NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19114151|ref|NP_593239|]
View 

U2 snRNP-associated protein Sap114 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
 214-442 4.88e-63

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


:

Pssm-ID: 403444  Cd Length: 213  Bit Score: 203.82  E-value: 4.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   214 NVRDPYSLLSKIQPRVRWQSHMESQKKKQKEEAEKEKLEYAQIDWNDFVVVEVIQFTKSDEHAKLAKPTNLADLQTATLE 293
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFDDSDEVLELPKPLTLEQLIYRSLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   294 QKSAMF--TMPDQNYTIEEAPPTAEPWEPISAPKKQEFGVSLPPSlaspekggisstTSVSPAAQASPVLSTTTQPKVQK 371
Cdd:pfam12230  81 QKSKALeeADPVTDVEMEEDEEEEEPSKDKIAKKSKPSAVSDSPP------------KNMKIRAAGEPRLKKRKNPTPPA 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114151   372 PVPKAfqpkvpmeISPFSGELVPATELEEHMRLKLLDPRWQEQRK--VEESRKSTLNLENVNVAANMKRLVSQ 442
Cdd:pfam12230 149 QKKKA--------KCPITGQLIPEDEFDEHMRILLLDPRYKEQKDkyVQKNFKESSNLTTDDVYRNLKRLAKK 213
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 42-95 1.86e-21

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 87.26  E-value: 1.86e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 19114151     42 REIIDKSASYVARNGPAFEEKIRQNEQANTKFAFLHANDPYHPYYQHKLTEARE 95
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 145-197 2.43e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 67.23  E-value: 2.43e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 19114151    145 LDVLRLTARYAAVRGSSFLVSLSQKEWNNTQFDFLKPNNALYPYFMRIVQQYT 197
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
 
Name Accession Description Interval E-value
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
 214-442 4.88e-63

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 403444  Cd Length: 213  Bit Score: 203.82  E-value: 4.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   214 NVRDPYSLLSKIQPRVRWQSHMESQKKKQKEEAEKEKLEYAQIDWNDFVVVEVIQFTKSDEHAKLAKPTNLADLQTATLE 293
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFDDSDEVLELPKPLTLEQLIYRSLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   294 QKSAMF--TMPDQNYTIEEAPPTAEPWEPISAPKKQEFGVSLPPSlaspekggisstTSVSPAAQASPVLSTTTQPKVQK 371
Cdd:pfam12230  81 QKSKALeeADPVTDVEMEEDEEEEEPSKDKIAKKSKPSAVSDSPP------------KNMKIRAAGEPRLKKRKNPTPPA 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114151   372 PVPKAfqpkvpmeISPFSGELVPATELEEHMRLKLLDPRWQEQRK--VEESRKSTLNLENVNVAANMKRLVSQ 442
Cdd:pfam12230 149 QKKKA--------KCPITGQLIPEDEFDEHMRILLLDPRYKEQKDkyVQKNFKESSNLTTDDVYRNLKRLAKK 213
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 42-95 1.86e-21

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 87.26  E-value: 1.86e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 19114151     42 REIIDKSASYVARNGPAFEEKIRQNEQANTKFAFLHANDPYHPYYQHKLTEARE 95
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 43-92 6.33e-21

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 85.65  E-value: 6.33e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19114151    43 EIIDKSASYVARNGPAFEEKIRQNEQANTKFAFLH-ANDPYHPYYQHKLTE 92
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYRWKLEE 51
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 145-197 2.43e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 67.23  E-value: 2.43e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 19114151    145 LDVLRLTARYAAVRGSSFLVSLSQKEWNNTQFDFLKPNNALYPYFMRIVQQYT 197
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 146-196 1.53e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 62.15  E-value: 1.53e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19114151   146 DVLRLTARYAAVRGSSFLVSLSQKEWNNTQFDFLKPNN-ALYPYFMRIVQQY 196
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDdPLHAYYRWKLEEY 52
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 302-401 1.90e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151  302 PDQNYTIEEAPPTAEPWEPISAPKKQEFGVSLPPSlASPEKGGISSTTSVSPAAQASPVLSTTTQPKVQKPVPKafQPKV 381
Cdd:PRK14949 700 PPPVPDPYDRPPWEEAPEVASANDGPNNAAEGNLS-ESVEDASNSELQAVEQQATHQPQVQAEAQSPASTTALT--QTSS 776

                         90       100
                 ....*....|....*....|
gi 19114151  382 PMEISPFSGELVPATELEEH 401
Cdd:PRK14949 777 EVQDTELNLVLLSSGSITGH 796
 
Name Accession Description Interval E-value
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
 214-442 4.88e-63

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 403444  Cd Length: 213  Bit Score: 203.82  E-value: 4.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   214 NVRDPYSLLSKIQPRVRWQSHMESQKKKQKEEAEKEKLEYAQIDWNDFVVVEVIQFTKSDEHAKLAKPTNLADLQTATLE 293
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFDDSDEVLELPKPLTLEQLIYRSLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151   294 QKSAMF--TMPDQNYTIEEAPPTAEPWEPISAPKKQEFGVSLPPSlaspekggisstTSVSPAAQASPVLSTTTQPKVQK 371
Cdd:pfam12230  81 QKSKALeeADPVTDVEMEEDEEEEEPSKDKIAKKSKPSAVSDSPP------------KNMKIRAAGEPRLKKRKNPTPPA 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114151   372 PVPKAfqpkvpmeISPFSGELVPATELEEHMRLKLLDPRWQEQRK--VEESRKSTLNLENVNVAANMKRLVSQ 442
Cdd:pfam12230 149 QKKKA--------KCPITGQLIPEDEFDEHMRILLLDPRYKEQKDkyVQKNFKESSNLTTDDVYRNLKRLAKK 213
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 42-95 1.86e-21

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 87.26  E-value: 1.86e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 19114151     42 REIIDKSASYVARNGPAFEEKIRQNEQANTKFAFLHANDPYHPYYQHKLTEARE 95
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 43-92 6.33e-21

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 85.65  E-value: 6.33e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19114151    43 EIIDKSASYVARNGPAFEEKIRQNEQANTKFAFLH-ANDPYHPYYQHKLTE 92
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYRWKLEE 51
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 145-197 2.43e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 67.23  E-value: 2.43e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 19114151    145 LDVLRLTARYAAVRGSSFLVSLSQKEWNNTQFDFLKPNNALYPYFMRIVQQYT 197
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 146-196 1.53e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 62.15  E-value: 1.53e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19114151   146 DVLRLTARYAAVRGSSFLVSLSQKEWNNTQFDFLKPNN-ALYPYFMRIVQQY 196
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDdPLHAYYRWKLEEY 52
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 302-401 1.90e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114151  302 PDQNYTIEEAPPTAEPWEPISAPKKQEFGVSLPPSlASPEKGGISSTTSVSPAAQASPVLSTTTQPKVQKPVPKafQPKV 381
Cdd:PRK14949 700 PPPVPDPYDRPPWEEAPEVASANDGPNNAAEGNLS-ESVEDASNSELQAVEQQATHQPQVQAEAQSPASTTALT--QTSS 776

                         90       100
                 ....*....|....*....|
gi 19114151  382 PMEISPFSGELVPATELEEH 401
Cdd:PRK14949 777 EVQDTELNLVLLSSGSITGH 796
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH