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Conserved domains on  [gi|19075424|ref|NP_587924|]
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transcription factor TFIIIC subunit Sfc4 [Schizosaccharomyces pombe]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
402-600 2.04e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAWgMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG0457   48 LGLAYLRLGRYEEALADYEQALELDPDDAE-ALNNLGLALQALGRYEEALEDYDKALELDP-DDAEALYNLGLALLELGR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  482 YEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRNINELEREQSQNEDHEKNVGSQLFVGNQKV 561
Cdd:COG0457  126 YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 19075424  562 PQDKWEKRARISRSKEEARQFTIWKTEETQRRFHKLDIL 600
Cdd:COG0457  206 ALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
142-306 6.95e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 6.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG0457   17 AYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG----RYEEALADYEQALELDPDDAEALNNLGLALQALGRY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  222 DQADYCYNRAVSAKPpnksELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQFE 301
Cdd:COG0457   93 EEALEDYDKALELDP----DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168


                 ....*
gi 19075424  302 IAWKY 306
Cdd:COG0457  169 KLEAA 173
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
402-600 2.04e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAWgMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG0457   48 LGLAYLRLGRYEEALADYEQALELDPDDAE-ALNNLGLALQALGRYEEALEDYDKALELDP-DDAEALYNLGLALLELGR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  482 YEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRNINELEREQSQNEDHEKNVGSQLFVGNQKV 561
Cdd:COG0457  126 YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 19075424  562 PQDKWEKRARISRSKEEARQFTIWKTEETQRRFHKLDIL 600
Cdd:COG0457  206 ALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
142-306 6.95e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 6.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG0457   17 AYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG----RYEEALADYEQALELDPDDAEALNNLGLALQALGRY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  222 DQADYCYNRAVSAKPpnksELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQFE 301
Cdd:COG0457   93 EEALEDYDKALELDP----DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168


                 ....*
gi 19075424  302 IAWKY 306
Cdd:COG0457  169 KLEAA 173
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 135-551 8.17e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 8.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    135 MLSLAnHLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKL 214
Cdd:TIGR02917  162 KLGLA-QLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLG----NIELALAAYRKAIALRPNNIAVLLALATI 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    215 SESLEFWDQADYcYNRAVSAKPPNKSELKKYiwnRSVLNKEHGSLKKAAEGFKFLLQSSP--YNASILKNLAEIYikiha 292
Cdd:TIGR02917  237 LIEAGEFEEAEK-HADALLKKAPNSPLAHYL---KALVDFQKKNYEDARETLQDALKSAPeyLPALLLAGASEYQ----- 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    293 preiLKQFEIAWKYFYQY--PAPPigndifDLPTLNLYAELLLLDHQWSNLIRLINRGVR------WFRGRKSESFWdef 364
Cdd:TIGR02917  308 ----LGNLEQAYQYLNQIlkYAPN------SHQARRLLASIQLRLGRVDEAIATLSPALGldpddpAALSLLGEAYL--- 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    365 dddREWDVDERRREFPNASEEHTNKEAYllphlfRTKLGIARLKTGELPEAELHFSVIKNLPPDYAWGMLYdIAKAYMDI 444
Cdd:TIGR02917  375 ---ALGDFEKAAEYLAKATELDPENAAA------RTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLL-LILSYLRS 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    445 ERLDLALEYFVLICNHEPAqNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAAL---- 520
Cdd:TIGR02917  445 GQFDKALAAAKKLEKKQPD-NASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIqrfe 523

                          410       420       430
                   ....*....|....*....|....*....|.
gi 19075424    521 EIVTNIFEQRRNINELEREQSQNEDHEKNVG 551
Cdd:TIGR02917  524 KVLTIDPKNLRAILALAGLYLRTGNEEEAVA 554
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 133-287 5.44e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.47  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  133 QQMLSLANHLFAQeGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKD-HELWFTC 211
Cdd:cd24142    1 DELLEKAEELLDQ-GNFELALKFLQRALELEPNNVEALELLGEILLELG----DVEEAREVLLRAIELDPDGgYEKYLYL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075424  212 AKLS---ESLEfwdqadyCYNRAVSAkppnkseLKKYIwnrSVLNKEHGSLKKAAEGFKFLLqsspynASILKNLAEIY 287
Cdd:cd24142   76 GQLSggeEALQ-------YYEKGIEI-------LEEEL---QALQAASAEAEEEAEELKRKL------SSALCALAEIY 131
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 137-287 4.90e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 4.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    137 SLANhLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGNgrvniEKCLIAWM-AAAHLKPKDHELWFTCAKLS 215
Cdd:TIGR02917  504 NLAR-IDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGN-----EEEAVAWLeKAAELNPQEIEPALALAQYY 577

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075424    216 ESLEFWDQADYCYNRAVSAKPPNKSelkkYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIY 287
Cdd:TIGR02917  578 LGKGQLKKALAILNEAADAAPDSPE----AWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAY 645
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
402-600 2.04e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAWgMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG0457   48 LGLAYLRLGRYEEALADYEQALELDPDDAE-ALNNLGLALQALGRYEEALEDYDKALELDP-DDAEALYNLGLALLELGR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  482 YEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRNINELEREQSQNEDHEKNVGSQLFVGNQKV 561
Cdd:COG0457  126 YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 19075424  562 PQDKWEKRARISRSKEEARQFTIWKTEETQRRFHKLDIL 600
Cdd:COG0457  206 ALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
142-306 6.95e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 6.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG0457   17 AYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG----RYEEALADYEQALELDPDDAEALNNLGLALQALGRY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  222 DQADYCYNRAVSAKPpnksELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQFE 301
Cdd:COG0457   93 EEALEDYDKALELDP----DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168


                 ....*
gi 19075424  302 IAWKY 306
Cdd:COG0457  169 KLEAA 173
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 135-322 3.44e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 3.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  135 MLSLAnHLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGNGrvniEKCLIAWMAAAHLKPKDHELWFTCAKL 214
Cdd:COG2956   79 LLELA-QDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW----EKAIEVLERLLKLGPENAHAYCELAEL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  215 SESLEFWDQADYCYNRAVSAKPpnksELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPR 294
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKLDP----DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE 229

                        170       180
                 ....*....|....*....|....*...
gi 19075424  295 EILKQFEIAWKyfyQYPAPPIGNDIFDL 322
Cdd:COG2956  230 EALELLRKALE---LDPSDDLLLALADL 254
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 374-529 3.91e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 3.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  374 ERRREFPNASEEHTNKEAyLLPHLFRTKLGIAR--LKTGELPEAELHFSVIKNLPPDYAwGMLYDIAKAYMDIERLDLAL 451
Cdd:COG2956   53 RRRGEYDRAIRIHQKLLE-RDPDRAEALLELAQdyLKAGLLDRAEELLEKLLELDPDDA-EALRLLAEIYEQEGDWEKAI 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075424  452 EYFVLICNHEPaQNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQ 529
Cdd:COG2956  131 EVLERLLKLGP-ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
402-521 6.60e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.71  E-value: 6.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAWGmLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEA-LYNLGLAYLRLGRYEEALADYEQALELDP-DDAEALNNLGLALQALGR 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 19075424  482 YEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALE 521
Cdd:COG0457   92 YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIE 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 135-312 1.95e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  135 MLSLANhLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKL 214
Cdd:COG2956   45 HLALGN-LYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG----LLDRAEELLEKLLELDPDDAEALRLLAEI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  215 SESLEFWDQADYCYNRAVSAKPPNkselKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPR 294
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLKLGPEN----AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                        170
                 ....*....|....*...
gi 19075424  295 EILKQFEIAWKYFYQYPA 312
Cdd:COG2956  196 EAIAALERALEQDPDYLP 213
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 384-521 8.21e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 8.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  384 EEHTNKEAYLLPHLFRTKLGIARLKTGELPEAELHFSVIKNLPPDYAWGmLYDIAKAYMDIERLDLALEYFVLICNHEPA 463
Cdd:COG3914   66 EAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEA-LFNLGNLLLALGRLEEALAALRRALALNPD 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19075424  464 qNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALE 521
Cdd:COG3914  145 -FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIA 201
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 142-303 1.68e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG2956   17 NYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRG----EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  222 DQADYCYNRAVSAKPPNKSELKKYIwnrsVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQFE 301
Cdd:COG2956   93 DRAEELLEKLLELDPDDAEALRLLA----EIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALE 168


                 ..
gi 19075424  302 IA 303
Cdd:COG2956  169 KA 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 399-536 9.90e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 9.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  399 RTKLGIARLKTGELPEAELHFSVIKNLPPDYAWgMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLE 478
Cdd:COG2956  113 LRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH-AYCELAELYLEQGDYDEAIEALEKALKLDP-DCARALLLLAELYLE 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19075424  479 LKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRNINEL 536
Cdd:COG2956  191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 395-532 2.06e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  395 PHLFRTKLGIARL--KTGELPEAELHFSVIKNLPPDYAWgMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNM 472
Cdd:COG2956   39 PETVEAHLALGNLyrRRGEYDRAIRIHQKLLERDPDRAE-ALLELAQDYLKAGLLDRAEELLEKLLELDP-DDAEALRLL 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  473 GVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEIVTNIFEQRRN 532
Cdd:COG2956  117 AEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPD 176
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 402-493 2.80e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAwGMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG3914  118 LGNLLLALGRLEEALAALRRALALNPDFA-EAYLNLGEALRRLGRLEEAIAALRRALELDP-DNAEALNNLGNALQDLGR 195

                         90
                 ....*....|..
gi 19075424  482 YEHAQQCMEAIL 493
Cdd:COG3914  196 LEEAIAAYRRAL 207
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 430-522 2.92e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.69  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  430 AWGMLydiAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEI 509
Cdd:COG4235   19 GWLLL---GRAYLRLGRYDEALAAYEKALRLDP-DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLA 94

                         90
                 ....*....|...
gi 19075424  510 NELQDNRDAALEI 522
Cdd:COG4235   95 AFQQGDYAEAIAA 107
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
141-312 3.17e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  141 HLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEF 220
Cdd:COG0457   50 LAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG----RYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  221 WDQADYCYNRAVSAKPPNKSELKkyiwNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQF 300
Cdd:COG0457  126 YDEAIEAYERALELDPDDADALY----NLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLL 201

                        170
                 ....*....|..
gi 19075424  301 EIAWKYFYQYPA 312
Cdd:COG0457  202 ALEQALRKKLAI 213
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 434-522 3.67e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  434 LYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQ 513
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDP-DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85


                 ....*....
gi 19075424  514 DNRDAALEI 522
Cdd:COG4783   86 GDYDEALAL 94
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 138-236 7.55e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 7.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  138 LANHLFAQeGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGNgrvnIEKCLIAWMAAAHLKPKDHELWFTCAKLSES 217
Cdd:COG3914  118 LGNLLLAL-GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGR----LEEAIAALRRALELDPDNAEALNNLGNALQD 192

                         90
                 ....*....|....*....
gi 19075424  218 LEFWDQADYCYNRAVSAKP 236
Cdd:COG3914  193 LGRLEEAIAAYRRALELDP 211
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 135-551 8.17e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 8.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    135 MLSLAnHLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKL 214
Cdd:TIGR02917  162 KLGLA-QLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLG----NIELALAAYRKAIALRPNNIAVLLALATI 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    215 SESLEFWDQADYcYNRAVSAKPPNKSELKKYiwnRSVLNKEHGSLKKAAEGFKFLLQSSP--YNASILKNLAEIYikiha 292
Cdd:TIGR02917  237 LIEAGEFEEAEK-HADALLKKAPNSPLAHYL---KALVDFQKKNYEDARETLQDALKSAPeyLPALLLAGASEYQ----- 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    293 preiLKQFEIAWKYFYQY--PAPPigndifDLPTLNLYAELLLLDHQWSNLIRLINRGVR------WFRGRKSESFWdef 364
Cdd:TIGR02917  308 ----LGNLEQAYQYLNQIlkYAPN------SHQARRLLASIQLRLGRVDEAIATLSPALGldpddpAALSLLGEAYL--- 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    365 dddREWDVDERRREFPNASEEHTNKEAYllphlfRTKLGIARLKTGELPEAELHFSVIKNLPPDYAWGMLYdIAKAYMDI 444
Cdd:TIGR02917  375 ---ALGDFEKAAEYLAKATELDPENAAA------RTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLL-LILSYLRS 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    445 ERLDLALEYFVLICNHEPAqNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAAL---- 520
Cdd:TIGR02917  445 GQFDKALAAAKKLEKKQPD-NASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIqrfe 523

                          410       420       430
                   ....*....|....*....|....*....|.
gi 19075424    521 EIVTNIFEQRRNINELEREQSQNEDHEKNVG 551
Cdd:TIGR02917  524 KVLTIDPKNLRAILALAGLYLRTGNEEEAVA 554
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 129-274 9.32e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 9.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  129 SVEVQQMLSLANHLFaQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELW 208
Cdd:COG4783    1 AACAEALYALAQALL-LAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG----DLDEAIVLLHEALELDPDEPEAR 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19075424  209 FTCAKLSESLEFWDQADYCYNRAVSAKPPNKSelkkYIWNRSVLNKEHGSLKKAAEGFKFLLQSSP 274
Cdd:COG4783   76 LNLGLALLKAGDYDEALALLEKALKLDPEHPE----AYLRLARAYRALGRPDEAIAALEKALELDP 137
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 391-522 1.17e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  391 AYLLPHLFRTKLGIARLKTGELPEAELHFSVIKNLPPDYAWGMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWY 470
Cdd:COG5010   14 LLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDP-NNPELYY 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19075424  471 NMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEI 522
Cdd:COG5010   93 NLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 399-521 1.27e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  399 RTKLGIARLKTGELPEAELHFSVIKNLPPDYAWGmLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLE 478
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEA-FALLGEILLQLGDLDEAIVLLHEALELDP-DEPEARLNLGLALLK 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 19075424  479 LKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALE 521
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
160-303 1.81e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  160 VRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFWDQADYCYNRAVSAKPpnk 239
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLG----RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP--- 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19075424  240 sELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIYIKIHAPREILKQFEIA 303
Cdd:COG0457   74 -DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 141-238 2.53e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  141 HLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGNgrvnIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEF 220
Cdd:COG4783   46 EILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD----YDEALALLEKALKLDPEHPEAYLRLARAYRALGR 121

                         90
                 ....*....|....*...
gi 19075424  221 WDQADYCYNRAVSAKPPN 238
Cdd:COG4783  122 PDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
440-521 3.74e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  440 AYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKEYEHAQQCMEAILIvDNSNTNALIKLAEINELQDNRDAA 519
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDP-DNADALNNLGLLLLEQGRYDEAIALEKALKL-DPNNAEALLNLAELLLELGDYDEA 78


                 ..
gi 19075424  520 LE 521
Cdd:COG3063   79 LA 80
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 133-287 5.44e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.47  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  133 QQMLSLANHLFAQeGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKD-HELWFTC 211
Cdd:cd24142    1 DELLEKAEELLDQ-GNFELALKFLQRALELEPNNVEALELLGEILLELG----DVEEAREVLLRAIELDPDGgYEKYLYL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075424  212 AKLS---ESLEfwdqadyCYNRAVSAkppnkseLKKYIwnrSVLNKEHGSLKKAAEGFKFLLqsspynASILKNLAEIY 287
Cdd:cd24142   76 GQLSggeEALQ-------YYEKGIEI-------LEEEL---QALQAASAEAEEEAEELKRKL------SSALCALAEIY 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
427-521 1.11e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  427 PDYAWGmLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKL 506
Cdd:COG0457    5 PDDAEA-YNNLGLAYRRLGRYEEAIEDYEKALELDP-DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                         90
                 ....*....|....*
gi 19075424  507 AEINELQDNRDAALE 521
Cdd:COG0457   83 GLALQALGRYEEALE 97
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 141-301 4.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  141 HLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEF 220
Cdd:COG2956  118 EIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG----DYDEAIEALEKALKLDPDCARALLLLAELYLEQGD 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  221 WDQADYCYNRAVSAKPPNKSELKKYIWnrsvLNKEHGSLKKAAEGFKFLLQSSPYNASILkNLAEIYIKIHAPREILKQF 300
Cdd:COG2956  194 YEEAIAALERALEQDPDYLPALPRLAE----LYEKLGDPEEALELLRKALELDPSDDLLL-ALADLLERKEGLEAALALL 268


                 .
gi 19075424  301 E 301
Cdd:COG2956  269 E 269
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
142-236 6.22e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 6.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKClIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQG----RYDEA-IALEKALKLDPNNAEALLNLAELLLELGDY 75

                         90
                 ....*....|....*
gi 19075424  222 DQADYCYNRAVSAKP 236
Cdd:COG3063   76 DEALAYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 142-236 7.58e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 7.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  142 LFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTCAKLSESLEFW 221
Cdd:COG5010   63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG----DKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQD 138

                         90
                 ....*....|....*
gi 19075424  222 DQADYCYNRAVSAKP 236
Cdd:COG5010  139 DEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 402-512 1.18e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  402 LGIARLKTGELPEAELHFSVIKNLPPDYAwGMLYDIAKAYMDIERLDLALEYFVLICNHEPaQNIGLWYNMGVCYLELKE 481
Cdd:COG4235   23 LGRAYLRLGRYDEALAAYEKALRLDPDNA-DALLDLAEALLAAGDTEEAEELLERALALDP-DNPEALYLLGLAAFQQGD 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 19075424  482 YEHAQQCMEAILIVDNSNTNALIKLAEINEL 512
Cdd:COG4235  101 YAEAIAAWQKLLALLPADAPARLLEASIAEA 131
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 404-493 4.07e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.05  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  404 IARLKTGELPEAELHF-SVIKNLPPD-YAWGMLYDIAKAYMDIERLDLALEYFVLICNHEPAQNIGL--WYNMGVCYLEL 479
Cdd:COG1729    1 KALLKAGDYDEAIAAFkAFLKRYPNSpLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPdaLLKLGLSYLEL 80

                         90
                 ....*....|....
gi 19075424  480 KEYEHAQQCMEAIL 493
Cdd:COG1729   81 GDYDKARATLEELI 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 132-238 4.07e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.45  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424  132 VQQMLSLANHLFAQeGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGngrvNIEKCLIAWMAAAHLKPKDHELWFTC 211
Cdd:COG4235   17 AEGWLLLGRAYLRL-GRYDEALAAYEKALRLDPDNADALLDLAEALLAAG----DTEEAEELLERALALDPDNPEALYLL 91

                         90       100
                 ....*....|....*....|....*..
gi 19075424  212 AKLSESLEFWDQADYCYNRAVSAKPPN 238
Cdd:COG4235   92 GLAAFQQGDYAEAIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 137-287 4.90e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 4.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075424    137 SLANhLFAQEGNFDEAQKLAEEIVRIDNNVIAAWKMLGECHRQRGNgrvniEKCLIAWM-AAAHLKPKDHELWFTCAKLS 215
Cdd:TIGR02917  504 NLAR-IDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGN-----EEEAVAWLeKAAELNPQEIEPALALAQYY 577

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075424    216 ESLEFWDQADYCYNRAVSAKPPNKSelkkYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKNLAEIY 287
Cdd:TIGR02917  578 LGKGQLKKALAILNEAADAAPDSPE----AWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAY 645
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 464-522 4.93e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 4.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19075424  464 QNIGLWYNMGVCYLELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAALEI 522
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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