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Conserved domains on  [gi|429241997|ref|NP_593309|]
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Rho guanine nucleotide exchange factor [Schizosaccharomyces pombe]

Protein Classification

RhoGEF domain-containing protein( domain architecture ID 4023)

RhoGEF domain-containing protein contains guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family

CATH:  1.20.900.10
Gene Ontology:  GO:0005085

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhoGEF super family cl47571
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
52-205 6.29e-03

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


The actual alignment was detected with superfamily member pfam00621:

Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 37.28  E-value: 6.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997   52 ILQEIISTEYNYSVDLKkTLNEIIMPIEGQSM---EREAIGICTCFKTLNQLHTKLYQQMISSGSPVYSL---------- 118
Cdd:pfam00621   1 VIKELLQTERSYVRDLE-ILVEVFLPPNSKPLsesEEEIKTIFSNIEEIYELHRQLLLEELLKEWISIQRigdiflkfap 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997  119 --------SQSLPAFRDVYHMYTINLSGISAIEKIISDPSSCNSQ-----LLIPLQHLLRYPIHLARVCKmlrKYPFLNG 185
Cdd:pfam00621  80 gfkvystyCSNYPKALKLLKKLLKKNPKFRAFLEELEANPECRGLdlnsfLIKPVQRIPRYPLLLKELLK---HTPPDHP 156
                         170       180
                  ....*....|....*....|
gi 429241997  186 DFRMAVKTLDDFRELCSYID 205
Cdd:pfam00621 157 DYEDLKKALEAIKEVAKQIN 176
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
52-205 6.29e-03

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 37.28  E-value: 6.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997   52 ILQEIISTEYNYSVDLKkTLNEIIMPIEGQSM---EREAIGICTCFKTLNQLHTKLYQQMISSGSPVYSL---------- 118
Cdd:pfam00621   1 VIKELLQTERSYVRDLE-ILVEVFLPPNSKPLsesEEEIKTIFSNIEEIYELHRQLLLEELLKEWISIQRigdiflkfap 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997  119 --------SQSLPAFRDVYHMYTINLSGISAIEKIISDPSSCNSQ-----LLIPLQHLLRYPIHLARVCKmlrKYPFLNG 185
Cdd:pfam00621  80 gfkvystyCSNYPKALKLLKKLLKKNPKFRAFLEELEANPECRGLdlnsfLIKPVQRIPRYPLLLKELLK---HTPPDHP 156
                         170       180
                  ....*....|....*....|
gi 429241997  186 DFRMAVKTLDDFRELCSYID 205
Cdd:pfam00621 157 DYEDLKKALEAIKEVAKQIN 176
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
52-205 6.29e-03

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 37.28  E-value: 6.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997   52 ILQEIISTEYNYSVDLKkTLNEIIMPIEGQSM---EREAIGICTCFKTLNQLHTKLYQQMISSGSPVYSL---------- 118
Cdd:pfam00621   1 VIKELLQTERSYVRDLE-ILVEVFLPPNSKPLsesEEEIKTIFSNIEEIYELHRQLLLEELLKEWISIQRigdiflkfap 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241997  119 --------SQSLPAFRDVYHMYTINLSGISAIEKIISDPSSCNSQ-----LLIPLQHLLRYPIHLARVCKmlrKYPFLNG 185
Cdd:pfam00621  80 gfkvystyCSNYPKALKLLKKLLKKNPKFRAFLEELEANPECRGLdlnsfLIKPVQRIPRYPLLLKELLK---HTPPDHP 156
                         170       180
                  ....*....|....*....|
gi 429241997  186 DFRMAVKTLDDFRELCSYID 205
Cdd:pfam00621 157 DYEDLKKALEAIKEVAKQIN 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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