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Conserved domains on  [gi|28571205|ref|NP_573068|]
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mevalonate diphosphate decarboxylase, isoform A [Drosophila melanogaster]

Protein Classification

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein( domain architecture ID 706585)

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein similar to diphosphomevalonate decarboxylase (DMD) that catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP), and mevalonate 3,5-bisphosphate decarboxylase (MBD) that catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate

EC:  4.1.1.-
Gene Ontology:  GO:0016831|GO:0008299
PubMed:  8382990|7947744|31268677

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MDD_C super family cl28577
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 1-322 6.41e-142

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


The actual alignment was detected with superfamily member PLN02407:

Pssm-ID: 475042  Cd Length: 343  Bit Score: 407.26  E-value: 6.41e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205    1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPFEeSSRLQRCLNE 80
Cdd:PLN02407   1 VVMVTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLS-GGRYQNCLRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   81 VHRLAV-----ASG---SQKVPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDI--PLNEELTTVARQGSGSA 150
Cdd:PLN02407  80 IRARATdvedeEKGikiTKKDWEKLHVHIASYNNFPTAAGLASSAAGFACLVFALAKLMNVkeDFPGELSAIARQGSGSA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  151 CRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIR 230
Cdd:PLN02407 160 CRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHRAKEVVPKRILQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  231 LREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHV 310
Cdd:PLN02407 240 MEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIALNRKV 319

                        330
                 ....*....|...
gi 28571205  311 P-HLLSAIQKVFP 322
Cdd:PLN02407 320 AaQLLQRLLYYFP 332
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 1-322 6.41e-142

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 407.26  E-value: 6.41e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205    1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPFEeSSRLQRCLNE 80
Cdd:PLN02407   1 VVMVTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLS-GGRYQNCLRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   81 VHRLAV-----ASG---SQKVPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDI--PLNEELTTVARQGSGSA 150
Cdd:PLN02407  80 IRARATdvedeEKGikiTKKDWEKLHVHIASYNNFPTAAGLASSAAGFACLVFALAKLMNVkeDFPGELSAIARQGSGSA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  151 CRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIR 230
Cdd:PLN02407 160 CRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHRAKEVVPKRILQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  231 LREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHV 310
Cdd:PLN02407 240 MEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIALNRKV 319

                        330
                 ....*....|...
gi 28571205  311 P-HLLSAIQKVFP 322
Cdd:PLN02407 320 AaQLLQRLLYYFP 332
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 188-374 3.24e-98

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 289.84  E-value: 3.24e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   188 VLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVY 267
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   268 MNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFPNDlADGGTYLRGLPIPKVQDAESSK 347
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPS-TNGDQFFKGLPVLPSELSEELK 159

                         170       180
                  ....*....|....*....|....*..
gi 28571205   348 LDSLDVHAKNAFRYIIHTKVGEGPKEL 374
Cdd:pfam18376 160 ASLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 4-321 1.05e-87

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 267.59  E-value: 1.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205     4 VTCVAPVNIALIKYWGKRHEELILPVNDSISMTLstDELCAKTTVTASESFETNRMWLNGEEVPFEESSRLQRCLNEVHR 83
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQHSIDNEKTSNCLDDFRQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205    84 LAVASGsqkvpptwKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDIPLNE-ELTTVARQGSGSACRSLYGGFVQWH 162
Cdd:TIGR01240  79 LRKEQE--------KLHIVSQNNFPTAAGLASSASGLAALVSACAKLYQLPLDTsELSRIARKGSGSACRSLFGGYVAWE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   163 RGalDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDrIIRLREAIASHDFQA 242
Cdd:TIGR01240 151 KG--KDDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWIEHVVPD-FEV*RKAIKTKDFAT 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28571205   243 FAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNErmGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVF 321
Cdd:TIGR01240 228 FGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLRQ--GGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 1-323 1.60e-87

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 267.83  E-value: 1.60e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLstDELCAKTTVTASESFETNRMWLNGEEVPFEESSRLQRCLNE 80
Cdd:COG3407   3 MGSATARAHSNIALIKYWGKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKGKFLPKISKFLDR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  81 VHRLAvasgsqkvPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDIPLNE-ELTTVARQGSGSACRSLYGGFV 159
Cdd:COG3407  81 VRALA--------GKSYHARIESENNFPTAAGLASSASGFAALALAANSAEGLDLDDrKLSRLARLGSGSACRSIFGGFV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205 160 QWHRGALDDgsDSVARQIAPsDHWPnMHVLILVVNDARKKTASTRGMqQAVKTSQLIKHRVDQvVPDRIIRLREAIASHD 239
Cdd:COG3407 153 EWGKGEDDE--DSYAVPIPA-EDWD-LADIILVVDKGEKKVSSREGM-KTAETSPFYPAWVEQ-AEEDLEKLKEAIKAGD 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205 240 FQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYneRMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQK 319
Cdd:COG3407 227 FEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVREL--REEGLPVYFTLDAGPNVKVLCPEEDAEKVAAFLAA 304


                ....
gi 28571205 320 VFPN 323
Cdd:COG3407 305 ELVN 308
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 1-322 6.41e-142

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 407.26  E-value: 6.41e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205    1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLSTDELCAKTTVTASESFETNRMWLNGEEVPFEeSSRLQRCLNE 80
Cdd:PLN02407   1 VVMVTAQAPTNIAVIKYWGKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLS-GGRYQNCLRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   81 VHRLAV-----ASG---SQKVPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDI--PLNEELTTVARQGSGSA 150
Cdd:PLN02407  80 IRARATdvedeEKGikiTKKDWEKLHVHIASYNNFPTAAGLASSAAGFACLVFALAKLMNVkeDFPGELSAIARQGSGSA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  151 CRSLYGGFVQWHRGALDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIR 230
Cdd:PLN02407 160 CRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHRAKEVVPKRILQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  231 LREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHV 310
Cdd:PLN02407 240 MEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIALNRKV 319

                        330
                 ....*....|...
gi 28571205  311 P-HLLSAIQKVFP 322
Cdd:PLN02407 320 AaQLLQRLLYYFP 332
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 188-374 3.24e-98

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 289.84  E-value: 3.24e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   188 VLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDRIIRLREAIASHDFQAFAEITMKDSNQFHAIALDTYPPCVY 267
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   268 MNDVSHSIVSFVHDYNERMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVFPNDlADGGTYLRGLPIPKVQDAESSK 347
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPS-TNGDQFFKGLPVLPSELSEELK 159

                         170       180
                  ....*....|....*....|....*..
gi 28571205   348 LDSLDVHAKNAFRYIIHTKVGEGPKEL 374
Cdd:pfam18376 160 ASLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 4-321 1.05e-87

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 267.59  E-value: 1.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205     4 VTCVAPVNIALIKYWGKRHEELILPVNDSISMTLstDELCAKTTVTASESFETNRMWLNGEEVPFEESSRLQRCLNEVHR 83
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQHSIDNEKTSNCLDDFRQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205    84 LAVASGsqkvpptwKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDIPLNE-ELTTVARQGSGSACRSLYGGFVQWH 162
Cdd:TIGR01240  79 LRKEQE--------KLHIVSQNNFPTAAGLASSASGLAALVSACAKLYQLPLDTsELSRIARKGSGSACRSLFGGYVAWE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   163 RGalDDGSDSVARQIAPSDHWPNMHVLILVVNDARKKTASTRGMQQAVKTSQLIKHRVDQVVPDrIIRLREAIASHDFQA 242
Cdd:TIGR01240 151 KG--KDDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWIEHVVPD-FEV*RKAIKTKDFAT 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28571205   243 FAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYNErmGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQKVF 321
Cdd:TIGR01240 228 FGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLRQ--GGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 1-323 1.60e-87

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 267.83  E-value: 1.60e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205   1 MFSVTCVAPVNIALIKYWGKRHEELILPVNDSISMTLstDELCAKTTVTASESFETNRMWLNGEEVPFEESSRLQRCLNE 80
Cdd:COG3407   3 MGSATARAHSNIALIKYWGKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKGKFLPKISKFLDR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205  81 VHRLAvasgsqkvPPTWKLHIASVNNFPTAAGLASSAAGYACLVYSLSRLYDIPLNE-ELTTVARQGSGSACRSLYGGFV 159
Cdd:COG3407  81 VRALA--------GKSYHARIESENNFPTAAGLASSASGFAALALAANSAEGLDLDDrKLSRLARLGSGSACRSIFGGFV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205 160 QWHRGALDDgsDSVARQIAPsDHWPnMHVLILVVNDARKKTASTRGMqQAVKTSQLIKHRVDQvVPDRIIRLREAIASHD 239
Cdd:COG3407 153 EWGKGEDDE--DSYAVPIPA-EDWD-LADIILVVDKGEKKVSSREGM-KTAETSPFYPAWVEQ-AEEDLEKLKEAIKAGD 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571205 240 FQAFAEITMKDSNQFHAIALDTYPPCVYMNDVSHSIVSFVHDYneRMGSYHAAYTFDAGPNACLYVLAEHVPHLLSAIQK 319
Cdd:COG3407 227 FEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVREL--REEGLPVYFTLDAGPNVKVLCPEEDAEKVAAFLAA 304


                ....
gi 28571205 320 VFPN 323
Cdd:COG3407 305 ELVN 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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