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Conserved domains on  [gi|19075782|ref|NP_588282|]
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chitin synthase regulatory factor [Schizosaccharomyces pombe]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
226-448 1.92e-35

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.92e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 226 ALYLLAVCYGTGALRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMHRMAL 305
Cdd:COG0790  28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 306 IYFRGLmSVKRDPVKAMYYLNLGAlEADHefPQALYDLAELYEHGssyldGLLELSPRKAFVLYHIAAKYGLKDAQLRVA 385
Cdd:COG0790 108 MYEEGL-GVPQDYAKALEWYEKAA-EQGD--ADAQYNLGLLYLNG-----EGVPKDPAKAAEWYRKAAEQGDADAQYNLG 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075782 386 RCFELGQlECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGvdDVIYPNPELANEWAKAAA 448
Cdd:COG0790 179 VLYENGR-GVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNG--EGVEKDLEKALRWLRKAA 238
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
226-448 1.92e-35

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.92e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 226 ALYLLAVCYGTGALRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMHRMAL 305
Cdd:COG0790  28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 306 IYFRGLmSVKRDPVKAMYYLNLGAlEADHefPQALYDLAELYEHGssyldGLLELSPRKAFVLYHIAAKYGLKDAQLRVA 385
Cdd:COG0790 108 MYEEGL-GVPQDYAKALEWYEKAA-EQGD--ADAQYNLGLLYLNG-----EGVPKDPAKAAEWYRKAAEQGDADAQYNLG 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075782 386 RCFELGQlECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGvdDVIYPNPELANEWAKAAA 448
Cdd:COG0790 179 VLYENGR-GVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNG--EGVEKDLEKALRWLRKAA 238
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 261-293 2.44e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 2.44e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19075782   261 VQAAYRVAICLQMGFGVTQNTEEAIHYFFRAAS 293
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 261-296 1.40e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.08  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19075782    261 VQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQH 296
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
226-448 1.92e-35

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.92e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 226 ALYLLAVCYGTGALRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMHRMAL 305
Cdd:COG0790  28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 306 IYFRGLmSVKRDPVKAMYYLNLGAlEADHefPQALYDLAELYEHGssyldGLLELSPRKAFVLYHIAAKYGLKDAQLRVA 385
Cdd:COG0790 108 MYEEGL-GVPQDYAKALEWYEKAA-EQGD--ADAQYNLGLLYLNG-----EGVPKDPAKAAEWYRKAAEQGDADAQYNLG 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075782 386 RCFELGQlECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGvdDVIYPNPELANEWAKAAA 448
Cdd:COG0790 179 VLYENGR-GVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNG--EGVEKDLEKALRWLRKAA 238
TPR COG0790
TPR repeat [General function prediction only];
222-412 4.64e-34

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.51  E-value: 4.64e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 222 GYSEALYLLAVCYGTGaLRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMH 301
Cdd:COG0790  61 GGAEAQYNLGLMYAEG-RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQY 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 302 RMALIYFRGlMSVKRDPVKAMYYLNLGAlEADHefPQALYDLAELYEHGSSyldglLELSPRKAFVLYHIAAKYGLKDAQ 381
Cdd:COG0790 140 NLGLLYLNG-EGVPKDPAKAAEWYRKAA-EQGD--ADAQYNLGVLYENGRG-----VPKDPAKALEWYRKAAEQGDADAQ 210

                       170       180       190
                ....*....|....*....|....*....|.
gi 19075782 382 LRVARCFELGQlECDINLVRSFVWYRRLARK 412
Cdd:COG0790 211 YNLGRLYLNGE-GVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
194-374 2.99e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 112.71  E-value: 2.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 194 RNREYVARKKEEAFDYLTSFVSQGNSffgysEALYLLAVCYGTGaLRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQM 273
Cdd:COG0790  74 AEGRGVPKDYEKALEWFEKAAEQGDA-----EAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLN 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 274 GFGVTQNTEEAIHYFFRAASGQHVGAMHRMALIYFRGLmSVKRDPVKAMYYLNLGAlEADHefPQALYDLAELYEHGSSy 353
Cdd:COG0790 148 GEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR-GVPKDPAKALEWYRKAA-EQGD--ADAQYNLGRLYLNGEG- 222

                       170       180
                ....*....|....*....|.
gi 19075782 354 ldglLELSPRKAFVLYHIAAK 374
Cdd:COG0790 223 ----VEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
199-332 1.34e-21

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 93.84  E-value: 1.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 199 VARKKEEAFDYLTSFVSQGNSffgysEALYLLAVCYGTGALrTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVT 278
Cdd:COG0790 115 VPQDYAKALEWYEKAAEQGDA-----DAQYNLGLLYLNGEG-VPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVP 188

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19075782 279 QNTEEAIHYFFRAASGQHVGAMHRMALIYFRGLmSVKRDPVKAMYYLNLGALEA 332
Cdd:COG0790 189 KDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE-GVEKDLEKALRWLRKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
291-455 5.68e-17

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 80.36  E-value: 5.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 291 AASGQHVGAMHRMALIYFRGLMSVKRDPVKAMYYLNLGALEADHEFPQALYDLAELYEHGSSyldglLELSPRKAFVLYH 370
Cdd:COG0790  17 ALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRG-----VPKDYEKALEWFE 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 371 IAAKYGLKDAQLRVARCFELGqLECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGvdDVIYPNPELANEWAKAAAYK 450
Cdd:COG0790  92 KAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDPAKAAEWYRKAAEQ 168


                ....*
gi 19075782 451 NHHLA 455
Cdd:COG0790 169 GDADA 173
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 261-293 2.44e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 2.44e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19075782   261 VQAAYRVAICLQMGFGVTQNTEEAIHYFFRAAS 293
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 225-381 7.04e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 7.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 225 EALYLLAVCYgtgaLRTEiNEKEAYRLYKMAADLNHVQAAYRVAicLQMGFGVTQNTEEAIHYFFRA--ASGQHVGAMHR 302
Cdd:COG2956 111 EALRLLAEIY----EQEG-DWEKAIEVLERLLKLGPENAHAYCE--LAELYLEQGDYDEAIEALEKAlkLDPDCARALLL 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 303 MALIYFRglmsvKRDPVKAMYYLNLgALEADHEFPQALYDLAELYEH------GSSYLDGLLELSPRKAFVLY---HIAA 373
Cdd:COG2956 184 LAELYLE-----QGDYEEAIAALER-ALEQDPDYLPALPRLAELYEKlgdpeeALELLRKALELDPSDDLLLAladLLER 257


                ....*...
gi 19075782 374 KYGLKDAQ 381
Cdd:COG2956 258 KEGLEAAL 265
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 261-296 1.40e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.08  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19075782    261 VQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQH 296
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 224-260 2.41e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 38.31  E-value: 2.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19075782    224 SEALYLLAVCYGTGaLRTEINEKEAYRLYKMAADLNH 260
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
223-455 3.30e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 3.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 223 YSEALYLLAVCYgtgalrTEINE-KEAYRLYKMAADLN--HVQAAYRVAICLQMgfgvTQNTEEAIHYFFRAAS--GQHV 297
Cdd:COG0457   7 DAEAYNNLGLAY------RRLGRyEEAIEDYEKALELDpdDAEALYNLGLAYLR----LGRYEEALADYEQALEldPDDA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 298 GAMHRMALIYFRglmsvKRDPVKAMYYLNLgALEADHEFPQALYDLAEL------YEHGSSYLDGLLELSPRKAFVLYHI 371
Cdd:COG0457  77 EALNNLGLALQA-----LGRYEEALEDYDK-ALELDPDDAEALYNLGLAllelgrYDEAIEAYERALELDPDDADALYNL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075782 372 AAKYG----LKDAQLRVARCFELGQLECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGVDDVIYPNPELANEWAKAA 447
Cdd:COG0457 151 GIALEklgrYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALL 230


                ....*...
gi 19075782 448 AYKNHHLA 455
Cdd:COG0457 231 LALRLAAL 238
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 299-329 1.19e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.35  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19075782   299 AMHRMALIYFRGLMsVKRDPVKAMYYLNLGA 329
Cdd:pfam08238   3 AQYRLGYLYLYGLG-VPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 415-452 1.85e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.00  E-value: 1.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19075782    415 PEAMWKLSQFYLNGvdDVIYPNPELANEWAKAAAYKNH 452
Cdd:smart00671   1 AEAQYNLGQMYEYG--LGVPKDLEKALEYYKKAAELGN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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