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Conserved domains on  [gi|295442750|ref|NP_587748|]
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transporter [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 48-479 8.04e-143

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 414.67  E-value: 8.04e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHV-SEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 TIFSGFIFALSLPLLaetypktllgekarklnksektnkyhtewnlehiprlklvtpalmrpirmlftqPIVILCSTYMA 287
Cdd:cd17323  160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYLKRRNNGKMAPEFRVPVILLGTFF 367
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 368 FPAGLFIYGWTAQYHTHWIGPDIGAAMFNIGLMLGWRGIQTYLIDSFMIYAASSTAVACCVRSIAAFAFPLFGQDMYDTL 447
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|..
gi 295442750 448 GYGWGNSLLAFIVLGSSIITCSLLWFgGKRLR 479
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKY-GKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 48-479 8.04e-143

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 414.67  E-value: 8.04e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHV-SEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 TIFSGFIFALSLPLLaetypktllgekarklnksektnkyhtewnlehiprlklvtpalmrpirmlftqPIVILCSTYMA 287
Cdd:cd17323  160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYLKRRNNGKMAPEFRVPVILLGTFF 367
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 368 FPAGLFIYGWTAQYHTHWIGPDIGAAMFNIGLMLGWRGIQTYLIDSFMIYAASSTAVACCVRSIAAFAFPLFGQDMYDTL 447
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|..
gi 295442750 448 GYGWGNSLLAFIVLGSSIITCSLLWFgGKRLR 479
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKY-GKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-414 4.68e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 144.73  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  43 RKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIF 122
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 123 IVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKW 202
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 203 IFWSTTIFSGFIFALSLPLLAETYPKTllgekarklnksektnkyhtewnlehiprlklvTPALMRPIRMLFTQPIVILC 282
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAA---------------------------------RARLRGSLRELLRRPRLLLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 283 STYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYlkrrnngkmapefrvPVIL 362
Cdd:COG2814  213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR---------------RLLL 277

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 295442750 363 LGTFFFPAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSF 414
Cdd:COG2814  278 IGLLLLALGLLLLALAGSLWLLL----LALFLLGFGFGLLFPLLQALVAELA 325
2_A_01_02 TIGR00880
Multidrug resistance protein;
89-225 6.98e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 105.42  E-value: 6.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   89 SIYLLVFAISPMISAPLSEV----FGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLF 164
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750  165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
48-437 1.57e-25

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 107.12  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   48 LILVSAFALLGPMASSMVAPCLdqIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLL--LAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  208 TIFSGFIFALSLPLLAETYPKTLLGEKARKLnksektnkyhtewnlehiprlklvtpALMRPIRMLFTQPIVILcsTYMA 287
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARL--------------------------SLIVAWKALLRDPVLWL--LLAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDktfrylkrrnngKMAPEFRVPVILLGTFF 367
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD------------RLGRRRRLLLALLLLIL 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750  368 FPAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSFMI-YAASSTAVACCVRSIAAFAFP 437
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLL----LALLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
57-228 2.08e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 80.73  E-value: 2.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  57 LGPMASSMVAPCLDQIADRFHIqnSTEKALI-LSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTK 135
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGV--SAGSVQMtLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 136 AQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVA----VMSLAPLLGPTIGpvvsGFIAEYTTYKWIFWSTTIFS 211
Cdd:PRK11102  80 DQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIAPLLAPIIG----GWLLVWFSWHAIFWVLALAA 155

                        170
                 ....*....|....*..
gi 295442750 212 GFIFALSLPLLAETYPK 228
Cdd:PRK11102 156 ILAAALVFFFIPETLPK 172
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 48-479 8.04e-143

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 414.67  E-value: 8.04e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHV-SEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 TIFSGFIFALSLPLLaetypktllgekarklnksektnkyhtewnlehiprlklvtpalmrpirmlftqPIVILCSTYMA 287
Cdd:cd17323  160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYLKRRNNGKMAPEFRVPVILLGTFF 367
Cdd:cd17323  186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 368 FPAGLFIYGWTAQYHTHWIGPDIGAAMFNIGLMLGWRGIQTYLIDSFMIYAASSTAVACCVRSIAAFAFPLFGQDMYDTL 447
Cdd:cd17323  266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                        410       420       430
                 ....*....|....*....|....*....|..
gi 295442750 448 GYGWGNSLLAFIVLGSSIITCSLLWFgGKRLR 479
Cdd:cd17323  346 GVGWAFTLLAFISLAMIPIPFIFYKY-GKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-414 4.68e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 144.73  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  43 RKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIF 122
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 123 IVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKW 202
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 203 IFWSTTIFSGFIFALSLPLLAETYPKTllgekarklnksektnkyhtewnlehiprlklvTPALMRPIRMLFTQPIVILC 282
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAA---------------------------------RARLRGSLRELLRRPRLLLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 283 STYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYlkrrnngkmapefrvPVIL 362
Cdd:COG2814  213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR---------------RLLL 277

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 295442750 363 LGTFFFPAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSF 414
Cdd:COG2814  278 IGLLLLALGLLLLALAGSLWLLL----LALFLLGFGFGLLFPLLQALVAELA 325
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 49-467 4.02e-28

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 114.98  E-value: 4.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  49 ILVSAFALLgpMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMA 128
Cdd:cd17325    1 LSLALFLDM--LGYGIIIPILPLYAESLGA-SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 129 CGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTT 208
Cdd:cd17325   78 FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 209 IFSGFIFALSLPLLAETYPKTLLGEKARKLNKSektnkyhtewnlehiprlklvtpalmrPIRMLFTQPIVILCSTYMAI 288
Cdd:cd17325  158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRS---------------------------GLRLLLRDRRLLALFLAIFV 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 289 QYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDktfRYLkrrnngkmapefRVPVILLGTFFF 368
Cdd:cd17325  211 LAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD---RIG------------RKPLILIGLLLS 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 369 PAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSF------MIYAASSTAvaccvRSIAAFAFPLFGQD 442
Cdd:cd17325  276 AVALLLLPLATSFWLLL----LLLALLGLGLGLVFPATLALLADIVppegrgTAMGLFNTA-----FSLGMVLGPLLGGF 346

                        410       420
                 ....*....|....*....|....*
gi 295442750 443 MYDTLGYGWGNSLLAFIVLGSSIIT 467
Cdd:cd17325  347 LYDAFGFATPFLAAAALLLLAAVLF 371
2_A_01_02 TIGR00880
Multidrug resistance protein;
89-225 6.98e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 105.42  E-value: 6.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   89 SIYLLVFAISPMISAPLSEV----FGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLF 164
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750  165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 48-402 1.41e-26

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 110.74  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:cd17320   80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 TIFSGFIFALSLPLLAETYPktllgEKARKLNKSektnkyhtewnlehiprlklvtpALMRPIRMLFTQPIVILCSTYMA 287
Cdd:cd17320  160 ALLGLLLLLLVLLFLPETLP-----EEKRKPLLS-----------------------SLLRAYKRVLKNRRFLGYALALG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGifidktfRYLKRRNNGKMapefrVPVILLGTFF 367
Cdd:cd17320  212 LSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNG-------RLVRRFGPRRL-----LRLGLLLLLA 279

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 295442750 368 FPAGLFIYGWTAQYHTHWIGPDIGAAMFNIGLMLG 402
Cdd:cd17320  280 AALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFP 314
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 48-473 1.22e-25

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 108.04  E-value: 1.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGA-SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYtTYKWIFWST 207
Cdd:cd17474   80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 TIFSGFIFALSLPLLAETYPKTllgekarklnksektnkyhtewnlEHIPRLKLVTPALMRPIRMLFTqpIVILCSTYMA 287
Cdd:cd17474  159 AALIPVAFLAILFLLPEPKEKA------------------------KSSSATKLRDLKKALRGRGLLT--FLVSAFLYFF 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 iqygILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYLKrrnngkmapefrvpVILLGTFF 367
Cdd:cd17474  213 ----LYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARR--------------ILVIGLLL 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 368 FPAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSF-MIYAASSTAVACCVRSI-AAFAFPLFGqdmyd 445
Cdd:cd17474  275 YALSLLLLGFVPSLALLL----IAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFVRFLgQAVGPLLFG----- 345

                        410       420
                 ....*....|....*....|....*...
gi 295442750 446 tLGYGWGNSLLAFIVLGSSIITCSLLWF 473
Cdd:cd17474  346 -LLLEIFGLSAPFLVGAAIALAAAVLLA 372
MFS_1 pfam07690
Major Facilitator Superfamily;
48-437 1.57e-25

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 107.12  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   48 LILVSAFALLGPMASSMVAPCLdqIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLL--LAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  208 TIFSGFIFALSLPLLAETYPKTLLGEKARKLnksektnkyhtewnlehiprlklvtpALMRPIRMLFTQPIVILcsTYMA 287
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARL--------------------------SLIVAWKALLRDPVLWL--LLAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDktfrylkrrnngKMAPEFRVPVILLGTFF 367
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD------------RLGRRRRLLLALLLLIL 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750  368 FPAGLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSFMI-YAASSTAVACCVRSIAAFAFP 437
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLL----LALLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 42-221 1.68e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.05  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  42 ARKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVI 121
Cdd:COG0477   10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGA-SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 122 FIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYK 201
Cdd:COG0477   89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180
                 ....*....|....*....|
gi 295442750 202 WIFWSTTIFSGFIFALSLPL 221
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRL 188
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
43-473 1.21e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 104.95  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  43 RKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIF 122
Cdd:COG2271    7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 123 IVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKW 202
Cdd:COG2271   86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 203 IFWSTTIFSGFIFALSlpllaetypktllgekarklnksektnkyhtewnlehiprlklvtpalmrpirmlftqpiVILC 282
Cdd:COG2271  166 AFLILGLPGLLLALLR------------------------------------------------------------FWLL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 283 STYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYlkrrnngkmapefRVPVIL 362
Cdd:COG2271  186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------------RKLVLA 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 363 LGTFFFPAGLFIYGWTaqyHTHWIGPdIGAAMFNIGLMLGWRGIQTYLIDSF-MIYAASSTAVACCVRSIAAFAFPLFGQ 441
Cdd:COG2271  253 IGLLLAALALLLLALL---PSPALAI-ALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVG 328

                        410       420       430
                 ....*....|....*....|....*....|..
gi 295442750 442 DMYDTLGYGWgnsllAFIVLGSSIITCSLLWF 473
Cdd:COG2271  329 YLLDATGYQA-----AFLLLAALALLAALLAL 355
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 51-223 8.66e-24

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 102.64  E-value: 8.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  51 VSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACG 130
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGA-SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 131 LARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIF 210
Cdd:cd17321   80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159

                        170
                 ....*....|...
gi 295442750 211 SGFIFALSLPLLA 223
Cdd:cd17321  160 GLVALLLARTFSG 172
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 64-339 5.10e-23

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 100.32  E-value: 5.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  64 MVAPCLDQIADRFHIQNSTeKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRF 143
Cdd:cd17324   17 VIQGLLPDIARDFGVSVAQ-AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 144 LAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLla 223
Cdd:cd17324   96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL-- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 224 etypktllgekarklnksektnkyhtewnLEHIPRLKLVTPALMRPIRMLFTQPIVILCSTYMAIQYGILYLVLTTYPTL 303
Cdd:cd17324  174 -----------------------------LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPF 224

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 295442750 304 WTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDK 339
Cdd:cd17324  225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 49-411 6.22e-23

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 99.56  E-value: 6.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  49 ILVSAFalLGPMASSMVAPCLDQIADRFHiqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMA 128
Cdd:cd17502    1 LMLALF--LAALDQTIVATALPTIVAEFG--GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 129 CGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTT 208
Cdd:cd17502   77 CGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 209 IFSGFIFALSlpllaetypktllgekarklnksektnkyhtewnlehiprlklvtpalmrpirmlftqPIVILCSTYMAI 288
Cdd:cd17502  157 PIGGLALALL----------------------------------------------------------RTILLSSIFGFL 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 289 QYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRYlkrrnngkmapefrVPVILLGTFFF 368
Cdd:cd17502  179 FGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRY--------------KPLIVIGTILM 244

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 295442750 369 PAGlfiYGWTAQYHTHWIGPDIGAAMFNIGLMLGWrGIQTYLI 411
Cdd:cd17502  245 SVG---AGLLTTLTLDTSKWLLIGYLILLGLGLGI-GFQQPLV 283
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 55-222 8.40e-22

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 96.88  E-value: 8.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  55 ALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLART 134
Cdd:cd17503    5 AFMAILDTTIVNVALPTIMGDLGA-SLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 135 KAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFI 214
Cdd:cd17503   84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163


                 ....*...
gi 295442750 215 FALsLPLL 222
Cdd:cd17503  164 LLL-APLL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 60-467 2.96e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 95.19  E-value: 2.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  60 MASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMY 139
Cdd:cd06174   10 LARGLISPLLPALLQSFGL-SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 140 IFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTY--KWIFWSTTIFSGFIFAL 217
Cdd:cd06174   89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAALALLAAIL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 218 SLPLLAETYPKTLLGEKARKlnksektnkyhtewnlehiprlklvTPALMRPIRMLFTQPIVILCSTYMAIQYGILYLVL 297
Cdd:cd06174  169 LLLVVPDPPESARAKNEEAS-------------------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 298 TTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRylkrrnngkmapefRVPVILLGTFFFPAGLFIYGW 377
Cdd:cd06174  224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------------RKPLLLIGLLLMALGLALLLL 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 378 TAQYHTHWIGPDIGAAMFNIGLMLGWRGIQtyLIDSFMIYAASSTAVACCVRSIAAFAFPLFGQDMYDTLGYGWGNSLLA 457
Cdd:cd06174  290 APSLLLLLLLLLLLGFGLGGLLPLSFALIA--ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367

                        410
                 ....*....|
gi 295442750 458 FIVLGSSIIT 467
Cdd:cd06174  368 VLLLLAAILL 377
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 48-339 1.56e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 90.14  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   48 LILVSAFALLGPMASSMVAPCLDQIADRFHIQNSTEKaLILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:TIGR00710   7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQ-MTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWst 207
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA-- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  208 tiFSGFIFALSLPLLAETYPKTLLGEKARKLNKSEKTnkyhtewnlehiprlklvtpalmrpIRMLFTQPIVILCSTYMA 287
Cdd:TIGR00710 164 --FLSLAGILLSALIFFILPETLPYEARIQISTYFET-------------------------FLLLLKSKMFWGYALIYG 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295442750  288 IQYGILYLVLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDK 339
Cdd:TIGR00710 217 ASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKK 268
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
57-228 2.08e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 80.73  E-value: 2.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  57 LGPMASSMVAPCLDQIADRFHIqnSTEKALI-LSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTK 135
Cdd:PRK11102   2 LMPLAIDMYLPALPVIAADFGV--SAGSVQMtLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 136 AQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVA----VMSLAPLLGPTIGpvvsGFIAEYTTYKWIFWSTTIFS 211
Cdd:PRK11102  80 DQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIAPLLAPIIG----GWLLVWFSWHAIFWVLALAA 155

                        170
                 ....*....|....*..
gi 295442750 212 GFIFALSLPLLAETYPK 228
Cdd:PRK11102 156 ILAAALVFFFIPETLPK 172
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 55-222 2.41e-15

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 77.62  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  55 ALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLART 134
Cdd:cd17504    5 ALAVMLVETMLSPALPTIQREFGT-SAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 135 KAQMYIFRFLAGFGSATpMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFsGFI 214
Cdd:cd17504   84 LPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV-AVL 161


                 ....*...
gi 295442750 215 FALSLPLL 222
Cdd:cd17504  162 LAALVPLI 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 55-466 3.10e-15

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 76.85  E-value: 3.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  55 ALLGPMASSMVAPCLDQIADRFHIQNSTekALILSIYLLVFAISPMISAP----LSEVFGRRMLLQVGNVIFIVFNMACG 130
Cdd:cd17330    5 VFLDALGFGIVFPVLPFYVREFNKLGAS--GYYVGLLQSSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 131 LARTKAQMYIFRFLAGFGSATpMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttiF 210
Cdd:cd17330   83 LSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFL----V 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 211 SGFIFALSLpllaetypktllgekarklnksektnkyhtewnlehiprlkLVTPALMRPIRMLFtqpIVILCSTYMAIQY 290
Cdd:cd17330  158 AAALALLNL-----------------------------------------VLVLFFLPPLRRLL---LVYFLIALAFAGL 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 291 gilylvLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFgsqASGIFIDKTFRYLKRRNngkmapefrvpVILLGTFFFPA 370
Cdd:cd17330  194 ------ESVFSLFLKDRFGFSPSQIGLLLALVGIAGIL---AQLLLIPRLAKRLGERK-----------LLRLGLLLAII 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 371 GLFIYGWTAQYHTHWigpdIGAAMFNIGLMLGWRGIQTYLIDSFMIYAASSTA-VACCVRSIAAFAFPLFGQDMYDTLGY 449
Cdd:cd17330  254 GLLLLPFASSVPLLV----LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQgIIQSLQSLARIIGPLLAGPLYSFLGP 329

                        410       420
                 ....*....|....*....|
gi 295442750 450 G---WGNSLLAFIVLGSSII 466
Cdd:cd17330  330 GvpfLLAAGLLLIALFLLSL 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
42-339 1.26e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.30  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  42 ARKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVI 121
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL-SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 122 FIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYK 201
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 202 WIFWSTTIFSGFIFALSLPLLAETYPKTLLGEKARklnksektnkyhtewnlehiprlklvtpalMRPIRMLFTQPIVIL 281
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS------------------------------LRDQLEALRDPRFWL 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 282 CSTYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGlnYIASGIGL--IFGSQASGIFIDK 339
Cdd:COG2223  210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG--LLAALFALlgALGRPLGGWLSDR 267
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 69-217 1.74e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 74.53  E-value: 1.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  69 LDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFG 148
Cdd:cd17319   26 APTIMKDLGL-SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295442750 149 SATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFsGFIFAL 217
Cdd:cd17319  105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL-GLLLAV 172
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 49-219 4.78e-14

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 73.45  E-value: 4.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  49 ILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMA 128
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 129 CGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTP-DERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST 207
Cdd:cd17476   80 AGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159

                        170
                 ....*....|..
gi 295442750 208 TIFSGFIFALSL 219
Cdd:cd17476  160 AILAAIVAVAAI 171
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 48-381 1.18e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 72.22  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALlgpMASSMVAPCLDQIADRFHIQNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd17473    4 LLLASTLTV---MAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYtTYKWIFWst 207
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFL-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 208 tifsgfIFALSLPLLAETYpkTLLGEKARklnKSEKTNKYHTEWNLEHIPRLKLvtpalmrpirmlftqPIVILCSTYMA 287
Cdd:cd17473  158 ------VYLLALPVLILVL--LFLPEPAR---KSKSAASPGAATAAALPWKRVL---------------PIYFLAFLAML 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 288 iqygILYLVLTTYPTLWTEEYHERPSIAGLnyiasgigLIFGSQASGIFIDKTFRYLKRRnngkmapEFRVPVILLGTFF 367
Cdd:cd17473  212 ----LFYVIPIQLPFLLQERGGGSAALIGL--------ALAIASLAGAIGALLFGRLKRR-------LGKRRLLAIGFAL 272

                        330
                 ....*....|....
gi 295442750 368 FPAGLFIYGWTAQY 381
Cdd:cd17473  273 MALGFLLLALASGL 286
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 91-228 5.40e-13

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 70.87  E-value: 5.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   91 YLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERG 170
Cdd:TIGR00711  46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRG 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 295442750  171 KAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAETYPK 228
Cdd:TIGR00711 126 RAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 78-217 2.41e-12

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 68.81  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  78 IQNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLArTKAQMYIFRF-LAGFGSATpMGLG 156
Cdd:cd06179   28 LGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTA-KSVNMLIGGQaLIGIGAGT-QGLG 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295442750 157 SGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYT--TYKWIFWSTTIFSGFIFAL 217
Cdd:cd06179  106 AAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALALIL 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-226 8.17e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 66.43  E-value: 8.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRR--MLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISD 162
Cdd:COG2271  219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295442750 163 LFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAETY 226
Cdd:COG2271  299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 48-241 1.95e-10

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 62.64  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIQNStekaliLSIYL-LVFAISPMISAP----LSEVFGRRMLLQVGNVIF 122
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDS------LAGLLqTVFIISYMVLSPifgyLGDRYNRKWILAVGILIW 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 123 IVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYT-TYK 201
Cdd:cd17328   75 SAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWR 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 295442750 202 WIFWSTTIFsGFIFALSLPLLAETYPKTLLGEKARKLNKS 241
Cdd:cd17328  155 WAFRVTGVL-GVLLAILLLLFVREPPRGAAEGGVMAKSTA 193
emrD PRK11652
multidrug transporter EmrD;
48-228 1.99e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 62.62  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPCLDQIADRFHIQNSTEKAlILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:PRK11652  10 LFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQA-VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGfgsatpMGLGSG-----TIS-DLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYK 201
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQG------LGTGVGgvmarTLPrDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWR 162

                        170       180
                 ....*....|....*....|....*..
gi 295442750 202 WIFWSTTIFSGFIFALSLPLLAETYPK 228
Cdd:PRK11652 163 ACYLFLLLLGAGVTFSMARWMPETRPA 189
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 81-413 2.37e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 62.23  E-value: 2.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  81 STEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATpMGLGSGTI 160
Cdd:cd17489   30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGA-FTTAAATL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 161 SDLFTPDER-GKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLlaetypktllgekarkln 239
Cdd:cd17489  109 VADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV------------------ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 240 kSEKTNKYHTEWNLEHIPRLKLVTPALMRPIRMLFTQPIvilcsTYMAIQygilylvltTYPTLWTEEYHerPSIAGLNY 319
Cdd:cd17489  171 -KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASI-----AYGAIS---------TFLPLYAAERG--ISNAGLFF 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 320 IASGIGLIFGSQASGIFIDKtfrylKRRNngkmapefrvPVILLGTFFFPAGLFIYgWTAQYHTHWIgpdIGAAMFNIGL 399
Cdd:cd17489  234 TVYAIALLLSRPFSGKLSDR-----KGPK----------TVIIPGLLLLALGLLLL-SFAGSPWMLL---LAAVLYGLGF 294

                        330
                 ....*....|....
gi 295442750 400 MLGWRGIQTYLIDS 413
Cdd:cd17489  295 GLLFPALQALAVDL 308
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 65-227 1.00e-09

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 60.28  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  65 VAPCLDQIADRFHIQ-NSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRF 143
Cdd:cd17315   16 INGALLYIAKDLGFGlSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 144 LAGFGsatpMGLGSGT----ISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKW-IFWSTTIFSGFIFALS 218
Cdd:cd17315   96 LLGLG----VGLASVLvplyISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWrLMFALAAVPALLQLLL 171


                 ....*....
gi 295442750 219 LPLLAETYP 227
Cdd:cd17315  172 MFFLPESRA 180
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
53-228 1.48e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 59.65  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  53 AFALLGPMASSMVAPCLDQIADRFhiqNSTEKAL--ILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACG 130
Cdd:PRK10473  10 ALVLLYPAGIDMYLVGLPRIAADL---NASEAQLhiAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 131 LARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIF 210
Cdd:PRK10473  87 LAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAM 166

                        170
                 ....*....|....*...
gi 295442750 211 SGFIFALSLPLLAETYPK 228
Cdd:PRK10473 167 GILVLLLSLFILKETRPA 184
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 87-339 3.98e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 58.52  E-value: 3.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   87 ILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTP 166
Cdd:TIGR00895  57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  167 DERGKAVAVMslapLLGPTIGPVVSGFIAEY--TTYKW--IFWsttiFSGFIFALSLPLLAETYPKTL--LGEK-----A 235
Cdd:TIGR00895 137 RFRGTAVGLM----FCGYPIGAAVGGFLAGWliPVFGWrsLFY----VGGIAPLLLLLLLMRFLPESIdfLVSKrpetvR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  236 RKLNKSEKTNKYHTewnLEHIPRLKLVTPALMRPIRMLFTQPI----VILCSTYMAIQYGIlYLVLTTYPTLwTEEYHER 311
Cdd:TIGR00895 209 RIVNAIAPQMQAEA---QSALPEQKSTQGTKRSVFKALFQGKTaritVLLWLLYFMLLVGV-YFLTNWLPKL-MVELGFS 283

                         250       260
                  ....*....|....*....|....*...
gi 295442750  312 PSIAGLNYIASGIGLIFGSQASGIFIDK 339
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADR 311
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
88-238 4.32e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 58.41  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  88 LSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPD 167
Cdd:PRK15402  54 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEA 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750 168 ERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttiFSGFIFALSLPLLAETYPKTlLGEKARKL 238
Cdd:PRK15402 134 DAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFV----LFAALAALSFFGLWRAMPET-AGRVGEKL 199
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
29-225 6.03e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 57.96  E-value: 6.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  29 SPTDPKNPKNWIYARKWTQLILVSAFALLGPMASSmVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEV 108
Cdd:COG2807    2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITS-VGPLLPEIRADLGL-SATQAGLLTTLPLLAFGLFAPLAPRLARR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 109 FGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFtPDERGKAVAVMSLAPLLGPTIGP 188
Cdd:COG2807   80 FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAA 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 295442750 189 VVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAET 225
Cdd:COG2807  159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 85-225 8.66e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.21  E-value: 8.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLF 164
Cdd:cd17365   37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYA 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750 165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttiFSGFIFALSLPLLAET 225
Cdd:cd17365  117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL----LGGVPPLILLPLLRGT 173
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 83-458 3.87e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.39  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  83 EKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISD 162
Cdd:cd17371   35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 163 LFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTyKWIFWSTTIFSGFIFALSLPLLAETYPKTLLGEKARklnkse 242
Cdd:cd17371  115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLP-PEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAAR------ 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 243 ktnkyhtewnleHIPRLKLVTPAlmrpIRMLF---TQPIVILCSTYMAIQYGILYLVLTTYPTLWTEEYH--ERPSIAGL 317
Cdd:cd17371  188 ------------AARRHFADRPS----LRELFsppLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGlsFEGSAGYL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 318 NYIAsgIGLIFGSQASGIFIDKtfryLKRRNNgkmapefrvpvILLgtFFFPAGLFIYgWTAQYH-----THWIGPDIGa 392
Cdd:cd17371  252 VVTI--LGGFLGYLAGGFLADR----IGRRNN-----------FAL--FALGSAISIL-LYFFLPlsptlILILGFPLG- 310

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295442750 393 aMFNIGLMLGWrgiQTYLIDSFMIyAASSTAVACCV---RSIAAFAFPLFGqdmYDTLGYGWGNSLLAF 458
Cdd:cd17371  311 -FFASGPFSGM---GAYLTELFPT-AVRATAQGFCYnvgRIIGALFPFLVG---FLATSGSLGTAIAVF 371
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 81-371 2.33e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 52.76  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   81 STEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTI 160
Cdd:TIGR00881  29 KTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  161 SDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGF-IAEYTTYKWIFwsttIFSGF---IFALSLPLLAETYPKTllgekaR 236
Cdd:TIGR00881 109 TKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVF----IVPGIiaiIVSLICFLLLRDSPQS------C 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  237 KLNKSEKTNKYHTEWNLEHIPRLKLVTPALMRPIrmLFTQPIVILCSTYMAIqYGILYLVLTTYPTLWTEEYHERPSIAG 316
Cdd:TIGR00881 179 GLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYV--LLNKVLWYISLGYVFV-YVVRTGILDWSPLYLTQEKGFSKEKAS 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 295442750  317 LNYIASGIGLIFGSQASGIFIDKTFrylkRRNNGKMAPEFRVPVI--LLGTFFFPAG 371
Cdd:TIGR00881 256 WAFTLYELGGLVGTLLAGWLSDKLF----NGRRGPLAVFFMALIIvsLLVYWLNPAA 308
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 69-219 2.72e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 52.57  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  69 LDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFG 148
Cdd:cd17359   24 LPFLQTDFNL-TPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295442750 149 SATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEY--------TTYKWIFWSTTIFSGFIFALSL 219
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAggadwlgaEGWRWMLGLEAIPAILFLLGML 181
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 89-219 3.12e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 3.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  89 SIYLLVFAISPMISAP----LSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFL--AGFGSATPMGLGSgtISD 162
Cdd:cd17489  230 GLFFTVYAIALLLSRPfsgkLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLygLGFGLLFPALQAL--AVD 307

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295442750 163 LFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSL 219
Cdd:cd17489  308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
30-183 3.97e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.90  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  30 PTDPKNPKNWIYARKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIQNSTEKALILSIYLLVFAISPMISAPLSEVF 109
Cdd:COG2814  191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295442750 110 GRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLG 183
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 143-375 4.43e-07

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 52.42  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  143 FLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAE-YTTY---------------KWI--F 204
Cdd:TIGR00805 179 ILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQiYVDTgsvntedliitptdpRWIgaW 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  205 WSTTIFSGFI-FALSLPL--LAETYPKTLL-----GEKARKLNKSEKTNKYHTEWNLEHIPRLklvtpalmrpIRMLFTQ 276
Cdd:TIGR00805 259 WIGFLVCGFVaLLTSIPLffFPKTLPKEGKrvnvdVHEAEKLEKSRGEDRKKNSGITKDFPKF----------IKRLLCN 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  277 PIVILCSTYMAIQYGILYLVLTTYPTLWTEEYHERPS-----IAGLNYIASGIGLIFGSqasgiFIDKTFrylkrRNNGK 351
Cdd:TIGR00805 329 KIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAeanllIGVVNVPPIGLGYLIGG-----FIMKKF-----KLNVK 398

                         250       260
                  ....*....|....*....|....
gi 295442750  352 MAPEFRVPVILLGTFFFPAGLFIY 375
Cdd:TIGR00805 399 KAAYFAICLSTLEYLLYSPKFLIT 422
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
85-219 9.26e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 9.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSAT--PMGLgSGTISD 162
Cdd:COG0738  249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLmfPTIF-SLALDG 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295442750 163 LftPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSL 219
Cdd:COG0738  328 L--GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 56-466 1.31e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.30  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  56 LLGPMASSMVAPCL-DQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLART 134
Cdd:cd17329    9 FLNRLGFFMVWPFMaIYLHQQLGL-SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 135 KAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYtTYKWIFWSTTIFSGFI 214
Cdd:cd17329   88 PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 215 FALSLPLLAETYPKTLLGEKARKLNKSEKTNKYHtewnlehipRLKLVTPALMrPIRMLFTQPIVILcSTYMAIqygILY 294
Cdd:cd17329  167 ALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDR---------AFLLFLLASF-LISLIYFQLESTL-PVYVVE---ILG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 295 LVLTTYPTLWTeeyherpsiaglnyIASGIGLIFGSQASgifidktfRYLKRRNngkmapefRVPVILLGTFFFPAGLFI 374
Cdd:cd17329  233 LGESLLGLLLA--------------LNALLIVLLQFPVA--------RLVERFR--------LRKILMIGILLFAIGFAV 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 375 YGWTAQYhTHWIgpdIGAAMFNIGLMLGWRGIQTYLID--------SFMIYAASSTAVAccvRSIAafafPLFGQDMYDT 446
Cdd:cd17329  283 LAFANTL-AVLI---LAMIVLTLGEMLVFPAVQTLVAAlappdkrgSYMGFYALAWGLG---RAIG----PLVGGLLLDL 351

                        410       420
                 ....*....|....*....|
gi 295442750 447 LGYGWGNSLLAFIVLGSSII 466
Cdd:cd17329  352 LGPGLPWLILAALGLIAAAL 371
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 77-179 1.49e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 50.35  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  77 HIQNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGsatpMGLG 156
Cdd:cd17360   30 VVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG----VGIA 105

                         90       100
                 ....*....|....*....|....*..
gi 295442750 157 SGT----ISDLFTPDERGKAVAVMSLA 179
Cdd:cd17360  106 SMTvplyIAEAAPPRIRGRLVTINVLF 132
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 85-467 1.81e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLF 164
Cdd:cd17316   39 GLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTY----KWIFWSTTIFSGFIFALslpllaetypktllgekaRKlnk 240
Cdd:cd17316  119 PSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwRILFLIGALPALLALLL------------------RR--- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 241 sektnkyhtewnlehiprlklvtpalmrpirmlftqpIVILCSTYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGLNYI 320
Cdd:cd17316  178 -------------------------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 321 ASGIGLIFGSQASGIFIDKTFRYlkrrnngkmapefrvPVILLGTFFFPAGLFIYGWTAQYHTHWIGpdIGAAMFNIGLM 400
Cdd:cd17316  221 LISLGALVGALIAGLLSDRIGRK---------------KTLVIGLILSGILALPLFYLLSGSPTLLL--LLLFILSFFVG 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 401 LGWRGIQTYLIDSF---MIYAASSTAVACCvRSIAAFAFPLFGQDMYDTLGYGWGNSLLAFIVLGSSIIT 467
Cdd:cd17316  284 GVWGALYAYLAELFpteVRATGVGLSYNLG-RLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 105-228 2.48e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 49.53  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 105 LSEVFGRRML-LQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMglgSGTI--SDLFTPDERGKAVAVMSLAPL 181
Cdd:cd17490   54 LSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV---SFTVlyASYFPPDEAAKAMGLINLVNN 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 295442750 182 LGPTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAETYPK 228
Cdd:cd17490  131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREK 177
Sugar_tr pfam00083
Sugar (and other) transporter;
86-225 3.18e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.58  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750   86 LILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKA---QMYIFRFLAGFGsatpMGLGSGT--- 159
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIG----VGGASVLapm 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  160 -ISDLFTPDERGKAVAVMSLAPLLGPTIGPVV---SGFIAEYTTYKWIFWSTTIFSGFIFALsLPLLAET 225
Cdd:pfam00083 126 yISEIAPKKLRGALGSLYQLAITFGILLAYIFglgLNKTSNSDGWRIPLGLQLVPALLLIIG-LLFLPES 194
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 48-221 4.50e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 4.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGPMASSMVAPcldqIADRFHIQNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:cd06173  214 LLALALFALLGGALTVLLPL----LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSAtPMGLGSGTISDLFTPDE-RGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWS 206
Cdd:cd06173  290 VLGLSPSLWLLLAALFLLGLAGG-LFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368

                        170
                 ....*....|....*
gi 295442750 207 TTIFSGFIFALSLPL 221
Cdd:cd06173  369 AGALLLLAALLLLLL 383
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 85-259 4.53e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 48.79  E-value: 4.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIY-LLVFAISPMISApLSEVFGRRMLLQV---GNVIFIVFnMACglARTKAQMYIFRFLAGFGSATpMGLGSGTI 160
Cdd:cd17388   41 GVLLALYaLMQFIFAPILGA-LSDRFGRRPVLLLslaGAALDYLL-MAF--APTLWWLYLGRIIAGITGAT-GAVAAAYI 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 161 SDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTyKWIFWSTTIFSGFIFALSLPLLAETYPKTllgekARKLNK 240
Cdd:cd17388  116 ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-RAPFLVAAGLNGLNFLLGLFVLPESLPPE-----RRRAFR 189

                        170
                 ....*....|....*....
gi 295442750 241 SEKTNKYHTEWNLEHIPRL 259
Cdd:cd17388  190 WRRANPFGSLRWLTGFPGL 208
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 54-247 5.62e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.80  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  54 FALLGPMASSMVAPCLDQIADRF-----HIQNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMA 128
Cdd:cd17357   16 IGVVNAPQEVFKEFINDTLVDRYglnlsDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 129 CGLAR--TKAQMYIF-RFLAGFGSATPMGLGSGTISDLFTPDERGkavaVMSLAPLLGPTIGPVVSGFIA------EYTT 199
Cdd:cd17357   96 MFLSKsaKSPELLIFgRFLVGIACGLSTGFVPMYLQEISPSELRG----ALGSLTQIGVTLGILLGQVFGlpsvlgTETL 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 295442750 200 YKWIFWSTTIFSGFIFALsLPLLAETyPKTLLGEKARKlNKSEKTNKY 247
Cdd:cd17357  172 WPYLLFFPGIPALLQLAA-LPFFPES-PKFLLISKGDE-EEAEKSLKF 216
PRK10504 PRK10504
putative transporter; Provisional
 91-204 6.29e-06

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 48.57  E-value: 6.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  91 YLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERG 170
Cdd:PRK10504  54 YVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYM 133

                         90       100       110
                 ....*....|....*....|....*....|....
gi 295442750 171 KAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIF 204
Cdd:PRK10504 134 AAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF 167
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 79-210 7.73e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.03  E-value: 7.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  79 QNSTEKALILSIYLLVFAISPMISAP----LSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMG 154
Cdd:cd17391  233 GDASNLAFISGLVFSATGVSSLLSAPrlgkLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLP 312

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295442750 155 LGSGTISDLfTPDE-RGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIF 210
Cdd:cd17391  313 AINSLLAKI-TPKEvAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 84-221 1.64e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.80  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  84 KALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATpMGLGSGTISDL 163
Cdd:cd17317   27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAG-IFTVGFVLGME 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 295442750 164 FTPDERGKAVAVMSLAPLlgpTIGPVVSGFIAEYT-TYKWIFWSTTIFSGFIFALSLPL 221
Cdd:cd17317  106 IVGPKYRSFVGILFGLFW---ALGYMLLALLAYLIrDWRWLQLAISLPGLLFLLLLWWL 161
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
85-222 1.66e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.20  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTK--AQMYIFRFLAGFGSATPMGLGSGTISD 162
Cdd:COG2211  267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGLGAILVLPWAMLAD 346

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 295442750 163 LFTPDE-------RGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTY-----------KWIFWSTTIFSGFIFALSLPLL 222
Cdd:COG2211  347 VVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspsalTGIRLLFFLLPAVLLLLAALLL 424
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 86-230 2.01e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 46.88  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  86 LILSIY-LLVFAISPMISApLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFgSATPMGLGSGTISDLF 164
Cdd:cd17389   68 LIGSLFsLLQFLSSPITGA-ASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAIVADVT 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 295442750 165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTT--IFSGFIFALSLPLLAETYPKTL 230
Cdd:cd17389  146 SPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMpaLFALVLALADLLFIFFFLPETL 213
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 82-406 3.88e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.68  E-value: 3.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  82 TEKALILSIYLLVFAISPMISAPLSEV----FGRRMLLQVGN------VIFIVFNMACGLArTKAQMYIFRFLAGFGSAT 151
Cdd:cd06173   30 TGSALLVGLVLAAFFLPFLLFSPFAGVladrFDRRRLLILADllrallAAVLALLALLGSL-SLWLLLVLAFLLGIASAF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 152 PMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsTTIFSGFIFALSLPLLAETYPKTLL 231
Cdd:cd06173  109 FGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA-INALSFLLSALLLLFIRRPPPAAPG 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 232 GEKARKLNKSEKTNKYhtewnlehiprlklvtpalmrpirmLFTQPIVILCSTYMAIQYGILYLVLTTYPTLWTEEYHER 311
Cdd:cd06173  188 ESSSLLLRDLREGLRY-------------------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 312 PSIAGLNYIASGIGLIFGSQASGifidktfRYLKRRNNGKMapefrvpvILLGTFFFPAGLFIYGWTAQyhtHWIgpdIG 391
Cdd:cd06173  243 AAGYGLLLAAFGVGALLGALLLG-------RLSKRRRRGRL--------LLIGALLLGLALLVLGLSPS---LWL---LL 301

                        330
                 ....*....|....*
gi 295442750 392 AAMFNIGLMLGWRGI 406
Cdd:cd06173  302 AALFLLGLAGGLFNV 316
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
104-225 9.50e-05

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 44.82  E-value: 9.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 104 PLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLG 183
Cdd:PRK15403  73 PLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVA 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 295442750 184 PTIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFALSLPLLAET 225
Cdd:PRK15403 153 PIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
47-148 1.08e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.50  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  47 QLILVSAFALLGPMASSMVAPCLDQIADRFHIQNStEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFN 126
Cdd:PRK11043   7 FLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSAS-AVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGS 85

                         90       100
                 ....*....|....*....|..
gi 295442750 127 MACGLARTKAQMYIFRFLAGFG 148
Cdd:PRK11043  86 LGMLWVESAAQLLVLRFVQAVG 107
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 93-195 1.12e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 44.51  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  93 LVFAISPMISAPLSEVFG--------RRMLLQVGNVIFIVFNMACGLARTKAQ-----MYIFRFLAGFGsATPMGLGSGT 159
Cdd:cd17326   40 WVVAAYSLGQLVFSPVFGywsnktssVKEPLIVSILIAIVGNILYALAEYFPSnrkyvMLVARFLIGVG-AGNVAVLRAY 118

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 295442750 160 ISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIA 195
Cdd:cd17326  119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 49-226 1.16e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 44.49  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  49 ILVSAFALLGP----MASSMVAPCLDQIADR----FHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNV 120
Cdd:cd17358    1 LLATFVANLGSfsfgIAVGWSSPALPSLMSDnslsLPL-TVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 121 IFIVFNMACGLARTKAQMYIFRFLAGFGsatpMGLGSGT----ISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAe 196
Cdd:cd17358   80 PCILGWLLIAFAKDVWMLYLGRFLAGFG----GGAASVVvpvyIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP- 154

                        170       180       190
                 ....*....|....*....|....*....|
gi 295442750 197 yttYKWIFWSTTIFSgFIFALSLPLLAETY 226
Cdd:cd17358  155 ---WRTLALIGAIPP-VVFLILLFFIPESP 180
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 85-194 1.26e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.09  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIV---FNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTIS 161
Cdd:cd17321  207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgllLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286

                         90       100       110
                 ....*....|....*....|....*....|...
gi 295442750 162 DLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFI 194
Cdd:cd17321  287 SSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 72-468 1.29e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 44.15  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  72 IADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVfnMACGLARTKAQMYI--FRFLAGFGS 149
Cdd:cd17475   22 LQEDLHL-SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLlvLLFLVGAGY 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 150 ATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEytTYKW-----IFWSTTIFSGFIFALSLPllaE 224
Cdd:cd17475   99 GSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLAL--HYGWraafvVAGLVSILAAVLFWLFYR---E 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 225 TYPKTLLGEKARklnksektnkyhtewnlehiPRLKLVTPALMRPIrmlfTQPIVILCSTYMAIQYgilylVLTTYPTLW 304
Cdd:cd17475  174 PPAASAATESAS--------------------TLLRSLKEVLRNRD----VWLIAIAGALLVAPQF-----ALLTFLLLF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 305 -TEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKTFRylkRRnngkmapefRVPVILLGTFFFPAGLFIYGWTAQYHT 383
Cdd:cd17475  225 lHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFG---GR---------RRPVLVITAAIAAAALLVLSLLSPGTP 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 384 HWIgpdIGAAMFNIGLM-LGWRGIQ-TYLIDSFMI-YAASSTAVACCVRSIAAFAFP-LFGQDMYDTLGYGWGNSLLAFI 459
Cdd:cd17475  293 LWL---LVLLLILLGLFaIGWNGLYlTLVAESAGPeQAGTALGLANTINFIGIAIGPpLFGLLVDATHSYAPAWLALALL 369


                 ....*....
gi 295442750 460 VLGSSIITC 468
Cdd:cd17475  370 LVLAALLLL 378
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 86-222 2.15e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 43.37  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  86 LILSIYllvfAISPMISAP----LSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATpMGLGSGTIS 161
Cdd:cd17390   35 LIGSVY----GALQLFSSPlvgsWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHT-QSLCKAYLS 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295442750 162 DLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYkwiFWSTTIFSGFIFALSLPLL 222
Cdd:cd17390  110 DLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGG---FYYVALLCSAIFILNAGLV 167
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 105-217 3.06e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 42.97  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 105 LSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATpmGLGSGTISDLFTPDERGKAVAVMSLAPLLGP 184
Cdd:cd17472   55 LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVMALLADLTREENRTKAMALIGASIGIAF 132

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 295442750 185 TIGPVVSGFIAEYTTYKWIFWSTTI--FSGFIFAL 217
Cdd:cd17472  133 AISMVLGPLLAAHLGVSGLFLITAIlsLVSLLILL 167
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 81-472 3.39e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 42.65  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  81 STEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTI 160
Cdd:cd17312   37 KDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 161 SDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWSTTIfSGFIFALSLPLLAETYPktllgekarklnk 240
Cdd:cd17312  117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGI-VGLVVAIILFFFLRDSP------------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 241 sektnkyhtewnlehiprlklvtpalmrpirmlftqPIVILCSTYMAIQYGILYLVLTTYPTLWTEEYHERPSIAGLNYI 320
Cdd:cd17312  183 ------------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSS 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 321 ASGIGLIFGSQASGIFIDKTFrylkRRNNGKMAPEFRVPVI--LLGTFFFPAGLFIygwtaqyhthwigpdIGAAMFNIG 398
Cdd:cd17312  227 LYEVGGIAGTILAGLLSDKLF----GGRRAPIAVIYMLLMTlsLALFWFFPHNKLL---------------SIVLLFLIG 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 399 LMLG-----WRGIQTyliDSFMIYAASSTAVAccVRSIAAFAFPLFGQDM--YDTLGYGWGNSLLAFIVLGS-SIITCSL 470
Cdd:cd17312  288 FFVGgpinlIGGAAA---QDIGRKEAAGTATG--FVGLFGYLGASLAGLPlgYIIDHYGWSTVFYFLISAALlSVLLLLS 362


                 ..
gi 295442750 471 LW 472
Cdd:cd17312  363 LW 364
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 85-222 3.63e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLF 164
Cdd:cd17370  237 PLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLV 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295442750 165 TPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFwsttIFSGFIFALSLPLL 222
Cdd:cd17370  317 PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF----LFSAVLALIALLLL 370
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 105-217 4.80e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 105 LSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFtPDERGKAVAVMSLAPLLGP 184
Cdd:cd17471  258 LAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNASRIGS 336

                         90       100       110
                 ....*....|....*....|....*....|...
gi 295442750 185 TIGPVVSGFIAEYTTYKWIFWSTTIFSGFIFAL 217
Cdd:cd17471  337 LLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-223 5.67e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 5.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  85 ALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFrFLAGFGSATPMGLGS--GTISD 162
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLV-LFLLLGLALGGGNGAvfALVPD 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295442750 163 LFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYT-TYKWIFWSTTIFSGFIFALSLPLLA 223
Cdd:COG2223  323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYR 384
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 43-340 7.96e-04

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 41.62  E-value: 7.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  43 RKWTQLILVSAFALLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRM-------LL 115
Cdd:cd17334    1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDL-SASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIgvligaaLN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 116 QVGNVIFIVfnmACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIA 195
Cdd:cd17334   80 ALGSVLKCI---PLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 196 EYTT-----YKWIFWSTTIFSGFIFALSLPLLAETyPKTLLGEKARKLNKSEKTNKyhtewnlehiprlklvtpALMRPI 270
Cdd:cd17334  157 PPPKgtkkeFGAVFYGEFGFACLLLALVLALFPPK-PKYPPSAASARQQNSEHVIL------------------ELQKSI 217

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295442750 271 RMLFTQ-PIVILCstymaIQYGILYLVLTTYPTLWT---EEYHERPSIAGLNYIASGIGLIFGSQASGIFIDKT 340
Cdd:cd17334  218 SELLRNePFVLLA-----VAFSIMMGVFAGFSSVLAqilLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT 286
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 80-217 8.31e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 8.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  80 NSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTK--AQMYIFRFLAGFGSATPMGLGS 157
Cdd:cd17316  211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGspTLLLLLLFILSFFVGGVWGALY 290

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 158 GTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTtykwIFWSTTIFSGFIFAL 217
Cdd:cd17316  291 AYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST----GGTGVPALILALLAI 346
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 46-248 1.12e-03

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 41.18  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  46 TQLILVSAFALLGpMASSMVAPCLDQIADRFHIQNSTEKALILSIYLLVFaISPMISAPLSEVFGRRMLLQVGNVIFIVF 125
Cdd:cd17396    1 TALGLYFNYFVHG-MGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRL-LTILFAGVLSDKFGRKPSVLLGMVLYALF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 126 NMACGLARTKAQMYIFRFLAGfgsATPMGLGSGT---ISDLFtPDERGKAV----AVMSLAPLLGPTIgpvVSGFIAEYT 198
Cdd:cd17396   79 FVGILFSPNLIIAYVFALLAG---AANSFLDTGTypaLMEAF-PKASGSANilvkAFVSFGQFLLPFI---IAFLAANNL 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 295442750 199 TYKWIFwstTIFSGFIFALSLPLLAETYPKTLLGEKARKLN-KSEKTNKYH 248
Cdd:cd17396  152 WYGWSF---IVPAAVLVLNALLLLKLSFPPQTVTAANTKQKeIPVKREKPK 199
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
48-339 1.18e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  48 LILVSAFALLGpMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNM 127
Cdd:COG0738   11 IAIYLLFFLWG-FATALWGPLIPALKDAFGL-SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 128 ACGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLftpdERGKAVAVMSLAPL---LGPTIGPVVSGFIAEYTTYKWIF 204
Cdd:COG0738   89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL----GPETAASRLNLLHAffsLGALLGPLLGGLLILLGLSLSWH 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 205 WSTTIFSGFIFALSLPLLAETYPKTllgekarKLNKSEKTNKYHTEWNLEHIPRLKLvtpalmrpirmlftqpIVILCST 284
Cdd:COG0738  165 LPYLILAVLLLLLALLFLRSKLPEI-------EEEEEEAAGSAASLKSLLKNPRLLL----------------GGLAIFL 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295442750 285 YMAIQYGIlylvLTTYPTLWTEEYHERPSIAGLNYIASGIGLIFGSQASGIFIDK 339
Cdd:COG0738  222 YVGAEGAI----GDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR 272
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 100-223 1.29e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.10  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 100 MISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLA--GFGSATPM--GLGSGTISdlftPDERGKAVAV 175
Cdd:PRK11551  68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTgvGLGGALPNliALTSEAVG----PRLRGTAVSL 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 295442750 176 MSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttiFSGFIFALSLPLLA 223
Cdd:PRK11551 144 MYCGVPFGGALASVIGVLAAGDAAWRHIFY----VGGVGPLLLVPLLM 187
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 56-241 1.32e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  56 LLGPMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAIS-PMISApLSEVFGRRMLLQVGNVIFIVFNMACGLART 134
Cdd:cd17478    6 FLNDFYQGFLPALLPLLIAKLGL-SYAQAGLLVSVFSITSSLLqPLFGY-LADRKPRRYLLPLGPLLTGLGLSLLGFAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 135 KAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDeRGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWST---TIFS 211
Cdd:cd17478   84 YWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLiipGLAV 162

                        170       180       190
                 ....*....|....*....|....*....|
gi 295442750 212 GFIFALSLPLLAETYPKTLLGEKARKLNKS 241
Cdd:cd17478  163 ALLLLRLRPLKKPEAKKAAAKSSARSTLKG 192
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 80-223 1.84e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 40.68  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  80 NSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGL-ARTKAQMYIF-RFLAGFGSATPMGLGS 157
Cdd:cd17318   54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLaARGGYGALIVlRILQGLAQGVTFPAMH 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295442750 158 GTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttiFSGFI--------FALSLPLLA 223
Cdd:cd17318  134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY----IFGGLgllwcllwFFLVLPVWA 203
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 86-389 3.44e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 39.63  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  86 LILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSatpmGLGSGTISDL-- 163
Cdd:cd17343   42 LITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQ----GLGWPPCAKIlr 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 164 --FTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAeyTTYKW-----IFWSTTIFSGFIFALSL---PLlAETYPKTLLGE 233
Cdd:cd17343  118 kwFSPSQFGTWWSVLSTSMNLAGSLGPILATLLA--LSYGWrstlsISGTVAVVMSVVCLLFIknePS-DVGLNNIEEEE 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 234 KARKLNKSEKTNKYHTEwnLEHIPRLKLVTPALMrpirmlftqpiVILCSTYMAIQYGILYLVlttyptlwtEEYHERPS 313
Cdd:cd17343  195 SKGKKKKSPRGESTLKE--LLLSPFLWLLSLGYL-----------VVFGVKTAVTDWGQLFLI---------QDKGQSAL 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 295442750 314 IAGLNYIASGIGLIFGSQASGIFIDktfrYLKRRNNGKMAPEFRVPVILlgtfffpagLFIYGWTAQYH--THWIGPD 389
Cdd:cd17343  253 TGSSFMSSLEVGGFVGSIAAGYLSD----WAVAKHGSSSRGNPRMPLAL---------VFMAGLTVSLHlfRVHITSD 317
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 49-223 4.29e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  49 ILVSAFALLgpMASSMVAPCLDQIADRFHIqNSTEKALILSIYLLVFAISPMISAPLSEVFGRRMLLQVGNVIFIVFNMA 128
Cdd:cd17477    1 LLLSVALLG--LGSGLLLPLLSLRLEREGV-STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750 129 CGLARTKAQMYIFRFLAGFGSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYTtykwifWSTT 208
Cdd:cd17477   78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG------ALPF 151

                        170
                 ....*....|....*
gi 295442750 209 IFSGFIFALSLPLLA 223
Cdd:cd17477  152 LIAAVLLLLALVPLL 166
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 77-219 4.87e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  77 HIQNSTEKALILSIYLLVFAISPMISAPLSE---VFGRRMLLQVGNVIFIVFNMACGLARTKAQMYIFRFLAGFGSATPM 153
Cdd:cd17319  210 RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAAS 289

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295442750 154 GLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAEYT-TYKWIFwsttIFSGFIFALSL 219
Cdd:cd17319  290 PVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAF----LFLAAVALLAA 352
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 86-215 5.45e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.17  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295442750  86 LILSIYLLVFAISPMISAPLSEVFGRR-MLLQVGNVI-FIVFNMAcgLARTKAQMYIFRFLagfgsatpMGLGSGTISDL 163
Cdd:cd17391   40 LAFSSTFLVSAIFSPIWGRLADRYGRKpMLLRASLGMaIVIGLMA--FVTNVWQLLILRLL--------QGVFSGYVPNA 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 295442750 164 F------TPDER-GKAVAVMSLAPLLGPTIGPVVSGFIAEYTTYKWIFWsttIFSGFIF 215
Cdd:cd17391  110 TaliasqTPKEKsGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFF---ITGGLLF 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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