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Conserved domains on  [gi|24643147|ref|NP_573335|]
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uncharacterized protein Dmel_CG7326, isoform A [Drosophila melanogaster]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10561263)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 9-381 1.88e-56

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


:

Pssm-ID: 462911  Cd Length: 362  Bit Score: 191.52  E-value: 1.88e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147     9 ELRPNLRSGVVFLRFDqqvSQSQKTRVVVRDYNVYISEKPKNQAIdldsssesdsedsdkLMLIRHAQYGMDIvCLSTFL 88
Cdd:pfam09814   1 ELLPNIRSISVVVSLP---SPLKSTRVSLSDDGLLLVRHNGSSET---------------IRLPAEVSVGSSL-GRSQLP 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147    89 VSGRNISFRFNYNQIDLASVD---------GSAVDVPLAPLLLSCQenepITINCRDCRAELVAGRSYRRLREFPS---- 155
Cdd:pfam09814  62 LPGDELSFRLPLADSSSKFGSfdlesslsaQKELEVPWSAKDLSPG----FSFCCRSCGNVLVESRNIKRWKDLPSenwa 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   156 LLVDptEFFCHNHGPAGKTQPI------SLVPAETDLFYGLNYVVINFNEESSCMLN-----RDDHLYCQRCMRYLGLTM 224
Cdd:pfam09814 138 EMMD--FWHCHKPDDHDHLATKgygansKLVPQEGDGLVGLTFFLLNESDCQGLKLSskppkDNLSVSCKRCGALLGEVD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   225 FdGAAARIWADAVRWRPAGAATNaPDRHFFQNSTLTQLFKRLLHSlwpqplpqlclNTSRAVLVTSLPNrNQQYMFLHVV 304
Cdd:pfam09814 216 S-LDGLKLYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISR-----------SSTRKFLIQPEDG-ETHYLLLWVF 281

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643147   305 ESQLRVLrrIRPNSNRLRCFRACKLYYGVFG-ANPPLLEKWQAQQTLPQMDVSPNMFLKIQKRLETNGHLIPDALSTN 381
Cdd:pfam09814 282 NPDLLVS--SSSSSNSLIAKRAMKVLYKDCIdSEEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKF 357
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 9-381 1.88e-56

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 191.52  E-value: 1.88e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147     9 ELRPNLRSGVVFLRFDqqvSQSQKTRVVVRDYNVYISEKPKNQAIdldsssesdsedsdkLMLIRHAQYGMDIvCLSTFL 88
Cdd:pfam09814   1 ELLPNIRSISVVVSLP---SPLKSTRVSLSDDGLLLVRHNGSSET---------------IRLPAEVSVGSSL-GRSQLP 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147    89 VSGRNISFRFNYNQIDLASVD---------GSAVDVPLAPLLLSCQenepITINCRDCRAELVAGRSYRRLREFPS---- 155
Cdd:pfam09814  62 LPGDELSFRLPLADSSSKFGSfdlesslsaQKELEVPWSAKDLSPG----FSFCCRSCGNVLVESRNIKRWKDLPSenwa 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   156 LLVDptEFFCHNHGPAGKTQPI------SLVPAETDLFYGLNYVVINFNEESSCMLN-----RDDHLYCQRCMRYLGLTM 224
Cdd:pfam09814 138 EMMD--FWHCHKPDDHDHLATKgygansKLVPQEGDGLVGLTFFLLNESDCQGLKLSskppkDNLSVSCKRCGALLGEVD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   225 FdGAAARIWADAVRWRPAGAATNaPDRHFFQNSTLTQLFKRLLHSlwpqplpqlclNTSRAVLVTSLPNrNQQYMFLHVV 304
Cdd:pfam09814 216 S-LDGLKLYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISR-----------SSTRKFLIQPEDG-ETHYLLLWVF 281

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643147   305 ESQLRVLrrIRPNSNRLRCFRACKLYYGVFG-ANPPLLEKWQAQQTLPQMDVSPNMFLKIQKRLETNGHLIPDALSTN 381
Cdd:pfam09814 282 NPDLLVS--SSSSSNSLIAKRAMKVLYKDCIdSEEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKF 357
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 9-381 1.88e-56

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 191.52  E-value: 1.88e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147     9 ELRPNLRSGVVFLRFDqqvSQSQKTRVVVRDYNVYISEKPKNQAIdldsssesdsedsdkLMLIRHAQYGMDIvCLSTFL 88
Cdd:pfam09814   1 ELLPNIRSISVVVSLP---SPLKSTRVSLSDDGLLLVRHNGSSET---------------IRLPAEVSVGSSL-GRSQLP 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147    89 VSGRNISFRFNYNQIDLASVD---------GSAVDVPLAPLLLSCQenepITINCRDCRAELVAGRSYRRLREFPS---- 155
Cdd:pfam09814  62 LPGDELSFRLPLADSSSKFGSfdlesslsaQKELEVPWSAKDLSPG----FSFCCRSCGNVLVESRNIKRWKDLPSenwa 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   156 LLVDptEFFCHNHGPAGKTQPI------SLVPAETDLFYGLNYVVINFNEESSCMLN-----RDDHLYCQRCMRYLGLTM 224
Cdd:pfam09814 138 EMMD--FWHCHKPDDHDHLATKgygansKLVPQEGDGLVGLTFFLLNESDCQGLKLSskppkDNLSVSCKRCGALLGEVD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643147   225 FdGAAARIWADAVRWRPAGAATNaPDRHFFQNSTLTQLFKRLLHSlwpqplpqlclNTSRAVLVTSLPNrNQQYMFLHVV 304
Cdd:pfam09814 216 S-LDGLKLYKWALSLQPSEGSDS-IPRSFPPESIVAALLLELISR-----------SSTRKFLIQPEDG-ETHYLLLWVF 281

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643147   305 ESQLRVLrrIRPNSNRLRCFRACKLYYGVFG-ANPPLLEKWQAQQTLPQMDVSPNMFLKIQKRLETNGHLIPDALSTN 381
Cdd:pfam09814 282 NPDLLVS--SSSSSNSLIAKRAMKVLYKDCIdSEEANSLLDENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKF 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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