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Conserved domains on  [gi|18859687|ref|NP_572917|]
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uncharacterized protein Dmel_CG11151, isoform A [Drosophila melanogaster]

Protein Classification

SCP2 sterol-binding domain-containing protein( domain architecture ID 10488469)

SCP2 sterol-binding domain-containing protein may have lipid-transfer activity, such as Candida tropicalis oleate-induced peroxisomal protein POX18 and Arabidopsis thaliana sterol carrier protein 2

CATH:  3.30.1050.10
Gene Ontology:  GO:0008289
PubMed:  18084051|28284963|11330036
SCOP:  4000360

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCP2 pfam02036
SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the ...
 9-110 2.34e-21

SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the SCP2 protein as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.


:

Pssm-ID: 460423 [Multi-domain]  Cd Length: 100  Bit Score: 81.15  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859687     9 FQKIIDGLKENEAKAKAVNG-VFLYKITKDGKvakEWTLDCKNAKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQAA 87
Cdd:pfam02036   1 LNQLLARDPAARELLKKLNGkVIRFDLTDLGL---SLTLDLKDGGGRVLAGDEGKADVTLSASDSDLLALATGKLNPQKA 77

                          90       100
                  ....*....|....*....|...
gi 18859687    88 FMKGKLKIAGNIMLTQKLAPLLK 110
Cdd:pfam02036  78 FMQGKLKIEGDMELAQKLEGLLK 100
 
Name Accession Description Interval E-value
SCP2 pfam02036
SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the ...
 9-110 2.34e-21

SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the SCP2 protein as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.


Pssm-ID: 460423 [Multi-domain]  Cd Length: 100  Bit Score: 81.15  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859687     9 FQKIIDGLKENEAKAKAVNG-VFLYKITKDGKvakEWTLDCKNAKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQAA 87
Cdd:pfam02036   1 LNQLLARDPAARELLKKLNGkVIRFDLTDLGL---SLTLDLKDGGGRVLAGDEGKADVTLSASDSDLLALATGKLNPQKA 77

                          90       100
                  ....*....|....*....|...
gi 18859687    88 FMKGKLKIAGNIMLTQKLAPLLK 110
Cdd:pfam02036  78 FMQGKLKIEGDMELAQKLEGLLK 100
SCP2 COG3255
Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];
6-110 8.09e-18

Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];


Pssm-ID: 442486 [Multi-domain]  Cd Length: 104  Bit Score: 72.25  E-value: 8.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859687   6 DAVFQKIIDGLKENEAkAKAVNGVFLYKITKDGKVakEWTLDCKNAKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQ 85
Cdd:COG3255   1 DEWAEALCEKLNAADA-AAGWDGVVQFVITGEGGG--AYYLVIDDGKCTVSEGDDDDADVTLTASYEDWKKLLTGELDPM 77

                        90       100
                ....*....|....*....|....*
gi 18859687  86 AAFMKGKLKIAGNIMLTQKLAPLLK 110
Cdd:COG3255  78 TAFMTGKLKVEGDMGLAMKLMSLFK 102
 
Name Accession Description Interval E-value
SCP2 pfam02036
SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the ...
 9-110 2.34e-21

SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the SCP2 protein as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.


Pssm-ID: 460423 [Multi-domain]  Cd Length: 100  Bit Score: 81.15  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859687     9 FQKIIDGLKENEAKAKAVNG-VFLYKITKDGKvakEWTLDCKNAKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQAA 87
Cdd:pfam02036   1 LNQLLARDPAARELLKKLNGkVIRFDLTDLGL---SLTLDLKDGGGRVLAGDEGKADVTLSASDSDLLALATGKLNPQKA 77

                          90       100
                  ....*....|....*....|...
gi 18859687    88 FMKGKLKIAGNIMLTQKLAPLLK 110
Cdd:pfam02036  78 FMQGKLKIEGDMELAQKLEGLLK 100
SCP2 COG3255
Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];
6-110 8.09e-18

Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];


Pssm-ID: 442486 [Multi-domain]  Cd Length: 104  Bit Score: 72.25  E-value: 8.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859687   6 DAVFQKIIDGLKENEAkAKAVNGVFLYKITKDGKVakEWTLDCKNAKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQ 85
Cdd:COG3255   1 DEWAEALCEKLNAADA-AAGWDGVVQFVITGEGGG--AYYLVIDDGKCTVSEGDDDDADVTLTASYEDWKKLLTGELDPM 77

                        90       100
                ....*....|....*....|....*
gi 18859687  86 AAFMKGKLKIAGNIMLTQKLAPLLK 110
Cdd:COG3255  78 TAFMTGKLKVEGDMGLAMKLMSLFK 102
Alkyl_sulf_C pfam14864
Alkyl sulfatase C-terminal; This domain is found at the C-terminus of alkyl sulfatases. ...
 54-109 6.47e-03

Alkyl sulfatase C-terminal; This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.


Pssm-ID: 405542 [Multi-domain]  Cd Length: 124  Bit Score: 33.70  E-value: 6.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859687    54 YEGPAQGIKVDTTLTVADEDMVDIALGKLNPQAAFMKGKLKIAGNIMLTQKLAPLL 109
Cdd:pfam14864  57 YRKGRQADDADATLTLTRADLLALLLGKATLGKLIAAGKIKVEGDPSALAELLSLL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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