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Conserved domains on  [gi|24642093|ref|NP_572998|]
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cytochrome c oxidase copper chaperone COX17 [Drosophila melanogaster]

Protein Classification

cytochrome c oxidase copper chaperone( domain architecture ID 10523686)

cytochrome c oxidase copper chaperone COX17 is required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (COX)

CATH:  1.10.287.1130
Gene Ontology:  GO:0008047|GO:0006825|GO:0033617|GO:0016531|GO:0005507|GO:0005758

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX17 pfam05051
Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of ...
 43-88 3.49e-19

Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. The structure of Cox17 shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.


:

Pssm-ID: 428283  Cd Length: 47  Bit Score: 72.98  E-value: 3.49e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 24642093   43 PKCKACCACPETKRARDACIVENG-EENCLALIEAHKKCMRDAGFNI 88
Cdd:pfam05051  1 KKPKPCCACPETKKARDECILFNGaEEKCKDLIEAHKACMRGYGFKI 47
 
Name Accession Description Interval E-value
COX17 pfam05051
Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of ...
 43-88 3.49e-19

Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. The structure of Cox17 shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.


Pssm-ID: 428283  Cd Length: 47  Bit Score: 72.98  E-value: 3.49e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 24642093   43 PKCKACCACPETKRARDACIVENG-EENCLALIEAHKKCMRDAGFNI 88
Cdd:pfam05051  1 KKPKPCCACPETKKARDECILFNGaEEKCKDLIEAHKACMRGYGFKI 47
 
Name Accession Description Interval E-value
COX17 pfam05051
Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of ...
 43-88 3.49e-19

Cytochrome C oxidase copper chaperone (COX17); Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. The structure of Cox17 shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.


Pssm-ID: 428283  Cd Length: 47  Bit Score: 72.98  E-value: 3.49e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 24642093   43 PKCKACCACPETKRARDACIVENG-EENCLALIEAHKKCMRDAGFNI 88
Cdd:pfam05051  1 KKPKPCCACPETKKARDECILFNGaEEKCKDLIEAHKACMRGYGFKI 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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