NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19075819|ref|NP_588319|]
View 

protein Mic26 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ApoO super family cl10749
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 22-134 3.32e-14

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


The actual alignment was detected with superfamily member pfam09769:

Pssm-ID: 462891  Cd Length: 131  Bit Score: 65.65  E-value: 3.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075819    22 WLADRIHEGRSSIFHALGYVGLKTENAFGWFLSTERKTISTAkNEVFSSDERKLPGVAYVVVGGMAGNIFARNRIAPARW 101
Cdd:pfam09769  15 RLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTI-ASLAPPPEDLLPGLIYILVAGLAGSILARRRSILKRF 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 19075819   102 LITSLSTAATFMFCFPKTSKNIGAFV----EKRFPAI 134
Cdd:pfam09769  94 AYPLAFGGAAASYFLPQTFRNTGDLLwkyeQEKFPAV 130
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 22-134 3.32e-14

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 65.65  E-value: 3.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075819    22 WLADRIHEGRSSIFHALGYVGLKTENAFGWFLSTERKTISTAkNEVFSSDERKLPGVAYVVVGGMAGNIFARNRIAPARW 101
Cdd:pfam09769  15 RLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTI-ASLAPPPEDLLPGLIYILVAGLAGSILARRRSILKRF 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 19075819   102 LITSLSTAATFMFCFPKTSKNIGAFV----EKRFPAI 134
Cdd:pfam09769  94 AYPLAFGGAAASYFLPQTFRNTGDLLwkyeQEKFPAV 130
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 22-134 3.32e-14

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 65.65  E-value: 3.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075819    22 WLADRIHEGRSSIFHALGYVGLKTENAFGWFLSTERKTISTAkNEVFSSDERKLPGVAYVVVGGMAGNIFARNRIAPARW 101
Cdd:pfam09769  15 RLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTI-ASLAPPPEDLLPGLIYILVAGLAGSILARRRSILKRF 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 19075819   102 LITSLSTAATFMFCFPKTSKNIGAFV----EKRFPAI 134
Cdd:pfam09769  94 AYPLAFGGAAASYFLPQTFRNTGDLLwkyeQEKFPAV 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH