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Conserved domains on  [gi|429242359|ref|NP_593657|]
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acyltransferase [Schizosaccharomyces pombe]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10158635)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 86-275 8.94e-24

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


:

Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 95.56  E-value: 8.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359  86 FGCLKLSKSTsgsfVQGDSLQPGDILAVNHSSPLDVLVLSCL------YNCTFAVCDSKTSNVSIISAqAYFWSCFFSPS 159
Cdd:cd06551    9 FGFVRLEVKG----PPPPPGGGPVLFVSNHSSWWDGLILFLLlerglrRDVYGLMDEELLERYPFFTR-LGAFSVDRDSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 160 KlkiTDAKPLAKVAAKASKIGTVVILFPEGVCTNGRA-LCQFTPCFD--SAKETDRIFPLYIKYLPPCVtlpvpsllsfa 236
Cdd:cd06551   84 R---SAAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAhlAEKAGVPIVPVALRYTFELF----------- 149

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 429242359 237 rsvllTVSFEIRIRFSAEPLIPRNCTdVTESAQEVLSKL 275
Cdd:cd06551  150 -----EQFPEIFVRIGPPIPYAETAL-GEELAAELANRL 182
 
Name Accession Description Interval E-value
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 86-275 8.94e-24

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 95.56  E-value: 8.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359  86 FGCLKLSKSTsgsfVQGDSLQPGDILAVNHSSPLDVLVLSCL------YNCTFAVCDSKTSNVSIISAqAYFWSCFFSPS 159
Cdd:cd06551    9 FGFVRLEVKG----PPPPPGGGPVLFVSNHSSWWDGLILFLLlerglrRDVYGLMDEELLERYPFFTR-LGAFSVDRDSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 160 KlkiTDAKPLAKVAAKASKIGTVVILFPEGVCTNGRA-LCQFTPCFD--SAKETDRIFPLYIKYLPPCVtlpvpsllsfa 236
Cdd:cd06551   84 R---SAAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAhlAEKAGVPIVPVALRYTFELF----------- 149

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 429242359 237 rsvllTVSFEIRIRFSAEPLIPRNCTdVTESAQEVLSKL 275
Cdd:cd06551  150 -----EQFPEIFVRIGPPIPYAETAL-GEELAAELANRL 182
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 110-221 1.84e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 65.84  E-value: 1.84e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359   110 ILAVNHSSPLDVLVLSCLYNCTFA----VCDSKTSNVSIISAQAYFWSCFFSPSKLKITDAKPLAKvAAKASKIGTVVIL 185
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGrvrfVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALRE-AVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 429242359   186 FPEGVCTNGRALCQFTPCFDS-AKETD-RIFPLYIKYL 221
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARlALEAGvPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 110-219 2.75e-08

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 51.51  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359  110 ILAVNHSSPLDVLVLSCL-----YNCTFAVCDSkTSNVSIISAQAYFWSCFFSpSKLKITDAKPLAKVAAKASKIGTVVI 184
Cdd:pfam01553  17 IVVANHQSYLDVLLLSLAlykrgRPLVFVAKKE-LFDIPLVGWLMRLLGCIFI-DRKNRKDAAGTLEYLVELLREGKLVV 94

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 429242359  185 LFPEGVCTNGRALCQFTP-CFDSAKETDR-IFPLYIK 219
Cdd:pfam01553  95 IFPEGTRSREGELLPFKKgAFRLAIEAGVpIVPVAIS 131
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 110-275 8.47e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 36.91  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 110 ILAVNHSSPLDVLVLSCLYNCtfavcdsktsNVSIISAQAYFWSCFFSP--SKL--------KITDAKPLAKVAAKASKI 179
Cdd:COG0204   46 LIVANHQSWLDILLLLAALPR----------PVRFVAKKELFKIPLLGWllRALgaipvdrsKRRAALRALRQAVEALKA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 180 GTVVILFPEGVCTNGRALCQFTP-CFDSAKETD-RIFPLYIKYlppcvTLPVPSLLSFARSVLLTVSFEIRIRFSAepLI 257
Cdd:COG0204  116 GESLVIFPEGTRSPDGRLLPFKTgAARLALEAGvPIVPVAIDG-----TERALPKGFLPRPGKVTVRIGPPIDPSD--LE 188

                        170
                 ....*....|....*...
gi 429242359 258 PRNCTDVTESAQEVLSKL 275
Cdd:COG0204  189 GEDRRELAERLRAAIEAL 206
 
Name Accession Description Interval E-value
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 86-275 8.94e-24

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 95.56  E-value: 8.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359  86 FGCLKLSKSTsgsfVQGDSLQPGDILAVNHSSPLDVLVLSCL------YNCTFAVCDSKTSNVSIISAqAYFWSCFFSPS 159
Cdd:cd06551    9 FGFVRLEVKG----PPPPPGGGPVLFVSNHSSWWDGLILFLLlerglrRDVYGLMDEELLERYPFFTR-LGAFSVDRDSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 160 KlkiTDAKPLAKVAAKASKIGTVVILFPEGVCTNGRA-LCQFTPCFD--SAKETDRIFPLYIKYLPPCVtlpvpsllsfa 236
Cdd:cd06551   84 R---SAAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAhlAEKAGVPIVPVALRYTFELF----------- 149

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 429242359 237 rsvllTVSFEIRIRFSAEPLIPRNCTdVTESAQEVLSKL 275
Cdd:cd06551  150 -----EQFPEIFVRIGPPIPYAETAL-GEELAAELANRL 182
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 110-221 1.84e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 65.84  E-value: 1.84e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359   110 ILAVNHSSPLDVLVLSCLYNCTFA----VCDSKTSNVSIISAQAYFWSCFFSPSKLKITDAKPLAKvAAKASKIGTVVIL 185
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGrvrfVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALRE-AVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 429242359   186 FPEGVCTNGRALCQFTPCFDS-AKETD-RIFPLYIKYL 221
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARlALEAGvPIVPVAIRGT 118
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 101-270 2.51e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 56.08  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 101 QGDSLQPGDILAVNHSSPLDVLVLSCLYNCTFaVCDSKTSNVSIISAQAYFWSC-FFSPSKLKITD--AKPLAKVAAKAS 177
Cdd:cd07991   18 KPDPPEAPRIIVANHTSFIDPLILFSDLFPSI-VAKKELGKLPFIGTILRALGCiFVDRSEPKDRKkvVEEIKERATDPN 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 178 KIGtvVILFPEGVCTNGRALCQF-TPCFDSAKEtdrIFPLYIKYLPPCVTLPVPSL-LSFARSVLLTVSfEIRIRFSAEP 255
Cdd:cd07991   97 WPP--ILIFPEGTTTNGKALIMFkKGAFEPGVP---VQPVAIRYPNKFVDAFWNSSgYSSLMYLFRLLT-QPANVLEVEF 170

                        170
                 ....*....|....*
gi 429242359 256 LIPRNCTDVTESAQE 270
Cdd:cd07991  171 LPVYTPSEEGEDPKE 185
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 110-219 2.75e-08

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 51.51  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359  110 ILAVNHSSPLDVLVLSCL-----YNCTFAVCDSkTSNVSIISAQAYFWSCFFSpSKLKITDAKPLAKVAAKASKIGTVVI 184
Cdd:pfam01553  17 IVVANHQSYLDVLLLSLAlykrgRPLVFVAKKE-LFDIPLVGWLMRLLGCIFI-DRKNRKDAAGTLEYLVELLREGKLVV 94

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 429242359  185 LFPEGVCTNGRALCQFTP-CFDSAKETDR-IFPLYIK 219
Cdd:pfam01553  95 IFPEGTRSREGELLPFKKgAFRLAIEAGVpIVPVAIS 131
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 110-275 1.27e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 41.87  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 110 ILAVNHSSPLDVLVLSCLYNctfavcdsktSNVSIISAQAYFWSCFFSP----------SKLKITDAKPLAKVAAKASKI 179
Cdd:cd07989   27 IIVANHQSYLDPLVLGAALP----------RPIRFVAKKELFKIPFLGWllrllgaipiDRGNGRSAREALREAIEALKE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 180 GTVVILFPEGVCTNGRALCQFTP-CFDSAKETD-RIFPLYIKYLPPcvtlpvpsllSFARSVLLTVSFEIRIRFsAEPLI 257
Cdd:cd07989   97 GESVVIFPEGTRSRDGELLPFKSgAFRLAKEAGvPIVPVAISGTWG----------SLPKGKKLPRPGRVTVRI-GEPIP 165

                        170
                 ....*....|....*...
gi 429242359 258 PRNCTDVTESAQEVLSKL 275
Cdd:cd07989  166 PEGLELAEEDRKELREKV 183
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 110-275 8.47e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 36.91  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 110 ILAVNHSSPLDVLVLSCLYNCtfavcdsktsNVSIISAQAYFWSCFFSP--SKL--------KITDAKPLAKVAAKASKI 179
Cdd:COG0204   46 LIVANHQSWLDILLLLAALPR----------PVRFVAKKELFKIPLLGWllRALgaipvdrsKRRAALRALRQAVEALKA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429242359 180 GTVVILFPEGVCTNGRALCQFTP-CFDSAKETD-RIFPLYIKYlppcvTLPVPSLLSFARSVLLTVSFEIRIRFSAepLI 257
Cdd:COG0204  116 GESLVIFPEGTRSPDGRLLPFKTgAARLALEAGvPIVPVAIDG-----TERALPKGFLPRPGKVTVRIGPPIDPSD--LE 188

                        170
                 ....*....|....*...
gi 429242359 258 PRNCTDVTESAQEVLSKL 275
Cdd:COG0204  189 GEDRRELAERLRAAIEAL 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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