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Conserved domains on  [gi|442616931|ref|NP_573375|]
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uncharacterized protein Dmel_CG8028, isoform D [Drosophila melanogaster]

Protein Classification

MCT family MFS transporter( domain architecture ID 13023897)

monocarboxylate transporter (MCT) family major facilitator superfamily (MFS) transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 1-454 3.38e-68

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.43  E-value: 3.38e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17352   40 IAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelke 160
Cdd:cd17352  120 YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR--------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 161 lsptvvirvqpetplkatreepnfhtadpgarklshaeeqmlkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrr 240
Cdd:cd17352      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 241 pstiagasgavapahatkkswvrtivdfldltLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAI 320
Cdd:cd17352  179 --------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSI 226

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 321 GAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARFAFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPK 398
Cdd:cd17352  227 IGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAFPLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGL 304

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442616931 399 ERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAAPWVLE 454
Cdd:cd17352  305 EKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 1-454 3.38e-68

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.43  E-value: 3.38e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17352   40 IAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelke 160
Cdd:cd17352  120 YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR--------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 161 lsptvvirvqpetplkatreepnfhtadpgarklshaeeqmlkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrr 240
Cdd:cd17352      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 241 pstiagasgavapahatkkswvrtivdfldltLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAI 320
Cdd:cd17352  179 --------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSI 226

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 321 GAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARFAFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPK 398
Cdd:cd17352  227 IGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAFPLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGL 304

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442616931 399 ERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAAPWVLE 454
Cdd:cd17352  305 EKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-127 4.42e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.20  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAE 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442616931  81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:COG2271  126 WFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173
MFS_1 pfam07690
Major Facilitator Superfamily;
1-129 6.29e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.51  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931    1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-LLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 442616931   81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNA 129
Cdd:pfam07690 113 WFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 2-154 2.19e-08

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 56.29  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931    2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:TIGR00892  57 AWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKY 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616931   82 FVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEE 154
Cdd:TIGR00892 137 FYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKE 209
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 1-454 3.38e-68

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.43  E-value: 3.38e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17352   40 IAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelke 160
Cdd:cd17352  120 YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR--------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 161 lsptvvirvqpetplkatreepnfhtadpgarklshaeeqmlkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrr 240
Cdd:cd17352      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 241 pstiagasgavapahatkkswvrtivdfldltLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAI 320
Cdd:cd17352  179 --------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSI 226

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 321 GAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARFAFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPK 398
Cdd:cd17352  227 IGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAFPLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGL 304

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442616931 399 ERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAAPWVLE 454
Cdd:cd17352  305 EKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 4-132 7.25e-14

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 73.19  E-value: 7.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   4 ITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFV 83
Cdd:cd17423   43 ITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFS 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 442616931  84 KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAV 132
Cdd:cd17423  123 RRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLV 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-127 4.42e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.20  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAE 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442616931  81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:COG2271  126 WFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-159 3.94e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.14  E-value: 3.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG2814   47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS-LWLLLAARFLQGLGAGALFPAALALIAD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELK 159
Cdd:COG2814  126 LVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205
MFS_1 pfam07690
Major Facilitator Superfamily;
1-129 6.29e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.51  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931    1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-LLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 442616931   81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNA 129
Cdd:pfam07690 113 WFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-148 1.34e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.97  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLI-AARALQGIGAGGLMPGALALIAE 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442616931  81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRV 148
Cdd:COG0477  130 LFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLAL 198
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 2-154 2.19e-08

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 56.29  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931    2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:TIGR00892  57 AWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKY 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616931   82 FVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEE 154
Cdd:TIGR00892 137 FYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKE 209
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 6-123 2.95e-08

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 55.61  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   6 SAFFSSMSFA-----GLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17429   40 TAWISSLSMGitlivGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQ 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 123
Cdd:cd17429  120 YFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFI 162
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 22-146 3.31e-08

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 55.55  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  22 LFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGS 101
Cdd:cd17425   61 LVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGL 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442616931 102 MLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMR 146
Cdd:cd17425  141 TLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVMRPFCSNTR 185
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 4-127 1.20e-07

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 53.60  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   4 ITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFV 83
Cdd:cd17422   43 IISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFK 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 442616931  84 KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:cd17422  123 KRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGAL 166
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-138 2.20e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.93  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQklmswygfrgcLLILTGLNAHAVFGMLVM 138
Cdd:COG0738  124 LGPETAASRLNLLHAFFSLGALLGPLLGG-----------LLILLGLSLSWHLPYLIL 170
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 2-149 2.67e-07

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 52.66  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTF-NH 80
Cdd:cd17355   41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAW 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAhavfgmLVMHPVEWHMRRVP 149
Cdd:cd17355  121 WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAL------LVLVPVLLLLRRRP 183
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-149 4.26e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.18  E-value: 4.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:COG2807   55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL-AGTALIGAGIAVGNVLLPGLIKR 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLnahAVFGMLVMHPVEWHMRRVP 149
Cdd:COG2807  134 WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALL---ALLALLLWLPLLRRRPAAA 199
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 2-142 3.45e-06

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 48.96  E-value: 3.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:cd17430   41 AWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRY 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442616931  82 FVKNRVMwmsfAQTLIGLGSMLYPIVM----QKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVE 142
Cdd:cd17430  121 FDKRRPL----ANGLAAAGSPVFLSALsplgQILLEEYGWRGGFLILGGLLLNCCTCGAVMRPLD 181
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-168 4.99e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLL-LLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  82 FVKNRV-MWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILtglnahAVFGMLVMHPVEWHMRRVPIQPEEQEELKE 160
Cdd:COG2223  122 FPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL------GILLLVVAVLAWLFLRDPPAGAAAAAKASL 195


                 ....*...
gi 442616931 161 LSPTVVIR 168
Cdd:COG2223  196 RDQLEALR 203
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 2-138 9.35e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 9.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLF----QRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYT- 76
Cdd:cd17473  232 AALIGLALAIASLAGAIGALLFgrlkRRLGKRRLLAIGFALMALGFLL-LALASGLWVVLLGAILAGLGFGLLLPTLNSw 310

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616931  77 TFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWY-GFRGCLLILTGLNAHAVFGMLVM 138
Cdd:cd17473  311 AMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLL 373
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 1-141 1.09e-05

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 47.50  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17427   40 IAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGK 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616931  81 YFVKNRVM--WMSFAQTLIGLgSMLYPIvMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPV 141
Cdd:cd17427  120 YFYKKRPIanGLAMAGSPVFL-STLAPL-NQFLFNQFGWRGSFLILGGLLLNCCVAGSLMRPL 180
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 26-127 1.19e-05

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 47.50  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  26 FGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYP 105
Cdd:cd17428   65 FGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYA 144

                         90       100
                 ....*....|....*....|..
gi 442616931 106 IVMQKLMSWYGFRGCLLILTGL 127
Cdd:cd17428  145 ALQRELIELYGLDGCLLIVGAL 166
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 10-127 1.37e-05

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 47.11  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  10 SSMSFAGLfsGSLFQRFGMRQVGVT-GGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVM 88
Cdd:cd17424   50 TTMLCAPL--GSLISNHLSCQVGIIlGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKAL 127

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 442616931  89 WMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:cd17424  128 AYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGF 166
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-161 1.96e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.65  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLhLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW-LLLLGRFLLGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  82 FV-KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSW--YGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEEL 158
Cdd:cd06174  113 FPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSV 192


                 ...
gi 442616931 159 KEL 161
Cdd:cd06174  193 LKL 195
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 271-448 1.53e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.95  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 271 LTLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAadLASRIFLAITAVCIQVPS--RYIYL 348
Cdd:cd06174  197 KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG--LAGALGSLLLGLLSDRLIgrKPLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 349 AGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRD 428
Cdd:cd06174  275 IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354

                        170       180
                 ....*....|....*....|
gi 442616931 429 KTRDYIFVFHILNGFMILCA 448
Cdd:cd06174  355 ATFGLTGAFLVLAVLLLLAA 374
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 2-124 1.68e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.75  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:cd17353   41 ALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKW 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 442616931  82 FVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLIL 124
Cdd:cd17353  121 FPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLIL 163
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
2-127 3.70e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVqGFAFGLMVPTCYTTFNHY 81
Cdd:COG0738  249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV-GLGLSLMFPTIFSLALDG 327

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442616931  82 FVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:COG0738  328 LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-140 3.93e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFA-TSTLHLIMAFSVVQGFAFGLMVPTCYTTFN 79
Cdd:COG2271  218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWALAA 297

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616931  80 HYFVKNRV-MWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHP 140
Cdd:COG2271  298 ELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 2-142 4.11e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 42.78  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:cd17314   41 ATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQY 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442616931  82 FVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVE 142
Cdd:cd17314  121 FPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKE 181
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 271-448 5.55e-04

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 42.04  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 271 LTLLKKPIFVnivLGITFALYSDITFFTmQPVYLFEL----GYSRPDTATIIAIGAAADLASRIFLAITAVCIQVPSRYI 346
Cdd:cd17422  177 LRVLKEPGFI---CYALFGLFATLGFFA-PQLYIIPLslslGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYI 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 347 YLAGAVFTVFARFAFNGITQFVGMACITAVIGFLR---TWLHVPLpLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIV 423
Cdd:cd17422  253 ELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFgtvAGTHIPL-LAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLG 331

                        170       180
                 ....*....|....*....|....*
gi 442616931 424 GFIRDKTRDYIFVFHILNGFMILCA 448
Cdd:cd17422  332 GVLVDWTQNYGSAFYSCAAGMALGA 356
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
14-141 6.26e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  14 FAGLFSGSLFQRFG-MRQVGVTGGILYFLGTGMQLFATSTLhlIMAFSVVQGFAFGLMVPTCYTTFNHYF--VKNRVMWM 90
Cdd:COG2807  265 PGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSL--PWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALS 342

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442616931  91 SFAQTLIGLGSMLYPIVMQKLMSWYG-FRGCLLILTGLN-AHAVFGMLVMHPV 141
Cdd:COG2807  343 GMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAvLMLVAGLLAGRPY 395
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 10-149 7.91e-04

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 41.73  E-value: 7.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  10 SSMSF-AGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVM 88
Cdd:cd17421   48 SSLRLsAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLAT 127

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442616931  89 WMSFAQTLIGLGSMLYPIVmQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVP 149
Cdd:cd17421  128 AYAIARSGMGLTFALAPFT-QLLLDEYDWQGALLIFGGIMLNLVASGMLLRPIDFSLLKDP 187
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-107 8.34e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-FALLLAGRALQGIGAAGLGPLALTLIGDL 115

                         90       100
                 ....*....|....*....|....*..
gi 442616931  82 F-VKNRVMWMSFAQTLIGLGSMLYPIV 107
Cdd:cd17474  116 FeGGERAKAMGLYEAALGLGIAVGPLL 142
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-138 8.55e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   3 IITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGLMVPTcYTTFNHYF 82
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS-FWLLLLLLALLGLGLGLVFPA-TLALLADI 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442616931  83 VKNRV--MWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVM 138
Cdd:cd17325  317 VPPEGrgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 329-449 1.00e-03

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 41.34  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 329 RIFLAITAVCIQVPSRYIYLAGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWLHVpLPLVFADYLPKERFATGYGLF 408
Cdd:cd17428  236 KLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSI-FPYVTTKTVGIEKLGHAYGIL 314

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442616931 409 MFIQGNAMFLIGPIVGFIRDKTRDYIFVFH------ILNGFMILCAA 449
Cdd:cd17428  315 MFFAGLGNSLGPPIVGWFYDWTQTYDIAFYfsgfcvLLGGFLLLLAA 361
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 16-107 1.50e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  16 GLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFV-KNRVMWMSFAQ 94
Cdd:cd17473   52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFEgEERAKMLGLQS 130

                         90
                 ....*....|...
gi 442616931  95 TLIGLGSMLYPIV 107
Cdd:cd17473  131 AAMSLGGVVFLLL 143
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-149 2.25e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  82 F-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYG-FRGCLLILTGLnahAVFGMLVMHPVEWHMRRVP 149
Cdd:COG2223  324 FpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVL---ALVALVLTLLLYRRPRRAA 390
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 3-168 2.62e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   3 IITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGlMVPTCYTTF--NH 80
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS-VALLLVLRLIHGIGWG-AFTTAAATLvaDI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  81 YFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLnahAVFGMLVMhpveWHMRRVPIQPEEQEELKE 160
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL---ALLALLLV----FLVKDPPPVAAEEAEAGT 185


                 ....*...
gi 442616931 161 LSPTVVIR 168
Cdd:cd17489  186 RAFRRLVE 193
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 4-141 2.69e-03

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   4 ITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFV 83
Cdd:cd17426   43 ISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFY 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616931  84 KNRvmwmSFAQTLIGLGSMLYPIVMQKLMSW----YGFRGCLLILTGLNAHAVFGMLVMHPV 141
Cdd:cd17426  123 KKR----PLANGLAMAGSPVFLSTLAPLNQWffdiFGWRGSFLILGGLLLNCCVAGSLMRPI 180
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-123 2.73e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFfsSMSFAG--LFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTF 78
Cdd:cd17321   33 LQWVVNAY--LLAFAAllLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLI-AARALQGIGAAAIMPASLALI 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442616931  79 NHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 123
Cdd:cd17321  110 AATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-123 2.90e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.89  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLhLIMAFSVVQGFAFGLMVPTCYTTFN- 79
Cdd:cd17316   38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI-LLLVLRFLQGIGIGGEYPGASTYVAe 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442616931  80 HYFVKNRVMWMSFAQTLIGLGSML----YPIVMQKLMSWYGFRGCLLI 123
Cdd:cd17316  117 FAPSKRRGFALGLLQSGWALGALLaalvASLLIPLLSGDWGWRILFLI 164
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 5-133 3.00e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   5 TSAFFSSMSFAGLFS-----GSLFQRFGMRQVGVTGGILYFLGTGMQLFAtSTLHLIMAFSVVQGFAFGLMVPtCYTTFN 79
Cdd:cd17330  212 IGLLLALVGIAGILAqllliPRLAKRLGERKLLRLGLLLAIIGLLLLPFA-SSVPLLVLAAAILAFGTGIVFP-ALSALL 289

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442616931  80 HYFV--KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVF 133
Cdd:cd17330  290 SKSVpsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-127 3.29e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17325   33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL-LARFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442616931  81 YF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 127
Cdd:cd17325  112 IApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 1-123 4.04e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.56  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRqvgvtggilYFLGTGMqlFATSTLHLIMAFS----------VVQGFAFGLM 70
Cdd:cd17312   40 LGIIGSAFLIAYAVGKFISGFLSDRSNIR---------RFMSAGL--LLSALANIFMGFStslwffavlwGLNGLFQSMG 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442616931  71 VPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 123
Cdd:cd17312  109 WPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 6-136 4.05e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.48  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   6 SAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTgMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFN-HYFVK 84
Cdd:cd17320   41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS-LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRdLYSGA 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442616931  85 NRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGML 136
Cdd:cd17320  120 ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVL 171
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-127 4.14e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   1 MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNH 80
Cdd:cd17319   40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY-VLRFLLGVAEAGFFPGAIKALAE 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442616931  81 YFVKNRvmwMSFAQTL----IGLGSMLYPIVMQKLMSWYGFRGcLLILTGL 127
Cdd:cd17319  119 WFPARE---RGRATGLfnsgAPLGAAIGPPLSGWLLLLFGWRW-AFIIEGL 165
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 344-453 5.76e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 5.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931 344 RYIYLAGAVFTVFARFAFnGITQFVGMACITAVIGFLRTWLH-VPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPI 422
Cdd:cd17370  264 KKLLILGYLSLALAYLGF-ALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLI 342

                         90       100       110
                 ....*....|....*....|....*....|..
gi 442616931 423 VGFIRDKT-RDYIFVFHILngfMILCAAPWVL 453
Cdd:cd17370  343 AGYLWDLIsPSAAFLFSAV---LALIALLLLL 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-101 6.32e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931   2 AIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHY 81
Cdd:COG2814  246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL-LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         90       100
                 ....*....|....*....|.
gi 442616931  82 F-VKNRVMWMSFAQTLIGLGS 101
Cdd:COG2814  325 ApPEARGRASGLYNSAFFLGG 345
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 11-139 6.99e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.73  E-value: 6.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616931  11 SMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPtcytTFNHYFVK-----N 85
Cdd:cd17489  239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAA-VLYGLGFGLLFP----ALQALAVDlvpphR 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442616931  86 RVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLnahAVFGMLVMH 139
Cdd:cd17489  314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVV---VLLALVLYI 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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