SFTPTHN--DLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLH 325
Cdd:cd18448  12 TFAEQHNrvDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKH 78
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
144-233 9.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 36.32  E-value: 9.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859807 144 DIVLLVDGKEFPAHRVILCASSDVFQVMLM-NPEwnecSKHVIELHEEaccSAVFPQFIKYLYVGQIEVTlQTVMPMLAL 222
Cdd:cd18226  24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSkNPN----TDAVTLDHVS---YSVFQHLLEFLYTSEFFVY-ENEIPLVLE 95
                        90
                ....*....|.
gi 18859807 223 SDKYniRDLID 233
Cdd:cd18226  96 AAKF--LDIID 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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