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Conserved domains on  [gi|19075862|ref|NP_588362|]
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diacylglycerol-binding protein [Schizosaccharomyces pombe]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655294)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 362-562 2.89e-58

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 197.80  E-value: 2.89e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQaedldfipssdlNSLKSLNLQSFVKNICCDVPLPPKGLLQL--QVNVGP 439
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLF-KKFLDELYRRRT------------ISPLPNPIERFIANLLYEVPFPPPGRTQKlkPLGGTE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   440 LNLYAFRSPvNEIPGwNDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVL 519
Cdd:pfam02141  68 PILLQRPED-SELPL-EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVL 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19075862   520 PRRLISCFEAPCSYIIGTLSYFFHMDDVPLDNIPLVvcDLDKN 562
Cdd:pfam02141 146 PASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLV--DLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 174-256 1.75e-17

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 78.15  E-value: 1.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    174 AATHPFERRYPPSLLHQFPSsKDIKNEtptidrcDFPNYVPMFAFPNDITIKESDVRPVSTYHSFALTSDNNSHLYGICV 253
Cdd:smart00800  15 SDTGPLGRSYKPEILQRYPE-KDFEDF-------PLPDSIPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                   ...
gi 19075862    254 VVW 256
Cdd:smart00800  87 RFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 833-911 2.40e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.08  E-value: 2.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075862    833 SQQILVTFLKFFIKILGSYRNYLRkphmsrenfgISKGSGGLIGSFDFNKFTRQASKVHGSWISSLCSSQAFAEFIGDR 911
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLR----------ELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 362-562 2.89e-58

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 197.80  E-value: 2.89e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQaedldfipssdlNSLKSLNLQSFVKNICCDVPLPPKGLLQL--QVNVGP 439
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLF-KKFLDELYRRRT------------ISPLPNPIERFIANLLYEVPFPPPGRTQKlkPLGGTE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   440 LNLYAFRSPvNEIPGwNDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVL 519
Cdd:pfam02141  68 PILLQRPED-SELPL-EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVL 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19075862   520 PRRLISCFEAPCSYIIGTLSYFFHMDDVPLDNIPLVvcDLDKN 562
Cdd:pfam02141 146 PASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLV--DLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 363-562 1.91e-46

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 164.29  E-value: 1.91e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    363 IPNAYGLLSKHSHLQSFcRDWLRIVcssiqaedldfipSSDLNSLKSLNLQSFVKNICCdvPLPPKGLLQLQVNVGPLNL 442
Cdd:smart00799   1 APKCICILSRLPFFELF-RKILNEL-------------YRLLPSSSNLPLELLISLLLY--PVPPPGGSLVLVSLGPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    443 YAFRSPV-NEIPGWnDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVLPR 521
Cdd:smart00799  65 IELQRPLdSSLPLI-DFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPA 143

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 19075862    522 RLISCFEAPCSYIIGTLSYFFHMDDVPLDNIpLVVCDLDKN 562
Cdd:smart00799 144 SLLDVLSAPTPFIIGVHSSYFEEVKELPDED-VVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 174-256 1.75e-17

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 78.15  E-value: 1.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    174 AATHPFERRYPPSLLHQFPSsKDIKNEtptidrcDFPNYVPMFAFPNDITIKESDVRPVSTYHSFALTSDNNSHLYGICV 253
Cdd:smart00800  15 SDTGPLGRSYKPEILQRYPE-KDFEDF-------PLPDSIPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                   ...
gi 19075862    254 VVW 256
Cdd:smart00800  87 RFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 185-254 8.22e-13

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 63.78  E-value: 8.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   185 PSLLHQFPSSKDiknetptiDRCDFPNYVPMFAFPNDITIKESDVrpvSTYHSFALTSDNNSHLYGICVV 254
Cdd:pfam03456   1 PEVLDRYPEDDW--------SDPPLPDGIPMFCFPEGLETLSSRE---PTFFSFVLTDEDGSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 833-911 2.40e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.08  E-value: 2.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075862    833 SQQILVTFLKFFIKILGSYRNYLRkphmsrenfgISKGSGGLIGSFDFNKFTRQASKVHGSWISSLCSSQAFAEFIGDR 911
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLR----------ELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 878-927 1.20e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 19075862   878 FDFNKFTRQASKVHGSWISSLCSSQAFAEFIGDRceLDLNDPRVALFDQL 927
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEER--LESSDPSIDLFDEE 48
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 362-562 2.89e-58

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 197.80  E-value: 2.89e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQaedldfipssdlNSLKSLNLQSFVKNICCDVPLPPKGLLQL--QVNVGP 439
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLF-KKFLDELYRRRT------------ISPLPNPIERFIANLLYEVPFPPPGRTQKlkPLGGTE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   440 LNLYAFRSPvNEIPGwNDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVL 519
Cdd:pfam02141  68 PILLQRPED-SELPL-EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVL 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19075862   520 PRRLISCFEAPCSYIIGTLSYFFHMDDVPLDNIPLVvcDLDKN 562
Cdd:pfam02141 146 PASLLDVLSAPTPFIIGVHSRYFDLLEDPLDDVVLV--DLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 363-562 1.91e-46

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 164.29  E-value: 1.91e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    363 IPNAYGLLSKHSHLQSFcRDWLRIVcssiqaedldfipSSDLNSLKSLNLQSFVKNICCdvPLPPKGLLQLQVNVGPLNL 442
Cdd:smart00799   1 APKCICILSRLPFFELF-RKILNEL-------------YRLLPSSSNLPLELLISLLLY--PVPPPGGSLVLVSLGPGDL 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    443 YAFRSPV-NEIPGWnDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVLPR 521
Cdd:smart00799  65 IELQRPLdSSLPLI-DFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPA 143

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 19075862    522 RLISCFEAPCSYIIGTLSYFFHMDDVPLDNIpLVVCDLDKN 562
Cdd:smart00799 144 SLLDVLSAPTPFIIGVHSSYFEEVKELPDED-VVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 174-256 1.75e-17

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 78.15  E-value: 1.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862    174 AATHPFERRYPPSLLHQFPSsKDIKNEtptidrcDFPNYVPMFAFPNDITIKESDVRPVSTYHSFALTSDNNSHLYGICV 253
Cdd:smart00800  15 SDTGPLGRSYKPEILQRYPE-KDFEDF-------PLPDSIPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                   ...
gi 19075862    254 VVW 256
Cdd:smart00800  87 RFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 185-254 8.22e-13

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 63.78  E-value: 8.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   185 PSLLHQFPSSKDiknetptiDRCDFPNYVPMFAFPNDITIKESDVrpvSTYHSFALTSDNNSHLYGICVV 254
Cdd:pfam03456   1 PEVLDRYPEDDW--------SDPPLPDGIPMFCFPEGLETLSSRE---PTFFSFVLTDEDGSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 833-911 2.40e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.08  E-value: 2.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075862    833 SQQILVTFLKFFIKILGSYRNYLRkphmsrenfgISKGSGGLIGSFDFNKFTRQASKVHGSWISSLCSSQAFAEFIGDR 911
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLR----------ELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 878-927 1.20e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 19075862   878 FDFNKFTRQASKVHGSWISSLCSSQAFAEFIGDRceLDLNDPRVALFDQL 927
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEER--LESSDPSIDLFDEE 48
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 460-566 1.32e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 39.58  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   460 LYPLFRALS--IPNILVLFEAALMEAKVIFLSENLGmLGYASQ---ALLHLLYPL----TWQGLYIPVLPRRLISCFEAP 530
Cdd:pfam08616   1 NHSLLKLLGpfTPPIILLINALLTSKRIIFLSYQRS-AGEVSEfvlALCNLISGGfvlrGFTNNSFPYVDLSKLDALRKV 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19075862   531 CSYIIGTLSYFFHMDDVPLDniplVVCDLDKNSVST 566
Cdd:pfam08616  80 PGYIAGVTNPIFENQDQWWD----VLCDLDSGSVKL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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