NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19113759|ref|NP_592847|]
View 

chitin synthase regulatory factor-like Chr3 [Schizosaccharomyces pombe]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
658-897 9.45e-43

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 155.86  E-value: 9.45e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 658 DLGKAFELYSLAAKKGHPLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEMDVVEAMFRIALIYLNGLlGQKRNISLGVQ 737
Cdd:COG0790  10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 738 WLERACKSKgpeSVRAMYELAKIYEQpdRYGVSATPERKFELYKQSAVYGYAAAQCKLGECYEHGLlGCLAEPRRSIFWY 817
Cdd:COG0790  89 WFEKAAEQG---DAEAQYNLGLMYEE--GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE-GVPKDPAKAAEWY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 818 TRAAEQDYGEAELGLSGWYLTGsEGIlPKNGEEALLWAHKAACKGLAKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQ 897
Cdd:COG0790 163 RKAAEQGDADAQYNLGVLYENG-RGV-PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 638-674 1.15e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.93  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19113759    638 PEALFLIGQFHSQGvLGFRRDLGKAFELYSLAAKKGH 674
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 54-254 6.70e-03

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 40.16  E-value: 6.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759  54 YPtLSHEPVYTN--VLDLSSRIDANRASIMSATMGTPPSALKFSKKKI--SRPVVSED-TFKDKLPRATIPVKPEPQPQY 128
Cdd:COG5028   9 YP-QAQSQVHTGaaSSKKSARPHRAYANFSAGQMGMPPYTTPPLQQQSrrQIDQAATAmHNTGANNPAPSVMSPAFQSQQ 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 129 KIPaAPAPTSkrvvnrgLKLNTNLRQASPILPSPSLKldrqDAPIQINheqkEDFLVSIPRPTPMTNLDDGkDEIGQPDP 208
Cdd:COG5028  88 KFS-SPYGGS-------MADGTAPKPTNPLVPVDLFE----DQPPPIS----DLFLPPPPIVPPLTTNFVG-SEQSNCSP 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 19113759 209 H--RKYM-APPRVNSIsrvqRRMSYIPYG-GFDDFLDNYYKDDDTVLEDN 254
Cdd:COG5028 151 KyvRSTMyAIPETNDL----LKKSKIPFGlVIRPFLELYPEEDPVPLVED 196
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
658-897 9.45e-43

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 155.86  E-value: 9.45e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 658 DLGKAFELYSLAAKKGHPLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEMDVVEAMFRIALIYLNGLlGQKRNISLGVQ 737
Cdd:COG0790  10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 738 WLERACKSKgpeSVRAMYELAKIYEQpdRYGVSATPERKFELYKQSAVYGYAAAQCKLGECYEHGLlGCLAEPRRSIFWY 817
Cdd:COG0790  89 WFEKAAEQG---DAEAQYNLGLMYEE--GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE-GVPKDPAKAAEWY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 818 TRAAEQDYGEAELGLSGWYLTGsEGIlPKNGEEALLWAHKAACKGLAKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQ 897
Cdd:COG0790 163 RKAAEQGDADAQYNLGVLYENG-RGV-PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 864-898 1.33e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.32  E-value: 1.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19113759    864 AKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQG 898
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 864-898 5.24e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 5.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19113759   864 AKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQG 898
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 638-674 1.15e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.93  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19113759    638 PEALFLIGQFHSQGvLGFRRDLGKAFELYSLAAKKGH 674
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 638-673 5.25e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.27  E-value: 5.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19113759   638 PEALFLIGQFHSQGvLGFRRDLGKAFELYSLAAKKG 673
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 54-254 6.70e-03

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 40.16  E-value: 6.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759  54 YPtLSHEPVYTN--VLDLSSRIDANRASIMSATMGTPPSALKFSKKKI--SRPVVSED-TFKDKLPRATIPVKPEPQPQY 128
Cdd:COG5028   9 YP-QAQSQVHTGaaSSKKSARPHRAYANFSAGQMGMPPYTTPPLQQQSrrQIDQAATAmHNTGANNPAPSVMSPAFQSQQ 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 129 KIPaAPAPTSkrvvnrgLKLNTNLRQASPILPSPSLKldrqDAPIQINheqkEDFLVSIPRPTPMTNLDDGkDEIGQPDP 208
Cdd:COG5028  88 KFS-SPYGGS-------MADGTAPKPTNPLVPVDLFE----DQPPPIS----DLFLPPPPIVPPLTTNFVG-SEQSNCSP 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 19113759 209 H--RKYM-APPRVNSIsrvqRRMSYIPYG-GFDDFLDNYYKDDDTVLEDN 254
Cdd:COG5028 151 KyvRSTMyAIPETNDL----LKKSKIPFGlVIRPFLELYPEEDPVPLVED 196
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
658-897 9.45e-43

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 155.86  E-value: 9.45e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 658 DLGKAFELYSLAAKKGHPLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEMDVVEAMFRIALIYLNGLlGQKRNISLGVQ 737
Cdd:COG0790  10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 738 WLERACKSKgpeSVRAMYELAKIYEQpdRYGVSATPERKFELYKQSAVYGYAAAQCKLGECYEHGLlGCLAEPRRSIFWY 817
Cdd:COG0790  89 WFEKAAEQG---DAEAQYNLGLMYEE--GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE-GVPKDPAKAAEWY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 818 TRAAEQDYGEAELGLSGWYLTGsEGIlPKNGEEALLWAHKAACKGLAKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQ 897
Cdd:COG0790 163 RKAAEQGDADAQYNLGVLYENG-RGV-PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
585-823 1.24e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 150.08  E-value: 1.24e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 585 LAKVYLNALETLENKPSLAPDQASYNTRINVYRTRAVELLKKNAYPSKTQNTVPEALFLIGQFHSQGvLGFRRDLGKAFE 664
Cdd:COG0790  10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEG-RGVPKDYEKALE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 665 LYSLAAKKGHPLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEMDVVEAMFRIALIYLNGlLGQKRNISLGVQWLERACK 744
Cdd:COG0790  89 WFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNG-EGVPKDPAKAAEWYRKAAE 167

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113759 745 sKGpeSVRAMYELAKIYEQPDryGVSATPERKFELYKQSAVYGYAAAQCKLGECYEHGlLGCLAEPRRSIFWYTRAAEQ 823
Cdd:COG0790 168 -QG--DADAQYNLGVLYENGR--GVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNG-EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
751-908 4.55e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 4.55e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 751 VRAMYELAKIYEQPDryGVSATPERKFELYKQSAVYGYAAAQCKLGECYEHGLlGCLAEPRRSIFWYTRAAEQDYGEAEL 830
Cdd:COG0790  63 AEAQYNLGLMYAEGR--GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL-GVPQDYAKALEWYEKAAEQGDADAQY 139

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19113759 831 GLSGWYLTGsEGIlPKNGEEALLWAHKAACKGLAKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQGFPKAKKRLEE 908
Cdd:COG0790 140 NLGLLYLNG-EGV-PKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGR 215
TPR COG0790
TPR repeat [General function prediction only];
816-906 1.11e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 59.94  E-value: 1.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 816 WYTRAAEQDYGEAELGLSGWYLTGSEGILPKNGEEALLWAHKAACKGLAKAQYAVGFMMEQGIGVAADPSSAHNWYIRAA 895
Cdd:COG0790  15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAA 94

                        90
                ....*....|.
gi 19113759 896 KQGFPKAKKRL 906
Cdd:COG0790  95 EQGDAEAQYNL 105
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 592-858 4.28e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.59  E-value: 4.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 592 ALETLENKPSLAPDQAS-YNTRINVYRTR-----AVELLKK--NAYPSKtqntvPEALFLIGQ-FHSQGvlgfrrDLGKA 662
Cdd:COG2956  27 AIDLLEEALELDPETVEaHLALGNLYRRRgeydrAIRIHQKllERDPDR-----AEALLELAQdYLKAG------LLDRA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 663 FELYSLAAKK--GHPLSNYRVAVC-LQTGtgvkpDTSKCVAIYKKAAEM--DVVEAMFRIALIYLngllgQKRNISLGVQ 737
Cdd:COG2956  96 EELLEKLLELdpDDAEALRLLAEIyEQEG-----DWEKAIEVLERLLKLgpENAHAYCELAELYL-----EQGDYDEAIE 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 738 WLERACKSKgPESVRAMYELAKIYEQPDRYgvsatpERKFELYKQSAVY--GYAAAQCKLGECYEHgllgcLAEPRRSIF 815
Cdd:COG2956 166 ALEKALKLD-PDCARALLLLAELYLEQGDY------EEAIAALERALEQdpDYLPALPRLAELYEK-----LGDPEEALE 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19113759 816 WYTRAAEQDYGEAELGLSGWYLTGSEGIlpkngEEALLWAHKA 858
Cdd:COG2956 234 LLRKALELDPSDDLLLALADLLERKEGL-----EAALALLERQ 271
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 864-898 1.33e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.32  E-value: 1.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19113759    864 AKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQG 898
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 864-898 5.24e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 5.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19113759   864 AKAQYAVGFMMEQGIGVAADPSSAHNWYIRAAKQG 898
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 638-674 1.15e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.93  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19113759    638 PEALFLIGQFHSQGvLGFRRDLGKAFELYSLAAKKGH 674
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 789-824 1.62e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.51  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19113759   789 AAAQCKLGECYEHGlLGCLAEPRRSIFWYTRAAEQD 824
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 675-709 3.10e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.74  E-value: 3.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19113759   675 PLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEMD 709
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 711-744 5.69e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.97  E-value: 5.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19113759   711 VEAMFRIALIYLNGLlGQKRNISLGVQWLERACK 744
Cdd:pfam08238   1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 789-825 8.64e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 40.62  E-value: 8.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19113759    789 AAAQCKLGECYEHGlLGCLAEPRRSIFWYTRAAEQDY 825
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 711-744 2.35e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.08  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19113759    711 VEAMFRIALIYLNGLlGQKRNISLGVQWLERACK 744
Cdd:smart00671   1 AEAQYNLGQMYEYGL-GVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 638-673 5.25e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.27  E-value: 5.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19113759   638 PEALFLIGQFHSQGvLGFRRDLGKAFELYSLAAKKG 673
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 675-708 9.99e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.54  E-value: 9.99e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19113759    675 PLSNYRVAVCLQTGTGVKPDTSKCVAIYKKAAEM 708
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAEL 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
694-911 1.62e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 694 DTSKCVAIYKKAAEMD--VVEAMFRIALIYLNglLGQKRNislGVQWLERACKSKgPESVRAMYELAKIYEQPDRYgvsa 771
Cdd:COG0457  23 RYEEAIEDYEKALELDpdDAEALYNLGLAYLR--LGRYEE---ALADYEQALELD-PDDAEALNNLGLALQALGRY---- 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 772 tpERKFELYKQsAV---YGYAAAQCKLGECYEHgllgcLAEPRRSIFWYTRAAEQDYGEAELglsgWYLTGSEGILPKNG 848
Cdd:COG0457  93 --EEALEDYDK-ALeldPDDAEALYNLGLALLE-----LGRYDEAIEAYERALELDPDDADA----LYNLGIALEKLGRY 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113759 849 EEALLWAHKAACKGLAKAQYAVGFmmEQGIGVAADPSSAHNWYIRAAKQGFPKAKKRLEEQAL 911
Cdd:COG0457 161 EEALELLEKLEAAALAALLAAALG--EAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 54-254 6.70e-03

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 40.16  E-value: 6.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759  54 YPtLSHEPVYTN--VLDLSSRIDANRASIMSATMGTPPSALKFSKKKI--SRPVVSED-TFKDKLPRATIPVKPEPQPQY 128
Cdd:COG5028   9 YP-QAQSQVHTGaaSSKKSARPHRAYANFSAGQMGMPPYTTPPLQQQSrrQIDQAATAmHNTGANNPAPSVMSPAFQSQQ 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113759 129 KIPaAPAPTSkrvvnrgLKLNTNLRQASPILPSPSLKldrqDAPIQINheqkEDFLVSIPRPTPMTNLDDGkDEIGQPDP 208
Cdd:COG5028  88 KFS-SPYGGS-------MADGTAPKPTNPLVPVDLFE----DQPPPIS----DLFLPPPPIVPPLTTNFVG-SEQSNCSP 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 19113759 209 H--RKYM-APPRVNSIsrvqRRMSYIPYG-GFDDFLDNYYKDDDTVLEDN 254
Cdd:COG5028 151 KyvRSTMyAIPETNDL----LKKSKIPFGlVIRPFLELYPEEDPVPLVED 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH