NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19075823|ref|NP_588323|]
View 

anthranilate synthase component I [Schizosaccharomyces pombe]

Protein Classification

anthranilate synthase component I family protein( domain architecture ID 1006716)

anthranilate synthase component I family protein similar to the component I of anthranilate synthase and aminodeoxychorismate synthase, which are part of complexes that catalyze the two-step biosynthesis of anthranilate and 4-amino-4-deoxychorismate (ADC), respectively

CATH:  3.60.120.10
Gene Ontology:  GO:0046872|GO:0000162
PubMed:  11450855|16042594

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13566 super family cl47121
anthranilate synthase component I;
30-475 0e+00

anthranilate synthase component I;


The actual alignment was detected with superfamily member TIGR00564:

Pssm-ID: 481461 [Multi-domain]  Cd Length: 454  Bit Score: 577.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    30 ADMLTPSVAYLKLnqGKKYSFILESVTQGESVSRYSFIG-SPYRILMANGKT--------------DPLARLERELKEVK 94
Cdd:TIGR00564   1 ADTLTPISAYLKL--AQPGSFLLESAEPGSERGRYSFIGlNPVLTIKTEGGTeylgaddrrsgivgNPLDEIRDVMETFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    95 TAPVEGLP-SFSGGAVGYVSYDCIKYFEPTTEmPLEDTLGLPEAMFFMTDDLVAFDHAYQTVKIISHVCIQQGRPIEEAY 173
Cdd:TIGR00564  79 QHSDPELPiPFTGGAVGYLGYDTVRLFEKITL-PPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNRTTASRSAKAAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   174 EAAVFKINMLKKKLESPEIPLPEQKKVHLGyeakSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYR 253
Cdd:TIGR00564 158 DARLEALVADLQDPLLPEVPVPYPAALSFT----SNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   254 HLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLAR 333
Cdd:TIGR00564 234 VLRIVNPSPYMYYLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   334 NDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYA 413
Cdd:TIGR00564 314 NDIGRVCEPGSVEVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYG 393

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075823   414 GAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:TIGR00564 394 GAVGYLSF-DGDMDTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
 
Name Accession Description Interval E-value
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 30-475 0e+00

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 577.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    30 ADMLTPSVAYLKLnqGKKYSFILESVTQGESVSRYSFIG-SPYRILMANGKT--------------DPLARLERELKEVK 94
Cdd:TIGR00564   1 ADTLTPISAYLKL--AQPGSFLLESAEPGSERGRYSFIGlNPVLTIKTEGGTeylgaddrrsgivgNPLDEIRDVMETFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    95 TAPVEGLP-SFSGGAVGYVSYDCIKYFEPTTEmPLEDTLGLPEAMFFMTDDLVAFDHAYQTVKIISHVCIQQGRPIEEAY 173
Cdd:TIGR00564  79 QHSDPELPiPFTGGAVGYLGYDTVRLFEKITL-PPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNRTTASRSAKAAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   174 EAAVFKINMLKKKLESPEIPLPEQKKVHLGyeakSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYR 253
Cdd:TIGR00564 158 DARLEALVADLQDPLLPEVPVPYPAALSFT----SNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   254 HLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLAR 333
Cdd:TIGR00564 234 VLRIVNPSPYMYYLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   334 NDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYA 413
Cdd:TIGR00564 314 NDIGRVCEPGSVEVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYG 393

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075823   414 GAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:TIGR00564 394 GAVGYLSF-DGDMDTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 21-476 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 555.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  21 KIPIYGVIPAdMLTPSVAYLKLNQGKkYSFILESVTQGESVSRYSFIGS-PYRILMANGKT--------------DPLAR 85
Cdd:COG0147   2 RIPVYRELLA-LETPVSLFLKLADGP-YAFLLESAEGGEKWGRYSFIGAdPLATLTVRGGRvtiegggevepsegDPLDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  86 LERELKEVKTAPVEGLPSFSGGAVGYVSYDCIKYFEPTTEMPlEDTLGLPEAMFFMTDDLVAFDHAYQTVkiishvciqq 165
Cdd:COG0147  80 LRALLARFRLPPLPGLPPFTGGLVGYFGYDLVRYFERLPDLA-PDDLGLPDAALGLYDRLLVFDHLKGTR---------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 166 grpieeayeaavfkinmlkkklespeiplpeqkkvhlgyeakSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTD 245
Cdd:COG0147 149 ------------------------------------------SNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFE 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 246 LHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEH 325
Cdd:COG0147 187 GDPLALYRALRRINPSPYMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEH 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 326 VMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLE 405
Cdd:COG0147 267 LMLVDLARNDLGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELE 346

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075823 406 KEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEE 476
Cdd:COG0147 347 PTRRGVYGGAVGYLSF-DGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 5-480 1.97e-156

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 454.10  E-value: 1.97e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    5 PDLKQVQELAEKHKAnkIPIYGVIPADMLTPSVAYLKLNQGKKYSFILESVTQGESVSRYSFIG--SPYRILMANGKT-- 80
Cdd:PRK13571   8 TSREDFRALAAEHRV--VPVTRKVLADSETPVGAYRKLAANRPGTFLLESAENGRSWSRWSFIGvgSPAALTVRDGEAvw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   81 ------------DPLARLERELKEVKTAPVEGLPSFSGGAVGYVSYDCIKYFEPTTEMPlEDTLGLPEAMFFMTDDLVAF 148
Cdd:PRK13571  86 lgtppagaptggDPLAALRATLELLATPRLPGLPPLTGGMVGFLGYDAVRRLERLPELA-VDDLGLPEMLLLLATDLAAV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  149 DHAYQTVKIISHVCIQQGRP--IEEAYEAAVFKINMLKKKLESPEIPLPEQKKVHLGyEAKSNVGEDGYKAFVSNLKEHI 226
Cdd:PRK13571 165 DHHEGTITLIANAVNWNGTDerVDAAYDDAVARLDVMTAALAQPLPSTVATFSRPVP-EFRAQRTVEEFGAAVEKLVEEI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  227 FNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCD------DFDIIGASPELLVKSEHGRIINHPIAGTVP 300
Cdd:PRK13571 244 RAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPSPYMYLLRVPnsdggtDFSIVGSSPEALVTVTDGRATTHPIAGTRW 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  301 RGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAF 380
Cdd:PRK13571 324 RGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAV 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  381 RSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVgrwGYED--DNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQD 458
Cdd:PRK13571 404 TACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVV---GYLDfaGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDY 480

                        490       500
                 ....*....|....*....|..
gi 19075823  459 EYVETLNKLRSNVTAIEETEKL 480
Cdd:PRK13571 481 EDNEARNKAAAVLRAIAAAETL 502
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 213-466 2.53e-123

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 360.33  E-value: 2.53e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   213 DGYKAFVSNLKEHIFNGDIFQAVPSQRIARR--TDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRI 290
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPlaGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   291 INHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVL 370
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   371 RPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGI 450
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDP-DGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 19075823   451 VFDSDEQDEYVETLNK 466
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
 
Name Accession Description Interval E-value
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 30-475 0e+00

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 577.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    30 ADMLTPSVAYLKLnqGKKYSFILESVTQGESVSRYSFIG-SPYRILMANGKT--------------DPLARLERELKEVK 94
Cdd:TIGR00564   1 ADTLTPISAYLKL--AQPGSFLLESAEPGSERGRYSFIGlNPVLTIKTEGGTeylgaddrrsgivgNPLDEIRDVMETFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    95 TAPVEGLP-SFSGGAVGYVSYDCIKYFEPTTEmPLEDTLGLPEAMFFMTDDLVAFDHAYQTVKIISHVCIQQGRPIEEAY 173
Cdd:TIGR00564  79 QHSDPELPiPFTGGAVGYLGYDTVRLFEKITL-PPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNRTTASRSAKAAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   174 EAAVFKINMLKKKLESPEIPLPEQKKVHLGyeakSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYR 253
Cdd:TIGR00564 158 DARLEALVADLQDPLLPEVPVPYPAALSFT----SNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   254 HLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLAR 333
Cdd:TIGR00564 234 VLRIVNPSPYMYYLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   334 NDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYA 413
Cdd:TIGR00564 314 NDIGRVCEPGSVEVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYG 393

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075823   414 GAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:TIGR00564 394 GAVGYLSF-DGDMDTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 21-476 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 555.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  21 KIPIYGVIPAdMLTPSVAYLKLNQGKkYSFILESVTQGESVSRYSFIGS-PYRILMANGKT--------------DPLAR 85
Cdd:COG0147   2 RIPVYRELLA-LETPVSLFLKLADGP-YAFLLESAEGGEKWGRYSFIGAdPLATLTVRGGRvtiegggevepsegDPLDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  86 LERELKEVKTAPVEGLPSFSGGAVGYVSYDCIKYFEPTTEMPlEDTLGLPEAMFFMTDDLVAFDHAYQTVkiishvciqq 165
Cdd:COG0147  80 LRALLARFRLPPLPGLPPFTGGLVGYFGYDLVRYFERLPDLA-PDDLGLPDAALGLYDRLLVFDHLKGTR---------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 166 grpieeayeaavfkinmlkkklespeiplpeqkkvhlgyeakSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTD 245
Cdd:COG0147 149 ------------------------------------------SNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFE 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 246 LHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEH 325
Cdd:COG0147 187 GDPLALYRALRRINPSPYMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEH 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 326 VMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLE 405
Cdd:COG0147 267 LMLVDLARNDLGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELE 346

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075823 406 KEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEE 476
Cdd:COG0147 347 PTRRGVYGGAVGYLSF-DGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 5-480 1.97e-156

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 454.10  E-value: 1.97e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    5 PDLKQVQELAEKHKAnkIPIYGVIPADMLTPSVAYLKLNQGKKYSFILESVTQGESVSRYSFIG--SPYRILMANGKT-- 80
Cdd:PRK13571   8 TSREDFRALAAEHRV--VPVTRKVLADSETPVGAYRKLAANRPGTFLLESAENGRSWSRWSFIGvgSPAALTVRDGEAvw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   81 ------------DPLARLERELKEVKTAPVEGLPSFSGGAVGYVSYDCIKYFEPTTEMPlEDTLGLPEAMFFMTDDLVAF 148
Cdd:PRK13571  86 lgtppagaptggDPLAALRATLELLATPRLPGLPPLTGGMVGFLGYDAVRRLERLPELA-VDDLGLPEMLLLLATDLAAV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  149 DHAYQTVKIISHVCIQQGRP--IEEAYEAAVFKINMLKKKLESPEIPLPEQKKVHLGyEAKSNVGEDGYKAFVSNLKEHI 226
Cdd:PRK13571 165 DHHEGTITLIANAVNWNGTDerVDAAYDDAVARLDVMTAALAQPLPSTVATFSRPVP-EFRAQRTVEEFGAAVEKLVEEI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  227 FNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCD------DFDIIGASPELLVKSEHGRIINHPIAGTVP 300
Cdd:PRK13571 244 RAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPSPYMYLLRVPnsdggtDFSIVGSSPEALVTVTDGRATTHPIAGTRW 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  301 RGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAF 380
Cdd:PRK13571 324 RGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAV 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  381 RSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVgrwGYED--DNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQD 458
Cdd:PRK13571 404 TACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVV---GYLDfaGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDY 480

                        490       500
                 ....*....|....*....|..
gi 19075823  459 EYVETLNKLRSNVTAIEETEKL 480
Cdd:PRK13571 481 EDNEARNKAAAVLRAIAAAETL 502
TrpE-arch TIGR01820
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ...
 35-475 1.24e-140

anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273819 [Multi-domain]  Cd Length: 435  Bit Score: 411.37  E-value: 1.24e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    35 PSVAYLKLNQGKKYSFILESVTQGESVSRYSFIG-SPYRILMANGKT----------DPLARLERELKEVKTAPV-EGLP 102
Cdd:TIGR01820   1 PLELYKAIRADGDYAFLLESAEKPSKKARYSFIGwDPEFVVRINGKGksvegipedgDVVDKLRNAFPKLKGINIpGEDR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   103 SFSGGAVGYVSYDCIK-YFEPTTEMPLEDTlGLPEAMFFMTDDLVAFDHAYQTVKIIShvciqqgrpiEEAYEAAVFKIN 181
Cdd:TIGR01820  81 RFKGGLVGYIAYDAVRdYWEGIVDLKRKAE-DWPPAEFFIYPNTIVYDHLEGKVYYVS----------TPEPEAELERIV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   182 MLKKKLESPEiplpeqkkvHLGYEA--KSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVN 259
Cdd:TIGR01820 150 ERAKRATDPG---------EAGVSFegESLSDREEFEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREIN 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   260 PSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRV 339
Cdd:TIGR01820 221 PSPYMFLLKFGDRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKV 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   340 CDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRW 419
Cdd:TIGR01820 301 SEPGSVKVPEFMYVEKYSHVQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYF 380

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19075823   420 GyEDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:TIGR01820 381 S-WNGDADFAIAIRTAEIDKDKLRIQAGAGIVADSIPEREFEETENKMKAVLKAIG 435
PLN02445 PLN02445
anthranilate synthase component I
 18-466 1.08e-138

anthranilate synthase component I


Pssm-ID: 215244 [Multi-domain]  Cd Length: 523  Bit Score: 409.45  E-value: 1.08e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   18 KANKIPIYGVIPADMLTPSVAY---LKLNQGKKYSFILESVTQGE---SVSRYSFIGS-PYR---------ILMANGK-- 79
Cdd:PLN02445   7 GGNLVPLYRRIFSDHLTPVLAYrclVKEDDREAPSFLFESVEPGSqssNVGRYSVVGAqPAMeivakenkvTIMDHEKgt 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   80 ------TDPLARLERELKEVKTAPVEGLP-SFSGGAVGYVSYDCIKYFE----PTTEMPLEDTlGLPEAMFFMTDDLVAF 148
Cdd:PLN02445  87 rteeivEDPMEIPRRISEKWNPQLIDGLPdVFCGGWVGYFSYDTVRYVEkkklPFSGAPEDDR-NLPDIHLGLYDDVIVF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  149 DHAYQTVKIISHVCIQQGRPIEEAYEAAVFKINMLKKKLESPEIP--LPEQKKVHLGYE----AKSNVGEDGYKAFVSNL 222
Cdd:PLN02445 166 DHVEKKAYVIHWVRLDRYSSVEEAYEDGMKRLEALVSRLQDINPPklSPGSVKLSTNQFgpslEKSNMTSEEYKNAVLQA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  223 KEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRG 302
Cdd:PLN02445 246 KEHILAGDIFQIVLSQRFERRTFADPFEVYRALRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRG 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  303 KTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRS 382
Cdd:PLN02445 326 KTPEEDKALEKDLLADEKQCAEHIMLVDLGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRA 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  383 IFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGYEDDnMDTCIAIRTMV------------YKDG------TVYL 444
Cdd:PLN02445 406 ALPVGTVSGAPKVRAMELIDELEVTRRGPYSGGFGGVSFTGD-MDIALALRTMVfptaarydtmysYKDTnsrrewVAHL 484

                        490       500
                 ....*....|....*....|..
gi 19075823  445 QAGGGIVFDSDEQDEYVETLNK 466
Cdd:PLN02445 485 QAGAGIVADSDPEDEYRECVNK 506
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 213-466 2.53e-123

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 360.33  E-value: 2.53e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   213 DGYKAFVSNLKEHIFNGDIFQAVPSQRIARR--TDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRI 290
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPlaGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   291 INHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVL 370
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   371 RPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGI 450
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDP-DGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 19075823   451 VFDSDEQDEYVETLNK 466
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
PRK13564 PRK13564
anthranilate synthase component 1;
90-474 1.42e-103

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 319.09  E-value: 1.42e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   90 LKEVKTAPVEGLPSFSGGAVgyvSYDCIKYFEPTTEMPLEDTLglPEAMFFMTDDLVAFDHAYQTVKIISHvCIQQGRPI 169
Cdd:PRK13564 131 QKLVNTPKEEREALFLGGLF---AYDLVAGFEPLPQLPAGNNC--PDYCFYLAETLLVIDHQKKSARLQAS-LFTPDEEE 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  170 EEAYEAavfKINMLKKKLESPEIPLPEQKKVHLgyEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSqriaRRTDL--- 246
Cdd:PRK13564 205 KQRLAA---RLAQLKQQLTQPAPPLPVTSVPDM--EVSVNISDEEFCAVVRKLKEHIRAGDIFQVVPS----RRFSLpcp 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  247 HPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVK-SEHGRIIN-HPIAGTVPRGKTKE---EDEAYAK---DLLAS 318
Cdd:PRK13564 276 SPLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPESALKyDASSRQVEiYPIAGTRPRGRRADgsiDRDLDSRielELRTD 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  319 VKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAI 398
Cdd:PRK13564 356 HKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAM 435

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075823  399 QLVYGLEKEKRGIYAGAVgrwGY--EDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAI 474
Cdd:PRK13564 436 QLIREVEGQRRGSYGGAV---GYltGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDSDPQSEADETRNKAQAVLRAI 510
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 31-475 3.04e-99

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 305.12  E-value: 3.04e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   31 DMLTPSVAYLKLNQgKKYSFILESVTQGESVSRYSFIGS-PYRILMANGKT-----------DPLarleRELKEVKTAPV 98
Cdd:PRK13572   7 DYVNPLKLYSVLRD-EGYPFILESAEKGQRKARYTYISAnPEFMVRIGNKTkvdgetiskesNPF----KALKENFKITQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   99 EGlPSFSGGAVGYVSYDCIK-YFEPTTEMPledtlglpeAMFFMTDDLVAFDHAYQTVKIISHvciqqGRPIEEAYEAav 177
Cdd:PRK13572  82 SG-DRFTGGFVGYIAYDAVHnYIGGKIEEP---------SVFGYYDHVFVYDHVTRKFYFHSL-----NNNPEELFNA-- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  178 fkiNMLKKKLESPEIPLPEQKKVHLGYEAksnvGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRT 257
Cdd:PRK13572 145 ---EKIVEKAKRFEIEEEDGGSEVLGCDA----DREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLRE 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  258 VNPSPYMFYIHCDDfDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVS 337
Cdd:PRK13572 218 INPSPYMFLLEFDK-DVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVR 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  338 RVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVG 417
Cdd:PRK13572 297 KVSKSGSVRLERFFDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVG 376

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19075823  418 RWGYEdDNMDTCIAIRtMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:PRK13572 377 YFSNS-GNADLAIAIR-MAEIDKVCRVRAGAGIVADSVPEKEFYETERKMAAVLKALG 432
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 51-474 9.39e-98

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 300.96  E-value: 9.39e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   51 ILESVTQGESVSRYSFIGSPYRILMaNGKTDPLARLERELKEVKTAPVEGLpsFSGGAVGYVSYDCIKYFEPTTEMP--L 128
Cdd:PRK13574  28 LLESIGGPQYKARYSVIAWGTNGYL-KIHDDPVNILNSYLKDLKLVDIPGL--FKGGMIGYISYDAVRFWEKIRDLKpaA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  129 EDtlgLPEAMFFMTDDLVAFDHAYQTVKI---ISHV--CIQQGRpieeayeaavFKInmlkkkleSPEIPLPEQKkvhlg 203
Cdd:PRK13574 105 ED---WPYAEFFIPDNIIIYDHNEGKVYVngdLSSVggCGDMGE----------FKI--------SFYDESLNKN----- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  204 yeaksnvgedGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLV 283
Cdd:PRK13574 159 ----------NYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFDERYLIGSSPELLF 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  284 KSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLV 363
Cdd:PRK13574 229 RVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQHIV 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  364 SQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGyEDDNMDTCIAIRT-MVYKDgTV 442
Cdd:PRK13574 309 SKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFIS-ADGNAEFAIAIRTaFLNKD-LL 386

                        410       420       430
                 ....*....|....*....|....*....|..
gi 19075823  443 YLQAGGGIVFDSDEQDEYVETLNKLRSNVTAI 474
Cdd:PRK13574 387 RIQAGAGIVYDSNPESEYFETEHKLRALKTAI 418
PabB-clade2 TIGR01824
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ...
 106-468 1.53e-95

aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.


Pssm-ID: 130883  Cd Length: 355  Bit Score: 292.83  E-value: 1.53e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   106 GGAVGYVSYDCIKYFEPTTEMPLEDTlGLPEAMFFMTDDLVAFDHAYQTVkiisHVCIQQGRPiEEAYEAAVFKINMLKK 185
Cdd:TIGR01824   1 GGRLGWLAYDVARRLEGIPDLGTSDG-GWPVAADFRYEAAVARDHQRQIV----ALATVPAET-EGEFATSSDQLPAVAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   186 --KLESPEIPLPEQKKVHLgyeaksnVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRT--DLHPFNLYRHLRTVNPS 261
Cdd:TIGR01824  75 atSLPSPDVGPLPVDLEAS-------IDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIaaDVDPLQLFLALRAPNPA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   262 PYMFYIHCDDFDIIGASPELLVKSEhGRIIN-HPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVC 340
Cdd:TIGR01824 148 PYAIYLEEPGVDVASASPELFLARE-GRVVQtRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVC 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   341 DLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWG 420
Cdd:TIGR01824 227 ATGTVRVPELCAVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWID 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 19075823   421 YeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLR 468
Cdd:TIGR01824 307 A-DGNADLNILIRTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKAR 353
PRK05940 PRK05940
anthranilate synthase component I;
51-476 1.21e-89

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 281.62  E-value: 1.21e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   51 ILESVTQGES----VSRYSFI-GSPYRILM---ANGKTDPLARLERELKEVKTAPVEGLPsFSGGAVGYVSYDCIKYFEp 122
Cdd:PRK05940  36 LLESPYPTPAdyppLSRYSICaGSPRKPRLwtpKLGEILPFLRQLLARSLDPSALPEHLP-FTGGWLGWLGYDLAWEIE- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  123 ttEMPLE--DTLGLPEAMFFMTDDLVAFDHayqtvkiishvciQQGRPIEEAYEAAvfKINMLKKKLE--SPEIPLPEQK 198
Cdd:PRK05940 114 --RLPHLnpDPLPFPVAYWYEPESFAILDH-------------QEQILWLAASDPS--QLDRLEQQLEqpTPEPDLPLDL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  199 KVHLGyEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGAS 278
Cdd:PRK05940 177 RTPPS-SLIFYTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRRLQQINPSPFASYWRTPWGDVVSCS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  279 PELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSH 358
Cdd:PRK05940 256 PERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEVDELLTIERYSH 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  359 VQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGYEdDNMDTCIAIRTMVY- 437
Cdd:PRK05940 336 VIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQR-GNLDLNILIRTLLYt 414

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 19075823  438 ----KDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEE 476
Cdd:PRK05940 415 plsrGLSTIWGQVGAGIVADSDPEKEWLESLQKAKAQLAALNL 457
trpE_proteo TIGR00565
anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other ...
 88-477 2.71e-89

anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes proteobacteria such as E. coli and Helicobacter pylori but also the gram-positive organism Corynebacterium glutamicum. The second group includes eukaryotes, archaea, and most other bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from this group. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273143 [Multi-domain]  Cd Length: 498  Bit Score: 281.78  E-value: 2.71e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    88 RELKEVKTAPVEGLPSFSGGAVgyvSYDCIKYFEPTTEMPLEDTlGLPEAMFFMTDDLVAFDHAYQTVKIIShVCIQQgr 167
Cdd:TIGR00565 112 RLFKSLKTKPKHPFTLFSGGLF---SYDLVAFFEDLPHLKAKNN-NCPDFIFYLAENLIIIDHQEKSVEILG-ACFAE-- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   168 piEEAYEAAVFKINMLKKKLESPEIPLPEQKKVHLgyEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTdLH 247
Cdd:TIGR00565 185 --RFETQIAQALQDLKELQKSIKSDFVPKKSKQSR--EVSANCSDSEFEGRVLSLQEEIKKGEIFQAVPSRRFSLEC-PE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   248 PFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVK--SEHGRIINHPIAGTVPRGKTK------EEDEAYAKDLLASV 319
Cdd:TIGR00565 260 GLAAYYHLKLTNPSPYMFYMKDSDFILFGASPESALKynALTRQAEIYPIAGTRPRGKDAqgnidyDLDSRMELELRHDH 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   320 KDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQ 399
Cdd:TIGR00565 340 KERAEHLMLVDLARNDMARVCKSGKRYVAKLLKVDRYSNVMHLVSRVVGELRKGLDALHAYRACMNMGTLSGAPKISAMQ 419

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075823   400 LVYGLEKEKRGIYAGAVGRWGYEDDnMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEET 477
Cdd:TIGR00565 420 LIYQLENQRRGSYGGAVGYLTSEGS-MDTCIVIRSAFVKNGRAVVQAGAGIVLDSVPQNEADETRAKAQAVLDAIRKT 496
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 25-469 4.13e-84

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 267.40  E-value: 4.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   25 YGVIPADMlTPSVaylkLNQGKKYSFILESVTQGESVSRYSFIGSPY--RILMANGKTdpLARLERELKEVKTAPVEGLP 102
Cdd:PRK13567   5 YKKIKANV-TPEV----LAQLHSKKIILESTNQQQTKGRYSVVIFDIygTLTLDNDVL--SVSTLKESYQITERPYHYLT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  103 S------------------FSGGAVGYVSYDCIKY-FEPTTEMPLEDtLGLPEAMFFMTDDLVAFDHAYQTVKIIShvCI 163
Cdd:PRK13567  78 TkinedyhniqdeqlkslpFISGYVGTCSFDLVRHeFPKLQSIQLED-HKQHDVRLYMVEQVYVFDHYKDELYIIA--TN 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  164 QQGRPIEEAYEAAVfkINMLkKKLESPEIPLPEQKKVHLGYEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSqRIAR- 242
Cdd:PRK13567 155 QFSNSTKSDLENRV--NKSI-EDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPS-RIYKy 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  243 ----RTDLHP--FNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLL 316
Cdd:PRK13567 231 ahhaSQHLNQlsFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  317 ASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVR 396
Cdd:PRK13567 311 NDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLR 390

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075823  397 AIQLVYGLEKEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRS 469
Cdd:PRK13567 391 AIERIYEQYPHKRGVYSGGVGYINC-NHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKS 462
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
47-477 2.92e-83

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 264.26  E-value: 2.92e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   47 KYSFILESVTQGESVSRYSFIgspyriLMANGKTdplARLERE-----------LKEVKTA------PVEGLPS--FSGG 107
Cdd:PRK09070  23 RYPALLESSASGTAQGRWDVL------LLAQGKC---LRLDPDgvtrqllegdfLDALDAAwqaervPHDGESSlpFRGG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  108 AVGYVSYDCIKYFEPTTEMPLeDTLGLPEAMFFMTDDLVAFDHAyqtvkiiSHVCIQQGRPIEEA-YEAAVFKINMLKKK 186
Cdd:PRK09070  94 WAVLLDYELAGQVEPILKLPM-RTDGLPLALALRAPAAVLRDRH-------SGRCVLVAEPGREHlLDQIEADLAACAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  187 LESPEIPLPEQkkvhlgyeaksnVGEDGYKAF---VSNLKEHIFNGDIFQAVPSQ--RIARRTDLHPFNLYRHLRTVNPS 261
Cdd:PRK09070 166 PPLPVWLAPQA------------VEEDPPERFtdgVERVLDYIRAGDVFQVNLSRawQAQFANAVDPAALYARLRAANPA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  262 PYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKtKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCD 341
Cdd:PRK09070 234 PFSGLFVAAGRAIVSSSPERLVSVQGGVVQTRPIAGTRPRFA-GDDDAALIRELVGHPKERAEHVMLIDLERNDLGRICA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  342 LDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGY 421
Cdd:PRK09070 313 PGSVEVDELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFG-YLN 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19075823  422 EDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEET 477
Cdd:PRK09070 392 RDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQA 447
pabB PRK15465
aminodeoxychorismate synthase component 1;
81-467 2.46e-67

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 223.26  E-value: 2.46e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   81 DPLARLERELKE--VKTAPVEGLPsFSGGAVGYVSYDCIKYFEPTTEMPLEDtLGLPEAMFFMTDDLVAFDHAYQTVKII 158
Cdd:PRK15465  78 DPLQVLQQVLDRadIRPTHNEDLP-FQGGALGLFGYDLGRRFESLPEIAEQD-IVLPDMAVGIYDWALIVDHQRQTVSLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  159 SHvciqqgrpieeayeaavFKINMLKKKLESPEIPlpEQKKVHLGYEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQ 238
Cdd:PRK15465 156 SH-----------------NDVNARRAWLESQQFS--PQEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVNLAQ 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  239 RIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLAS 318
Cdd:PRK15465 217 RFHATYSGDEWQAFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANS 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  319 VKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAI 398
Cdd:PRK15465 297 AKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAM 376

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075823  399 QLVYGLEKEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKL 467
Cdd:PRK15465 377 EIIDELEPQRRNAWCGSIGYLSF-CGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKV 444
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
215-468 5.76e-65

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 214.49  E-value: 5.76e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  215 YKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVK-SEHGRIINH 293
Cdd:PRK07508 114 YAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRSPELFFRvDGEGWIETH 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  294 PIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPD 373
Cdd:PRK07508 194 PMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQMVSRVRARLLPG 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  374 KTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGYEDDNMDTCIAIRTMV-YKDGTVYLQAGGGIVF 452
Cdd:PRK07508 274 LGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIG-WIAPDGRMRFNVAIRTLSlFPGGRAVFNVGGGIVF 352

                        250
                 ....*....|....*.
gi 19075823  453 DSDEQDEYVETLNKLR 468
Cdd:PRK07508 353 DSTAEAEYEECLLKAR 368
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 99-479 3.58e-60

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 212.40  E-value: 3.58e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   99 EGLP-SFSGGAVGYVSYD----C---IKYFEPTTempledtlglPEAMFFMTDDLVAFDHAYQTVKIIShvcIQQGRPIE 170
Cdd:PLN02889 532 EGLPfDFHGGYVGYIGYDlkveCgmaSNRHKSTT----------PDACFFFADNVVVIDHHYDDVYILS---LHEGSTAT 598

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  171 EAY-EAAVFKINMLK----KKLESPEIPLPEQKKVHLGYeaksnVGEDGYKAFVSNLK---EHIFNGDIFQ-AVPSQRIA 241
Cdd:PLN02889 599 TQWlDDTEQKLLGLKasatRKLEVQTSPTATFSPSKAGF-----LADKSREQYIKDVQkclKYIKDGESYElCLTTQMRK 673

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  242 RRTDLHPFNLYRHLRTVNPSPYMFYIHC--DDFDIIGASPELLVK-SEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLAS 318
Cdd:PLN02889 674 RIGEIDSLGLYLHLREKNPAPYAAWLNFsnENLCICSSSPERFLKlDRNGMLEAKPIKGTIARGSTPEEDEQLKLQLQYS 753

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  319 VKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAI 398
Cdd:PLN02889 754 EKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSM 833

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  399 QLVYGLEKEKRGIYAGAVGRWGYeDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRSNVTAIEETE 478
Cdd:PLN02889 834 ELLDSLESSSRGIYSGSIGFFSY-NQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILKTRAPANAVIEFQ 912


                 .
gi 19075823  479 K 479
Cdd:PLN02889 913 K 913
PRK13566 PRK13566
anthranilate synthase component I;
107-466 2.21e-59

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 207.85  E-value: 2.21e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  107 GAVGYvsyDCIKYFEPttempLEDTLGLPEA----MFFMTDDLVAFDHAYQTVKIIShvciqqgrpieeaYEAAVFKINM 182
Cdd:PRK13566 159 GAFGY---DLAFQFEP-----IEQKLPRPDDqrdlVLYLPDEILVVDHYAARAWVDR-------------YEFAVGGVST 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  183 LKKKLESPEIPLPEQKKVHLgyEAKSNVGEdgYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDLHPFNLYRHLRTVNPSP 262
Cdd:PRK13566 218 EGLPRETAPSPYKPTTARPG--FADHAPGE--YAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSP 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  263 YMFYIHCDDFD-IIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCD 341
Cdd:PRK13566 294 YGFFINLGDGEyLVGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCE 373

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  342 LDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGY 421
Cdd:PRK13566 374 PGSVKVIGRRQIEMYSRLIHTVDHVEGRLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGF 453

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 19075823  422 eDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNK 466
Cdd:PRK13566 454 -DGDMNTGLTLRTIRIKDGVAEVRVGATLLFDSDPEAEEAETELK 497
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 203-469 2.13e-56

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 191.24  E-value: 2.13e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  203 GYEAKSNVG---EDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTDlhPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASP 279
Cdd:PRK06404  92 SFKTVKLKGnynDISLSLKIKELIELIRAGEVLQVVISREFEANID--FKEKLSEFINNDRSRYVFYYRFGKYRVVGSSP 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  280 ELLVKSEHGRIINHPIAGTVPrgktkeeDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHV 359
Cdd:PRK06404 170 ENVFTVNGNIINVDPIAGTYD-------DKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSV 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  360 QHLVSQVSGVLrPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGyeDDNMDTCIAIRTMVYKD 439
Cdd:PRK06404 243 KHLVSQVTAKF-SNASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS--KGYTDMALVIRTAYSHG 319

                        250       260       270
                 ....*....|....*....|....*....|
gi 19075823  440 GTVYLQAGGGIVFDSDEQDEYVETLNKLRS 469
Cdd:PRK06404 320 NGFRVRAGAGIVKDSDPEDEVNEIYSKARS 349
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 194-468 1.24e-51

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 178.81  E-value: 1.24e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 194 LPEqkkVHLGYEAKSNVGEDGYKAFVSNLKEHIFNGDIFQAVPSQRIARRTD--LHPFNLYRHLRTVNPSPYMFYIHCDD 271
Cdd:COG1169  73 LPR---LLLRRSRRGVPDPAEWREAVAQALEAIRAGELDKVVLARALDLTLDepIDPRALLARLRRRNPDCYTFAVELGA 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 272 FDI-IGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCdlDTTSVDKL 350
Cdd:COG1169 150 GDGfVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLC--SSLDVPEE 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823 351 MTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVgrwGYEDDNMDT-- 428
Cdd:COG1169 228 PELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPV---GWVDADGDGef 304

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19075823 429 CIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLR 468
Cdd:COG1169 305 AVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLR 344
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 224-466 1.80e-44

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 161.02  E-value: 1.80e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  224 EHIFNGDIFQAVPSQRIARRTDLHPFNLY----RHLRtvnPSpYMFYIHCDDFDIIGASPELLVKSEHGRIINHPIAGTV 299
Cdd:PRK05877 153 EAIAAGEVYQACVCTQFTGTVTGSPLDFFadgvARTA---PA-RAAYLAGDWGAVASLSPELFLRRRGSVVTSSPIKGTL 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  300 PRgktkeedEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDA 379
Cdd:PRK05877 229 PL-------DADPSALRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQVPDELPMSDL 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  380 FRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGYEDDNMDTCIAIRTMVYK-DGTVYLQAGGGIVFDSDEQD 458
Cdd:PRK05877 302 LDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVG-LASPVAGCELNVAIRTVEFDaDGNAVLGVGGGITADSDPDA 380


                 ....*...
gi 19075823  459 EYVETLNK 466
Cdd:PRK05877 381 EWQECLHK 388
salicyl_syn TIGR03494
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional ...
 213-469 2.21e-42

salicylate synthase; Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis.


Pssm-ID: 132533 [Multi-domain]  Cd Length: 425  Bit Score: 155.71  E-value: 2.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   213 DGYKAFVSNLKEHIFNGDIFQAVPSQRIARrtdlhPFNL-----YRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEH 287
Cdd:TIGR03494 162 SAYRARVARAVAEIAAGRYHKVILSRAVPL-----PFAIdfpatLLLGRRHNTPVRSFLLRLGGIEALGFSPELVMSVRA 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   288 -GRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQV 366
Cdd:TIGR03494 237 dGKVVTEPLAGTRALGGGPEHDKQLRDELLSDSKEIVEHAISVKEAIEELEQVCEPGTVVVEDFMTVRERGSVQHLGSTV 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   367 SGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAV------GRWgyeddnmDTCIAIRTMVYKDG 440
Cdd:TIGR03494 317 SGQLAPSKDAWDAFEVLFPAITASGIPKAAALEAIMRLEKTPRGLYSGAVllldadGTL-------DAALVLRAAYQDSG 389

                         250       260
                  ....*....|....*....|....*....
gi 19075823   441 TVYLQAGGGIVFDSDEQDEYVETLNKLRS 469
Cdd:TIGR03494 390 RTWLQAGAGIIAQSTPERELTETCEKLAS 418
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 212-468 8.48e-39

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 144.43  E-value: 8.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   212 EDGYKAFVSNLKEHIFNGDIFQAVPS--QRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDDFDI-IGASPELLVKSEHG 288
Cdd:TIGR00543  89 KAAWRTAVEEALENIRQGPLDKVVLAraLTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVfLGATPERLLSREKG 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   289 RIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCdlDTTSVDKLMTIEKFSHVQHLVSQVSG 368
Cdd:TIGR00543 169 ELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPIC--TSLDVSETPELLKLANVQHLYTPISA 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823   369 VLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGYEDDNMDTCIAIRTMVYKDGTVYLQAGG 448
Cdd:TIGR00543 247 RLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLG-WLDGEGNGEFAVGIRSALVEDGQVRLYAGA 325

                         250       260
                  ....*....|....*....|
gi 19075823   449 GIVFDSDEQDEYVETLNKLR 468
Cdd:TIGR00543 326 GIVADSDPESEWEETELKLQ 345
PRK07054 PRK07054
isochorismate synthase;
219-475 4.77e-36

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 139.51  E-value: 4.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  219 VSNLKEHIFNGDIFQAVPSQR--------IARR------TDLHPFNLYRHLRTVNPSPYMFYIHCDDFDIIGASPELLVK 284
Cdd:PRK07054 189 ASALQAREWQHEVRRAVDAIRggafgkvvLARDvlqqyaRPVAIGPLLRRLRLRDPHAHLFAFRRGNACFLGATPERLVR 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  285 SEHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCD-LDTTSVDKLmtiEKFSHVQHLV 363
Cdd:PRK07054 269 VAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSRaLDIPDQPSL---HRLPRLQHLS 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  364 SQVSGVLRPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGYEDDNMDTCIAIRTMVYKDGTVY 443
Cdd:PRK07054 346 TPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIG-WLDAHGNGDFAVALRSALITGGACR 424

                        250       260       270
                 ....*....|....*....|....*....|..
gi 19075823  444 LQAGGGIVFDSDEQDEYVETLNKLRSNVTAIE 475
Cdd:PRK07054 425 LFAGCGIVADSEPASEYRETCLKLSGMREALR 456
PRK07912 PRK07912
salicylate synthase;
240-469 1.80e-32

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 128.76  E-value: 1.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  240 IARRTDLhPFNL-----YRHLRTVNPSPYMFYIHCDDFDIIGASPELLVKSEH-GRIINHPIAGTVPRGKTKEEDEAYAK 313
Cdd:PRK07912 207 LSRCVEV-PFAVdfpatYRLGRRHNTPVRSFLLRLGGIRALGYSPELVTAVRAdGVVITEPLAGTRAFGRGAAIDRLARD 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  314 DLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSP 393
Cdd:PRK07912 286 DLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIP 365

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19075823  394 KVRAIQLVYGLEKEKRGIYAGAVGRWGyEDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRS 469
Cdd:PRK07912 366 KAAGVDAIFRLDEAPRGLYSGAVVMLS-ADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLST 440
PRK07093 PRK07093
para-aminobenzoate synthase component I; Validated
 168-466 1.73e-31

para-aminobenzoate synthase component I; Validated


Pssm-ID: 235932 [Multi-domain]  Cd Length: 323  Bit Score: 123.44  E-value: 1.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  168 PIEEAYEAAV-FKINMLKKKLESPEIPLPEQ-KKVHLGYEAksnvgedgYKAFVSNLKEHIFNGDIFQAVPSQRIARRTD 245
Cdd:PRK07093  35 PLEELAESGIlFDFNGKTNVPSQVRPHKPFElQKEPISFEE--------YQQGFELVQEEIQAGNSYLLNLTYPTPIETN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  246 LHPFNLYRHLRtvnpSPYMFYIHcDDFdiIGASPELLVKSEHGRIINHPIAGTV----PRGKTKeedeayakdLLASVKD 321
Cdd:PRK07093 107 LSLEEIFQASK----AKYKLLFK-DQF--VCFSPEPFVRIEDNKISTYPMKGTIdaslPNAEEK---------LLNDEKE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  322 RAEHVMLVDLARNDVSRVCDldTTSVDKLMTIEKFSHVQ----HLVSQVSGVLRPD-KTRF-DAFRSIFPAGTVSGSPKV 395
Cdd:PRK07093 171 FAEHATIVDLLRNDLSMVAK--NVRVTRFRYIDKIKTNKgeilQTSSEISGTLPENwQENIgDILAKLLPAGSITGAPKE 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075823  396 RAIQLVYGLEKEKRGIYAGAvgrWGYED-DNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNK 466
Cdd:PRK07093 249 KTVEIIEQAEGYERGFYTGV---FGYFDgESLDSAVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
PRK06772 PRK06772
salicylate synthase;
213-469 4.75e-29

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 118.68  E-value: 4.75e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  213 DGYKAFVSNLKEHIFNGDIFQAVPSQRIA--RRTDLHPFNLYRhlRTVNPSPYMFYIHCDDFDIIGASPELLVKSEHGRI 290
Cdd:PRK06772 173 EAYKQQVARAVAEIRRGEYVKVIVSRAIPlpSRIDMPATLLYG--RQANTPVRSFMFRQEGREALGFSPELVMSVTGNKV 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  291 INHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDLARNDVSRVCDLDTTSVDKLMTIEKFSHVQHLVSQVSGVL 370
Cdd:PRK06772 251 VTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  371 RPDKTRFDAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVgrWGYEDDNMDTCIAIRTMVYKDGTVYLQAGGGI 450
Cdd:PRK06772 331 AENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAI--LLLDDTRFDAALVLRSVFQDSQRCWIQAGAGI 408

                        250
                 ....*....|....*....
gi 19075823  451 VFDSDEQDEYVETLNKLRS 469
Cdd:PRK06772 409 IAQSTPERELTETREKLAS 427
Anth_synt_I_N pfam04715
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ...
 31-157 4.47e-27

Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).


Pssm-ID: 428082 [Multi-domain]  Cd Length: 140  Bit Score: 105.85  E-value: 4.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823    31 DMLTPSVAYLKLnQGKKYSFILESVTQGESvsRYSFIGSP--YRILMANGKT--------------DPLARLERELKEVK 94
Cdd:pfam04715   1 DLLTPLSVYLKL-AGEPHSFLLESAEGGEG--RYSFIGINplLTIKSKNGEVsvsgpdgqeleqedGPLDALRALLARFR 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19075823    95 -TAPVEGLPSFSGGAVGYVSYDCIKYFEPtTEMPLEDTLGLPEAMFFMTDDLVAFDHAYQTVKI 157
Cdd:pfam04715  78 iEDSPPTLPPFSGGLVGYLGYDLVRYIEK-LPRTAPDDLNLPDARLILYEDLIVFDHQENKLYL 140
PLN02786 PLN02786
isochorismate synthase
 237-462 7.92e-27

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 113.34  E-value: 7.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  237 SQRIARRTDLHPFNLYRHLRTVNPSPYMFYIHCDD---FdiIGASPELLVKSEHGRIINHPIAGTVPRGKTKEEDEAYAK 313
Cdd:PLN02786 288 SSRIITDTDIDPIAWLACLQVEGQNAYQFCLQPPDapaF--IGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIEL 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  314 DLLASVKDRAEHVMLVDLARNDVSRVCDldTTSVDKLMTIEKFSHVQHLVSQVSGVLRPDKTRFDAFRSIFPAGTVSGSP 393
Cdd:PLN02786 366 DLLTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHP 443

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  394 KVRAIQLVYGLEKEKRGIYAGAVGRWGYEDDNMdtCIAIRT-MVYKDGTVYLQAGGGIVFDSDEQDEYVE 462
Cdd:PLN02786 444 TEEARLLIAETESFDRGMYAGPVGWFGGGESEF--AVGIRSaLVEKGLGALIYAGTGIVEGSNPSSEWNE 511
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 251-469 5.16e-25

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 106.74  E-value: 5.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  251 LYRHLRTVNPSPYMFYIHCDDFD------IIGASPELLVkSEHG-RIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRA 323
Cdd:PRK06923 162 LLRELAEHNKHGYTFAVNLPKDEnensktLIGASPELLV-SRHGmQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  324 EHVMLVDLARNDVSRVCdlDTTSVDKLMTIEKFSHVQHLVSQVSGVLR-PDKTRFDAFRSIFPAGTVSGSPKVRAIQLVY 402
Cdd:PRK06923 241 EHAVVVEAVAAALRPYC--HTLHVPEKPSVIHTEAMWHLSTEVKGELKdPNTSSLELAIALHPTPAVCGTPTEEAREAIQ 318

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075823  403 GLEKEKRGIYAGAVGrWGyeDDNMDT--CIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETLNKLRS 469
Cdd:PRK06923 319 QIEPFDREFFTGMLG-WS--DLNGDGewIVTIRCAEVEENTLRLYAGAGVVAESKPEDELAETSAKFQT 384
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 230-467 1.84e-18

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 87.24  E-value: 1.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  230 DIFQAVPSQRIARRTDLHPFN--LYRHLRTVNPSPYMFYIHCDDFDII-GASPELLVKSEHGRIINHPIAGTVPRGKTKE 306
Cdd:PRK15016 144 QVDKVVLSRLIDITTDAAIDSgaLLERLIAQNPVSYNFHVPLADGGVLlGASPELLLRKDGERFSSLPLAGSARRQPDEV 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  307 EDEAYAKDLLASVKDRAEHvMLVDLARNDV--SRVCDLDTTSVDKLMTIEKfshVQHLVSQVSGVLRPDKTRFDAFRSIF 384
Cdd:PRK15016 224 LDREAGNRLLASEKDRHEH-ELVTQAMKEVlrERSSELHVPSSPQLITTPT---LWHLATPFEGKANAQENALTLACLLH 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  385 PAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGrWGYEDDNMDTCIAIRTMVYKDGTVYLQAGGGIVFDSDEQDEYVETL 464
Cdd:PRK15016 300 PTPALSGFPHQAAKQVIAELEPFDRELFGGIVG-WCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETG 378


                 ...
gi 19075823  465 NKL 467
Cdd:PRK15016 379 VKL 381
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 213-469 5.04e-12

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 67.56  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  213 DGYKAFVSNLKEHIFNGDIFQAVpsqrIARRTDLH---PFN---LYRHLRTVNPSPYMFYIHCD-DFDIIGASPELLVKS 285
Cdd:PRK15012 170 TGWTQLIELATKTIAEGELDKVV----LARATDLHfasPVNaaaMMAASRRLNLNCYHFYMAFDaENAFLGSSPERLWRR 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  286 EHGRIINHPIAGTVPRGKTKEEDEAYAKDLLASVKDRAEHVMLVDlarnDVSRVCDLDTTSVDKL-MTIEKFSHVQHLVS 364
Cdd:PRK15012 246 RDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE----DICQRLQADTQTLDVLpPQVLRLRKVQHLRR 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075823  365 QVSGVL-RPDKTRfdAFRSIFPAGTVSGSPKVRAIQLVYGLEKEKRGIYAGAVGRWGYEDDNMdtCIAIRTMVYKDGTVY 443
Cdd:PRK15012 322 CIWTSLnKADDVI--CLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQQSEF--CVSLRSAKVSGNVVR 397

                        250       260
                 ....*....|....*....|....*....
gi 19075823  444 LQAGGGIVFDSDEQDEYVETLNK---LRS 469
Cdd:PRK15012 398 LYAGAGIVRGSDPEQEWQEIDNKaagLRT 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH