View
Concise Results
Standard Results
Full Results
ubiquitin-protein ligase E3 [Schizosaccharomyces pombe]
Protein Classification
HECT-type E3 ubiquitin transferase ( domain architecture ID 11472073 )
HECT-type E3 ubiquitin transferase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates
List of domain hits
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-1029
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 844.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 155 SNSNDSW L WQRF S SL L LNC L VS S IN S H R I E GTDTSA E TSLLHC L A Y V A PYL K SSE LS TYYDS V MTFY A QIYPK QN MTN L E 234
Cdd:COG5021 1 DLRVGGL L LEDL S CR L FSE L FR S NS S V R A E FDLSKD E SGVRNS L D Y G A AGN K NMS LS DEKGL V RSSI A ALDGL QN RDC L R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 235 DIMS LS L L TPVSSK T D E NANS SSA FLFH V LASD C FS sie NCIPPDL I IDK V FSS S L Q LSE E ACI S S L L NLG MIK V F S - L A 313
Cdd:COG5021 81 SLDP LS V L SVDGLQ T S E TSFR SSA LNPY V NEFL C EN --- DVRLSSS I TIQ V SDE S K Q NVI E DVF S G L E NLG SVD V L S t E A 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 314 GNCLHL L HTEYKNSS L WKF CS YIL D A L YVF SG E SV N SR IQV VS D V DDD E D D ENA F SQN Y Y S H L Q M VAKHFSKNYA N Q SG I 393
Cdd:COG5021 158 TKGIDF L EILITRDF L FSS CS LNS D F L KII SG S SV K SR KLA VS N V EKS E P D NVL F GLP Y R S A L T M RTNFLKLDTG N L SG E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 394 VQ RSF A EC IS STFIT K af KL VSSNTLQ A M S HFYATM I K L FPS N RTSI L M YI SLVETN E G SL T R SF S R FS WDMF S ESPV Y Q 473
Cdd:COG5021 238 VQ ALL A RY IS IKLVI K -- KL YLGPGPD A S S RISTLI I R L SNT N LNRR L S YI LSHSSF E D SL L R LN S L FS TRAD S FGRT Y Y 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 474 L F H KKFDV Q NVLKNDSGYWFQLQLLID V YS r MLFTM I D D EF H NDKQ NP LYPVMA EF CTV LKN LVL G LYW D VQAAKDVDCK 553
Cdd:COG5021 316 L D H DRILT Q YSRPLLEETLGESTSFLV V NN - DDSSS I K D LP H QVGS NP FLEAHP EF SEL LKN QSR G TTR D FRNKPTGWSS 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 554 S VV D IS Q LRV S STSLLQQL Y RINS R K Q FLP E DFFLMSEYF N LNEF ea N A LQ E SE L A S HAEAEI N IT Y K F DNFSESRPR L N 633
Cdd:COG5021 395 S IE D LG Q FLF S DFLTSSST Y EDLR R E Q LGR E SDESFYVAS N VQQQ -- R A SR E GP L L S GWKTRL N NL Y R F YFVEHRKKT L T 472
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 634 ILNN --- CSFF L P -- FHF RI HLLQQLL L LDKQAN g Y A QP F GHLK H AVI RR N R I F D D GFDAFYNFGKLLKGP irit FVDEH 708
Cdd:COG5021 473 KNDS rlg SFIS L N kl DIR RI KEDKRRK L FYSLKQ - K A KI F DPYL H IKV RR D R V F E D SYREIMDESGDDLKK ---- TLEIE 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 709 G V V EEGID G GGLT K E F L TSIC K TV F DIN YGLF SETKAH L LYPNTHAYAQ - DV E R L RCYE FLG ML IGK C IY EGIQI D AA F A 787
Cdd:COG5021 548 F V G EEGID A GGLT R E W L FLLS K EM F NPD YGLF EYITED L YTLPINPLSS i NP E H L SYFK FLG RV IGK A IY DSRIL D VQ F S 627
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 788 SF F VA K W LG H P SYFD DL T SLDP N LY EG LV F L K N Y D G D VEN d MA L N FTV VHEE FG VRNVID LIPNG S NISVTNEN RLQ Y IH 867
Cdd:COG5021 628 KA F YK K L LG K P VSLV DL E SLDP E LY RS LV W L L N N D I D ETI - LD L T FTV EDDS FG ESRTVE LIPNG R NISVTNEN KKE Y VK 706
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 868 L V SN Y Y LN A R LSR Q CR AF TN GF TQ II D P HW L AM F H ESE IQI L V GG D P VP IDIDD LRRH T V Y a G GY EPN SP T IV L FWE VLR 947
Cdd:COG5021 707 K V VD Y K LN K R VEK Q FS AF KS GF SE II P P DL L QI F D ESE LEL L I GG I P ED IDIDD WKSN T A Y - H GY TED SP I IV W FWE IIS 785
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 948 EF EE E DKRSFVK FVT SVA R P PI L GFK A L MP S ----- F C I RVN G E D ET RLP T A S TC V N L LKLP M YS T K QT LR D KLLTA VRS 1022
Cdd:COG5021 786 EF DF E ERAKLLQ FVT GTS R I PI N GFK D L QG S dgvrk F T I EKG G T D DD RLP S A H TC F N R LKLP E YS S K EK LR S KLLTA INE 865
....*..
gi 19114290 1023 G V GFG FS 1029
Cdd:COG5021 866 G A GFG LL 872
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-1029
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 844.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 155 SNSNDSW L WQRF S SL L LNC L VS S IN S H R I E GTDTSA E TSLLHC L A Y V A PYL K SSE LS TYYDS V MTFY A QIYPK QN MTN L E 234
Cdd:COG5021 1 DLRVGGL L LEDL S CR L FSE L FR S NS S V R A E FDLSKD E SGVRNS L D Y G A AGN K NMS LS DEKGL V RSSI A ALDGL QN RDC L R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 235 DIMS LS L L TPVSSK T D E NANS SSA FLFH V LASD C FS sie NCIPPDL I IDK V FSS S L Q LSE E ACI S S L L NLG MIK V F S - L A 313
Cdd:COG5021 81 SLDP LS V L SVDGLQ T S E TSFR SSA LNPY V NEFL C EN --- DVRLSSS I TIQ V SDE S K Q NVI E DVF S G L E NLG SVD V L S t E A 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 314 GNCLHL L HTEYKNSS L WKF CS YIL D A L YVF SG E SV N SR IQV VS D V DDD E D D ENA F SQN Y Y S H L Q M VAKHFSKNYA N Q SG I 393
Cdd:COG5021 158 TKGIDF L EILITRDF L FSS CS LNS D F L KII SG S SV K SR KLA VS N V EKS E P D NVL F GLP Y R S A L T M RTNFLKLDTG N L SG E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 394 VQ RSF A EC IS STFIT K af KL VSSNTLQ A M S HFYATM I K L FPS N RTSI L M YI SLVETN E G SL T R SF S R FS WDMF S ESPV Y Q 473
Cdd:COG5021 238 VQ ALL A RY IS IKLVI K -- KL YLGPGPD A S S RISTLI I R L SNT N LNRR L S YI LSHSSF E D SL L R LN S L FS TRAD S FGRT Y Y 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 474 L F H KKFDV Q NVLKNDSGYWFQLQLLID V YS r MLFTM I D D EF H NDKQ NP LYPVMA EF CTV LKN LVL G LYW D VQAAKDVDCK 553
Cdd:COG5021 316 L D H DRILT Q YSRPLLEETLGESTSFLV V NN - DDSSS I K D LP H QVGS NP FLEAHP EF SEL LKN QSR G TTR D FRNKPTGWSS 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 554 S VV D IS Q LRV S STSLLQQL Y RINS R K Q FLP E DFFLMSEYF N LNEF ea N A LQ E SE L A S HAEAEI N IT Y K F DNFSESRPR L N 633
Cdd:COG5021 395 S IE D LG Q FLF S DFLTSSST Y EDLR R E Q LGR E SDESFYVAS N VQQQ -- R A SR E GP L L S GWKTRL N NL Y R F YFVEHRKKT L T 472
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 634 ILNN --- CSFF L P -- FHF RI HLLQQLL L LDKQAN g Y A QP F GHLK H AVI RR N R I F D D GFDAFYNFGKLLKGP irit FVDEH 708
Cdd:COG5021 473 KNDS rlg SFIS L N kl DIR RI KEDKRRK L FYSLKQ - K A KI F DPYL H IKV RR D R V F E D SYREIMDESGDDLKK ---- TLEIE 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 709 G V V EEGID G GGLT K E F L TSIC K TV F DIN YGLF SETKAH L LYPNTHAYAQ - DV E R L RCYE FLG ML IGK C IY EGIQI D AA F A 787
Cdd:COG5021 548 F V G EEGID A GGLT R E W L FLLS K EM F NPD YGLF EYITED L YTLPINPLSS i NP E H L SYFK FLG RV IGK A IY DSRIL D VQ F S 627
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 788 SF F VA K W LG H P SYFD DL T SLDP N LY EG LV F L K N Y D G D VEN d MA L N FTV VHEE FG VRNVID LIPNG S NISVTNEN RLQ Y IH 867
Cdd:COG5021 628 KA F YK K L LG K P VSLV DL E SLDP E LY RS LV W L L N N D I D ETI - LD L T FTV EDDS FG ESRTVE LIPNG R NISVTNEN KKE Y VK 706
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 868 L V SN Y Y LN A R LSR Q CR AF TN GF TQ II D P HW L AM F H ESE IQI L V GG D P VP IDIDD LRRH T V Y a G GY EPN SP T IV L FWE VLR 947
Cdd:COG5021 707 K V VD Y K LN K R VEK Q FS AF KS GF SE II P P DL L QI F D ESE LEL L I GG I P ED IDIDD WKSN T A Y - H GY TED SP I IV W FWE IIS 785
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 948 EF EE E DKRSFVK FVT SVA R P PI L GFK A L MP S ----- F C I RVN G E D ET RLP T A S TC V N L LKLP M YS T K QT LR D KLLTA VRS 1022
Cdd:COG5021 786 EF DF E ERAKLLQ FVT GTS R I PI N GFK D L QG S dgvrk F T I EKG G T D DD RLP S A H TC F N R LKLP E YS S K EK LR S KLLTA INE 865
....*..
gi 19114290 1023 G V GFG FS 1029
Cdd:COG5021 866 G A GFG LL 872
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
676-1027
5.70e-148
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 444.32
E-value: 5.70e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 676 I RR N RI FD D GFDAFYNFG - KL LK GPIRIT FV D E hgvve EGID G GG L T K EF L T SIC K TV F DIN YGLF -- SETKAH LLYPN T 752
Cdd:cd00078 5 V RR D RI LE D ALRQLSKVS s SD LK KVLEVE FV G E ----- EGID A GG V T R EF F T LVS K EL F NPS YGLF ry TPDDSG LLYPN P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 753 HAY A q D VER L RCYE FLG M L I GK CI YEG IQI D AA F ASF F VA K W LG H P SYFD DL TS LDP N LY EG L VF L KNY DGD VE n D MA L N 832
Cdd:cd00078 80 SSF A - D EDH L KLFR FLG R L L GK AL YEG RLL D LP F SRA F YK K L LG K P LSLE DL EE LDP E LY KS L KE L LDN DGD ED - D LE L T 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 833 FT VVHEE - FG VRNVID L I P N G SN I S VTNEN RLQ Y IH L VSN Y Y LN ARLSR Q CR AF TN GF TQI I DPHW L AM F HES E IQI L VG 911
Cdd:cd00078 158 FT IELDS s FG GAVTVE L K P G G RD I P VTNEN KEE Y VD L YVD Y R LN KGIEE Q VE AF RD GF SEV I PEEL L SL F TPE E LEL L IC 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 912 G DP v P ID ID DL RRH T V Y A GGY EPN SPTI VL FWEVL RE F EE E DKRS F VK FVT SVA R P P IL GF KA L M P S F C IR VN G EDET RL 991
Cdd:cd00078 238 G SE - D ID LE DL KKN T E Y K GGY SSD SPTI QW FWEVL ES F TN E ERKK F LQ FVT GSS R L P VG GF AD L N P K F T IR RV G SPDD RL 316
330 340 350
....*....|....*....|....*....|....*.
gi 19114290 992 PTA S TC V NLLKLP M YS T K QT LR D KLL T A VRS G V GFG 1027
Cdd:cd00078 317 PTA H TC F NLLKLP P YS S K EI LR E KLL Y A INE G A GFG 352
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
695-1026
2.33e-143
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 431.66
E-value: 2.33e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 695 L L K GPIR I T F VD E hgvve EG I DGGG L T K EF LTSIC K TV F DIN YGLF SETKAH - LLYPN THAYAQDV E R L RCYE F L G MLI G 773
Cdd:smart00119 2 L K K RVLE I E F EG E ----- EG L DGGG V T R EF FFLLS K EL F NPD YGLF RYSPND y LLYPN PRSGFANE E H L SYFR F I G RVL G 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 774 K CI Y EGIQI D AA FA SF F VA K W LG H P SYFD DL T SLDP N LY EG L VF L K n YDG D VENDMA L N F T - V VHE EFG VRN V ID L I P N G 852
Cdd:smart00119 77 K AL Y DNRLL D LF FA RP F YK K L LG K P VTLH DL E SLDP E LY KS L KW L L - LNN D TSEELD L T F S i V LTS EFG QVK V VE L K P G G 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 853 SNI S VT N EN RLQ Y I HLV SN Y Y LN ARLSR Q CR AF TN GF TQI I DPHW L AM F HES E IQI L VG G D P v P ID I DDL RRH T V Y A GGY 932
Cdd:smart00119 156 SNI P VT E EN KKE Y V HLV IE Y R LN KGIEK Q LE AF RE GF SEV I PENL L KL F DPE E LEL L IC G S P - E ID V DDL KSN T E Y K GGY 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 933 EP NS P TI VL FWEV LRE F EE E DK R SFVK FVT SVA R P P IL GF K AL M P S F C IR VN G E D ET RLPTA S TC V N L LKLP M YS T K QT L 1012
Cdd:smart00119 235 SA NS Q TI KW FWEV VES F TN E ER R KLLQ FVT GSS R L P VG GF A AL S P K F T IR KA G S D DE RLPTA H TC F N R LKLP P YS S K EI L 314
330
....*....|....
gi 19114290 1013 R D KLL T A VRS G V GF 1026
Cdd:smart00119 315 R E KLL L A INE G K GF 328
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
726-1029
1.64e-113
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 352.68
E-value: 1.64e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 726 T SIC K TV FD I NYGLF SE -- TKAHLLYP N THAYAQ - D V E R L RCYE FLG M L I GK C IY E GI QI D AA F AS FF VA K W LG H P SYFD 802
Cdd:pfam00632 1 T LLS K EL FD P NYGLF EY et EDDRTYWF N PSSSES p D L E L L DYFK FLG K L L GK A IY N GI LL D LP F PP FF YK K L LG E P LTLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 803 DL T S L DP N LY EG L VF L K N Y D G D VEN D MA L N FT V vh EE FG VRNV I D LIPNG S NI S VTNEN RLQ YI H L VSN Y Y LN ARLSR Q C 882
Cdd:pfam00632 81 DL E S I DP E LY KS L KS L L N M D N D DDE D LG L T FT I -- PV FG ESKT I E LIPNG R NI P VTNEN KEE YI R L YVD Y R LN KSIEP Q L 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 883 R AF TN GF TQI I DPHW L AM F HES E IQI L VG G D P V p ID ID DL RRH T V Y A GGY EP NSPTI VL FWE V L R EF EE E DK R S F V KFVT 962
Cdd:pfam00632 159 E AF RK GF YSV I PKEA L SL F TPE E LEL L IC G S P E - ID VE DL KKN T E Y D GGY TK NSPTI QW FWE I L E EF SP E QR R L F L KFVT 237
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114290 963 SVA R P P IL GFK A L m P S F C I - R VN G E D ET RLPTA S TC V N L LKLP M YS T K QT L RD KLL T A VRS G V GFG F S 1029
Cdd:pfam00632 238 GSS R L P VG GFK S L - P K F T I v R KG G D D DD RLPTA H TC F N R LKLP D YS S K EI L KE KLL I A IEE G E GFG L S 304
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-1029
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 844.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 155 SNSNDSW L WQRF S SL L LNC L VS S IN S H R I E GTDTSA E TSLLHC L A Y V A PYL K SSE LS TYYDS V MTFY A QIYPK QN MTN L E 234
Cdd:COG5021 1 DLRVGGL L LEDL S CR L FSE L FR S NS S V R A E FDLSKD E SGVRNS L D Y G A AGN K NMS LS DEKGL V RSSI A ALDGL QN RDC L R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 235 DIMS LS L L TPVSSK T D E NANS SSA FLFH V LASD C FS sie NCIPPDL I IDK V FSS S L Q LSE E ACI S S L L NLG MIK V F S - L A 313
Cdd:COG5021 81 SLDP LS V L SVDGLQ T S E TSFR SSA LNPY V NEFL C EN --- DVRLSSS I TIQ V SDE S K Q NVI E DVF S G L E NLG SVD V L S t E A 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 314 GNCLHL L HTEYKNSS L WKF CS YIL D A L YVF SG E SV N SR IQV VS D V DDD E D D ENA F SQN Y Y S H L Q M VAKHFSKNYA N Q SG I 393
Cdd:COG5021 158 TKGIDF L EILITRDF L FSS CS LNS D F L KII SG S SV K SR KLA VS N V EKS E P D NVL F GLP Y R S A L T M RTNFLKLDTG N L SG E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 394 VQ RSF A EC IS STFIT K af KL VSSNTLQ A M S HFYATM I K L FPS N RTSI L M YI SLVETN E G SL T R SF S R FS WDMF S ESPV Y Q 473
Cdd:COG5021 238 VQ ALL A RY IS IKLVI K -- KL YLGPGPD A S S RISTLI I R L SNT N LNRR L S YI LSHSSF E D SL L R LN S L FS TRAD S FGRT Y Y 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 474 L F H KKFDV Q NVLKNDSGYWFQLQLLID V YS r MLFTM I D D EF H NDKQ NP LYPVMA EF CTV LKN LVL G LYW D VQAAKDVDCK 553
Cdd:COG5021 316 L D H DRILT Q YSRPLLEETLGESTSFLV V NN - DDSSS I K D LP H QVGS NP FLEAHP EF SEL LKN QSR G TTR D FRNKPTGWSS 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 554 S VV D IS Q LRV S STSLLQQL Y RINS R K Q FLP E DFFLMSEYF N LNEF ea N A LQ E SE L A S HAEAEI N IT Y K F DNFSESRPR L N 633
Cdd:COG5021 395 S IE D LG Q FLF S DFLTSSST Y EDLR R E Q LGR E SDESFYVAS N VQQQ -- R A SR E GP L L S GWKTRL N NL Y R F YFVEHRKKT L T 472
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 634 ILNN --- CSFF L P -- FHF RI HLLQQLL L LDKQAN g Y A QP F GHLK H AVI RR N R I F D D GFDAFYNFGKLLKGP irit FVDEH 708
Cdd:COG5021 473 KNDS rlg SFIS L N kl DIR RI KEDKRRK L FYSLKQ - K A KI F DPYL H IKV RR D R V F E D SYREIMDESGDDLKK ---- TLEIE 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 709 G V V EEGID G GGLT K E F L TSIC K TV F DIN YGLF SETKAH L LYPNTHAYAQ - DV E R L RCYE FLG ML IGK C IY EGIQI D AA F A 787
Cdd:COG5021 548 F V G EEGID A GGLT R E W L FLLS K EM F NPD YGLF EYITED L YTLPINPLSS i NP E H L SYFK FLG RV IGK A IY DSRIL D VQ F S 627
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 788 SF F VA K W LG H P SYFD DL T SLDP N LY EG LV F L K N Y D G D VEN d MA L N FTV VHEE FG VRNVID LIPNG S NISVTNEN RLQ Y IH 867
Cdd:COG5021 628 KA F YK K L LG K P VSLV DL E SLDP E LY RS LV W L L N N D I D ETI - LD L T FTV EDDS FG ESRTVE LIPNG R NISVTNEN KKE Y VK 706
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 868 L V SN Y Y LN A R LSR Q CR AF TN GF TQ II D P HW L AM F H ESE IQI L V GG D P VP IDIDD LRRH T V Y a G GY EPN SP T IV L FWE VLR 947
Cdd:COG5021 707 K V VD Y K LN K R VEK Q FS AF KS GF SE II P P DL L QI F D ESE LEL L I GG I P ED IDIDD WKSN T A Y - H GY TED SP I IV W FWE IIS 785
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 948 EF EE E DKRSFVK FVT SVA R P PI L GFK A L MP S ----- F C I RVN G E D ET RLP T A S TC V N L LKLP M YS T K QT LR D KLLTA VRS 1022
Cdd:COG5021 786 EF DF E ERAKLLQ FVT GTS R I PI N GFK D L QG S dgvrk F T I EKG G T D DD RLP S A H TC F N R LKLP E YS S K EK LR S KLLTA INE 865
....*..
gi 19114290 1023 G V GFG FS 1029
Cdd:COG5021 866 G A GFG LL 872
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
676-1027
5.70e-148
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 444.32
E-value: 5.70e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 676 I RR N RI FD D GFDAFYNFG - KL LK GPIRIT FV D E hgvve EGID G GG L T K EF L T SIC K TV F DIN YGLF -- SETKAH LLYPN T 752
Cdd:cd00078 5 V RR D RI LE D ALRQLSKVS s SD LK KVLEVE FV G E ----- EGID A GG V T R EF F T LVS K EL F NPS YGLF ry TPDDSG LLYPN P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 753 HAY A q D VER L RCYE FLG M L I GK CI YEG IQI D AA F ASF F VA K W LG H P SYFD DL TS LDP N LY EG L VF L KNY DGD VE n D MA L N 832
Cdd:cd00078 80 SSF A - D EDH L KLFR FLG R L L GK AL YEG RLL D LP F SRA F YK K L LG K P LSLE DL EE LDP E LY KS L KE L LDN DGD ED - D LE L T 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 833 FT VVHEE - FG VRNVID L I P N G SN I S VTNEN RLQ Y IH L VSN Y Y LN ARLSR Q CR AF TN GF TQI I DPHW L AM F HES E IQI L VG 911
Cdd:cd00078 158 FT IELDS s FG GAVTVE L K P G G RD I P VTNEN KEE Y VD L YVD Y R LN KGIEE Q VE AF RD GF SEV I PEEL L SL F TPE E LEL L IC 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 912 G DP v P ID ID DL RRH T V Y A GGY EPN SPTI VL FWEVL RE F EE E DKRS F VK FVT SVA R P P IL GF KA L M P S F C IR VN G EDET RL 991
Cdd:cd00078 238 G SE - D ID LE DL KKN T E Y K GGY SSD SPTI QW FWEVL ES F TN E ERKK F LQ FVT GSS R L P VG GF AD L N P K F T IR RV G SPDD RL 316
330 340 350
....*....|....*....|....*....|....*.
gi 19114290 992 PTA S TC V NLLKLP M YS T K QT LR D KLL T A VRS G V GFG 1027
Cdd:cd00078 317 PTA H TC F NLLKLP P YS S K EI LR E KLL Y A INE G A GFG 352
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
695-1026
2.33e-143
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 431.66
E-value: 2.33e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 695 L L K GPIR I T F VD E hgvve EG I DGGG L T K EF LTSIC K TV F DIN YGLF SETKAH - LLYPN THAYAQDV E R L RCYE F L G MLI G 773
Cdd:smart00119 2 L K K RVLE I E F EG E ----- EG L DGGG V T R EF FFLLS K EL F NPD YGLF RYSPND y LLYPN PRSGFANE E H L SYFR F I G RVL G 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 774 K CI Y EGIQI D AA FA SF F VA K W LG H P SYFD DL T SLDP N LY EG L VF L K n YDG D VENDMA L N F T - V VHE EFG VRN V ID L I P N G 852
Cdd:smart00119 77 K AL Y DNRLL D LF FA RP F YK K L LG K P VTLH DL E SLDP E LY KS L KW L L - LNN D TSEELD L T F S i V LTS EFG QVK V VE L K P G G 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 853 SNI S VT N EN RLQ Y I HLV SN Y Y LN ARLSR Q CR AF TN GF TQI I DPHW L AM F HES E IQI L VG G D P v P ID I DDL RRH T V Y A GGY 932
Cdd:smart00119 156 SNI P VT E EN KKE Y V HLV IE Y R LN KGIEK Q LE AF RE GF SEV I PENL L KL F DPE E LEL L IC G S P - E ID V DDL KSN T E Y K GGY 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 933 EP NS P TI VL FWEV LRE F EE E DK R SFVK FVT SVA R P P IL GF K AL M P S F C IR VN G E D ET RLPTA S TC V N L LKLP M YS T K QT L 1012
Cdd:smart00119 235 SA NS Q TI KW FWEV VES F TN E ER R KLLQ FVT GSS R L P VG GF A AL S P K F T IR KA G S D DE RLPTA H TC F N R LKLP P YS S K EI L 314
330
....*....|....
gi 19114290 1013 R D KLL T A VRS G V GF 1026
Cdd:smart00119 315 R E KLL L A INE G K GF 328
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
726-1029
1.64e-113
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 352.68
E-value: 1.64e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 726 T SIC K TV FD I NYGLF SE -- TKAHLLYP N THAYAQ - D V E R L RCYE FLG M L I GK C IY E GI QI D AA F AS FF VA K W LG H P SYFD 802
Cdd:pfam00632 1 T LLS K EL FD P NYGLF EY et EDDRTYWF N PSSSES p D L E L L DYFK FLG K L L GK A IY N GI LL D LP F PP FF YK K L LG E P LTLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 803 DL T S L DP N LY EG L VF L K N Y D G D VEN D MA L N FT V vh EE FG VRNV I D LIPNG S NI S VTNEN RLQ YI H L VSN Y Y LN ARLSR Q C 882
Cdd:pfam00632 81 DL E S I DP E LY KS L KS L L N M D N D DDE D LG L T FT I -- PV FG ESKT I E LIPNG R NI P VTNEN KEE YI R L YVD Y R LN KSIEP Q L 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114290 883 R AF TN GF TQI I DPHW L AM F HES E IQI L VG G D P V p ID ID DL RRH T V Y A GGY EP NSPTI VL FWE V L R EF EE E DK R S F V KFVT 962
Cdd:pfam00632 159 E AF RK GF YSV I PKEA L SL F TPE E LEL L IC G S P E - ID VE DL KKN T E Y D GGY TK NSPTI QW FWE I L E EF SP E QR R L F L KFVT 237
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114290 963 SVA R P P IL GFK A L m P S F C I - R VN G E D ET RLPTA S TC V N L LKLP M YS T K QT L RD KLL T A VRS G V GFG F S 1029
Cdd:pfam00632 238 GSS R L P VG GFK S L - P K F T I v R KG G D D DD RLPTA H TC F N R LKLP D YS S K EI L KE KLL I A IEE G E GFG L S 304
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
