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Conserved domains on  [gi|24642287|ref|NP_573075|]
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EF-hand domain containing 1.1 [Drosophila melanogaster]

Protein Classification

EF-hand domain-containing family member C2( domain architecture ID 12218346)

EF-hand domain-containing family member C2 (EFHC2) is a protein with one predicted calcium-binding EF-hand motif and three DM10 domains, whose function is unknown

Gene Symbol:  EFHC2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 82-189 9.97e-49

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 167.10  E-value: 9.97e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287     82 DKKVLCFHAYFKQTLQEVYhapyLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNV 161
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 24642287    162 DQTVQIFDRQYHITDCDPFTRTFLNKRG 189
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 232-370 2.59e-37

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 135.13  E-value: 2.59e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    232 DRQILKFQAYWDDR-TEFGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTvFLKRGRLAREfeglqlpgqmtpmtllnv 310
Cdd:smart00676   1 DKKVLRFDAYWEDPvAMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQGT-FLRRQRVPKP------------------ 61

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    311 lgtnmrnvrycvdplntGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRY 370
Cdd:smart00676  62 -----------------PPDDPEYYHASDLNVGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 424-530 1.12e-33

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


:

Pssm-ID: 461948  Cd Length: 104  Bit Score: 124.50  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   424 FKKFIKYDRYVLRFGAKM--LSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQErfsckQPQ 501
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWddPTESPEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTG-----GPE 75

                          90       100
                  ....*....|....*....|....*....
gi 24642287   502 YYMPWNFFVGSTMSLKDFIFHIVSADEYT 530
Cdd:pfam06565  76 YYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
 
Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 82-189 9.97e-49

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 167.10  E-value: 9.97e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287     82 DKKVLCFHAYFKQTLQEVYhapyLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNV 161
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 24642287    162 DQTVQIFDRQYHITDCDPFTRTFLNKRG 189
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 232-370 2.59e-37

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 135.13  E-value: 2.59e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    232 DRQILKFQAYWDDR-TEFGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTvFLKRGRLAREfeglqlpgqmtpmtllnv 310
Cdd:smart00676   1 DKKVLRFDAYWEDPvAMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQGT-FLRRQRVPKP------------------ 61

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    311 lgtnmrnvrycvdplntGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRY 370
Cdd:smart00676  62 -----------------PPDDPEYYHASDLNVGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 75-181 7.10e-37

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 133.75  E-value: 7.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    75 MPPWLAYDKKVLCFHAYFKQTlQEVYHAPYlvRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFM 154
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDP-TESPEDEY--RKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTGGPEYY 77

                          90       100
                  ....*....|....*....|....*..
gi 24642287   155 SLIDLNVDQTVQIFDRQYHITDCDPFT 181
Cdd:pfam06565  78 TPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 424-530 1.12e-33

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 124.50  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   424 FKKFIKYDRYVLRFGAKM--LSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQErfsckQPQ 501
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWddPTESPEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTG-----GPE 75

                          90       100
                  ....*....|....*....|....*....
gi 24642287   502 YYMPWNFFVGSTMSLKDFIFHIVSADEYT 530
Cdd:pfam06565  76 YYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 225-362 4.65e-33

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 122.96  E-value: 4.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   225 FAQFLKYDRQILKFQAYWDDRTE--FGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPtVFLKRGRLAREFEGLQlpgqm 302
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPTEspEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGG-KFLKRQRIPKPGTGGP----- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   303 tpmtllnvlgtnmrnvrycvdplntgnkeiHYYREKDLQIGSVINVYGRAVVITELDPFT 362
Cdd:pfam06565  75 ------------------------------EYYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 431-538 2.18e-30

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 115.10  E-value: 2.18e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    431 DRYVLRFGAKMLSTI-KANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERfsckqPQYYMPWNFF 509
Cdd:smart00676   1 DKKVLRFDAYWEDPVaMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDD-----PEYYHASDLN 75

                           90       100
                   ....*....|....*....|....*....
gi 24642287    510 VGSTMSLKDFIFHIVSADEYTLMYMEHHP 538
Cdd:smart00676  76 VGTTINVFGRQFRIYDCDEFTRNYLESKG 104
 
Name Accession Description Interval E-value
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 82-189 9.97e-49

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 167.10  E-value: 9.97e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287     82 DKKVLCFHAYFKQTLQEVYhapyLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNV 161
Cdd:smart00676   1 DKKVLRFDAYWEDPVAMFY----LIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDDPEYYHASDLNV 76

                           90       100
                   ....*....|....*....|....*...
gi 24642287    162 DQTVQIFDRQYHITDCDPFTRTFLNKRG 189
Cdd:smart00676  77 GTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 232-370 2.59e-37

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 135.13  E-value: 2.59e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    232 DRQILKFQAYWDDR-TEFGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTvFLKRGRLAREfeglqlpgqmtpmtllnv 310
Cdd:smart00676   1 DKKVLRFDAYWEDPvAMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQGT-FLRRQRVPKP------------------ 61

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    311 lgtnmrnvrycvdplntGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRY 370
Cdd:smart00676  62 -----------------PPDDPEYYHASDLNVGTTINVFGRQFRIYDCDEFTRNYLESKG 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 75-181 7.10e-37

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 133.75  E-value: 7.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    75 MPPWLAYDKKVLCFHAYFKQTlQEVYHAPYlvRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFM 154
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDP-TESPEDEY--RKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTGGPEYY 77

                          90       100
                  ....*....|....*....|....*..
gi 24642287   155 SLIDLNVDQTVQIFDRQYHITDCDPFT 181
Cdd:pfam06565  78 TPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 424-530 1.12e-33

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 124.50  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   424 FKKFIKYDRYVLRFGAKM--LSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQErfsckQPQ 501
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWddPTESPEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGGKFLKRQRIPKPGTG-----GPE 75

                          90       100
                  ....*....|....*....|....*....
gi 24642287   502 YYMPWNFFVGSTMSLKDFIFHIVSADEYT 530
Cdd:pfam06565  76 YYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 225-362 4.65e-33

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 122.96  E-value: 4.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   225 FAQFLKYDRQILKFQAYWDDRTE--FGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPtVFLKRGRLAREFEGLQlpgqm 302
Cdd:pfam06565   1 LPKFLENDRKVLRFYAYWDDPTEspEDEYRKFVISYYLADDTIEIFEPPVRNSGRPGG-KFLKRQRIPKPGTGGP----- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287   303 tpmtllnvlgtnmrnvrycvdplntgnkeiHYYREKDLQIGSVINVYGRAVVITELDPFT 362
Cdd:pfam06565  75 ------------------------------EYYTPKDLYVGATVNIYGRRFLLYDCDEFT 104
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 431-538 2.18e-30

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 115.10  E-value: 2.18e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642287    431 DRYVLRFGAKMLSTI-KANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERfsckqPQYYMPWNFF 509
Cdd:smart00676   1 DKKVLRFDAYWEDPVaMFYLIRRFKIYYYLEDDTIEVFEPDVRNSGILQGTFLRRQRVPKPPPDD-----PEYYHASDLN 75

                           90       100
                   ....*....|....*....|....*....
gi 24642287    510 VGSTMSLKDFIFHIVSADEYTLMYMEHHP 538
Cdd:smart00676  76 VGTTINVFGRQFRIYDCDEFTRNYLESKG 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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