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Conserved domains on  [gi|19114023|ref|NP_593111|]
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proteasome regulatory subunit Rpn6 [Schizosaccharomyces pombe]

Protein Classification

26S proteasome non-ATPase regulatory subunit 11; COP9 signalosome complex subunit 2( domain architecture ID 11474053)

26S proteasome non-ATPase regulatory subunit 11 (PSMD11) is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins| COP9 signalosome complex subunit 2 (CSN2) is a subunit of COP9 signalosome (CSN) which is a highly conserved protein complex that consists of eight subunits known as CSN1 to CSN8 in higher eukaryotes; CSN complex is a general modulator of diverse cellular and developmental processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-421 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 682.03  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023   1 MSSKSSLELANNAVKSNDIEKAIDLYKEVLNKGVSKDEKVANEQEQALTNLSDLYVRENRHNDLAQLVQQSRPLMANFSK 80
Cdd:COG5159   1 MSSKSSLELANNAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAMEDFTK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023  81 AKSAKIVRTLIDKFSGEKKSLPLQIEVANDCIKWAIKEKRTFLRQALETKLISLYYDNSSYTDAINLINTLLSELKRMDD 160
Cdd:COG5159  81 PKITKIIRTLIEKFPYSSDSLEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDALALINPLLHELKKYDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 161 KMLLTEVHLLESKVYHAIRNIPKARASLTAAKTSANAVYCPPMLQGNLDLQSGILHADDMDFKTAYSYFYEAYEGFTSLD 240
Cdd:COG5159 161 KINLITVHLLESKVYHEIRNVSKSKASLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGFTLLK 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 241 DDKKALSSLKYMLLSQIMLNSVSEVKSLLTGKHAIR-YAGRDIEAMRAIAQAHENRSLADFEKALQDYKPELASDPIIRS 319
Cdd:COG5159 241 MDVKACVSLKYMLLSKIMLNRREEVKAVLRNKNTLKhYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSFIRS 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 320 HLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGILDQGSGCLIVYDEPQQDKTYEAAL 399
Cdd:COG5159 321 HLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYDEAL 400
                       410       420
                ....*....|....*....|..
gi 19114023 400 EVIKNMGTVVDLLIEnKASALL 421
Cdd:COG5159 401 EQVEALDCVVDSLYE-KASALL 421
 
Name Accession Description Interval E-value
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-421 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 682.03  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023   1 MSSKSSLELANNAVKSNDIEKAIDLYKEVLNKGVSKDEKVANEQEQALTNLSDLYVRENRHNDLAQLVQQSRPLMANFSK 80
Cdd:COG5159   1 MSSKSSLELANNAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAMEDFTK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023  81 AKSAKIVRTLIDKFSGEKKSLPLQIEVANDCIKWAIKEKRTFLRQALETKLISLYYDNSSYTDAINLINTLLSELKRMDD 160
Cdd:COG5159  81 PKITKIIRTLIEKFPYSSDSLEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDALALINPLLHELKKYDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 161 KMLLTEVHLLESKVYHAIRNIPKARASLTAAKTSANAVYCPPMLQGNLDLQSGILHADDMDFKTAYSYFYEAYEGFTSLD 240
Cdd:COG5159 161 KINLITVHLLESKVYHEIRNVSKSKASLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGFTLLK 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 241 DDKKALSSLKYMLLSQIMLNSVSEVKSLLTGKHAIR-YAGRDIEAMRAIAQAHENRSLADFEKALQDYKPELASDPIIRS 319
Cdd:COG5159 241 MDVKACVSLKYMLLSKIMLNRREEVKAVLRNKNTLKhYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSFIRS 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 320 HLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGILDQGSGCLIVYDEPQQDKTYEAAL 399
Cdd:COG5159 321 HLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYDEAL 400
                       410       420
                ....*....|....*....|..
gi 19114023 400 EVIKNMGTVVDLLIEnKASALL 421
Cdd:COG5159 401 EQVEALDCVVDSLYE-KASALL 421
RPN6_N pfam18055
26S proteasome regulatory subunit RPN6 N-terminal domain; This is the N-terminal domain found ...
12-127 6.32e-50

26S proteasome regulatory subunit RPN6 N-terminal domain; This is the N-terminal domain found in RPN6 proteins (26S proteasome regulatory subunit). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6). Phosphorylation of Rpn6 enhances proteasome ATPase activity and promotes the formation of doubly capped (30S) proteasome, hence accelerating the degradation of short-lived proteins.


Pssm-ID: 465630  Cd Length: 117  Bit Score: 164.58  E-value: 6.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023    12 NAVKSNDIEKAIDLYKEVLNKGVSKDEKVANEQEQALTNLSDLYVRENRHNDLAQLVQQSRPLMANFSKAKSAKIVRTLI 91
Cdd:pfam18055   2 RELAKSDPAKAEALYKEILSKDPGTDEAALREQEQALLELGELYRDQKNAEELAELITSSRPFLSSFAKAKTAKLVRTLI 81
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19114023    92 DKFSGEKKSLPLQIEVANDCIKWAIKEKRTFLRQAL 127
Cdd:pfam18055  82 DLFSDIPNSLDLQIEVCKECIEWAKSEKRTFLRQSL 117
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
319-400 3.61e-15

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 70.35  E-value: 3.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023    319 SHLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGILDQGSGCLIVYDEP----QQDKT 394
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDprrsEPLAQ 80

                   ....*.
gi 19114023    395 YEAALE 400
Cdd:smart00088  81 FAETLK 86
 
Name Accession Description Interval E-value
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-421 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 682.03  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023   1 MSSKSSLELANNAVKSNDIEKAIDLYKEVLNKGVSKDEKVANEQEQALTNLSDLYVRENRHNDLAQLVQQSRPLMANFSK 80
Cdd:COG5159   1 MSSKSSLELANNAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAMEDFTK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023  81 AKSAKIVRTLIDKFSGEKKSLPLQIEVANDCIKWAIKEKRTFLRQALETKLISLYYDNSSYTDAINLINTLLSELKRMDD 160
Cdd:COG5159  81 PKITKIIRTLIEKFPYSSDSLEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDALALINPLLHELKKYDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 161 KMLLTEVHLLESKVYHAIRNIPKARASLTAAKTSANAVYCPPMLQGNLDLQSGILHADDMDFKTAYSYFYEAYEGFTSLD 240
Cdd:COG5159 161 KINLITVHLLESKVYHEIRNVSKSKASLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGFTLLK 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 241 DDKKALSSLKYMLLSQIMLNSVSEVKSLLTGKHAIR-YAGRDIEAMRAIAQAHENRSLADFEKALQDYKPELASDPIIRS 319
Cdd:COG5159 241 MDVKACVSLKYMLLSKIMLNRREEVKAVLRNKNTLKhYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSFIRS 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023 320 HLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGILDQGSGCLIVYDEPQQDKTYEAAL 399
Cdd:COG5159 321 HLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYDEAL 400
                       410       420
                ....*....|....*....|..
gi 19114023 400 EVIKNMGTVVDLLIEnKASALL 421
Cdd:COG5159 401 EQVEALDCVVDSLYE-KASALL 421
RPN6_N pfam18055
26S proteasome regulatory subunit RPN6 N-terminal domain; This is the N-terminal domain found ...
12-127 6.32e-50

26S proteasome regulatory subunit RPN6 N-terminal domain; This is the N-terminal domain found in RPN6 proteins (26S proteasome regulatory subunit). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6). Phosphorylation of Rpn6 enhances proteasome ATPase activity and promotes the formation of doubly capped (30S) proteasome, hence accelerating the degradation of short-lived proteins.


Pssm-ID: 465630  Cd Length: 117  Bit Score: 164.58  E-value: 6.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023    12 NAVKSNDIEKAIDLYKEVLNKGVSKDEKVANEQEQALTNLSDLYVRENRHNDLAQLVQQSRPLMANFSKAKSAKIVRTLI 91
Cdd:pfam18055   2 RELAKSDPAKAEALYKEILSKDPGTDEAALREQEQALLELGELYRDQKNAEELAELITSSRPFLSSFAKAKTAKLVRTLI 81
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19114023    92 DKFSGEKKSLPLQIEVANDCIKWAIKEKRTFLRQAL 127
Cdd:pfam18055  82 DLFSDIPNSLDLQIEVCKECIEWAKSEKRTFLRQSL 117
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
283-387 1.91e-24

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 96.90  E-value: 1.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023   283 EAMRAIAQAHENRSLADFEKALQDYKPELASDPIIRSHLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGK 362
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 19114023   363 LSQMILDKIFYGILDQGSGCLIVYD 387
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
319-400 3.61e-15

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 70.35  E-value: 3.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114023    319 SHLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLSTVQVEGKLSQMILDKIFYGILDQGSGCLIVYDEP----QQDKT 394
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDprrsEPLAQ 80

                   ....*.
gi 19114023    395 YEAALE 400
Cdd:smart00088  81 FAETLK 86
RPN6_C_helix pfam18503
26S proteasome subunit RPN6 C-terminal helix domain; This is the C-terminal helix domain found ...
391-417 4.81e-09

26S proteasome subunit RPN6 C-terminal helix domain; This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly.


Pssm-ID: 465788  Cd Length: 27  Bit Score: 51.25  E-value: 4.81e-09
                          10        20
                  ....*....|....*....|....*..
gi 19114023   391 QDKTYEAALEVIKNMGTVVDLLIENKA 417
Cdd:pfam18503   1 QDKTYEAALETIKNMGKVVDSLYEKAA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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