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Conserved domains on  [gi|19075931|ref|NP_588431|]
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BAX inhibitor family protein Bxi1 [Schizosaccharomyces pombe]

Protein Classification

Bax inhibitor-1 family protein( domain architecture ID 10179630)

Bax inhibitor-1 family protein similar to protein lifeguard 4 (LFG4/GAAP) which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli and to yeast Bax inhibitor Bxi1p which links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 29-261 6.55e-103

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


:

Pssm-ID: 198411  Cd Length: 233  Bit Score: 298.75  E-value: 6.55e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  29 NESATENPAVDQFKNTTPVAECAKSIRMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVL 108
Cdd:cd10429   1 GSRYAEADIPDDFKYGTNVASAEPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 109 FGLIMKPYSYPRNYIFLFLFTALEGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLI 188
Cdd:cd10429  81 IALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALI 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075931 189 LTPLIFFFVPSTPFIDMAFAGFGTLVFCGYILFDTYNILHRYSPEEFIMSSLMLYLDFINLFIRILQILGMLQ 261
Cdd:cd10429 161 LLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 29-261 6.55e-103

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 298.75  E-value: 6.55e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  29 NESATENPAVDQFKNTTPVAECAKSIRMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVL 108
Cdd:cd10429   1 GSRYAEADIPDDFKYGTNVASAEPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 109 FGLIMKPYSYPRNYIFLFLFTALEGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLI 188
Cdd:cd10429  81 IALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALI 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075931 189 LTPLIFFFVPSTPFIDMAFAGFGTLVFCGYILFDTYNILHRYSPEEFIMSSLMLYLDFINLFIRILQILGMLQ 261
Cdd:cd10429 161 LLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 56-257 2.71e-43

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 146.17  E-value: 2.71e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931    56 MAFLRKVYAILTAQLFVTSLFGGIFYLHPAFsFWVQMHPWFLILNFFISLVVLFGLIM----KPYSYPRNYIFLFLFTAL 131
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPAL-LFPSLHPPLFWVLIIAPLGLLFGALLlarkRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931   132 EGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFAGFG 211
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPS-SALSLAISYLG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 19075931   212 TLVFCGYILFDTYNILHRYSPEE---FIMSSLMLYLDFINLFIRILQIL 257
Cdd:pfam01027 159 VLLFSGFILYDTQRIIKRYGEYGdydAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 55-258 1.19e-35

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 126.83  E-value: 1.19e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  55 RMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVLFGL--IMKPYSYPRNYIFLFLFTALE 132
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLskLANRANSAAALALLFAYTALM 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 133 GLTLGTAITFFSAR----IILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFA 208
Cdd:COG0670  99 GLTLSPILLVYTGLsgpaSIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQS-PALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 19075931 209 GFGTLVFCGYILFDTYNILHRY-SPEEFIMSSLMLYLDFINLFIRILQILG 258
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRIKHGYeTNKQYIMAALSLYLDFINLFLSLLRLLG 228
PRK10447 PRK10447
FtsH protease modulator YccA;
101-263 1.40e-07

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 50.99  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  101 FFISLVVLFGLIMKPY---SYPRNYIFLFLFTALEGLTLGTAITFFSARIILEAVFITLG----VFVALTAFTFQSKWDF 173
Cdd:PRK10447  52 LILTLVGMYGLMFLTYktaNKPTGILSAFAFTGFLGYILGPILNTYLSAGMGDVIALALGgtalVFFCCSAYVLTTRKDM 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  174 SRLGGFLYVSLWSLILTPLIFFFVpSTPFIDMAFAGFGTLVFCGYILFDTYNILHRySPEEFIMSSLMLYLDFINLFIRI 253
Cdd:PRK10447 132 SFLGGMLMAGIVVVLIGMVANIFL-QLPALHLAISAVFILISSGAILFETSNIIHG-GETNYIRATVSLYVSLYNIFVSL 209

                        170
                 ....*....|
gi 19075931  254 LQILGMLQNN 263
Cdd:PRK10447 210 LSILGFASRD 219
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 29-261 6.55e-103

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 298.75  E-value: 6.55e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  29 NESATENPAVDQFKNTTPVAECAKSIRMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVL 108
Cdd:cd10429   1 GSRYAEADIPDDFKYGTNVASAEPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 109 FGLIMKPYSYPRNYIFLFLFTALEGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLI 188
Cdd:cd10429  81 IALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALI 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075931 189 LTPLIFFFVPSTPFIDMAFAGFGTLVFCGYILFDTYNILHRYSPEEFIMSSLMLYLDFINLFIRILQILGMLQ 261
Cdd:cd10429 161 LLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 50-258 5.59e-46

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 153.47  E-value: 5.59e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  50 CAKSIRMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVLFGLIMKPY---SYPRNYIFLF 126
Cdd:cd10428   3 DDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGlrrRFPWNLILLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 127 LFTALEGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMA 206
Cdd:cd10428  83 IFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYV-KWLHIV 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19075931 207 FAGFGTLVFCGYILFDTYNIL----HRYSPEEFIMSSLMLYLDFINLFIRILQILG 258
Cdd:cd10428 162 YASLGALLFSLYLAVDTQLLMggrkYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 56-257 2.71e-43

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 146.17  E-value: 2.71e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931    56 MAFLRKVYAILTAQLFVTSLFGGIFYLHPAFsFWVQMHPWFLILNFFISLVVLFGLIM----KPYSYPRNYIFLFLFTAL 131
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPAL-LFPSLHPPLFWVLIIAPLGLLFGALLlarkRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931   132 EGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFAGFG 211
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPS-SALSLAISYLG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 19075931   212 TLVFCGYILFDTYNILHRYSPEE---FIMSSLMLYLDFINLFIRILQIL 257
Cdd:pfam01027 159 VLLFSGFILYDTQRIIKRYGEYGdydAILAALSLYLDFINLFLSLLRIL 207
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 55-258 4.21e-36

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 127.68  E-value: 4.21e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  55 RMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILnfFISLVVLFGL---IMKPySYPRNYIFLFLFTAL 131
Cdd:cd10432   2 LRSFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGSPLMWVLL--IAELALVFGLsfrINKM-SVATALPLFFAFAAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 132 EGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFAGFG 211
Cdd:cd10432  79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQS-SALQFAISAIG 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 19075931 212 TLVFCGYILFDTYNILHRYSPEEF-------IMSSLMLYLDFINLFIRILQILG 258
Cdd:cd10432 158 VLIFSGLIAYDTQRIKRMYEAGGGesgykdaIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 55-258 1.19e-35

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 126.83  E-value: 1.19e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  55 RMAFLRKVYAILTAQLFVTSLFGGIFYLHPAFSFWVQMHPWFLILNFFISLVVLFGL--IMKPYSYPRNYIFLFLFTALE 132
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLskLANRANSAAALALLFAYTALM 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 133 GLTLGTAITFFSAR----IILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFA 208
Cdd:COG0670  99 GLTLSPILLVYTGLsgpaSIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQS-PALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 19075931 209 GFGTLVFCGYILFDTYNILHRY-SPEEFIMSSLMLYLDFINLFIRILQILG 258
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRIKHGYeTNKQYIMAALSLYLDFINLFLSLLRLLG 228
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 54-258 3.68e-29

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 109.42  E-value: 3.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  54 IRMAFLRKVYAILTAQLFVTSLfggifylhPAFSFWVQMHPWFLILNFFISLVVLFGLIMKPYS----YPRNYIFLFLFT 129
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAA--------TATAFTVCDPGWYWSPALMGLLTSMLALMATAAMirakMPVNLILLFGFT 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 130 ALEGLTLGTAITFFSARIILEAVFITLGVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILT--PLIFFFVpstPFIDMAF 207
Cdd:cd06181  73 GLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSflLNTFFYS---PWLHLVA 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 19075931 208 AGFGTLVFCGYILFDTYNILHR--YSPEEFIMSSLMLYLDFINLFIRILQILG 258
Cdd:cd06181 150 AAVGLVLFCGFLLYDTQLIIHKaeVGPEDYINACISLYLDIINIFIRLLTILA 202
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 59-257 3.10e-19

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 83.43  E-value: 3.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  59 LRKVYAILTAQLFVTSLfGGIFYLHPAFSFWvqmhpwfliLNFFISLVVLFGLIMKPYSY---PRNYIFLFLFTALEGLT 135
Cdd:cd10430  12 LKKVYLTLAVALLAAAV-GAYVHMVINIGGL---------LTGLLSLGLSLWLAFTPSTGknePKRLGLLLGFAFLTGAS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 136 LGTAITF---FSARIILEAVFITLGVFVALTAFTFQSK-WDFSRLGGFLyVSLWSLILTPLIFFFVPSTPFIDMAFAGFG 211
Cdd:cd10430  82 LGPLLDLviaINPSIIVTAFLGTAVIFACFSLAALLAKrREYLYLGGLL-SSALSILLLVSLANIFGGSKFLFQAELYLG 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 19075931 212 TLVFCGYILFDTYNILHRYS--PEEFIMSSLMLYLDFINLFIRILQIL 257
Cdd:cd10430 161 LLVFCGFVLFDTQMIIEKAEngDRDYIWHALDLFVDFVALFRRLLIIL 208
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 85-262 7.04e-19

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 82.25  E-value: 7.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  85 AFSFWVQMHPWFLILNFFISLVVLFGLIM---KPYSYPRNYIFLFLFTALEGLTLGTAITFF-----SARIILEAVFITL 156
Cdd:cd10433  22 ALGAGVSMAGGSPIMGLLLTLVGAYGLLFlieKTRNSAWGIVLVFAFTGFMGYTLGPILNMYlalpnGGQIIMTALGGTA 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 157 GVFVALTAFTFQSKWDFSRLGGFLYVSLWSLILTPLIFFFVPStPFIDMAFAGFGTLVFCGYILFDTYNILHRySPEEFI 236
Cdd:cd10433 102 AIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQI-PALSLAISAAFVLFSSGFILYDTSRIIHG-GETNYI 179

                       170       180
                ....*....|....*....|....*.
gi 19075931 237 MSSLMLYLDFINLFIRILQILGMLQN 262
Cdd:cd10433 180 MATVSLYVSIYNLFVSLLNLLGAFSG 205
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 94-263 7.73e-13

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 66.64  E-value: 7.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  94 PWFLIlnfFISLVVLFGLIM--KPYSYPRNYIFLFLFTALEGLTLGTA---ITFFSARIILEAVFITLGVFVALTAFTFQ 168
Cdd:cd10431  79 PWLAI---GATLAAMIGSGMlvRSYTYPENPGAKHLAWLGHSGVQGAVlapLCFLGGPLLIRAALYTAGIVGGLSTVAAC 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931 169 SKWD-FSRLGGFLYVSLWSLILTPLIFFFVPSTPFIDMAFAGF----GTLVFCGYILFDTYNILHR--------YSPEEF 235
Cdd:cd10431 156 APSEkFLYMGGPLAIGLGVVFASSLGSMFLPPTTALGAGLYSVslygGLVLFGGFLLYDTQKIIKRaethplygVRKYDP 235

                       170       180
                ....*....|....*....|....*...
gi 19075931 236 IMSSLMLYLDFINLFIRILQILGMLQNN 263
Cdd:cd10431 236 INASMSIYMDTINIFIRLVTILAGGGNR 263
PRK10447 PRK10447
FtsH protease modulator YccA;
101-263 1.40e-07

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 50.99  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  101 FFISLVVLFGLIMKPY---SYPRNYIFLFLFTALEGLTLGTAITFFSARIILEAVFITLG----VFVALTAFTFQSKWDF 173
Cdd:PRK10447  52 LILTLVGMYGLMFLTYktaNKPTGILSAFAFTGFLGYILGPILNTYLSAGMGDVIALALGgtalVFFCCSAYVLTTRKDM 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075931  174 SRLGGFLYVSLWSLILTPLIFFFVpSTPFIDMAFAGFGTLVFCGYILFDTYNILHRySPEEFIMSSLMLYLDFINLFIRI 253
Cdd:PRK10447 132 SFLGGMLMAGIVVVLIGMVANIFL-QLPALHLAISAVFILISSGAILFETSNIIHG-GETNYIRATVSLYVSLYNIFVSL 209

                        170
                 ....*....|
gi 19075931  254 LQILGMLQNN 263
Cdd:PRK10447 210 LSILGFASRD 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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