RING finger, HC subclass, found in the makorin (MKRN) proteins; The MKRN protein subfamily includes ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24642006  81 KMCGICLETVVKKrgrECRFGILPKCKHIFCLTCIRRWRQAEYIEDNVKRGCPECR 136
Cdd:cd16521   1 IECGICMEVVLEK---ERRFGILSNCNHVFCLECIREWRSSKDFENSIVRSCPICR 53

RING finger, HC subclass, found in the makorin (MKRN) proteins; The MKRN protein subfamily includes ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24642006  81 KMCGICLETVVKKrgrECRFGILPKCKHIFCLTCIRRWRQAEYIEDNVKRGCPECR 136
Cdd:cd16521   1 IECGICMEVVLEK---ERRFGILSNCNHVFCLECIREWRSSKDFENSIVRSCPICR 53

Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24642006     83 CGICLEtvvkkrgRECRFGILPKCKHIFCLTCIRRWRQAEYIEdnvkrgCPEC 135
Cdd:smart00184   1 CPICLE-------EYLKDPVILPCGHTFCRSCIRKWLESGNNT------CPIC 40

RING finger, HC subclass, found in the makorin (MKRN) proteins; The MKRN protein subfamily includes ribonucleoproteins that are characterized by a variety of zinc-finger motifs, including typical arrays of one to four C3H1-type zinc fingers and a C3HC4-type RING-HC finger. Another motif rich in Cys and His residues (CH), with so far unknown function, is also generally present in MKRN proteins. MKRN proteins may have E3 ubiquitin ligase activity.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24642006  81 KMCGICLETVVKKrgrECRFGILPKCKHIFCLTCIRRWRQAEYIEDNVKRGCPECR 136
Cdd:cd16521   1 IECGICMEVVLEK---ERRFGILSNCNHVFCLECIREWRSSKDFENSIVRSCPICR 53

RING finger, HC subclass, found in makorin-4 (MKRN4) and similar proteins; MKRN4, also known as makorin RING finger protein pseudogene 4, makorin RING finger protein pseudogene 5, RING finger protein 64 (RNF64), zinc finger protein 127-Xp (ZNF127-Xp), or zinc finger protein 127-like 1, is a new divergent member of the makorin protein family in vertebrates. It may have an ancestral gonad-specific function and maternal embryonic expression before duplication in vertebrates. MKRN4 contains typical arrays of one to four C3H1-type zinc fingers, a motif rich in Cys and His residues (CH) and a C3HC4-type RING-HC finger. The RING-HC finger of mammalian MKRN4 shows high sequence similarity with that of MKRN3, and is not included in this model.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642006  80 DKMCGICLETVVKKR-GRECRFGILPKCKHIFCLTCIRRWRQAEYIEDNVKRGCPECRVFS 139
Cdd:cd16732   1 DVACGICMDKVYEKAhAKERVFGILPNCNHAFCVGCIKKWRKSKDFQNEVIKACPQCRVKS 61

N1R/p28-like protein; Provisional

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24642006   78 SQDKMCGICLETVVKKRGRECRFGILPKCKHIFCLTCIRRWRQAeyiednvKRGCPECRVFSEFV 142
Cdd:PHA02929 172 SKDKECAICMEKVYDKEIKNMYFGILSNCNHVFCIECIDIWKKE-------KNTCPVCRTPFISV 229

p28-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642006   81 KMCGICLETVVKKRGRECRFGILPKCKHIFCLTCIRRWRqaeyIEDNVKRGCPECRVFSEFVC-------------PSAY 147
Cdd:PHA03096 179 KICGICLENIKAKYIIKKYYGILSEIKHEFNIFCIKIWM----TESLYKETEPENRRLNTVIVfiekinedlknniPSRY 254

                         90
                 ....*....|....*
gi 24642006  148 WVDTKEEKDKLLSEY 162
Cdd:PHA03096 255 WIDDKYDKNLLSFRY 269

RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3), Deltex-3-like (DTX3L) and similar proteins; This subfamily contains Deltex3 (DTX3) and Deltex-3-like (DTX3L), both of which are E3 ubiquitin-protein ligases belonging to the Deltex (DTX) family. DTX3, also known as RING finger protein 154 (RNF154), has a biological function that remains unclear. DTX3L, also known as B-lymphoma- and BAL-associated protein (BBAP) or Rhysin-2 (Rhysin2), regulates endosomal sorting of the G protein-coupled receptor CXCR4 from endosomes to lysosomes. It also regulates subcellular localization of its partner protein, B aggressive lymphoma (BAL), by a dynamic nucleocytoplasmic trafficking mechanism. In contrast to other DTXs, both DTX3 and DTX3L contain a C3HC4-type RING-HC finger, and a previously unidentified C-terminal domain. DTX3L can associate with DTX1 through its unique N termini and further enhance self-ubiquitination.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24642006  81 KMCGICLETVVKKRgrecrfgILPKCKHIFCLTCIRRWRQaeyiednVKRGCPECRVF 138
Cdd:cd16506   1 DTCPICLDEIQNKK-------TLEKCKHSFCEDCIDRALQ-------VKPVCPVCGVV 44

RING finger, HC subclass, found in RING finger protein 213 (RNF213) and similar proteins; RNF213, also known as ALK lymphoma oligomerization partner on chromosome 17 or Moyamoya steno-occlusive disease-associated AAA+ and RING finger protein (mysterin), is an intracellular soluble protein that functions as an E3 ubiquitin-protein ligase and AAA+ ATPase, which possibly contributes to vascular development through mechanical processes in the cell. It plays a unique role in endothelial cells for proper gene expression in response to inflammatory signals from the environment. Mutations in RNF213 may be associated with Moyamoya disease (MMD), an idiopathic cerebrovascular occlusive disorder prevalent in East Asia. It also acts as a nuclear marker for acanthomorph phylogeny. RNF213 contains two tandem enzymatically active AAA+ ATPase modules and a C3HC4-type RING-HC finger. It can form a huge ring-shaped oligomeric complex.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24642006  80 DKMCGICLETVvkkrgrecRFGILPKCKHIFCLTCIRRWRQAEyiednvkRGCPECRV 137
Cdd:cd16561   2 EQECSICLEDL--------NDPVKLPCDHVFCEECIRQWLPGQ-------MSCPLCRT 44

RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins; RNF10 is an E3 ubiquitin-protein ligase that interacts with mesenchyme Homeobox 2 (MEOX2) transcription factor, a regulator of the proliferation, differentiation and migration of vascular smooth muscle cells and cardiomyocytes; it enhances Meox2 activation of the p21 promoter. It also regulates the expression of myelin-associated glycoprotein (MAG) genes and is required for myelin production in Schwann cells of the peripheral nervous system. Moreover, RNF10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells. RNF10 contains a C3HC4-type RING-HC finger and three putative nuclear localization signals.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24642006  83 CGICLETVVKKRgrecrfgiLPKCKHIFCLTCIRRwrqaeYIEDNVK--RGCPEC 135
Cdd:cd16536   3 CPICLEPPVAPR--------ITRCGHIFCWPCILR-----YLSLSEKkwRKCPIC 44

RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins; DTX3L, also known as B-lymphoma- and BAL-associated protein (BBAP) or Rhysin-2 (Rhysin2), is a RING-domain E3 ubiquitin-protein ligase that regulates endosomal sorting of the G protein-coupled receptor CXCR4 from endosomes to lysosomes. It also regulates subcellular localization of its partner protein, B aggressive lymphoma (BAL), by a dynamic nucleocytoplasmic trafficking mechanism. DTX3L has a unique N-terminus, but lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex (DTX) family members, such as DTX1, DTX2, and DTX4. Moreover, its C-terminal region is highly homologous to DTX3. It includes a C3HC4-type RING-HC finger, and a previously unidentified C-terminal domain. DTX3L can associate with DTX1 through its unique N-terminus and further enhance self-ubiquitination.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24642006  83 CGICLETVVKKRgrecrfgILPKCKHIFCLTCIRRwrqaeyiEDNVKRGCPECRV 137
Cdd:cd16712   6 CPICMDRISNKK-------VLPKCKHVFCAACIDK-------AMKYKPVCPVCGT 46

RING finger, H2 subclass, found in Arabidopsis thaliana RING-H2 finger A1a (RHA1A), A1b (RHA1B) and similar proteins; This subfamily includes Arabidopsis thaliana RHA1A, RHA1B and XERICO. RHA1A is a probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro. RHA1B possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro. XERICO functions on abscisic acid homeostasis at post-translational level, probably through ubiquitin/proteasome-dependent substrate-specific degradation. Members of this subfamily contain a C3H2C3-type RING-H2 finger.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24642006  80 DKMCGICLETVVKkrgrECRFGILPKCKHIFCLTCIRRWrqaeyIEDNvKRGCPECRV 137
Cdd:cd23121   1 DDCCAICLSDFNS----DEKLRQLPKCGHIFHHHCLDRW-----IRYN-KITCPLCRA 48