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Conserved domains on  [gi|429242146|ref|NP_593450|]
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Ino80 complex actin-like protein Arp8 [Schizosaccharomyces pombe]

Protein Classification

COG5277 family protein( domain architecture ID 10009158)

COG5277 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 96-654 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


:

Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 524.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  96 KTIVLHIGSQNLRIGLASNKTPTTVPMVIARKMRAPFAQERCLlKDICHVNEDGNVAFDSEFDSNLKLLDSELKSWLKAQ 175
Cdd:cd10206    1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPED-VPPAVRNGEDSVESEEEREEALKEVERALKSRKKSN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 176 KKRSVPNgtQLVKNYNKISKPETVPPDDDPEKPDWIhFEQDDHVDVICGKEAFLLPLNEypEYKLFYPIKSGVFNES-DY 254
Cdd:cd10206   80 GRRRIPN--QVSAKQNKPSKPENVPEDLDASSGENW-TDTSDYPDFLVGEEALRLPPSE--EYNLHWPIRRGRLNVHsDG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 255 ASSQQLLADIYEIFKYSITSLLQIPVSQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSA 334
Cdd:cd10206  155 GSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHVKELVDLLLRRLGFSSVFVHQESVCATFGAGLSS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHFPYQDIDLKTPYDWSLANALKIKYCGLSEATY 414
Cdd:cd10206  235 ACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYRECNLNSPLDFLLLERLKETYCTLDQDDI 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 415 NVQLNSFFSRTPDKGTRKFTFKsldetmlaplgffrpdifenenklhdrytlfpvpvdvydnqpnnpeslaqttllqist 494
Cdd:cd10206  315 GVQLHEFYVREPGQPTLKYQFK---------------------------------------------------------- 336

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 495 pisnikangkddeekkeesdlvtpsvkfkpprvvycgslaapeikneklIYPLDDAINQSIfsacDGNLSDEKAKNLYSS 574
Cdd:cd10206  337 -------------------------------------------------LLPLDEAIVQSI----LSCASDELKRKMYSS 363

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 575 ILIVGGAGQFPGFAHLLEERIHSKR----ANIPTISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRV 650
Cdd:cd10206  364 ILLVGGGAKIPGLAEALEDRLLIKIpslfEAVETVEVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRA 443


                 ....
gi 429242146 651 LQYK 654
Cdd:cd10206  444 LRER 447
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 96-654 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 524.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  96 KTIVLHIGSQNLRIGLASNKTPTTVPMVIARKMRAPFAQERCLlKDICHVNEDGNVAFDSEFDSNLKLLDSELKSWLKAQ 175
Cdd:cd10206    1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPED-VPPAVRNGEDSVESEEEREEALKEVERALKSRKKSN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 176 KKRSVPNgtQLVKNYNKISKPETVPPDDDPEKPDWIhFEQDDHVDVICGKEAFLLPLNEypEYKLFYPIKSGVFNES-DY 254
Cdd:cd10206   80 GRRRIPN--QVSAKQNKPSKPENVPEDLDASSGENW-TDTSDYPDFLVGEEALRLPPSE--EYNLHWPIRRGRLNVHsDG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 255 ASSQQLLADIYEIFKYSITSLLQIPVSQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSA 334
Cdd:cd10206  155 GSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHVKELVDLLLRRLGFSSVFVHQESVCATFGAGLSS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHFPYQDIDLKTPYDWSLANALKIKYCGLSEATY 414
Cdd:cd10206  235 ACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYRECNLNSPLDFLLLERLKETYCTLDQDDI 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 415 NVQLNSFFSRTPDKGTRKFTFKsldetmlaplgffrpdifenenklhdrytlfpvpvdvydnqpnnpeslaqttllqist 494
Cdd:cd10206  315 GVQLHEFYVREPGQPTLKYQFK---------------------------------------------------------- 336

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 495 pisnikangkddeekkeesdlvtpsvkfkpprvvycgslaapeikneklIYPLDDAINQSIfsacDGNLSDEKAKNLYSS 574
Cdd:cd10206  337 -------------------------------------------------LLPLDEAIVQSI----LSCASDELKRKMYSS 363

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 575 ILIVGGAGQFPGFAHLLEERIHSKR----ANIPTISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRV 650
Cdd:cd10206  364 ILLVGGGAKIPGLAEALEDRLLIKIpslfEAVETVEVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRA 443


                 ....
gi 429242146 651 LQYK 654
Cdd:cd10206  444 LRER 447
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 214-654 5.70e-26

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 110.04  E-value: 5.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   214 EQDDHVDVICGKEAflLPLNEYPEYKlfYPIKSGVFNESDyassqqllaDIYEIFKYSITSLLQIpvsQLSQYSVIFIVP 293
Cdd:smart00268  40 MVGDAKDIFVGDEA--QEKRGGLELK--YPIENGIVENWD---------DMEKIWDYTFFNELRV---EPEEHPVLLTEP 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   294 DLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLL 373
Cdd:smart00268 104 PMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDY 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   374 FMKLLMRSHFPYQdidlkTPYDWSLANALKIKYCGLSE------ATYNVQLNS---FFSRTPDKGTrkfTFKSLDETMLA 444
Cdd:smart00268 184 LKELLSERGYQFN-----SSAEFEIVREIKEKLCYVAEdfekemKLARESSESsklEKTYELPDGN---TIKVGNERFRI 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   445 PLGFFRPDIFENENKlhdrytlfpvpvdvydnqpnnpeslaqttllqistpisnikangkddeekkeesdlvtpsvkfkp 524
Cdd:smart00268 256 PEILFSPELIGLEQK----------------------------------------------------------------- 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   525 prvvycgslaapeiknekliyPLDDAINQSIfSACDGNLsdekAKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPT 604
Cdd:smart00268 271 ---------------------GIHELVYESI-QKCDIDV----RKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLK 324

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 429242146   605 ISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYK 654
Cdd:smart00268 325 VKVIAPP---ERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERK 371
Actin pfam00022
Actin;
236-655 2.40e-15

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 78.50  E-value: 2.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  236 PEYKLFYPIKSGVFNESDYASsqqlladiyEIFKYSITSLLQIpvsQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFG 315
Cdd:pfam00022  56 PGMEVRSPVEDGIVVDWDAME---------EIWEHVLKEELQV---DPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  316 KAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHF---PYQDIDLKT 392
Cdd:pfam00022 124 ALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIeitPRYLIKSKK 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  393 PYDWSLANA-LKIKYCGLSEATYNVQL--------NSFFSRTPDKGTRKftfksldETMLAPLGFFRPD----IFENEnk 459
Cdd:pfam00022 204 PGDPAPAVTkRELPDTTYSYKTYQERRvleeikesVCYVSDDPFGDETT-------SSSIPTRVYELPDgstiILGAE-- 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  460 lhdRYT----LFpVPVDVYDNQPNNPESLAQTTllqistpisnikangkddeekkeesdlvtpsvkfkpPRVVYcgslaa 535
Cdd:pfam00022 275 ---RFRvpeiLF-NPSLIGSESELPPPQTAVGI------------------------------------PELIV------ 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  536 peiknekliypldDAINqsifsACDGNLSdekaKNLYSSILIVGGAGQFPGFAhlleERIHSKRANI----PTISVIPPP 611
Cdd:pfam00022 309 -------------DAIN-----ACDVDLR----PSLLANIVVTGGNSLFPGFT----ERLEKELAQLappgVKVKIIAPG 362

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 429242146  612 RSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKT 655
Cdd:pfam00022 363 NTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHGASVVERKC 406
PTZ00004 PTZ00004
actin-2; Provisional
 240-648 2.41e-08

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 56.70  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 240 LFYPIKSGVFNESDyassqqllaDIYEIFKYsiTSLLQIPVSQlSQYSVIFIVPDLYDRVYVEKILDILF--FDL---HF 314
Cdd:PTZ00004  68 LKYPIEHGIVTNWD---------DMEKIWHH--TFYNELRVAP-EEHPVLLTEAPLNPKANREKMTQIMFetHNVpamYV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 315 GKAAIVqeSLctsFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHF---PYQDIDLk 391
Cdd:PTZ00004 136 AIQAVL--SL---YASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTtftTTAEKEI- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 392 tpydWSlanALKIKYCGLSEATYNvqlnsfFSRTPDKGTrkftfksldetmlaplgffrpDIFENENKLHDrytlfpvpv 471
Cdd:PTZ00004 210 ----VR---DIKEKLCYIALDFDE------EMGNSAGSS---------------------DKYEESYELPD--------- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 472 dvydnqpnnpeslaqTTLLQISTpisnikangkddeekkeeSDLVTPSVKFKPPRVvycGSLAAPEIknEKLIYpldDAI 551
Cdd:PTZ00004 247 ---------------GTIITVGS------------------ERFRCPEALFQPSLI---GKEEPPGI--HELTF---QSI 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 552 NQsifsaCDGNLSdekaKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPRSMDAqfvAWKGACIYNRIR 631
Cdd:PTZ00004 286 NK-----CDIDIR----KDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVVAPPERKYS---VWIGGSILSSLP 353

                        410
                 ....*....|....*..
gi 429242146 632 IVSELWIKNSDWKMLGS 648
Cdd:PTZ00004 354 TFQQMWVTKEEYDESGP 370
FtsA COG0849
Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];
335-406 1.90e-03

Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440610 [Multi-domain]  Cd Length: 402  Bit Score: 41.27  E-value: 1.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSRIKInyGGDDITllfmkllmrshfpyQDI--DLKTPYDwsLANALKIKY 406
Cdd:COG0849  202 VALVDIGGGTTDIAVFKDGALRHTAVIPV--GGDHIT--------------NDIaiGLRTPLE--EAERLKIKY 257
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 96-654 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 524.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  96 KTIVLHIGSQNLRIGLASNKTPTTVPMVIARKMRAPFAQERCLlKDICHVNEDGNVAFDSEFDSNLKLLDSELKSWLKAQ 175
Cdd:cd10206    1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPED-VPPAVRNGEDSVESEEEREEALKEVERALKSRKKSN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 176 KKRSVPNgtQLVKNYNKISKPETVPPDDDPEKPDWIhFEQDDHVDVICGKEAFLLPLNEypEYKLFYPIKSGVFNES-DY 254
Cdd:cd10206   80 GRRRIPN--QVSAKQNKPSKPENVPEDLDASSGENW-TDTSDYPDFLVGEEALRLPPSE--EYNLHWPIRRGRLNVHsDG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 255 ASSQQLLADIYEIFKYSITSLLQIPVSQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSA 334
Cdd:cd10206  155 GSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHVKELVDLLLRRLGFSSVFVHQESVCATFGAGLSS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHFPYQDIDLKTPYDWSLANALKIKYCGLSEATY 414
Cdd:cd10206  235 ACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYRECNLNSPLDFLLLERLKETYCTLDQDDI 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 415 NVQLNSFFSRTPDKGTRKFTFKsldetmlaplgffrpdifenenklhdrytlfpvpvdvydnqpnnpeslaqttllqist 494
Cdd:cd10206  315 GVQLHEFYVREPGQPTLKYQFK---------------------------------------------------------- 336

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 495 pisnikangkddeekkeesdlvtpsvkfkpprvvycgslaapeikneklIYPLDDAINQSIfsacDGNLSDEKAKNLYSS 574
Cdd:cd10206  337 -------------------------------------------------LLPLDEAIVQSI----LSCASDELKRKMYSS 363

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 575 ILIVGGAGQFPGFAHLLEERIHSKR----ANIPTISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRV 650
Cdd:cd10206  364 ILLVGGGAKIPGLAEALEDRLLIKIpslfEAVETVEVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRA 443


                 ....
gi 429242146 651 LQYK 654
Cdd:cd10206  444 LRER 447
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 263-416 1.17e-28

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 115.28  E-value: 1.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 263 DIYEIFKYSITSLLQIpvsQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGA 342
Cdd:cd10169   28 DMEKIWEHVFYNLLRV---DPEEHPVLLTEPPLNPKANREKLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGE 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 429242146 343 QKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHFPYQdidlkTPYDWSLANALKIKYCGLSEATYNV 416
Cdd:cd10169  105 GVTHIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSFS-----TSAEREIVRDIKEKLCGLHELIYDS 173
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 214-654 5.70e-26

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 110.04  E-value: 5.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   214 EQDDHVDVICGKEAflLPLNEYPEYKlfYPIKSGVFNESDyassqqllaDIYEIFKYSITSLLQIpvsQLSQYSVIFIVP 293
Cdd:smart00268  40 MVGDAKDIFVGDEA--QEKRGGLELK--YPIENGIVENWD---------DMEKIWDYTFFNELRV---EPEEHPVLLTEP 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   294 DLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLL 373
Cdd:smart00268 104 PMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDY 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   374 FMKLLMRSHFPYQdidlkTPYDWSLANALKIKYCGLSE------ATYNVQLNS---FFSRTPDKGTrkfTFKSLDETMLA 444
Cdd:smart00268 184 LKELLSERGYQFN-----SSAEFEIVREIKEKLCYVAEdfekemKLARESSESsklEKTYELPDGN---TIKVGNERFRI 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   445 PLGFFRPDIFENENKlhdrytlfpvpvdvydnqpnnpeslaqttllqistpisnikangkddeekkeesdlvtpsvkfkp 524
Cdd:smart00268 256 PEILFSPELIGLEQK----------------------------------------------------------------- 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146   525 prvvycgslaapeiknekliyPLDDAINQSIfSACDGNLsdekAKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPT 604
Cdd:smart00268 271 ---------------------GIHELVYESI-QKCDIDV----RKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLK 324

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 429242146   605 ISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYK 654
Cdd:smart00268 325 VKVIAPP---ERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERK 371
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
 226-412 1.97e-15

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 78.12  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 226 EAFLLPLNEYP-EYKLFYPIKSGvfnesDYASSQQLLAdiyeIFKYSITSLLQIPVSQlSQYSVIFIVPDLYDRVYVEKI 304
Cdd:cd10208   20 ELLTPPTIEIPtRVEIIWPIQDG-----RVVDWDALEA----LWRHILFSLLSIPRPT-NNSPVLLSVPPSWSKSDLELL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 305 LDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLmRSHFP 384
Cdd:cd10208   90 TQLFFERLNVPAFAILEAPLAALYAAGATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQDCTAHLAQLL-KSDEP 168

                        170       180
                 ....*....|....*....|....*...
gi 429242146 385 YQDIDLKTPYDWSLANALKIKYCGLSEA 412
Cdd:cd10208  169 ELKSQAESGEEATLDLAEALKKSPICEV 196
Actin pfam00022
Actin;
236-655 2.40e-15

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 78.50  E-value: 2.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  236 PEYKLFYPIKSGVFNESDYASsqqlladiyEIFKYSITSLLQIpvsQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFG 315
Cdd:pfam00022  56 PGMEVRSPVEDGIVVDWDAME---------EIWEHVLKEELQV---DPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  316 KAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHF---PYQDIDLKT 392
Cdd:pfam00022 124 ALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIeitPRYLIKSKK 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  393 PYDWSLANA-LKIKYCGLSEATYNVQL--------NSFFSRTPDKGTRKftfksldETMLAPLGFFRPD----IFENEnk 459
Cdd:pfam00022 204 PGDPAPAVTkRELPDTTYSYKTYQERRvleeikesVCYVSDDPFGDETT-------SSSIPTRVYELPDgstiILGAE-- 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  460 lhdRYT----LFpVPVDVYDNQPNNPESLAQTTllqistpisnikangkddeekkeesdlvtpsvkfkpPRVVYcgslaa 535
Cdd:pfam00022 275 ---RFRvpeiLF-NPSLIGSESELPPPQTAVGI------------------------------------PELIV------ 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146  536 peiknekliypldDAINqsifsACDGNLSdekaKNLYSSILIVGGAGQFPGFAhlleERIHSKRANI----PTISVIPPP 611
Cdd:pfam00022 309 -------------DAIN-----ACDVDLR----PSLLANIVVTGGNSLFPGFT----ERLEKELAQLappgVKVKIIAPG 362

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 429242146  612 RSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKT 655
Cdd:pfam00022 363 NTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHGASVVERKC 406
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 263-626 8.71e-10

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 61.04  E-value: 8.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 263 DIYE-IFKYSITSLLQIpvsQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMG 341
Cdd:cd13395   86 DAFEkLWDHALKNRLRV---DPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVVDSG 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 342 AQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHF---PYQDIDLKTPYDwsLANALKIKYCGLSEATynvql 418
Cdd:cd13395  163 ATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIeiiPRYMIKSKEPVE--GGAPAKYTKKDLPNTT----- 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 419 NSFfsrtpDKGTRKFTFKSLDETMLA-PLGFFRPDIFENENKLHdrYTlFPvpvdvyDNQPNN--------PESLAQTtl 489
Cdd:cd13395  236 SSY-----HRYMVRRVLQDFKESVCQvSDSPFDESEAASIPTVS--YE-LP------DGYNIEfgaerfkiPELLFDP-- 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 490 lqistpiSNIKANGKDDEEKKEESDLvtpsvkfkpPRVVYcgslaapeiknekliyplddainQSIfSACDGNLSdekaK 569
Cdd:cd13395  300 -------SLVKGIPAPPSEGNELLGL---------PQLVY-----------------------TSI-GSCDVDIR----P 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 429242146 570 NLYSSILIVGGAGQFPGFAhlleERIHSKRANIPT----ISVIPPPRSMDAQFVAWKGACI 626
Cdd:cd13395  336 ELYGNVVLTGGNSLLPGFT----DRLNRELSEKAPgslkLKILASGNTVERRFSSWIGGSI 392
PTZ00004 PTZ00004
actin-2; Provisional
 240-648 2.41e-08

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 56.70  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 240 LFYPIKSGVFNESDyassqqllaDIYEIFKYsiTSLLQIPVSQlSQYSVIFIVPDLYDRVYVEKILDILF--FDL---HF 314
Cdd:PTZ00004  68 LKYPIEHGIVTNWD---------DMEKIWHH--TFYNELRVAP-EEHPVLLTEAPLNPKANREKMTQIMFetHNVpamYV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 315 GKAAIVqeSLctsFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHF---PYQDIDLk 391
Cdd:PTZ00004 136 AIQAVL--SL---YASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTtftTTAEKEI- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 392 tpydWSlanALKIKYCGLSEATYNvqlnsfFSRTPDKGTrkftfksldetmlaplgffrpDIFENENKLHDrytlfpvpv 471
Cdd:PTZ00004 210 ----VR---DIKEKLCYIALDFDE------EMGNSAGSS---------------------DKYEESYELPD--------- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 472 dvydnqpnnpeslaqTTLLQISTpisnikangkddeekkeeSDLVTPSVKFKPPRVvycGSLAAPEIknEKLIYpldDAI 551
Cdd:PTZ00004 247 ---------------GTIITVGS------------------ERFRCPEALFQPSLI---GKEEPPGI--HELTF---QSI 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 552 NQsifsaCDGNLSdekaKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPRSMDAqfvAWKGACIYNRIR 631
Cdd:PTZ00004 286 NK-----CDIDIR----KDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVVAPPERKYS---VWIGGSILSSLP 353

                        410
                 ....*....|....*..
gi 429242146 632 IVSELWIKNSDWKMLGS 648
Cdd:PTZ00004 354 TFQQMWVTKEEYDESGP 370
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 288-414 6.56e-08

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 55.09  E-value: 6.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 288 VIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGG 367
Cdd:cd10209   84 VLIAEPLLTSKAERERLTQLMFETFNVSGLYASEQAVLSLYAVGRISGCVVDVGHGKIDIAPVWEGAIQHNAVRRFEIGG 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429242146 368 DDITLLFMKLLMRSHfPYQDID------LKTPYDWSL--ANALKIKYCGLSEATY 414
Cdd:cd10209  164 RDLTELLAAELGKSN-PKVKLDrsiverLKEAVAWSAddEEAYEKKVLTCSPETY 217
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 239-644 1.24e-06

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 51.03  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 239 KLFYPIKSGVFNESDyassqqllaDIYEIFKYSITSLLQIpvsQLSQYSVIFIVPDLYDRVYVEKILDILFfdLHFG-KA 317
Cdd:cd13397   61 TLSYPIEHGIVTNWD---------DMEKIWHHTFENELRV---KPEEHPVLLTEAPLNPKQNREKMAEIMF--ETFGvPA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 318 AIVQ-ESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRShfpyqDIDLKTPYDW 396
Cdd:cd13397  127 FYVAiQAVLSLYSSGRTTGLVLDSGDGVTHTVPIYEGYALPHAVQRLDLAGRDLTEYLMKLLKER-----GHSFTTTAER 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 397 SLANALKIKYCglseatYnVQLNsffsrtPDKGTRKfTFKSLDETmlaplgffrpdifenenklhdrYTLfpvPvdvyDN 476
Cdd:cd13397  202 EIVRDIKEKLC------Y-VALD------YEEELKK-KSEELEKE----------------------YTL---P----DG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 477 QpnnpeslaqttLLQISTPisnikangkddeekkeesdlvtpsvKFKPPRVvycgsLAAPEIkNEKLIYPLDDAINQSIF 556
Cdd:cd13397  239 Q-----------VIKIGSE-------------------------RFRCPEA-----LFRPSL-IGREAPGIHKLVYNSIM 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 557 SaCDGNLSdekaKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPrsmDAQFVAWKGACIYNRIRIVSEL 636
Cdd:cd13397  277 K-CDIDIR----KDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKVKVIAPP---ERKYSVWIGGSILASLSTFKSM 348


                 ....*...
gi 429242146 637 WIKNSDWK 644
Cdd:cd13397  349 WITRAEYD 356
ASKHA_NBD_MamK cd24009
nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called ...
 220-417 2.96e-06

nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called magnetosome cytoskeleton protein MamK, is a protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that may organize magnetosomes into long chains running parallel to the long axis of the cell. Turnover of MamK filaments is probably promoted by MamK-like (e.g.. MamJ and/or LimJ), which provides a monomer pool. MamK forms twisted filaments in the presence of ATP or GTP. It serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. The MamK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466859 [Multi-domain]  Cd Length: 328  Bit Score: 49.90  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 220 DVICGKEAF--LLPLNeypeykLFYPIKSGVFNESDYASSQQlladIYEIFKYSITSLLQIPVSQLsqYSVIFiVPDLYD 297
Cdd:cd24009   44 EVLFGDEALenRLALD------LRRPLEDGVIKEGDDRDLEA----ARELLQHLIELALPGPDDEI--YAVIG-VPARAS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 298 RVYVEKILDIL--FFDlhfgKAAIVQESLCTSFGAGMSAAC-VVDMGAQKTSIsCVEEGVV-VPNSRIKINYGGDDITLL 373
Cdd:cd24009  111 AENKQALLEIAreLVD----GVMVVSEPFAVAYGLDRLDNSlIVDIGAGTTDL-CRMKGTIpTEEDQITLPKAGDYIDEE 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 429242146 374 FMKLLMRshfPYQDIDLkTPydwSLANALKIKYCGLSEATYNVQ 417
Cdd:cd24009  186 LVDLIKE---RYPEVQL-TL---NMARRWKEKYGFVGDASEPVK 222
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 224-407 9.68e-06

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 48.19  E-value: 9.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 224 GKEAFL--LPLNEYPEYKLFYPIKSGVFneSDYASSQqlladiyEIFKYSITSLLQIPVSQlsqYSVIFIVPDLYDRVYV 301
Cdd:cd10214   47 RKETFVgkELANVEPPLKLVNPLRHGIV--VDWDCVQ-------DIWEYIFEKEMKILPEE---HAVLVSDPPLSPTTNR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 302 EKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRS 381
Cdd:cd10214  115 EKYAELMFETFSIPAMHIAYQSRLSLYSYGRTSGLVVESGHGVSYVVPIHEGYNLPHITGRADYAGSDLTAYLMKLLNEA 194

                        170       180
                 ....*....|....*....|....*.
gi 429242146 382 HFPYQDIDLktpydwSLANALKIKYC 407
Cdd:cd10214  195 GNKFTDDQL------HIVEDIKKKCC 214
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
 549-643 2.54e-05

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 47.16  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 549 DAINQSIfSACDGNLsdekAKNLYSSILIVGGAGQFPGFahllEERIHSK-RANIPT---ISVIpppRSMDAQFVAWKGA 624
Cdd:cd10210  299 EAIVQSI-NACPEEL----QPLLYANIVLTGGNALFPGF----RERLEAElRSLAPDdydVNVT---LPEDPITYAWEGG 366

                         90
                 ....*....|....*....
gi 429242146 625 CIYNRIRIVSELWIKNSDW 643
Cdd:cd10210  367 SLLAQSPEFEELAVTRAEY 385
PTZ00466 PTZ00466
actin-like protein; Provisional
 513-656 3.09e-05

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 46.86  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 513 SDLVTPSVKFKPPRVVYCGSLAAPEIKNekliypLDDAINQSIfSACDGNLSdekaKNLYSSILIVGGAGQFPGFAHLLE 592
Cdd:PTZ00466 251 SQILIGSERYRAPEVLFNPSILGLEYLG------LSELIVTSI-TRADMDLR----RTLYSHIVLSGGTTMFHGFGDRLL 319

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 429242146 593 ERIHSKRANIPTISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKTL 656
Cdd:PTZ00466 320 NEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHRKTF 380
PTZ00452 PTZ00452
actin; Provisional
 500-654 4.23e-05

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 46.29  E-value: 4.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 500 KANGKDDEEKKEESDLVT-PSVKFKPPRVVYCGSLAAPEIKN-EKLIYplddainqSIFSACDGNLSDEKAKNlyssILI 577
Cdd:PTZ00452 232 ESNSQDSPYKLPDGNILTiKSQKFRCSEILFQPKLIGLEVAGiHHLAY--------SSIKKCDLDLRQELCRN----IVL 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 429242146 578 VGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYK 654
Cdd:PTZ00452 300 SGGTTLFPGIANRLSNELTNLVPSQLKIQVAAPP---DRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGPSIVHRK 373
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 561-643 5.37e-05

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 46.03  E-value: 5.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 561 GNLSDEKAKNLYSSILIVGGAGQFPGFahllEERIHSK-RANIPTISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIK 639
Cdd:cd10211  255 KRYPAEQQDRLVQNVFLTGGNALFPGL----KERLEKElRAIRPFGSPFNVVRAKDPVLDAWRGAAKWALDSTFEKVWIT 330


                 ....
gi 429242146 640 NSDW 643
Cdd:cd10211  331 KQEY 334
PTZ00281 PTZ00281
actin; Provisional
 569-654 8.13e-05

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 45.46  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 569 KNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGS 648
Cdd:PTZ00281 292 KDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPP---ERKYSVWIGGSILASLSTFQQMWISKEEYDESGP 368


                 ....*.
gi 429242146 649 RVLQYK 654
Cdd:PTZ00281 369 SIVHRK 374
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 217-457 1.13e-04

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 45.11  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 217 DHVDVICGKEAfllpLNEYPEYKLFYPIKSGVFNESDyassqqLLADIYE--IFKYsitsLLQIPvsqlSQYSVIFIVPD 294
Cdd:PTZ00280  50 EDLDFYIGDEA----LAASKSYTLTYPMKHGIVEDWD------LMEKFWEqcIFKY----LRCEP----EEHYFILTEPP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 295 LYDRVYVEKILDILF--FD---LHFGKAAIVqeSLCTSFGAGMSA-------ACVVDMGAQKTSISCVEEGVVVpNSRIK 362
Cdd:PTZ00280 112 MNPPENREYTAEIMFetFNvkgLYIAVQAVL--ALRASWTSKKAKelggtltGTVIDSGDGVTHVIPVVDGYVI-GSSIK 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 363 -INYGGDDITLLFMKLLMR--SHFPYQDIDLktpydwsLANALKIKYCGLSE------ATYNVQLNSFFSRTPDKGTR-- 431
Cdd:PTZ00280 189 hIPLAGRDITNFIQQMLRErgEPIPAEDILL-------LAQRIKEKYCYVAPdiakefEKYDSDPKNHFKKYTAVNSVtk 261

                        250       260
                 ....*....|....*....|....*..
gi 429242146 432 -KFTFKSLDETMLAPLGFFRPDIFENE 457
Cdd:PTZ00280 262 kPYTVDVGYERFLGPEMFFHPEIFSSE 288
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
 297-368 2.46e-04

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 43.94  E-value: 2.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429242146 297 DRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGD 368
Cdd:cd10212  114 DMAILERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFGGD 185
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 509-655 4.98e-04

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 509 KKEESDLVTPSVK--FKPP--RVVYCGS--LAAPEIK-NEKLI---YP-LDDAINQSIFsACDGNLSdekaKNLYSSILI 577
Cdd:cd10216  221 QKEEKLEEEKTEKaqYTLPdgSTIEIGPerFRAPEILfNPELIgleYPgVHEVLVDSIQ-KSDLDLR----KTLYSNIVL 295

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 429242146 578 VGGAGQFPGFA-HLLEErIHSKRANIPTISVIPPPrsmDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKT 655
Cdd:cd10216  296 SGGSTLFKGFGdRLLSE-VKKLAPKDVKIRISAPP---ERLYSTWIGGSILASLSTFKKMWVSKKEYEEDGARILHRKT 370
FtsA COG0849
Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];
335-406 1.90e-03

Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440610 [Multi-domain]  Cd Length: 402  Bit Score: 41.27  E-value: 1.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSRIKInyGGDDITllfmkllmrshfpyQDI--DLKTPYDwsLANALKIKY 406
Cdd:COG0849  202 VALVDIGGGTTDIAVFKDGALRHTAVIPV--GGDHIT--------------NDIaiGLRTPLE--EAERLKIKY 257
ASKHA_NBD_FtsA cd24048
nucleotide-binding domain (NBD) of cell division protein FtsA and similar proteins; FtsA is an ...
 335-455 2.60e-03

nucleotide-binding domain (NBD) of cell division protein FtsA and similar proteins; FtsA is an essential cell division protein that assists in the assembly of the Z ring. It may serve as the principal membrane anchor for the Z ring. It is also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN. FtsA binds ATP. FtsA interacts with FtsZ. This interaction plays an essential role in cell division.


Pssm-ID: 466898 [Multi-domain]  Cd Length: 372  Bit Score: 40.59  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242146 335 ACVVDMGAQKTSISCVEEGVVVPNSriKINYGGDDITllfmkllmrshfpyQDI--DLKTPYDwsLANALKIKYCGLSEA 412
Cdd:cd24048  200 VALIDIGGGTTDIAVFKNGSLRYTA--VIPVGGNHIT--------------NDIaiGLNTPFE--EAERLKIKYGSALSE 261

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 429242146 413 TYNVQLNSFFSRTPDKGTRKFTFKSLDETMLAPLGffrpDIFE 455
Cdd:cd24048  262 EADEDEIIEIPGVGGREPREVSRRELAEIIEARVE----EILE 300
Actin_micro pfam17003
Putative actin-like family; This is a family of microsporidial-specific proteins of unknown ...
 604-658 5.75e-03

Putative actin-like family; This is a family of microsporidial-specific proteins of unknown function. There is distant homology to the Actin family.


Pssm-ID: 374929  Cd Length: 350  Bit Score: 39.36  E-value: 5.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 429242146  604 TISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKTLGY 658
Cdd:pfam17003 295 YINVVPPIIEEAKDSSILRGAKVFNNLELSKELWLTDKEWNSVRLRVLKEKVLFY 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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