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Conserved domains on  [gi|19075368|ref|NP_587868|]
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importin alpha family nuclear import signal receptor adaptor Cut15 [Schizosaccharomyces pombe]

Protein Classification

importin subunit alpha( domain architecture ID 11473712)

importin subunit alpha functions in nuclear protein import as an adapter protein for importin beta nuclear receptors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
3-531 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 903.88  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368   3 ASSRFIPEHRRQNYKGKGTFQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEET-IPLEQDKENdlelelQLP 81
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSfIPMEQQFYS------ELP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368  82 DLLKALYSDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFL-SHENNLLKFEASWALTNVASGSSNQTHVVV 160
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMdEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 161 EANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESNRR-LSMLRNSTWTLSNMCRGKNP 239
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 240 QPDWNSISQVIPVLSKLIYTLDEDVLVDALWAISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVT 319
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 320 GDDVQTQVIINCGALSALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAIS 399
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 400 NATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILRVGELDRANNPDKINLYAVYVEDAGGMDLIHE 479
Cdd:COG5064 395 NATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 19075368 480 CQNSSNSEIYQKAYNIIEKFFGEEDEIEELEPETVGDTFTFGTTQEPAGDFQ 531
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
3-531 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 903.88  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368   3 ASSRFIPEHRRQNYKGKGTFQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEET-IPLEQDKENdlelelQLP 81
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSfIPMEQQFYS------ELP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368  82 DLLKALYSDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFL-SHENNLLKFEASWALTNVASGSSNQTHVVV 160
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMdEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 161 EANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESNRR-LSMLRNSTWTLSNMCRGKNP 239
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 240 QPDWNSISQVIPVLSKLIYTLDEDVLVDALWAISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVT 319
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 320 GDDVQTQVIINCGALSALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAIS 399
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 400 NATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILRVGELDRANNPDKINLYAVYVEDAGGMDLIHE 479
Cdd:COG5064 395 NATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 19075368 480 CQNSSNSEIYQKAYNIIEKFFGEEDEIEELEPETVGDTFTFGTTQEPAGDFQ 531
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 12-99 5.25e-30

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 112.24  E-value: 5.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    12 RRQNYKGKGTfQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEETIPleqdkendlELELQLPDLLKALYSDD 91
Cdd:pfam01749   1 RRKSFKNKGK-DADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES---------QLLESLPEMVQGVNSDD 70


                  ....*...
gi 19075368    92 IEAQIQAT 99
Cdd:pfam01749  71 PELQLEAT 78
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 363-403 1.66e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 55.90  E-value: 1.66e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19075368    363 NSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAISNATS 403
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 83-192 6.22e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 46.25  E-value: 6.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    83 LLKALYSDDieAQIQATAKFRKA-LSKETNPPIQKVIDAGVVPRFVEFLSHENNL-LKFEASWALTNVASGSSNQTHVVV 160
Cdd:PLN03200  194 LVKLLSSGN--SDAQANAASLLArLMMAFESSISKVLDAGAVKQLLKLLGQGNEVsVRAEAAGALEALSSQSKEAKQAIA 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19075368   161 EANAVPVFVS--LLSSSE-------QDVREQAVWALGNIAG 192
Cdd:PLN03200  272 DAGGIPALINatVAPSKEfmqgefaQALQENAMGALANICG 312
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
3-531 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 903.88  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368   3 ASSRFIPEHRRQNYKGKGTFQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEET-IPLEQDKENdlelelQLP 81
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSfIPMEQQFYS------ELP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368  82 DLLKALYSDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFL-SHENNLLKFEASWALTNVASGSSNQTHVVV 160
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMdEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 161 EANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESNRR-LSMLRNSTWTLSNMCRGKNP 239
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 240 QPDWNSISQVIPVLSKLIYTLDEDVLVDALWAISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVT 319
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 320 GDDVQTQVIINCGALSALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAIS 399
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 400 NATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILRVGELDRANNPDKINLYAVYVEDAGGMDLIHE 479
Cdd:COG5064 395 NATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 19075368 480 CQNSSNSEIYQKAYNIIEKFFGEEDEIEELEPETVGDTFTFGTTQEPAGDFQ 531
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 12-99 5.25e-30

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 112.24  E-value: 5.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    12 RRQNYKGKGTfQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEETIPleqdkendlELELQLPDLLKALYSDD 91
Cdd:pfam01749   1 RRKSFKNKGK-DADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES---------QLLESLPEMVQGVNSDD 70


                  ....*...
gi 19075368    92 IEAQIQAT 99
Cdd:pfam01749  71 PELQLEAT 78
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 466-501 1.89e-13

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 64.53  E-value: 1.89e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19075368   466 VYVEDAGGMDLIHECQNSSNSEIYQKAYNIIEKFFG 501
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFS 36
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 363-403 3.35e-12

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 60.93  E-value: 3.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19075368   363 NSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAISNATS 403
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 363-403 1.66e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 55.90  E-value: 1.66e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19075368    363 NSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAISNATS 403
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-191 3.06e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 3.06e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19075368   152 SSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNIA 191
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-191 2.13e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 2.13e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19075368    152 SSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNIA 191
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 110-150 6.72e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.60  E-value: 6.72e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19075368   110 TNPPIQKVIDAGVVPRFVEFLSHENNLLKFEASWALTNVAS 150
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 137-190 3.57e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.98  E-value: 3.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19075368   137 LKFEASWALTNVASGSSnQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNI 190
Cdd:pfam13513   3 VREAAALALGSLAEGGP-DLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
80-191 6.75e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.86  E-value: 6.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368  80 LPDLLKALYSDDIEAQIQATakfrKALSKetnppiqkVIDAGVVPRFVEFLSHENNLLKFEASWALTNVASgssnqthvv 159
Cdd:COG1413  49 VPALLEALKDPDPEVRAAAA----EALGR--------IGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD--------- 107

                        90       100       110
                ....*....|....*....|....*....|..
gi 19075368 160 veANAVPVFVSLLSSSEQDVREQAVWALGNIA 191
Cdd:COG1413 108 --PAAVPALLEALKDPDWEVRRAAARALGRLG 137
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 110-150 8.65e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 8.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19075368    110 TNPPIQKVIDAGVVPRFVEFLSHENNLLKFEASWALTNVAS 150
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 280-319 1.94e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.37  E-value: 1.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19075368   280 NEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVT 319
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 409-448 2.43e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.37  E-value: 2.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19075368   409 PDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILR 448
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 194-235 5.59e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.21  E-value: 5.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19075368   194 SPMCRDHVLQCGVLEPLLNIIESNrRLSMLRNSTWTLSNMCR 235
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 408-446 1.55e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19075368    408 RPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENI 446
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT COG1413
HEAT repeat [General function prediction only];
161-317 1.71e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 1.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368 161 EANAVPVFVSLLSSSEQDVREQAVWALGNIaGDSPmcrdhvlqcgVLEPLLNIIESNRrlSMLRNST-WTLSNMcrgKNP 239
Cdd:COG1413  14 DPAAVPALIAALADEDPDVRAAAARALGRL-GDPR----------AVPALLEALKDPD--PEVRAAAaEALGRI---GDP 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075368 240 qpdwnsisQVIPVLSKLIYTLDEDVLVDALWAISYLSDganekiQAIIDAgiprrLVELLMHPSAQVQTPALRSVGNI 317
Cdd:COG1413  78 --------EAVPALIAALKDEDPEVRRAAAEALGRLGD------PAAVPA-----LLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
80-194 2.13e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 2.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368  80 LPDLLKALYSDDIEAQIQATakfrKALSKetnppIQkviDAGVVPRFVEFLSHENNLLKFEASWALTNVASgssnqthvv 159
Cdd:COG1413  18 VPALIAALADEDPDVRAAAA----RALGR-----LG---DPRAVPALLEALKDPDPEVRAAAAEALGRIGD--------- 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 19075368 160 veANAVPVFVSLLSSSEQDVREQAVWALGNIAGDS 194
Cdd:COG1413  77 --PEAVPALIAALKDEDPEVRRAAAEALGRLGDPA 109
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 280-318 3.27e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.26  E-value: 3.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19075368    280 NEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIV 318
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 348-400 4.65e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 41.20  E-value: 4.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19075368   348 VRKEACWTISNITAGNSSQIQYVIEaNIIPPLIHLLTTADFKIQKEACWAISN 400
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGR 54
HEAT COG1413
HEAT repeat [General function prediction only];
119-190 5.95e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 5.95e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075368 119 DAGVVPRFVEFLSHENNLLKFEASWALTNVASGSsnqthvvveanAVPVFVSLLSSSEQDVREQAVWALGNI 190
Cdd:COG1413  14 DPAAVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRI 74
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 83-192 6.22e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 46.25  E-value: 6.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    83 LLKALYSDDieAQIQATAKFRKA-LSKETNPPIQKVIDAGVVPRFVEFLSHENNL-LKFEASWALTNVASGSSNQTHVVV 160
Cdd:PLN03200  194 LVKLLSSGN--SDAQANAASLLArLMMAFESSISKVLDAGAVKQLLKLLGQGNEVsVRAEAAGALEALSSQSKEAKQAIA 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19075368   161 EANAVPVFVS--LLSSSE-------QDVREQAVWALGNIAG 192
Cdd:PLN03200  272 DAGGIPALINatVAPSKEfmqgefaQALQENAMGALANICG 312
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 247-277 3.27e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.27e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19075368   247 SQVIPVLSKLIYTLDEDVLVDALWAISYLSD 277
Cdd:pfam00514  11 AGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 70-332 2.75e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    70 KENDLELELQL----PDLLKALYSDDIEAQIqATAKFRKALSK---ETNPPIQKVIDAGVVPRFVEFLSHENNLLKFEAS 142
Cdd:PLN03200   87 KEEDLRVKVLLggciPPLLSLLKSGSAEAQK-AAAEAIYAVSSgglSDHVGSKIFSTEGVVPSLWDQLQPGNKQDKVVEG 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368   143 W---ALTNVASGSSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGN---IAGDSpmcRDHVLQCGVLEPLLNIIES 216
Cdd:PLN03200  166 LltgALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlmmAFESS---ISKVLDAGAVKQLLKLLGQ 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368   217 NrrlsmlrnstwtlsnmcrgknpqpdwNSISqvipvlskliytldedVLVDALWAISYLSDGANEKIQAIIDAGIPRRLV 296
Cdd:PLN03200  243 G--------------------------NEVS----------------VRAEAAGALEALSSQSKEAKQAIADAGGIPALI 280

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 19075368   297 ELLMHPS--------AQV-QTPALRSVGNIVTGddvQTQVIINCG 332
Cdd:PLN03200  281 NATVAPSkefmqgefAQAlQENAMGALANICGG---MSALILYLG 322
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 165-191 3.21e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 3.21e-03
                          10        20
                  ....*....|....*....|....*..
gi 19075368   165 VPVFVSLLSSSEQDVREQAVWALGNIA 191
Cdd:pfam02985   2 LPLLLKLLNDPSPEVREAAAEALGELA 28
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 80-188 6.18e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075368    80 LPDLLKALYSD-DIEAQIQATakfrKALSKetnppiqkVIDAGVVPRFVEFLSHENNLLKFEASWALTNVASgssnqthv 158
Cdd:pfam13646   1 LPALLQALLRDpDPEVRAAAI----RALGR--------IGDPEAVPALLELLKDEDPAVRRAAAEALGKIGD-------- 60

                          90       100       110
                  ....*....|....*....|....*....|.
gi 19075368   159 vveANAVPVFVSLL-SSSEQDVREQAVWALG 188
Cdd:pfam13646  61 ---PEALPALLELLrDDDDDVVRAAAAEALA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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