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Conserved domains on  [gi|24642035|ref|NP_572976|]
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uncharacterized protein Dmel_CG12539 [Drosophila melanogaster]

Protein Classification

GMC family oxidoreductase( domain architecture ID 11455227)

GMC (glucose-methanol-choline) family oxidoreductase is a flavoprotein that catalyzes the oxidation of an alcohol moiety to the corresponding aldehyde with the concomitant reduction of flavin adenine dinucleotide (FAD)

EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0050660
PubMed:  23578136|1542121
SCOP:  3000055

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 58-622 6.06e-177

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 512.45  E-value: 6.06e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGV-ENIAHLTPVVAGYLQQTSS-NWGYKSVPQKlschGMNNNECALP 135
Cdd:COG2303   5 YDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRdDDPLIRMPAGYAKLLGNPRyDWRYETEPQP----GLNGRRLYWP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 136 RGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQLQGleqSPYHNHSGPLSVEYVRFRSQMVD 215
Cdd:COG2303  81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGA---DAYHGRSGPLPVSDPPLPNPLSD 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 216 AFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDEatKSAYGVEF 294
Cdd:COG2303 158 AFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALK-RPNLTVRTGALVTRILFDG--GRATGVEY 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 295 HYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMchFGPTFVTNTTGQTTFTS 373
Cdd:COG2303 235 RDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPgVGRNLQDHL--EVSVVFRFKEPVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 374 RVTPAELISFLLAGN-PATRMssigGVEALAFLktqRSNLPNDWPDIELIMVTGSLASDEGtglklganfKDEIydrmyr 452
Cdd:COG2303 313 LRKARIGLQYLLTRSgPLTSN----VAEAGGFF---RSDPGLERPDLQFHFLPLGLTPRWG---------KKAL------ 370

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 453 elaqAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARllkRTV 532
Cdd:COG2303 371 ----HDGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGE---EIL 443

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 533 PGcEGHQFASDDYWrcsIRTLSYTLHHQVATCRMGaeSDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
Cdd:COG2303 444 PG-PDVQSDEELAF---IRARAYTIYHPVGTCRMG--TDPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLA 517

                       570
                ....*....|
gi 24642035 613 EKAADMIRTD 622
Cdd:COG2303 518 EKAADMILGD 527
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 58-622 6.06e-177

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 512.45  E-value: 6.06e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGV-ENIAHLTPVVAGYLQQTSS-NWGYKSVPQKlschGMNNNECALP 135
Cdd:COG2303   5 YDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRdDDPLIRMPAGYAKLLGNPRyDWRYETEPQP----GLNGRRLYWP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 136 RGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQLQGleqSPYHNHSGPLSVEYVRFRSQMVD 215
Cdd:COG2303  81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGA---DAYHGRSGPLPVSDPPLPNPLSD 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 216 AFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDEatKSAYGVEF 294
Cdd:COG2303 158 AFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALK-RPNLTVRTGALVTRILFDG--GRATGVEY 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 295 HYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMchFGPTFVTNTTGQTTFTS 373
Cdd:COG2303 235 RDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPgVGRNLQDHL--EVSVVFRFKEPVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 374 RVTPAELISFLLAGN-PATRMssigGVEALAFLktqRSNLPNDWPDIELIMVTGSLASDEGtglklganfKDEIydrmyr 452
Cdd:COG2303 313 LRKARIGLQYLLTRSgPLTSN----VAEAGGFF---RSDPGLERPDLQFHFLPLGLTPRWG---------KKAL------ 370

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 453 elaqAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARllkRTV 532
Cdd:COG2303 371 ----HDGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGE---EIL 443

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 533 PGcEGHQFASDDYWrcsIRTLSYTLHHQVATCRMGaeSDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
Cdd:COG2303 444 PG-PDVQSDEELAF---IRARAYTIYHPVGTCRMG--TDPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLA 517

                       570
                ....*....|
gi 24642035 613 EKAADMIRTD 622
Cdd:COG2303 518 EKAADMILGD 527
PRK02106 PRK02106
choline dehydrogenase; Validated
 58-620 3.46e-132

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 398.82  E-value: 3.46e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGVENIA----HLTPVVAGYLQQTSSNWGYKSVPQKlschGMNNNECA 133
Cdd:PRK02106   6 YDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDYRWdffiQMPAALAFPLQGKRYNWAYETEPEP----HMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  134 LPRGKILGGTSSINYMIYNRGNRRDFDAWAA-AGNPGWSYDEVLPYFLRSEHAQLQGleqSPYHNHSGPLSVEY-VRFRS 211
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAElPGLEGWSYADCLPYFKKAETRDGGE---DDYRGGDGPLSVTRgKPGTN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  212 QMVDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDEatKSAY 290
Cdd:PRK02106 159 PLFQAFVEAGVQAGYPRTdDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALK-RPNLTIVTHALTDRILFEG--KRAV 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  291 GVEFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHM-------CHfgptfv 362
Cdd:PRK02106 236 GVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPgVGENLQDHLevyiqyeCK------ 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  363 tnttgqttftsrvtpaELISFllagNPAT---RMSSIG--------------GVEALAFLktqRSNLPNDWPDIEL---- 421
Cdd:PRK02106 310 ----------------QPVSL----YPALkwwNKPKIGaewlftgtglgasnHFEAGGFI---RSRAGVDWPNIQYhflp 366

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  422 --IMVTGSLASDEgtglklganfkdeiydrmyrelaqaqqDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEE 499
Cdd:PRK02106 367 vaIRYDGSNAVKG---------------------------HGFQAHVGPMRSPSRGSVKLKSADPRAHPSILFNYMSTEQ 419

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  500 DVEYLLDGIKASLRIIEMPAMQRIGARLLKrtvPGCEghqFASD---DYWrcsIRTLSYTLHHQVATCRMGAesDPTTVV 576
Cdd:PRK02106 420 DWREFRDAIRLTREIMAQPALDPYRGREIS---PGAD---VQTDeeiDAF---VREHAETAYHPSCTCKMGT--DPMAVV 488

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....
gi 24642035  577 NHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIR 620
Cdd:PRK02106 489 DPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIR 532
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 59-620 2.31e-100

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 316.05  E-value: 2.31e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035    59 DFIVIGAGAAGCTLAARLSENPQVSVALIEAGG----VENIAHLTPVVAGYLQQTSSNWGYKSVPQKLschgMNNNECAL 134
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGsdypWDLLIQMPAALAYPAGNKRYNWIYETEPEPH----MNNRRVGH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   135 PRGKILGGTSSINYMIYNRGNRRDFDAWAAA-GNPGWSYDEVLPYFLRSEHAQLQgleQSPYHNHSGPLSVEYVRFRSQM 213
Cdd:TIGR01810  77 ARGKVLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGG---EKPYRGHDGPIKVRRGPADNPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   214 VDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDeaTKSAYGV 292
Cdd:TIGR01810 154 FQAFIEAGVEAGYNKTpDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMK-RPNLEVQTRAFVTKINFE--GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   293 EFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFgptfvtnttgqtTF 371
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPgVGENLQDHLEVY------------VQ 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   372 TSRVTPAELISFLlagnPATRMSSIG--------GV------EALAFLktqRSNLPNDWPDIELIMVTGSLASDeGTglk 437
Cdd:TIGR01810 299 HACKQPVSLYPSL----NWLKQPFIGaqwlfgrkGAgasnhfEGGGFV---RSNDDVDYPNIQYHFLPVAIRYD-GT--- 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   438 lganfkdeiydrmyrelAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEM 517
Cdd:TIGR01810 368 -----------------KAPKAHGFQVHVGPMYSNSRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQ 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   518 PAMQRIGARLLKrtvPGCEGHQFASDDYWrcsIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIP 597
Cdd:TIGR01810 431 KALDPYRGGEIS---PGPEVQTDEEIDEF---VRRHGETALHPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMP 504

                         570       580
                  ....*....|....*....|...
gi 24642035   598 FPPTAHTNAAAFMIGEKAADMIR 620
Cdd:TIGR01810 505 RITNGNLNAPVIMMGEKAADIIR 527
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 128-355 1.26e-46

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 163.61  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   128 NNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWA-AAGNPGWSYDEVLPYFLRSEhaqlqgleqspyhnhsGPLSV-- 204
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWAsEFGLEGWGYDDYLPYMDKVE----------------GPLGVtt 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   205 --EYVRFRSQmvdAFVEASVESGLPRT----DYNGESQLGVSYVQANTlnGRRHSAYSAYIKPVrdLRSNLQIFTFSQVT 278
Cdd:pfam00732  79 kgIEESPLNQ---ALLKAAEELGYPVEavprNSNGCHYCGFCGLGCPT--GAKQSTARTWLRPA--LERNLRILTGAKAE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24642035   279 RILIDEATKSAYGVEF--HYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNlrgigiplikalPVGKRMFDHMC 355
Cdd:pfam00732 152 KIIILGRGGRAVGVEArdGGGGIKRLITAAKEVVVAAGALNTPPLLLRSGLGKNPH------------PVGKNLQLHPV 218
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 58-622 6.06e-177

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 512.45  E-value: 6.06e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGV-ENIAHLTPVVAGYLQQTSS-NWGYKSVPQKlschGMNNNECALP 135
Cdd:COG2303   5 YDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRdDDPLIRMPAGYAKLLGNPRyDWRYETEPQP----GLNGRRLYWP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 136 RGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQLQGleqSPYHNHSGPLSVEYVRFRSQMVD 215
Cdd:COG2303  81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGA---DAYHGRSGPLPVSDPPLPNPLSD 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 216 AFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDEatKSAYGVEF 294
Cdd:COG2303 158 AFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALK-RPNLTVRTGALVTRILFDG--GRATGVEY 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 295 HYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMchFGPTFVTNTTGQTTFTS 373
Cdd:COG2303 235 RDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPgVGRNLQDHL--EVSVVFRFKEPVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 374 RVTPAELISFLLAGN-PATRMssigGVEALAFLktqRSNLPNDWPDIELIMVTGSLASDEGtglklganfKDEIydrmyr 452
Cdd:COG2303 313 LRKARIGLQYLLTRSgPLTSN----VAEAGGFF---RSDPGLERPDLQFHFLPLGLTPRWG---------KKAL------ 370

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 453 elaqAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARllkRTV 532
Cdd:COG2303 371 ----HDGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGE---EIL 443

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035 533 PGcEGHQFASDDYWrcsIRTLSYTLHHQVATCRMGaeSDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
Cdd:COG2303 444 PG-PDVQSDEELAF---IRARAYTIYHPVGTCRMG--TDPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLA 517

                       570
                ....*....|
gi 24642035 613 EKAADMIRTD 622
Cdd:COG2303 518 EKAADMILGD 527
PRK02106 PRK02106
choline dehydrogenase; Validated
 58-620 3.46e-132

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 398.82  E-value: 3.46e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGVENIA----HLTPVVAGYLQQTSSNWGYKSVPQKlschGMNNNECA 133
Cdd:PRK02106   6 YDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDYRWdffiQMPAALAFPLQGKRYNWAYETEPEP----HMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  134 LPRGKILGGTSSINYMIYNRGNRRDFDAWAA-AGNPGWSYDEVLPYFLRSEHAQLQGleqSPYHNHSGPLSVEY-VRFRS 211
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAElPGLEGWSYADCLPYFKKAETRDGGE---DDYRGGDGPLSVTRgKPGTN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  212 QMVDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDEatKSAY 290
Cdd:PRK02106 159 PLFQAFVEAGVQAGYPRTdDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALK-RPNLTIVTHALTDRILFEG--KRAV 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  291 GVEFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHM-------CHfgptfv 362
Cdd:PRK02106 236 GVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPgVGENLQDHLevyiqyeCK------ 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  363 tnttgqttftsrvtpaELISFllagNPAT---RMSSIG--------------GVEALAFLktqRSNLPNDWPDIEL---- 421
Cdd:PRK02106 310 ----------------QPVSL----YPALkwwNKPKIGaewlftgtglgasnHFEAGGFI---RSRAGVDWPNIQYhflp 366

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  422 --IMVTGSLASDEgtglklganfkdeiydrmyrelaqaqqDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEE 499
Cdd:PRK02106 367 vaIRYDGSNAVKG---------------------------HGFQAHVGPMRSPSRGSVKLKSADPRAHPSILFNYMSTEQ 419

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  500 DVEYLLDGIKASLRIIEMPAMQRIGARLLKrtvPGCEghqFASD---DYWrcsIRTLSYTLHHQVATCRMGAesDPTTVV 576
Cdd:PRK02106 420 DWREFRDAIRLTREIMAQPALDPYRGREIS---PGAD---VQTDeeiDAF---VREHAETAYHPSCTCKMGT--DPMAVV 488

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....
gi 24642035  577 NHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIR 620
Cdd:PRK02106 489 DPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIR 532
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 59-620 2.31e-100

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 316.05  E-value: 2.31e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035    59 DFIVIGAGAAGCTLAARLSENPQVSVALIEAGG----VENIAHLTPVVAGYLQQTSSNWGYKSVPQKLschgMNNNECAL 134
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGsdypWDLLIQMPAALAYPAGNKRYNWIYETEPEPH----MNNRRVGH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   135 PRGKILGGTSSINYMIYNRGNRRDFDAWAAA-GNPGWSYDEVLPYFLRSEHAQLQgleQSPYHNHSGPLSVEYVRFRSQM 213
Cdd:TIGR01810  77 ARGKVLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGG---EKPYRGHDGPIKVRRGPADNPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   214 VDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILIDeaTKSAYGV 292
Cdd:TIGR01810 154 FQAFIEAGVEAGYNKTpDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMK-RPNLEVQTRAFVTKINFE--GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   293 EFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFgptfvtnttgqtTF 371
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPgVGENLQDHLEVY------------VQ 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   372 TSRVTPAELISFLlagnPATRMSSIG--------GV------EALAFLktqRSNLPNDWPDIELIMVTGSLASDeGTglk 437
Cdd:TIGR01810 299 HACKQPVSLYPSL----NWLKQPFIGaqwlfgrkGAgasnhfEGGGFV---RSNDDVDYPNIQYHFLPVAIRYD-GT--- 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   438 lganfkdeiydrmyrelAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEM 517
Cdd:TIGR01810 368 -----------------KAPKAHGFQVHVGPMYSNSRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQ 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   518 PAMQRIGARLLKrtvPGCEGHQFASDDYWrcsIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIP 597
Cdd:TIGR01810 431 KALDPYRGGEIS---PGPEVQTDEEIDEF---VRRHGETALHPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMP 504

                         570       580
                  ....*....|....*....|...
gi 24642035   598 FPPTAHTNAAAFMIGEKAADMIR 620
Cdd:TIGR01810 505 RITNGNLNAPVIMMGEKAADIIR 527
Rv0697 TIGR03970
dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the ...
 59-620 6.07e-72

dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function.


Pssm-ID: 274888 [Multi-domain]  Cd Length: 487  Bit Score: 240.10  E-value: 6.07e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035    59 DFIVIGAGAAGCTLAARLSENPQVSVALIEAG-GVENIAHLTPVVAGYLQ-----QTSSNWGYKS----VPQKLSchgmn 128
Cdd:TIGR03970   2 DVLIVGAGSAGSVLAARLSEDPSCTVTVLEAGpGYRDPSRLPAQLTDGLRlpigpASPVVWRYGVeltdGPRRAS----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   129 nnecALPRGKILGGTSSINYMIYNRGNRRDFDAWAAagnPGWSYDEVLPYFLRSEhaqlQGLE-QSPYHNHSGPLSVEYV 207
Cdd:TIGR03970  77 ----QIVRGRVLGGSGAVNGGYFCRALPADFDAWPI---PGWSWDDVLPHFRAIE----TDLDfDGPLHGTAGPIPVRRT 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   208 RFRSQMVDAFVEASVESGLP-RTDYNG---ESQLGVSYVQANTLNGRRHSAYSAYIKPVRDlRSNLQIFTFSQVTRILId 283
Cdd:TIGR03970 146 AELDGISAAFVAAALGAGFGwIADLNGsgpGLPGGVGAVPLNVDGGRRVSTAVAYLLPALK-RPNLTVEADTRVVRILF- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   284 EATKsAYGVEFHYKNKAYTFKARKeVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALPVGKRMFDHmchfgPTFVT 363
Cdd:TIGR03970 224 SGTR-AVGVEVLGDGGPRTLRADR-VVLCAGAVESAHLLLLSGIGPAEQLRAAGIAVVLDLPVGSDFVDH-----PEWVL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   364 NTtgqttftsRVTPaelisfllagnPATRMSSIGGVEALafLKTQrsnlpndwpDIELIMVTGSlasdegtglklganFK 443
Cdd:TIGR03970 297 PY--------RWRP-----------THDRPPTSPVLETV--LNTA---------DIEIRPYTAG--------------FT 332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   444 DEIYDRmyrelaQAQQDHFTLLIMQfhPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRI 523
Cdd:TIGR03970 333 ALVPGS------PRDDPHLGVALMR--PHSRGRIRLASADPADPPRIEHRYDSSAADRAALRAGAALAHELLGSPELGPL 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   524 GARLLKRtvpgceghqfaSDDYWrcsIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAH 603
Cdd:TIGR03970 405 LEPAVRE-----------GEASW---VLARLATSQHLCGSCRMGGRDDPGAVVDARCRVRGVEGLWVVDGSILPVIPSRG 470

                         570
                  ....*....|....*..
gi 24642035   604 TNAAAFMIGEKAADMIR 620
Cdd:TIGR03970 471 PHATAVMVAERAAEFLG 487
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 128-355 1.26e-46

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 163.61  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   128 NNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWA-AAGNPGWSYDEVLPYFLRSEhaqlqgleqspyhnhsGPLSV-- 204
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWAsEFGLEGWGYDDYLPYMDKVE----------------GPLGVtt 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   205 --EYVRFRSQmvdAFVEASVESGLPRT----DYNGESQLGVSYVQANTlnGRRHSAYSAYIKPVrdLRSNLQIFTFSQVT 278
Cdd:pfam00732  79 kgIEESPLNQ---ALLKAAEELGYPVEavprNSNGCHYCGFCGLGCPT--GAKQSTARTWLRPA--LERNLRILTGAKAE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24642035   279 RILIDEATKSAYGVEF--HYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNlrgigiplikalPVGKRMFDHMC 355
Cdd:pfam00732 152 KIIILGRGGRAVGVEArdGGGGIKRLITAAKEVVVAAGALNTPPLLLRSGLGKNPH------------PVGKNLQLHPV 218
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 471-615 1.03e-42

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 150.24  E-value: 1.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   471 PKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMqRIGARLLKRTVPGCEGHQFASDDYWRCSI 550
Cdd:pfam05199   1 PRSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGL-VLGVELTPGPVPEVSDAAVTSDDELLAYI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24642035   551 RTLSYTLHHQVATCRMGAESDPTtVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKA 615
Cdd:pfam05199  80 RAAASTSYHPMGTCRMGADPDDA-VVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAERA 143
PLN02785 PLN02785
Protein HOTHEAD
 56-612 2.17e-24

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 107.58  E-value: 2.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035   56 SNYDFIVIGAGAAGCTLAARLSENpqVSVALIEAGGV----ENIAHLTPVVAGyLQQTSSNwgykSVPQK-LSCHGMNNn 130
Cdd:PLN02785  54 SAYDYIVVGGGTAGCPLAATLSQN--FSVLLLERGGVpfgnANVSFLENFHIG-LADTSPT----SASQAfISTDGVIN- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  131 ecalPRGKILGGTSSINYMIYNRGNRRDFDawaaagNPGWSYDEVLPYFLRSEHAQLQGLEQSPYHnhsgplsveyVRFR 210
Cdd:PLN02785 126 ----ARARVLGGGTCINAGFYSRASTRFIQ------KAGWDAKLVNESYPWVERQIVHWPKVAPWQ----------AALR 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  211 sqmvDAFVEASVesglprTDYNGESQLGVSYVQ-ANTL---NGRRHSAYS--AYIKPvrdlrSNLQIFTFSQVTRILIDE 284
Cdd:PLN02785 186 ----DSLLEVGV------SPFNGFTYDHVYGTKvGGTIfdeFGRRHTAAEllAAGNP-----NKLRVLLHATVQKIVFDT 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  285 ATKS--AYGVEFHYKN----KAY-TFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLI-KALPVGKRMFDhmch 356
Cdd:PLN02785 251 SGKRprATGVIFKDENgnqhQAFlSNNKGSEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPVVlHNEHVGKGMAD---- 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  357 fgptfvtnttgqttftsrvtpaelisfllagNPatrMSSIggvealaFLKTQRSnlpndwPDIELIMVTGslASDEGTGL 436
Cdd:PLN02785 327 -------------------------------NP---MNSI-------FVPSKAP------VEQSLIQTVG--ITKMGVYI 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  437 KLGANF---KDEI---YDRMYRELAQ------------AQQDHFT----LLIMQFH----------PKSVGRLWLKDRNP 484
Cdd:PLN02785 358 EASSGFgqsPDSIhchHGIMSAEIGQlstippkqrtpeAIQAYIHrkknLPHEAFNggfilekiagPISTGHLSLINTNV 437

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642035  485 LGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMP-----------AMQRIGARLLKRTVPGCEGH--------QFASDDY 545
Cdd:PLN02785 438 DDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVKTNhftnftqcdkqTMEKVLNMSVKANINLIPKHtndtksleQFCKDTV 517

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24642035  546 wrcsirtlsYTLHHQVATCRMGaesdptTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
Cdd:PLN02785 518 ---------ITIWHYHGGCHVG------KVVDQNYKVLGVSRLRVIDGSTFDESPGTNPQATVMMMG 569
Lycopene_cycl pfam05834
Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. ...
 59-90 9.11e-05

Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclization of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.


Pssm-ID: 310433 [Multi-domain]  Cd Length: 380  Bit Score: 45.10  E-value: 9.11e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 24642035    59 DFIVIGAGAAGCTLAARLSEN-PQVSVALIEAG 90
Cdd:pfam05834   1 DVVIIGAGPAGLSLAARLAAAkPGLSVVLIEPG 33
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
58-89 1.15e-04

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 44.75  E-value: 1.15e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 24642035  58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEA 89
Cdd:COG0579   5 YDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
PRK06370 PRK06370
FAD-containing oxidoreductase;
58-88 1.43e-04

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 44.81  E-value: 1.43e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 24642035   58 YDFIVIGAGAAGCTLAARLSENPQvSVALIE 88
Cdd:PRK06370   6 YDAIVIGAGQAGPPLAARAAGLGM-KVALIE 35
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
58-92 1.85e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 44.13  E-value: 1.85e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 24642035  58 YDFIVIGAGAAGCTLAARLSENpQVSVALIEAGGV 92
Cdd:COG0665   3 ADVVVIGGGIAGLSTAYHLARR-GLDVTVLERGRP 36
PLN02661 PLN02661
Putative thiazole synthesis
 59-88 8.20e-04

Putative thiazole synthesis


Pssm-ID: 178267  Cd Length: 357  Bit Score: 42.12  E-value: 8.20e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 24642035   59 DFIVIGAGAAGCTLAARLSENPQVSVALIE 88
Cdd:PLN02661  94 DVVIVGAGSAGLSCAYELSKNPNVKVAIIE 123
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 57-113 1.16e-03

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 42.02  E-value: 1.16e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24642035  57 NYDFIVIGAGAAGCTLAARLSENPQVSValieaggveniahltpVVAGYLQQTSSNW 113
Cdd:COG0029   4 KTDVLVIGSGIAGLSAALKLAERGRVTL----------------LTKGELGESNTRW 44
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 59-90 2.70e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 40.46  E-value: 2.70e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24642035    59 DFIVIGAGAAGCTLAARLSENPQvSVALIEAG 90
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGL-SVTLLERG 31
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 59-96 2.92e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 40.35  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24642035    59 DFIVIGAGAAGCTLAARLSENPQvSVALIEAGGVENIA 96
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGL-KVAVVEKGQPFGGA 37
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 57-92 3.18e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 40.46  E-value: 3.18e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24642035  57 NYDFIVIGAGAAGCTLAARLSENpQVSVALIEA---GGV 92
Cdd:COG1249   3 DYDLVVIGAGPGGYVAAIRAAQL-GLKVALVEKgrlGGT 40
PRK07251 PRK07251
FAD-containing oxidoreductase;
57-88 6.35e-03

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 39.35  E-value: 6.35e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 24642035   57 NYDFIVIGAGAAGCTLAARLSENPQvSVALIE 88
Cdd:PRK07251   3 TYDLIVIGFGKAGKTLAAKLASAGK-KVALVE 33
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
62-90 6.36e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.58  E-value: 6.36e-03
                          10        20
                  ....*....|....*....|....*....
gi 24642035    62 VIGAGAAGCTLAARLSENpQVSVALIEAG 90
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKR-GFRVLVLEKR 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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