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Conserved domains on  [gi|24642004|ref|NP_572968|]
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uncharacterized protein Dmel_CG15890, isoform A [Drosophila melanogaster]

Protein Classification

solute carrier 46 family transporter( domain architecture ID 13024389)

solute carrier 46 (SLC46) family transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 69-507 2.93e-137

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 403.97  E-value: 2.93e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004  69 NVTVEPILAAYIMPSVLSNLATQNLNlekacrvnmaygdevcdaltrrqtanytleeetvqqMVARMAAWKTVIQSLFPC 148
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNFV------------------------------------YAANFYLYMNLMGSIPPL 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 149 LLILFWGSWSDRHRRrKPCILIPVVGEFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGWFTMLMGVFSYIADITTEE 228
Cdd:cd17386  45 FSSLFLGSWSDRYGR-KPPLLMSLVGLLLSSLILVLIVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISSEK 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 229 DRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeepqsrpeksaeqkslladffdkeh 308
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------------------- 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 309 vvqtfrvafkkgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSH 388
Cdd:cd17386 179 -----------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRC 241

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 389 KLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMV 468
Cdd:cd17386 242 LLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLV 321

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 24642004 469 FAPMYTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLWMY 507
Cdd:cd17386 322 ASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 69-507 2.93e-137

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 403.97  E-value: 2.93e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004  69 NVTVEPILAAYIMPSVLSNLATQNLNlekacrvnmaygdevcdaltrrqtanytleeetvqqMVARMAAWKTVIQSLFPC 148
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNFV------------------------------------YAANFYLYMNLMGSIPPL 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 149 LLILFWGSWSDRHRRrKPCILIPVVGEFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGWFTMLMGVFSYIADITTEE 228
Cdd:cd17386  45 FSSLFLGSWSDRYGR-KPPLLMSLVGLLLSSLILVLIVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISSEK 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 229 DRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeepqsrpeksaeqkslladffdkeh 308
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------------------- 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 309 vvqtfrvafkkgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSH 388
Cdd:cd17386 179 -----------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRC 241

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 389 KLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMV 468
Cdd:cd17386 242 LLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLV 321

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 24642004 469 FAPMYTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLWMY 507
Cdd:cd17386 322 ASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
MFS_1 pfam07690
Major Facilitator Superfamily;
135-470 1.06e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 114.44  E-value: 1.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   135 MAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcILIpvVGEFLGVVGLMLCVYFEQAPMEAAAlteAIFPSLSGGWFTML 214
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLL--IGLLLFALGLLLLLFASSLWLLLVL---RVLQGLGAGALFPA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   215 MGVfsYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSA 294
Cdd:pfam07690 106 ALA--LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   295 EQKslladffdkehvvqtfRVAFKKGENQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFT 374
Cdd:pfam07690 184 EEA----------------RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   375 GLIGVIFcVGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLV--EIFNGTAFIAMRSIATKLVSKDELG 452
Cdd:pfam07690 248 GAIGRLL-LGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllGFGFGLVFPALNALVSDLAPKEERG 326

                         330
                  ....*....|....*...
gi 24642004   453 KVNSLFGVAEALMPMVFA 470
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
135-461 1.75e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 96.20  E-value: 1.75e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 135 MAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcILIpvVGEFLGVVGLMLCVYFEQAPMEAAAlteAIFPSLSGGWFTML 214
Cdd:COG2814  46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRR--VLL--LGLLLFALGSLLCALAPSLWLLLAA---RFLQGLGAGALFPA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 215 mgVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeePQSRPEKSA 294
Cdd:COG2814 119 --ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL--PESRPAARA 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 295 EQKSLLADFFdkehvvqtfrvafkkgenqRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFT 374
Cdd:COG2814 195 RLRGSLRELL-------------------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 375 GLIGVIFcVGILSHKLNIDDALVGVLSSTskILSSFVYAFATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVSKDELGK 453
Cdd:COG2814 256 GVLGALL-AGRLADRFGRRRLLLIGLLLL--ALGLLLLALAGSLWLLLLALFLLgFGFGLLFPLLQALVAELAPPEARGR 332


                ....*...
gi 24642004 454 VNSLFGVA 461
Cdd:COG2814 333 ASGLYNSA 340
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 69-507 2.93e-137

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 403.97  E-value: 2.93e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004  69 NVTVEPILAAYIMPSVLSNLATQNLNlekacrvnmaygdevcdaltrrqtanytleeetvqqMVARMAAWKTVIQSLFPC 148
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNFV------------------------------------YAANFYLYMNLMGSIPPL 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 149 LLILFWGSWSDRHRRrKPCILIPVVGEFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGWFTMLMGVFSYIADITTEE 228
Cdd:cd17386  45 FSSLFLGSWSDRYGR-KPPLLMSLVGLLLSSLILVLIVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISSEK 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 229 DRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeepqsrpeksaeqkslladffdkeh 308
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------------------- 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 309 vvqtfrvafkkgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSH 388
Cdd:cd17386 179 -----------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRC 241

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 389 KLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMV 468
Cdd:cd17386 242 LLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLV 321

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 24642004 469 FAPMYTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLWMY 507
Cdd:cd17386 322 ASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 153-505 2.18e-28

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 116.52  E-value: 2.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 153 FWGSWSDRHRRrKPCILIPVVGEFLGVVGLMLCVYFeqapmeAAALTEAIFPSLSGGWFTMlmgVFSYIADITTEEDRTL 232
Cdd:cd17330  53 LWGRLSDRYGR-KPVLLLSLAGSAVSYVLLGLSRNL------WLLFLARFLDGLTGGNVSV---AQAYIADITDEEERAK 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 233 RIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeepqsrpeksaeqkslladffdkehvvqt 312
Cdd:cd17330 123 AFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL----------------------------- 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 313 frvafkkgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSHKLNI 392
Cdd:cd17330 174 -------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 393 DDALVGVLSSTskILSSFVYAFATLPWHMYLGGLV-EIFNGTAFIAMRSIATKLVSKDELGKVN----SLFGVAEALMPM 467
Cdd:cd17330 241 RKLLRLGLLLA--IIGLLLLPFASSVPLLVLAAAIlAFGTGIVFPALSALLSKSVPSKEQGKAQgiiqSLQSLARIIGPL 318

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 24642004 468 VFAPMYTTLYaatlrvlPGAFFLLGGGLTLFSVFIFLW 505
Cdd:cd17330 319 LAGPLYSFLG-------PGVPFLLAAGLLLIALFLLSL 349
MFS_1 pfam07690
Major Facilitator Superfamily;
135-470 1.06e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 114.44  E-value: 1.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   135 MAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcILIpvVGEFLGVVGLMLCVYFEQAPMEAAAlteAIFPSLSGGWFTML 214
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLL--IGLLLFALGLLLLLFASSLWLLLVL---RVLQGLGAGALFPA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   215 MGVfsYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSA 294
Cdd:pfam07690 106 ALA--LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   295 EQKslladffdkehvvqtfRVAFKKGENQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFT 374
Cdd:pfam07690 184 EEA----------------RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   375 GLIGVIFcVGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLV--EIFNGTAFIAMRSIATKLVSKDELG 452
Cdd:pfam07690 248 GAIGRLL-LGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllGFGFGLVFPALNALVSDLAPKEERG 326

                         330
                  ....*....|....*...
gi 24642004   453 KVNSLFGVAEALMPMVFA 470
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 70-506 4.26e-26

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 111.05  E-value: 4.26e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004  70 VTVEPILAAYIMPSVLSN-LATQNLNLEKACRVNMAygdevcDALTRRQTANYTLEEETVQQMVARMAA-WKTVIQ---- 143
Cdd:cd17449   2 VTVEPVLFLAMFALVLQGpLTTQYLWDRLSADLGYN------GTRTRGCASNASTSADPLQQEVETLTAhWNLYINlggf 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 144 --SLFPCLLIlfwGSWSDRHRRRkPCILIPVVGEFLGVVGLMLCVYFeQAPMeAAALTEAIFPSLSGGWFTMLMGVFSYI 221
Cdd:cd17449  76 lvGLFSVTLL---GPWSDSVGRR-PVLILPSLGLALQAAVYLLVMYL-QLHV-AYFLIGRILSGLLGDFNGILAGCFAYV 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 222 ADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSrpeksaEQKSllA 301
Cdd:cd17449 150 ADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVK------EPKS--A 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 302 DFFDKEHVVQTFRVAFKKGENQRRKRVILLMIVVMVIIgPLHgeMAVTYLFTRFRFN----WSEVEFSFFSTYAMFTGLI 377
Cdd:cd17449 222 RLFTTRHHQSVVRLYVAPAPNGSRRKLALYSLALFVVV-TVH--FGAKDLLVLYELSsplcWDSDLIGYGSAAEHLTYLS 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 378 GVIfcvGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSL 457
Cdd:cd17449 299 SLL---GLRLLQLCLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFAS 375

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 24642004 458 FGVAEALMPMVFAPMYTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLWM 506
Cdd:cd17449 376 VACVEGLCSLVATGIFNSLYPATLHFMKGFPFLFGAALLLIPAGIIGLL 424
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 155-502 8.07e-24

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 103.87  E-value: 8.07e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHRRRkPCILIPVVGefLGVVGLMLCVyfeqAPMEAAALTEAIFPSLSGGWFTMLMgvfSYIADITTEEDRTLRI 234
Cdd:cd17388  59 GALSDRFGRR-PVLLLSLAG--AALDYLLMAF----APTLWWLYLGRIIAGITGATGAVAA---AYIADVTPPEQRARNF 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 235 GILNVCFSVGVPIGMAFSGvLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQsRPEKsaeqkslLADFFDKEHVVQ-TF 313
Cdd:cd17388 129 GLLGAAFGLGFIAGPALGG-LLGEISPRAPFLVAAGLNGLNFLLGLFVLPESL-PPER-------RRAFRWRRANPFgSL 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 314 RVAFkkgenqrRKRVILLMIVVMVIIGPLHGEMAVTY-LFTRFRFNWSEVEFSF-FSTYAMFTGLIGViFCVGILSHKLN 391
Cdd:cd17388 200 RWLT-------GFPGLLGLLAVFFLIQLIGQVPATTWvLFTEDRFDWSPTMVGLsLAVFGLLHALFQA-FVTGPIAKRLG 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 392 IDDA-LVGVLSSTskiLSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKvnsLFGVAEALM--PMV 468
Cdd:cd17388 272 EKRAiLLGLAADA---LGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGE---LQGVLTSLTslTSI 345

                       330       340       350
                ....*....|....*....|....*....|....*
gi 24642004 469 FAP-MYTTLYAATLRVLPGAFFLLGGGLTLFSVFI 502
Cdd:cd17388 346 IGPlLFTGIFAASPATWPGLAWIIGAALYLICLVL 380
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 115-506 6.21e-23

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 101.35  E-value: 6.21e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 115 RRQTANYTLEEETVQQMVARMAAwKTVIQSLFPCLLILF-WGSWSDRHRRRKPcILIPVVGEFLGVVGLMLCVYFeQAPM 193
Cdd:cd17448  50 KNKSSPAFVFQEEVQKKTSLFNM-QMDLSGLIPSLIVTLiLVSYSDRHGRKFS-IILPSIGALLTSLSYCLVSYF-SFPL 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 194 eAAALTEAIFPSLSGGWFTMLMGVFSYIADITTEE-DRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFY 272
Cdd:cd17448 127 -NLLIASSFISGLFGGFTTFIGGCFAYVADLCKDHkQKTIRMAVVDMILGVLTGLAGLSSGYFIRALGFNWPFLTIALLH 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 273 VIAFVYGFFFLeepqsrpeksaeqkslladffdkehVVqtfrvafkkgenqrrkrVILLMIVVMVIIGPLHGEMAvtyLF 352
Cdd:cd17448 206 VVNLLYILFFL-------------------------VV-----------------LCLLLFAFSTYLLANFGGAS---IF 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 353 TRFRFN----WSEVEF---SFFSTYAMFTGLIGVIfcvgILSHKLNidDALVGVLSSTSKILSSFVYAFATLPWHMYLGG 425
Cdd:cd17448 241 ILYELNaplcWNEVLVgygSAASTAIFLTSFVGVA----LFSRCLP--DIYIVFIGIFSVAGGMIMTAFAKTTLLMFLVR 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 426 LVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLW 505
Cdd:cd17448 315 LPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIYAATVAWFPGFSFLLSAGLCLIPASLLCV 394


                .
gi 24642004 506 M 506
Cdd:cd17448 395 L 395
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 144-507 9.67e-23

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 100.34  E-value: 9.67e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 144 SLFPCLLILFWGSWSDRHRRRKPCILipvvGEFLGVVGLMLCVYFEQAPMEAAALTeaifpsLSGGWFTMLM-GVFSYIA 222
Cdd:cd17325  41 ALAQLLFSPPAGRLSDRFGRKRLLLL----GLLLLAVSTLLFAFATSYWQLLLARF------LQGLASAAVWpAAMALIA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 223 DITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKsaeqksllad 302
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK---------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 303 ffdKEHVVQTFRVAFKKGENQRRKRVILLMIVV-MVIIGPLHGEMAVtYLFTRFRFNWSEVEFsFFSTYAMFTGLIGVIF 381
Cdd:cd17325 181 ---RAVSAARLRSGLRLLLRDRRLLALFLAIFVlAFAFGALEPFLPL-YAAELGGLSPAQIGL-LFGAQGLASALSQPPA 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 382 cvGILSHKlnIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVSKDELGKV----NS 456
Cdd:cd17325 256 --GKLSDR--IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAmglfNT 331

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 24642004 457 LFGVAEALMPMVFAPMYTTLYAATLrvlpgafFLLGGGLTLFSVFIFLWMY 507
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFATP-------FLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
135-461 1.75e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 96.20  E-value: 1.75e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 135 MAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcILIpvVGEFLGVVGLMLCVYFEQAPMEAAAlteAIFPSLSGGWFTML 214
Cdd:COG2814  46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRR--VLL--LGLLLFALGSLLCALAPSLWLLLAA---RFLQGLGAGALFPA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 215 mgVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeePQSRPEKSA 294
Cdd:COG2814 119 --ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL--PESRPAARA 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 295 EQKSLLADFFdkehvvqtfrvafkkgenqRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFT 374
Cdd:COG2814 195 RLRGSLRELL-------------------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 375 GLIGVIFcVGILSHKLNIDDALVGVLSSTskILSSFVYAFATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVSKDELGK 453
Cdd:COG2814 256 GVLGALL-AGRLADRFGRRRLLLIGLLLL--ALGLLLLALAGSLWLLLLALFLLgFGFGLLFPLLQALVAELAPPEARGR 332


                ....*...
gi 24642004 454 VNSLFGVA 461
Cdd:COG2814 333 ASGLYNSA 340
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 135-504 6.23e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 82.86  E-value: 6.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 135 MAAWKTVIQSLFPCLLILFWGSWSDRHRRRKPCILIPVVGeFLGVVGLMLCVYFEQApmeaaalteAIFPSLSGGWFTML 214
Cdd:cd06174  32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLF-ALGALLFAFAPSFWLL---------LLGRFLLGLGSGLI 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 215 MGVF-SYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQI--GFYGVFSISAAFYVIAFVYGFFFLEEPQSRPE 291
Cdd:cd06174 102 DPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 292 KSAEQKSLLadffdkeHVVQTFRVAFKkgenqrRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYA 371
Cdd:cd06174 182 AKNEEASSK-------SVLKLLKRVLK------NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 372 MFTGLIGVIFCvGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDEL 451
Cdd:cd06174 249 GLAGALGSLLL-GLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR 327

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 24642004 452 GKVNSLFGVAEALMPMVFAPMYTTLYAATLRvlPGAFFLLGGGLTLFSVFIFL 504
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILLL 378
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 221-504 8.56e-16

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 79.57  E-value: 8.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 221 IADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEE-PQSRPEKSAEQKSL 299
Cdd:cd17331 111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSnTKSKREKEAKESAS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 300 LADFFDKEHVVQTFRVafkkgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGV 379
Cdd:cd17331 191 PPSVFNLKEILRLLRL----------PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQ 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 380 IFCVGILSHKLNiDDALVgVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAF-IAMRSIATKLVSKDELGKV---- 454
Cdd:cd17331 261 GLLVGPLTKRFG-ERSLL-KLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLyTVITSLLTKAVPPEDTGTAlgls 338

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 24642004 455 NSLFGVAEALMPMVFAPMYTTLYaatlrvlPGAFFLLGGGL-TLFSVFIFL 504
Cdd:cd17331 339 HALFSLVRTVSPTIGGALLQAYG-------FPSFGLLGAAInGLLTVYLLL 382
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 133-506 5.47e-15

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 76.89  E-value: 5.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 133 ARMAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcILIPV-VGEFLGVVGLMLCVYFEQAPMEAAALTEAIFpSLSGGWF 211
Cdd:cd06173  33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRR--LLILAdLLRALLAAVLALLALLGSLSLWLLLVLAFLL-GIASAFF 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 212 TMlmGVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVyGFFFLeePQSRPE 291
Cdd:cd06173 110 GP--ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL-LLLFI--RRPPPA 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 292 KSAEQKSLLADffdkehvvQTFRVAFKKGENQRRKRVILLMIVVMVIIGPLhgeMAVTYLFTRFRFNWSEVEFSFFSTyA 371
Cdd:cd06173 185 APGESSSLLLR--------DLREGLRYLRRSPLLRLLLLALALFALLGGAL---TVLLPLLAKEVLGGGAAGYGLLLA-A 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 372 MFTGLIGVIFCVGILSHKLNidDALVGVLSSTSKILSSFVYAFATLPWHMYLG-GLVEIFNGTAFIAMRSIATKLVSKDE 450
Cdd:cd06173 253 FGVGALLGALLLGRLSKRRR--RGRLLLIGALLLGLALLVLGLSPSLWLLLAAlFLLGLAGGLFNVPLNTLLQLRVPDEL 330

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24642004 451 LGKVNSLFGVAEALMPMVFAPMYTTLYAATlrvLPGAFFLLGGGLTLFSVFIFLWM 506
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLLAGALLLLAALLLLLL 383
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 155-299 2.33e-12

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 68.73  E-value: 2.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHRRRKPCILIpvvGEFLGVVGLMLCVYFEQAPMeaAALTEAIFPSLSGGWFTMLmgvFSYI---ADITTEEDRT 231
Cdd:cd17471  53 GRLSDRGGDRKPLILL---ALLAGALGYLLFAFLRNYWV--LLLVGVVLLSLGAAAFPQL---FALAreyADRSSGRDAT 124

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642004 232 LRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSL 299
Cdd:cd17471 125 LFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSL 192
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
153-515 1.05e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 64.15  E-value: 1.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 153 FWGSWSDRHR----RRKPCILIpvvGEFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGWFTMLMGVF-SYIADITTE 227
Cdd:COG2211  65 LIGALSDRTRtrwgRRRPWILI---GAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYsALGAELTPD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 228 -EDRTLRIGILNVCFSVGVPIGMAFSGVLLK------QIGFYGVFSISAAFYVIAFVYGFFFLEEpqsRPEKSAEQKSLL 300
Cdd:COG2211 142 yEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaALGYRLTALIFAVLGLLAFLLTFFGTKE---RPVPEEEKVSLK 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 301 ADffdkehvvqtFRVAFKKgenqrrKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVI 380
Cdd:COG2211 219 ES----------LKALLKN------RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 381 FcVGILSHKlnIDDALVGVLSSTSKILSSFVYAFA---TLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDEL------ 451
Cdd:COG2211 283 L-WPRLAKR--FGKKKAFIIGLLLAALGLLLLFFLgpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrr 359

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24642004 452 -GKVNSLFGVAEALmPMVFAPM----------YTTLYAATLRVLPGAFFLLGGGLTLFSVFIFLWMYRFQVRQRR 515
Cdd:COG2211 360 eGLYFGIFTFAIKL-GQALAGAlaglllalfgYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
137-508 1.24e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 63.75  E-value: 1.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 137 AWKTVIQSLFPCLLILFWGSWSDRHRRRKPCILIPVVGeFLGVVGLMLCVYFEQApmeaaaLTEAIFPSLSGGwfTMLMG 216
Cdd:COG2223  43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL-GIGLLLLALAVSYWLL------LLLGLLLGIGGG--GSFAV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 217 VFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQ 296
Cdd:COG2223 114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 297 KslladffdkehvVQTFRVAFkkgenqRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFF-STYAMFTG 375
Cdd:COG2223 194 S------------LRDQLEAL------RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLaALFALLGA 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 376 LIGVIFcvGILSHKLNIDDALVGVLSSTskILSSFVYAFATLPWHMYLGG--LVEIFNGTAFIAMRSIATKLVSKDELGK 453
Cdd:COG2223 256 LGRPLG--GWLSDRIGGRRVLLIVFALM--ALGLLLLALALGSLWLFLVLflLLGLALGGGNGAVFALVPDIFPTKNAGA 331

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24642004 454 VNSLFGVAEALMPMVFAPMYTTLYAATLRvlPGAFFLLGGGLTLFSVFIFLWMYR 508
Cdd:COG2223 332 VYGLVGAAGGLGGFLGPLLFGALLDATGS--YTAAFLVFAVLALVALVLTLLLYR 384
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 125-500 3.23e-10

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 62.08  E-value: 3.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 125 EETVQQMVARMAAWKTVIQSLFPCLLILFWGSWSDRhRRRKPCILIPVVGEFLGVVGLMLCVYFEQaPME----AAALTe 200
Cdd:cd17450  42 EDAQQKAISNFYMIYNLVAGLSPLLPAYLLAKLGDR-RHRKITICVPLLGYLLSRALLLLVILLDW-PLEvmygAAALN- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 201 aifpSLSGGWFTMLMGVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQ--IGFYG---VFSISAAFYVIA 275
Cdd:cd17450 119 ----GLTGGFTAYWAGVMALASLASSEGRRSVRLITIELVYGLAGFLGSLASGHIFVHytINHHQgaiLAACSLVLYVLC 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 276 FVYGFFFLeepqsrpeksaeqkslladffdkehvvqtfrvafkkgenqrrkRVILLMIVVMVIIGPLH--GEMAVTYLFT 353
Cdd:cd17450 195 LLYSVFVL-------------------------------------------KITIALLFVGAILYDLAvaGGMDVLSVFV 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 354 -RFRFNWSEVEFSF--FSTYAMF-TGLIGVIF---CVGILSHklniddALVGVLSSTSKILssfVYAFATLPWHMYLGGL 426
Cdd:cd17450 232 lKEPLSWGAVEVGYgnAAGYMIFiTSFLGVFVfsrCLRDTTM------IMIGMVSFSSGIL---IMAFVKWTFMFYIARA 302

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24642004 427 VEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAATLRVLPGAFFLLGGGLTLFSV 500
Cdd:cd17450 303 VMLFALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDWFPGFCFILSSILGFLSI 376
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 153-500 1.84e-09

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 60.17  E-value: 1.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 153 FWGSWSDRHRRRKPCIlipVVGEFLGVVGLMLCVYFEQAPMEAAALTEAIfpSLSGGWFTMlmgVF--SYIADITTEEDR 230
Cdd:COG2270  71 VLGAIADRSGRKKPFL---AFFTLLGVLATAALFFVAPGGLWLGLLLFVL--ANIGFEGSL---VFynAFLPDIATPEEI 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 231 TlRI-----------GILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQsRPEKSAEQKSL 299
Cdd:COG2270 143 G-RVsglgwalgylgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERP-RPGPAPPRGAV 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 300 LADFFDkehVVQTFRvafkkgENQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGV 379
Cdd:COG2270 221 RAGFRE---LRRTLR------ELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGA 291

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 380 IFcVGILSHKLNIDDALVGVLSSTskILSSFVYAFATLPWHMY-LGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLF 458
Cdd:COG2270 292 LL-FGRLDDRIGPKRVILVSLVIW--IVVCLAAYFLTTALAFWiLGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLY 368

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 24642004 459 GVAEALmPMVFAP-MYTTLYAAT----LRVLPGAFFLLGGGLTLFSV 500
Cdd:COG2270 369 ALSGKA-ASFLGPlLFGLVTQLTgsqrLGILSLIVFFVIGLVLLLRV 414
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 152-507 5.75e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 58.39  E-value: 5.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 152 LFWGSWSDRHRRRKpcilIPVVGEFLGVVGLMLCVYFEQAPMEAAALteaIFPSLSGGWFtmLMGVFSYIADITTEEDRT 231
Cdd:cd17329  53 LIGGRLADRFGRKP----VMLAGLLLRALGFALLGFAHSPWLFAIAL---VLTGFGGGLF--EPASEAMIADVTTPENRT 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 232 LRIGILNVCFSVGVPIGMAFSGVLLkQIGFYGVFSISAAFYVIAFVYGFFFLEE--PQSRPEKSAEQKSLLADFFdkehv 309
Cdd:cd17329 124 RAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPEtrPKRRAAEKTEILRGYKIVL----- 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 310 vqtfrvafkkgenqRRKRVILLMIVVMVIIgplhgeMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVG--ILS 387
Cdd:cd17329 198 --------------RDRAFLLFLLASFLIS------LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLqfPVA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 388 HKLN-IDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLV----EIFngtAFIAMRSIATKLVSKDELGK----VNSLF 458
Cdd:cd17329 258 RLVErFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVltlgEML---VFPAVQTLVAALAPPDKRGSymgfYALAW 334

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 24642004 459 GVAEALMPMVFAPMYTTLyaatlrvLPGAFFLLGGGLTLFSVFIFLWMY 507
Cdd:cd17329 335 GLGRAIGPLVGGLLLDLL-------GPGLPWLILAALGLIAAALLLGLQ 376
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 209-505 6.36e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.99  E-value: 6.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 209 GWFTMLMGVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQS 288
Cdd:cd17489  97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 289 RPEKSAEQKSLLADFFdkehvvqtfrvafkkgenqrRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRfNWSEVEFsFFS 368
Cdd:cd17489 177 AAEEAEAGTRAFRRLV--------------------EKKVLPPALILFLASIAYGAISTFLPLYAAER-GISNAGL-FFT 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 369 TYAMFTGLIGVIFcvGILSHKLNidDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVS 447
Cdd:cd17489 235 VYAIALLLSRPFS--GKLSDRKG--PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYgLGFGLLFPALQALAVDLVP 310

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24642004 448 KDELGKVNSLFGVAEALmPMVFAPMYTTLYAATLRvlPGAFFLLGGGLTLFSVFIFLW 505
Cdd:cd17489 311 PHRRGAANGTFFIFFDL-GIGLGGLLLGLVAELFG--YRAMFLLAAVVVLLALVLYIF 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
136-286 1.54e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 136 AAWKTVIQSLFPCLLILFWGSWSDRHRRRKPCILIpvVGEFLGVVGLMLCVYFEQAPMEAAALTEAIFpslsgGWFTMLM 215
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA--IGLLLAALALLLLALLPSPALAIALLFLAGF-----GLGGAFG 290

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642004 216 GVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEP 286
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 155-506 1.82e-08

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 56.47  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHRRRkPCILIPVVGEFLGVVGLmlcvyfeqapmeAAALTEAIFPSLSGgwftmLMGVF--------SYIADITT 226
Cdd:cd17390  52 GSWSDVVGRR-PVLLICLLLTALGYVLL------------GFSTSLALLFLSRI-----PLGIFkhtqslckAYLSDLVS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 227 EEDRTLRIGILNVCFSVGVPIGMAFSGVLLK-QIGFYGVFSISAAFYVIAFVYGFFFLeepqsrpeksaeqkSLLADFFd 305
Cdd:cd17390 114 EQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNAGLVWFLL--------------SKLWDLL- 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 306 kehvvqTFRvafkkgenqrrkrvILLMIVVMviigpLHGEMAVTYLFTRFRFNWSEVEF--SFFSTYAMFTGligviFCV 383
Cdd:cd17390 179 ------LVR--------------FLMGFSVL-----LFRSNFSLYLEERFDLSPKTIGYliSYSGVLGALSG-----FLV 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 384 GILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWhMYLGGLV--EIFNGTAFIAMRSIATKLVSKDELGkvnSLFGVA 461
Cdd:cd17390 229 GRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIW-LLVLCLTplSISSAVLRTCSTSLLLSRGKSKERG---TLLGVG 304

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 24642004 462 EALMPM--VFAPMYTTLyaaTLRVLPGAFFLLGGGLTLFSVFIFLWM 506
Cdd:cd17390 305 QSVTSLarILAPLLSGL---LQEFSVSGPGLLGAVLALAAILLMLAR 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 142-283 2.14e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 2.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 142 IQSLFPCLLILFWGSWSDRHRRRKPCIlipvVGEFLGVVGLMLCVYFEQAPMEAAALteAIFpslSGGWFTMLMGVFSYI 221
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLIL----IGLLLSAVALLLLPLATSFWLLLLLL--ALL---GLGLGLVFPATLALL 313

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24642004 222 ADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFL 283
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
152-508 2.44e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.42  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 152 LFWGSWSDRHRRRKpcILIpvVGEFLGVVGLMLCVYfeqapmeAAALTEAIFPSLSGGWFT--MLMGVFSYIADITTEED 229
Cdd:COG2271  63 IPAGLLADRFGRRR--VLA--IGLLLWGLATLLFGF-------ATSFWQLLLLRFLLGLGEagFFPAALKLIAEWFPPKE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 230 RTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYgfffleepqsrpeksaeqkslladffdkehv 309
Cdd:COG2271 132 RGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 310 vqtfrvafkkgenqrrkRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCvGILSHK 389
Cdd:COG2271 181 -----------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLG-GWLSDR 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 390 LNIDDALVGVLSSTSKILSSFVYAFATLPWHMY-LGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMV 468
Cdd:COG2271 243 LGRRRKLVLAIGLLLAALALLLLALLPSPALAIaLLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL 322

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 24642004 469 FAPMYTTLYAATlrvLPGAFFLLGGGLTLFSVFIFLWMYR 508
Cdd:COG2271 323 GPLLVGYLLDAT---GYQAAFLLLAALALLAALLALLLLR 359
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 155-458 4.24e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 55.68  E-value: 4.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHRRrKPCILIpvvGEFLGVVGLMLCVYfeqapmeAAALTEAIFPSLSGGWFTMLMGVFSYIADITTEEDRTLRI 234
Cdd:cd17472  53 GLLSDRIGR-KPVILF---GLLLFIAGSLLAAY-------ATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAM 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 235 GILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLLADFFdkehvvqtfr 314
Cdd:cd17472 122 ALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLL---------- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 315 vafkkgenqRRKRVILLMIVVMViigpLHGEMAVTylFTRFRFNWSEVEFS-----FFSTYAMFTGLIGVIFCVgILSHK 389
Cdd:cd17472 192 ---------KNKRLLRLDFSIFI----LHFVLMAF--FYILPLLLTQLGGGkgqlwKVYLPAILIGFILMVPFV-IYAEK 255

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642004 390 LNIdDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFI--AMRSIATKLVSKDELGKVNSLF 458
Cdd:cd17472 256 KGK-MKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLeaLLPSLVSKIAPKEYRGTAMGIY 325
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 171-469 5.37e-08

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 55.50  E-value: 5.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 171 PVVGEFLGVVG----LMLCVYFEQAPMEAAALTE----AIFpSLSGGWFTMLMGVFSYIADITTEEDRTLRIGILNVCFS 242
Cdd:cd17387  54 PLIGALSDVWGrksfLLLTVFFTCAPIPLMRISPwwyfAMI-SVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFA 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 243 VGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVygFFFLEEPQSRPEKsaEQKSLLADFFDKEHvVQTFRVAFKKGEN 322
Cdd:cd17387 133 ASLVTSPALGAYLSESYGDNLVVLVATIVALLDIC--FILLAVPESLPEK--MRPASWGAPISWEQ-ADPFASLRKVGKD 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 323 qrrKRVILLMIVVMVIIGPLHGEM--AVTYLFTRFRFNWSEVefsffstyAMFTGLIGVIFCV------GILSHKL-NID 393
Cdd:cd17387 208 ---KTVLLICITVFLSYLPEAGQYssFFVYLKQVMGFEYEEV--------AAFIAVVGILSITaqtlllSILMRSIgAKN 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 394 DALVGVLsstSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLF----GVAEALMPMVF 469
Cdd:cd17387 277 TILLGLG---FQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMItgirGLCNGLGPALF 353
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 148-304 5.77e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.81  E-value: 5.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 148 CLLILFWGSWSDRHRRRKPCIlipvVGEFLGVVGLMLCVYFEQAPM-EAAALTEAIfpslsGGWFTMLMGvFSYIADITT 226
Cdd:cd17320  48 ALGQLLYGPLSDRFGRRPVLL----AGLLLFILASLLCALASSIEQlLIARFLQGL-----GAAAGSVVA-RAIVRDLYS 117

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642004 227 EEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLLADFF 304
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYK 195
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 136-277 1.60e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 50.65  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 136 AAWKTVIQSLFPCLLILFWGSWSDRH--RRRKPCILIPVvgeFLGVVGLMLCVYFEQAPMEAAALTEAIFpslsgGWFTM 213
Cdd:cd17319 217 VGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGL---LLAAVGLLLAYLTTSPVVAVILLSLAGF-----GIGAA 288

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24642004 214 LMGVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIG-FYGVFSISAAFYVIAFV 277
Cdd:cd17319 289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAAL 353
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 138-508 2.05e-06

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 50.29  E-value: 2.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 138 WKTVIQSLFPCLLILFWGSWSDRHRRRKPCIlipVVGEFLGVVGLMLCVYFEQAPMEAAALteaIFPS--LSGGWFTMLM 215
Cdd:cd17326  40 WVVAAYSLGQLVFSPVFGYWSNKTSSVKEPL---IVSILIAIVGNILYALAEYFPSNRKYV---MLVArfLIGVGAGNVA 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 216 GVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKqIGFYGV-------FS-------ISAAFYVIAFVYGFF 281
Cdd:cd17326 114 VLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTP-IGYPGYvigiklrFNmytapawLMAILGIINIILILF 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 282 FLEEpqsrpeksaeqkslladffdkehVVQTFrVAFkkgenqrrkrVILLMIVVMVIIGPlhgemavtyLFTRFRFNWSE 361
Cdd:cd17326 193 FFKE-----------------------VVCIF-LFF----------VVLFIFANLETIGT---------PLTMDMYGWTR 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 362 VEFSFFSTYAMF-TGLIGVI--FCVGILSHKLnIDDALVGVLSstskILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAM 438
Cdd:cd17326 230 EEAVLYNGIILAvSGVLSVLvfLLFKFLSLGL-IDERKILLGG----LILFFLGFVVTLPWGITGVILFGLGYPIGNVML 304

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 439 RSIATKLVSKDELGKVNSLFGVAEALMPMVfAPMYTTLYAATLRvlPGAFFLLGGGLTLFSVFIFLWMYR 508
Cdd:cd17326 305 YTLYSKILGPKPQGTMQGVLTASGSLARTL-GPIFVTAIYTHFG--PRWTWIITLGLLLLAIILLIVFYK 371
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
 240-425 2.42e-06

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


Pssm-ID: 308617  Cd Length: 432  Bit Score: 50.04  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   240 CFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLLADFfdkeHVVQTFRVAFKK 319
Cdd:pfam03092 132 CSAVGGIIGSVLSGPLLDTFKPQISFFVTAALQLLTCVVALLIKESSLGLPAKHEPKRPVPCLF----GLFEMNREVISR 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004   320 GENQRRKRVIL---LMIVVMVIIGPLHGEMAVTYLFTRfRFNWSEVEFSFFSTYAMFT---GLIGVIFCVGILSH----K 389
Cdd:pfam03092 208 NWKAFRYSEILtptLFAMLSQAILPLVIAKANVFFYTT-NVLGPNFSYSFYGTVKVIGsiaGLIGVTLYNRFLKKhpyrL 286

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 24642004   390 LNIDDALVGVLSS-TSKILSSFVYAFATLPWHMYLGG 425
Cdd:pfam03092 287 TFGVTTVLQVLSGlFDLILVKRWNRYIGISDHMYILG 323
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
318-506 4.55e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 4.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 318 KKGENQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFcVGILSHKLNIDDALV 397
Cdd:COG2271   1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIP-AGLLADRFGRRRVLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 398 GVLSSTSkiLSSFVYAFATLPWHMYLG-GLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTL 476
Cdd:COG2271  80 IGLLLWG--LATLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157

                       170       180       190
                ....*....|....*....|....*....|.
gi 24642004 477 YAAT-LRVLpgafFLLGGGLTLFSVFIFLWM 506
Cdd:COG2271 158 LAAFgWRAA----FLILGLPGLLLALLRFWL 184
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 155-295 5.49e-06

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 49.16  E-value: 5.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHR----RRKPCILIpvvGEFLGVVGLMLCVY---FEQAPMEAAALTEAIFPSLsggwFTMLMGVF--------- 218
Cdd:cd17313  55 GSLSDRCNsrigRRRPFILV---GAPLAALGLILIPNaadIGLALGDGPRTWALVLFVL----GIVLLDFAmnvcqgpvr 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 219 SYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGF--------YGVFSISAAFYVIAFVYGFFFLEEPQSRP 290
Cdd:cd17313 128 ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFgfalggnlKVPFYIGAIILLVCVLVTLFFVKEPPLSP 207


                ....*
gi 24642004 291 EKSAE 295
Cdd:cd17313 208 EAGEH 212
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 148-504 6.55e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.70  E-value: 6.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 148 CLLILFWGSWSDRHRRRKpciLIpVVGEFLGVVGLMLCVYfeqAPMEAAALTEAIFPSLSGGWFTMLmgVFSYIADITTE 227
Cdd:cd17324  48 ALGALLLGPLSDRIERRR---LL-LVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGGFWAI--AAAYAADLVPP 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 228 EDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLeePQSRPEKSAEQKSLLAdffdke 307
Cdd:cd17324 119 EKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL--PSLPPKKPGSLGLLSS------ 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 308 hvvqtFRVAFkkgenqRRKRVILLMIVVMVIIGPLHGemAVTYLFTRFRFNwsevefsFFSTYAMFTGLIGVIFCVGILS 387
Cdd:cd17324 191 -----LLLLL------RNPRLRLAYLITFLLFGGFFA--LYTYLAPFLTDV-------PGFSSSAIIGLLLLFGVAGVVG 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 388 HKLN---IDDALVGVLSSTSKILSSFVYAFATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSK---DELGKVNSLFGVA 461
Cdd:cd17324 251 SPLAgrlADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRlapEARGLASSLYLAA 330

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 24642004 462 ----EALMPMVFAPMYTTL-YAATlrvlpgafFLLGGGLTLFSVFIFL 504
Cdd:cd17324 331 ynlgGALGAALGGLVLDHGgWAGV--------GWVGAALLLLALLLAL 370
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 155-506 8.07e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 48.37  E-value: 8.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 155 GSWSDRHRRRKPCILIpvvgeflgvvGLMLCVyfeqapmeAAALTEAIFPSlsgGWFTMLMGVFSYIADIT--------- 225
Cdd:cd17490  52 GILSDRIGKRKLFIII----------GLLFTV--------LASLIMILFPS---PWGLLIARFLSGIAAATwvsftvlya 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 226 ---TEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLLAD 302
Cdd:cd17490 111 syfPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSV 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 303 FFDKEHVVqtfrvafkkgenqrrkrVILLMIVVMVIigplhgEMAVTYLFT---RFRFNWSEVEFSFFSTYAMFTGLIGV 379
Cdd:cd17490 191 LKDKKLLF-----------------FSLLAILQQMI------TFSTTFGFTpliAKQLGASSFQLGLLSIIYLLPNALAS 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 380 IFCVGILSHKlniddalvgvLSSTSKILSSF----VYAFATlPWHMYLGGL--VEIFNGTAFIAMRSIATKLVSKD-ELG 452
Cdd:cd17490 248 LLSGTLFYKK----------LGERNTIIIGFlllgAYCFLI-PFAPNLTLLylLQALNGFGTGILFPLLMSLSIEGvPAE 316

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24642004 453 KVNSLFGVAEAL--MPMVFAPMYTTlYAATLRVLPGAFFLLGGGLTLFSVFIFLWM 506
Cdd:cd17490 317 QRSTAMGFFQAIyaLGMFLGPVLVG-IISEAFGLQTGFFVIGVIALLAAILSLAYY 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
324-515 2.81e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 2.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 324 RRKRVILLMIVVMVIIGPLhGEMAVTYLFTRF--RFNWSEVEFSFFSTYAMFTGLIGVIFcVGILSHKLNIDDALVGVLS 401
Cdd:COG2814   6 RRRWLALLALALGAFLSGL-GIGIVLPALPLIaaDLGASPAQAGLVVTAYLLGAALGAPL-AGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 402 STskILSSFVYAFATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAAt 480
Cdd:COG2814  84 LF--ALGSLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL- 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24642004 481 lrVLPGAFFLLGGGLTLFSVFIFLWMYRFQVRQRR 515
Cdd:COG2814 161 --FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR 193
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 149-386 3.80e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 45.96  E-value: 3.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 149 LLILFWGSWSDRHRRRKPcILIPVVGEFLGVVGLMLcvyfeqAPMEAAALTEAIFPSLSGGwfTMLMGVFSYIADITTEE 228
Cdd:COG0477  64 IGLLLFGRLGDRYGRKRV-LLIGLLLFGLASLLCGL------APSPELLIAARALQGIGAG--GLMPGALALIAELFPAR 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 229 DRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFleePQSRPEKSAEQKSLLADFFDKEH 308
Cdd:COG0477 135 ERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL---PESRGLLLALLALALAALLLAAL 211

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642004 309 VVQTFRVAFKKGENQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGIL 386
Cdd:COG0477 212 ALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
201-508 4.86e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 4.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 201 AIFPSLSGGWFTMLMGVF--------------SYIADITTEEdRTLRIGILNVCFSVGVPIGMAFSGVLLKQ---IGFYG 263
Cdd:COG0738  87 LLLFALAPSYPLLLLALFllglglglldvaanPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHL 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 264 VFSISAAFYVIAFVYGFFF-LEEPQSRPEKSAEQKSLLADFFdkehvvqtfrvafkkgenqRRKRVILLMIVVMVIIGpl 342
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLL-------------------KNPRLLLGGLAIFLYVG-- 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 343 hGEMAV---TYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSHklnIDDALVGVLSSTSKILSSFVYAFATLPW 419
Cdd:COG0738 225 -AEGAIgdwLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR---FGPVRLLRLSALLAAVGLLLALLAPGPW 300

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 420 HMYLG-GLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLF---GVAEALMPMVFAPM--YTTLYAAtlrvlpgafFLLGG 493
Cdd:COG0738 301 LALIGlALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLimgIVGGAIGPPLIGFLadAFGLRAA---------FLVPL 371

                       330
                ....*....|....*
gi 24642004 494 GLTLFSVFIFLWMYR 508
Cdd:COG0738 372 VCYLLILLLALALKR 386
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 145-504 7.63e-05

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 45.30  E-value: 7.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 145 LFPCLLILFWGSWSDRHR-----RRKPCILIPVVGEFLGVVGLmlcvyfeqapmeAAALTEAIFPSLSGGWFtmLMGVFS 219
Cdd:cd17485  41 YLPWVLKFLWAPLVDRYGlprlgRRRSWLLPTQLGLALLLLAL------------AFLPPTTNLLAFLGLLF--LLNLFS 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 220 YIADITTeeD----RTLR---IGILNVCFSVGVPIGMAFSG----VLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQS 288
Cdd:cd17485 107 ATQDIAT--DglavELLTpeeRGLGNAAQVVGYKLGSLLGGggllWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELP 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 289 RPEKSAEQ----KSLLADFFdkehvvqtfrvafkkgenqRRKRVILLMIVVMVIIGPLHGEMAVTYLF-TRFRFNWSEVE 363
Cdd:cd17485 185 QQPPASERgaalKASLRAFL-------------------RRPGTRWLLLFLLLYKLGEQGALAMLPPFlVDRGFSLSQIG 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 364 FsFFSTYAMFTGLIGViFCVGILSHKLNIDDALVGVLSSTSkILSSFVYAFATLPWHMYLGGLV------EIFNGTAFIA 437
Cdd:cd17485 246 L-LSGVGGSLVSIAGS-LLGGYLLKRRGRRRLLLLGGLLRL-LLLGLYTLLALGGSGLNWVLLLaslallHLVGGMITTA 322

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24642004 438 MRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLyAATLRvlPGAFFLLGGGLTLFSVFIFL 504
Cdd:cd17485 323 LFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFL-ADHLG--YAAAFLLFAILSALSVLLLL 386
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 144-283 8.91e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 8.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 144 SLFPCLLIL---FWGSWSDRHRRRK---PCILIPVVGeflgvvglMLCVYFEQAPMEAAalteaIFPSLSGGWFTMLMGV 217
Cdd:cd17489 234 TVYAIALLLsrpFSGKLSDRKGPKTviiPGLLLLALG--------LLLLSFAGSPWMLL-----LAAVLYGLGFGLLFPA 300

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24642004 218 F-SYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFL 283
Cdd:cd17489 301 LqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
131-291 1.17e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.87  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 131 MVARMAAWKTVIQSLFPCLLILFWGSWSDRHRRRKPCILIpvvgeFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGW 210
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-----FALMALGLLLLALALGSLWLFLVLFLLLGLALGGG 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 211 FTMlmgVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFY-GVFSISAAFYVIAFVYGFFFLEEPQSR 289
Cdd:COG2223 313 NGA---VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtAAFLVFAVLALVALVLTLLLYRRPRRA 389


                ..
gi 24642004 290 PE 291
Cdd:COG2223 390 AA 391
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 136-303 1.21e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.92  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 136 AAWKTVIQSLFPCLLILFWGSWSDRHRRRkpciLIPVVGEFLGVVGLMLCVYFEQAPMEAAAlteAIFPSLSGGwfTMLM 215
Cdd:cd06179  34 STWISTAWSLAQAVLGPIVGRLSDLFGRR----WFFIGGNLLGVVGSIVAGTAKSVNMLIGG---QALIGIGAG--TQGL 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 216 GVFSyIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQ--IGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKS 293
Cdd:cd06179 105 GAAV-ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWRWIFYINAIFNALALILLFFFYHPPPRPQLHG 183

                       170
                ....*....|
gi 24642004 294 AEQKSLLADF 303
Cdd:cd06179 184 SSTRQKLKRL 193
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 221-498 9.09e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 9.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 221 IADITTEEDRTLRIGILNVCFSVGVPIGMAFSGvLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLL 300
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 301 ADFFdkehvvqtfrvafkkgenQRRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVI 380
Cdd:cd17474 191 LKKA------------------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 381 FCVGILSHKLNIDDALVGVLSSTSkiLSSFVYAFATLPWHMYLG-GLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFG 459
Cdd:cd17474 253 FVGRLLKKRFGARRILVIGLLLYA--LSLLLLGFVPSLALLLIAiVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 24642004 460 ----VAEALMPMVFAPMYTTLYAATLRVLPGAFFLLGGGLTLF 498
Cdd:cd17474 331 fvrfLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 136-448 1.22e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 41.42  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 136 AAWKTVIQSLFP---CLLILFWGSWSDRHRRRKPCILIPVVGEFLGVVGLmlcvyfeqapmeaaALTEAIFPSLSGGW-- 210
Cdd:cd17335  31 PTQIGILIGIRPfvrFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL--------------FFVAQIFWLLLLLVil 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 211 FTMLMGVFSYIAD---ITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLL----KQIGFYGVFSISAAFYVIAFVYGFFFL 283
Cdd:cd17335  97 GAFFSAPVVPLVDsitLQYLGEERERYGKQRLWGSIGFGIAALLVGILIdrssTYKNYTIAFYVFAVLMLLALLLALKFP 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 284 EEPQsRPEKSAEQKSLLADFfdkehvvqtfrvafkkgenqRRKRVILLMIVVMvIIGPLHGeMAVTYLFTRFR-FNWSEV 362
Cdd:cd17335 177 FRPK-HPEPNENTGGLLALL--------------------RNPRVLAFLLVAF-LMGFGHG-LIYSFLFWHLQdLGGSKT 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 363 EFSFFSTYAMFTGlIGVIFCVGILSHKLNIDDALvgVLSSTSKILSSFVYAFATLPWhmyLGGLVEIFNGTAFIAMRSIA 442
Cdd:cd17335 234 LIGLLWTVGVVSE-IPFFFFSSRLIQRFGHVGLL--YLGLLAYVVRWLLYSFLENPW---LVLPIELLHGLTFALVWAAA 307


                ....*.
gi 24642004 443 TKLVSK 448
Cdd:cd17335 308 VSYASA 313
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 219-430 1.64e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.07  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 219 SYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQI-GFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQK 297
Cdd:cd17328 110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMA 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 298 SLLADFFdkehvVQTFRVAFKKgenqrrKRVILLMI--VVMVIIGPLHGEMAVTYLFTRFRF-NWSEVEFSF-FSTYAMF 373
Cdd:cd17328 190 KSTATSF-----LADLKALAKN------PSFILSTLgfTAVSFVTGALAFWAPTFFLRAFGVgDLSSADVGLiFGAITCI 258

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24642004 374 TGLIGVIFcVGILSHKLNID----DALV---GVLSSTSKILSSFVYAFATLPWHMYLGGLVEIF 430
Cdd:cd17328 259 AGVLGVLL-GGILADRLRRKtpraDPLVcavGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFL 321
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 152-303 2.77e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.56  E-value: 2.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 152 LFWGSWSDRHR----RRKPCILIPVVGEFLGVVGLMLCVYFEQAPMEAAALTEAIFPSLSGGWFTMLMGV--FSYIADIT 225
Cdd:cd06176  53 VWIGHRSDTHPlrgyRRTPYIWLGMLLLALGLALAPFAALLLAGAAFWLGLALAVLAFLLYGIGVGAAGTafLALLADLT 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 226 TEEDRTLRIGILNVCFSVGVPIGMAFSGVLLK---QIGFYGVFSISAafyVIAFVYGFFFL--EEPQSRPEKSAEQKSLL 300
Cdd:cd06176 133 PEERRPRAVTVVWTMLILGIIVTAIVFGRLLDpysPERLIQVFQIVA---LVALLLALLALwgVERRRSRAALAAEEAPP 209


                ...
gi 24642004 301 ADF 303
Cdd:cd06176 210 ETF 212
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 134-281 3.23e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.30  E-value: 3.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 134 RMAAWKTVIQSLFPCLLILFWGSWSDRHRRRKpcilIPVVGEFLGVVGLMLCVYFeqaPMEAAALteAIFPSLSGGWFTM 213
Cdd:cd17313 281 RMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKK----VYLIGLVLFAVGMALMALV---HNVTVAL--VLFALGGIGWATI 351

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 214 LMGVFSYIADITTEEDRT--LRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFF 281
Cdd:cd17313 352 NINPYPLVSDYHSESGRGqgTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 142-282 6.16e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.13  E-value: 6.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 142 IQSLFPCLLILFWGSWSDRHRRRKPCILIPVvgefLGVVGLMLCVYFEQAPMEAAALTeAIFPSLSGGWFTMLmgvFSYI 221
Cdd:cd17353 257 ILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL----IQGVAMFLLPFIGSVAVLFVLGV-ALIGFCYGGGFALF---PALT 328

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642004 222 ADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFF 282
Cdd:cd17353 329 ADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 334-521 6.55e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 6.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 334 VVMVIIGPLHGEMAVTYLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCvGILSHKLNIDDALVgvLSSTSKILSSFVYA 413
Cdd:cd06174   3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLA-GLLADRFGRRPVLL--LGLLLFALGALLFA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 414 FATLPWHMYLGGLVE-IFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAATLRVLPGAFFLLG 492
Cdd:cd06174  80 FAPSFWLLLLGRFLLgLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159

                       170       180
                ....*....|....*....|....*....
gi 24642004 493 GGLTLFSVFIFLWMYRFQVRQRRNLASAD 521
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEAS 188
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
 131-309 9.56e-03

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 38.75  E-value: 9.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 131 MVARMAAWKTVIQSL--FPCLLILFWGSWSD----RHRRRKPCILIpvvGEFLGVVGLMlcvyfeqapmeAAALTEAIFP 204
Cdd:cd17484  27 DLHLGPASVQALTSIasLPWAIKPLYGLLSDsvpiFGYRRKPYLIL---AGALGALSWL-----------ALALVSNSSL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642004 205 SLSGGWFTmLMGVFSYIADITTE---------EDRTLRIGILNVCF---SVGVPIGMAFSGVLLKQIGFYGVFSISAAFY 272
Cdd:cd17484  93 ALALLLLL-LASLGVAFSDVVIDalvveasrgAPQSLAGDLQSLCWgssAIGGIVGSYFSGYLLELLGPRTVFAVTSFFP 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 24642004 273 VIAFVYGFFFLEEPQ---SRPEKSAEQKSLLADFFDKEHV 309
Cdd:cd17484 172 LLLLIVAFFVKEERVpphRTKENFDEQLKALWETVKQPSI 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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