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Conserved domains on  [gi|19114522|ref|NP_593610|]
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lysine methyltransferase Set8 [Schizosaccharomyces pombe]

Protein Classification

SET domain-containing protein( domain architecture ID 14410432)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 19-247 4.91e-45

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


:

Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 156.46  E-value: 4.91e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  19 ITIKKIRKKGNGIFSLNRYTSGTVLLEVPLENIIcrkTVEQFRNSCDKFASIATLEEWNDMSFRTQAMLFLCYLWLgiQP 98
Cdd:cd10527   2 VELAESPDGGRGLFATRDIAAGEVLLSVPRSLLL---TVETARESPLGGAALALLELDPELSWDVALALFLLYERA--RG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  99 RTNKWDKFLTVLP-LSINTPAQWPEKEVYSLQGTSIFNPVCVKRKILQQEWLSLNQR----YSDSWPSKITLPKWVHADA 173
Cdd:cd10527  77 PDSFWAPYLDSLPrPFEDTPLFWSEEELDALQGTPLLEAAAAQRRRLREEYEALVEAlpeaLPAEPGEAFTLEEFLWALA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 174 LFHSRCLESPFKD----PVLAPVIDLCNHSS-KSNAKWSFSED--AMQLYLDKDIDENEEVTINYGSeKGSAEFLFSYGF 246
Cdd:cd10527 157 LVLSRAFSLPVPDggggLALVPLADMLNHSPdAPNVRYEYDEDegSFVLVATRDIAAGEEVFISYGP-KSNDELLLYYGF 235


                .
gi 19114522 247 L 247
Cdd:cd10527 236 V 236
 
Name Accession Description Interval E-value
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 19-247 4.91e-45

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 156.46  E-value: 4.91e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  19 ITIKKIRKKGNGIFSLNRYTSGTVLLEVPLENIIcrkTVEQFRNSCDKFASIATLEEWNDMSFRTQAMLFLCYLWLgiQP 98
Cdd:cd10527   2 VELAESPDGGRGLFATRDIAAGEVLLSVPRSLLL---TVETARESPLGGAALALLELDPELSWDVALALFLLYERA--RG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  99 RTNKWDKFLTVLP-LSINTPAQWPEKEVYSLQGTSIFNPVCVKRKILQQEWLSLNQR----YSDSWPSKITLPKWVHADA 173
Cdd:cd10527  77 PDSFWAPYLDSLPrPFEDTPLFWSEEELDALQGTPLLEAAAAQRRRLREEYEALVEAlpeaLPAEPGEAFTLEEFLWALA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 174 LFHSRCLESPFKD----PVLAPVIDLCNHSS-KSNAKWSFSED--AMQLYLDKDIDENEEVTINYGSeKGSAEFLFSYGF 246
Cdd:cd10527 157 LVLSRAFSLPVPDggggLALVPLADMLNHSPdAPNVRYEYDEDegSFVLVATRDIAAGEEVFISYGP-KSNDELLLYYGF 235


                .
gi 19114522 247 L 247
Cdd:cd10527 236 V 236
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 156-238 1.76e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.72  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522    156 SDSWPSKITLPKWVHADALFHSRCLESPFKDP-VLAPVIDLCNHSSKSNAKWSF----SEDAMQLYLDKDIDENEEVTIN 230
Cdd:smart00317  37 SEEAEERPKAYDTDGAKAFYLFDIDSDLCIDArRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTID 116


                   ....*...
gi 19114522    231 YGSEKGSA 238
Cdd:smart00317 117 YGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 192-232 1.41e-04

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 41.35  E-value: 1.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 19114522   192 VIDLCNHSSKSNAKWSF----SEDAMQLYLDKDIDENEEVTINYG 232
Cdd:pfam00856  71 WARFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
197-240 2.62e-03

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 38.02  E-value: 2.62e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19114522 197 NHSSKSNAKWSFSEDAMQLYLDKDIDENEEVTINYGSEKGSAEF 240
Cdd:COG2940  81 NHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEY 124
 
Name Accession Description Interval E-value
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 19-247 4.91e-45

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 156.46  E-value: 4.91e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  19 ITIKKIRKKGNGIFSLNRYTSGTVLLEVPLENIIcrkTVEQFRNSCDKFASIATLEEWNDMSFRTQAMLFLCYLWLgiQP 98
Cdd:cd10527   2 VELAESPDGGRGLFATRDIAAGEVLLSVPRSLLL---TVETARESPLGGAALALLELDPELSWDVALALFLLYERA--RG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  99 RTNKWDKFLTVLP-LSINTPAQWPEKEVYSLQGTSIFNPVCVKRKILQQEWLSLNQR----YSDSWPSKITLPKWVHADA 173
Cdd:cd10527  77 PDSFWAPYLDSLPrPFEDTPLFWSEEELDALQGTPLLEAAAAQRRRLREEYEALVEAlpeaLPAEPGEAFTLEEFLWALA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 174 LFHSRCLESPFKD----PVLAPVIDLCNHSS-KSNAKWSFSED--AMQLYLDKDIDENEEVTINYGSeKGSAEFLFSYGF 246
Cdd:cd10527 157 LVLSRAFSLPVPDggggLALVPLADMLNHSPdAPNVRYEYDEDegSFVLVATRDIAAGEEVFISYGP-KSNDELLLYYGF 235


                .
gi 19114522 247 L 247
Cdd:cd10527 236 V 236
SET_SpSET10-like cd19180
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
 17-246 9.45e-28

SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).


Pssm-ID: 380957  Cd Length: 252  Bit Score: 110.51  E-value: 9.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  17 KQITIKKIRKKGNG-IFSLNRYTSGTVLLEVPLENIICRKTVEQFrnscdkF-ASIATLEEWNDMSFRTQAML-FLCYLW 93
Cdd:cd19180  13 PKLEFRYDPDSGISvVATENAIDPGETLLSIPTSLILTPENARKS------FlGALSLASAALESLLPRRLLLvFLLIER 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  94 LGiQPRTNKWDKFLTVLPLSINTPAQWPEKEVYSLQGTSIFNPVCVKRKILQQEWLSLNQRYSDSWPSK--ITLPKWVHA 171
Cdd:cd19180  87 RG-LGLGSFWGPYIDLLPKEFSTPLYWSDDELELLRGTNLFGAVQDRREQLEKEYEVLKEALKSEHPPKevFTFEDYLWA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 172 DALFHSRCL----------ESPFKDPVLAPVIDLCNHSSKSNAKWSFSEDAMQLYL--DKDIDENEEVTINYGsEKGSAE 239
Cdd:cd19180 166 YTIVSSRSFpsrlvsdsgdTSSESEPVLLPLLDLLNHKPGAKVTWNTTDTSSAFELvsGDDLAKGEQVFNNYG-PKSNEE 244


                ....*..
gi 19114522 240 FLFSYGF 246
Cdd:cd19180 245 LLLGYGF 251
SET_RBCMT cd19179
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
 40-247 7.33e-21

SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.


Pssm-ID: 380956  Cd Length: 237  Bit Score: 90.84  E-value: 7.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  40 GTVLLEVPLENIICRKTVeqfRNSCDKFASIATLEEWNDMsfrtqAMLFLCYLWLGiqpRTNKWDKFLTVLP--LSINTP 117
Cdd:cd19179  29 GERLLSVPESLWITAETA---ARSEIGGVLESGLKPWLAL-----ALFLLRERSRG---EASFWAPYIAVLPkeEELDSP 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 118 AQWPEKEVYSLQGTSIFNPVCVKRKILQQEWLSLNQRYsDSW------PSKITLPKWVHADALFHSRCLESP-FKDPVLA 190
Cdd:cd19179  98 LLWSEEELAELLGSPLLAATAERKAYVRAEYEALLEAV-FEKnpkvfpPEVFTLEAFKWAFGILFSRAFSLLaGGTLALV 176

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19114522 191 PVIDLCNHSSKSNAKWSF-----SEDAMQLYLDKDIDENEEVTINYGsEKGSAEFLFSYGFL 247
Cdd:cd19179 177 PWADLLNHSSGVSSDASYdvrggSSKAVVLTADRNYSAGEQVFISYG-PKSNAELLLDYGFV 237
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 19-246 3.53e-13

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 68.87  E-value: 3.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  19 ITIKKIRKKGNGIFSLNRYTSGTVLLEVPLENIICRKTVEQFRNSCDKFASIATLeewndMSFrtQAM-LFLCYLWLGIQ 97
Cdd:cd19177   5 LKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSLLGSLIKRVKPKL-----SSL--QLLaLFLALEKRRGE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  98 PRTnkWDKFLTVLPLS-INTPAQWPEKEVYSLqgtSIFNPVCVKRKILQQ--EWLSLNQRYSDSWPSK--------ITLP 166
Cdd:cd19177  78 NSF--WAPYLDSLPKSfDTHPLYWSLEELSLL---PPSLLEAVRKLLDKQkkRFESDWEIISSVLKSLpslfdseiFTLE 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 167 KWVHADALFHSRCL-----ESPFKDP-----VLAPVIDLCNHSSKSNAKWSFSED--AMQLYLDKDIDENEEVTINYGSE 234
Cdd:cd19177 153 EFRWAWLCVNTRCVyyklpLSDYLSSsedniALAPFLDLLNHSPDVNVKAGFNKSgkCYEIRTGTDYKKGEEVFISYGPH 232

                       250
                ....*....|...
gi 19114522 235 kgSAEFLFS-YGF 246
Cdd:cd19177 233 --SNDFLLLeYGF 243
SET_SETD6 cd19178
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
 28-246 1.19e-11

SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).


Pssm-ID: 380955 [Multi-domain]  Cd Length: 250  Bit Score: 64.63  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  28 GNGIFSLNRYTSGTVLLEVPLENIICRKTV---EQFRNscDKFASIATLEEWndmsfrtqAMLFLCYLWLGIQPRTnKWD 104
Cdd:cd19178  17 GRGMVATEDIKEGEVLFTVPRSALLSPETSsiaDLLEE--EEDASLQSLSGW--------VPLLLALMYEYTNPSS-RWR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 105 KFLTVLP--LSINTPAQWPEKEVYSLQGTSiFNPVCVKR--KILQQEW----LSLNQRYSDSW-PSKITLPKWVHADALF 175
Cdd:cd19178  86 PYLSLLPdfSELHHPMFWDEEEREELLGGT-GIAEAVDRdlKEIDEEYnsivLPFIKKHPELFsPEKHSLELYKRMVAFV 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 176 HSRCLESPFKD-------------PVLAPVIDLCNHSSKSNAKWSFSEDAMQLYLDKDIDENEEVTINYGsEKGSAEFLF 242
Cdd:cd19178 165 MAYSFTEPDEDeddddededddspPMMVPMADMLNHIANNNARLEFDPDCLRMIATRDIKKGEEIFNTYG-ELANWELLH 243


                ....
gi 19114522 243 SYGF 246
Cdd:cd19178 244 MYGF 247
SET_SETD3 cd19176
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
 19-248 1.05e-08

SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.


Pssm-ID: 380953  Cd Length: 251  Bit Score: 55.72  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  19 ITIKKIRKKGNGIFSLNRYTSGTVLLEVPLENIIcrkTVEQFRNS--CDKFASIATLeewndmsfrtQAM------LFLC 90
Cdd:cd19176  17 VEIAFFEEEGYGLRATRDIKAGELLLSIPRKLMI---TAEAAKSSvlGPLIESDPIL----------QAMpnvalaLHLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522  91 YLWLgiqpRTN-KWDKFLTVLPLSINTPAQWPEKEVYSLQGTSIFNPV------------CVKRKILQQEWLSLNQRysd 157
Cdd:cd19176  84 CERS----NPNsFWKPYIDILPSSYTTPLYFTPEELLLLKGSPAFEEAinqyrniarqyaYFYQLLQTSPLASKLNL--- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522 158 swPSKITLPKWVHADALFHSR------CLESPFKDPVLAPVIDLCNHSSkSNAKWSFS--EDAMQLYLDKDIDENEEVTI 229
Cdd:cd19176 157 --RNSFTFDDYRWAVSTVMTRqnqiptEDGTERSTLALIPLWDMCNHAN-GKITTDYNleSDSLECVAMEDFKAGEQVFI 233

                       250
                ....*....|....*....
gi 19114522 230 NYGSeKGSAEFLFSYGFLP 248
Cdd:cd19176 234 FYGP-RSNAELLLHSGFVP 251
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 156-238 1.76e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.72  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114522    156 SDSWPSKITLPKWVHADALFHSRCLESPFKDP-VLAPVIDLCNHSSKSNAKWSF----SEDAMQLYLDKDIDENEEVTIN 230
Cdd:smart00317  37 SEEAEERPKAYDTDGAKAFYLFDIDSDLCIDArRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTID 116


                   ....*...
gi 19114522    231 YGSEKGSA 238
Cdd:smart00317 117 YGSDYANE 124
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 197-234 6.43e-05

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 41.85  E-value: 6.43e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 19114522 197 NHSSKSNAKWS--FSEDAMQLYLDKDIDENEEVTINYGSE 234
Cdd:cd10540  70 NHSYTPNAEYEidFENQTIVFYALRDIEAGEELTINYGDD 109
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 192-232 1.41e-04

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 41.35  E-value: 1.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 19114522   192 VIDLCNHSSKSNAKWSF----SEDAMQLYLDKDIDENEEVTINYG 232
Cdd:pfam00856  71 WARFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 195-232 3.40e-04

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 40.05  E-value: 3.40e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19114522 195 LCNHSSKSNAKWSFSED-AMQLYLDKDIDENEEVTINYG 232
Cdd:cd20071  58 LLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYI 96
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 195-234 2.37e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 38.03  E-value: 2.37e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 19114522 195 LCNHSSKSNAK-WSFSEDAMQLYLDKDIDENEEVTINYGSE 234
Cdd:cd10524  79 FINHDCRPNCKfVPTGKSTACVKVLRDIEPGEEITVYYGDN 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
197-240 2.62e-03

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 38.02  E-value: 2.62e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19114522 197 NHSSKSNAKWSFSEDAMQLYLDKDIDENEEVTINYGSEKGSAEF 240
Cdd:COG2940  81 NHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEY 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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