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Conserved domains on  [gi|19114724|ref|NP_593812|]
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ribosome biogenesis protein Sqt1 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-396 7.26e-64

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 7.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  54 VQGFFEHKDSVFSVSINPVHSNLcASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKS 133
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 134 STGfEFITAFETVDEIVW-LSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGvgKRLATVDDSG 212
Cdd:COG2319 150 ATG-KLLRTLTGHSGAVTsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KLLASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 213 TLIVWNPATGAPECRMSSDDhrfdpgneetaAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIA 292
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHS-----------GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 293 LctaLP---ICACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQ 368
Cdd:COG2319 296 F---SPdgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372

                       330       340
                ....*....|....*....|....*...
gi 19114724 369 EPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:COG2319 373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-396 7.26e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 7.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  54 VQGFFEHKDSVFSVSINPVHSNLcASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKS 133
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 134 STGfEFITAFETVDEIVW-LSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGvgKRLATVDDSG 212
Cdd:COG2319 150 ATG-KLLRTLTGHSGAVTsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KLLASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 213 TLIVWNPATGAPECRMSSDDhrfdpgneetaAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIA 292
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHS-----------GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 293 LctaLP---ICACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQ 368
Cdd:COG2319 296 F---SPdgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372

                       330       340
                ....*....|....*....|....*...
gi 19114724 369 EPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:COG2319 373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-396 4.81e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.11  E-value: 4.81e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  60 HKDSVFSVSINPvHSNLCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEF 139
Cdd:cd00200   8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 140 ITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPgvGKRLATVDDSGTLIVWNP 219
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 220 ATGapECRMSSDDHrfdpgneetaagwtsfdcnaegnvlflggssgkvkvvninsshilasleaqTESVEAIALCTALPI 299
Cdd:cd00200 165 RTG--KCVATLTGH---------------------------------------------------TGEVNSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 300 CACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTpYLLTACA-DCVIRKWDVRSGQLLGEYTGHQEPILCMAIT 377
Cdd:cd00200 192 LLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                       330
                ....*....|....*....
gi 19114724 378 PDGKRVVTGSDDTELLVFD 396
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 93-132 1.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19114724     93 TGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWK 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
94-131 7.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 7.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19114724    94 GEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLW 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 60-165 5.64e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.49  E-value: 5.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   60 HKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQ--------ICQLTGHKDSIVAIDWSFDGTYI-ATGGMDSQVRL 130
Cdd:PTZ00420  73 HTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNI 152

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 19114724  131 WKSSTGFEfitAFETV--DEIVWLSWHPKGLFLAAGC 165
Cdd:PTZ00420 153 WDIENEKR---AFQINmpKKLSSLKWNIKGNLLSGTC 186
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 302-395 3.01e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 42.33  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   302 CASVDGTVALYDSASLKFRKSLPH----EQAVIDckflPNTPYLLTACAD----CVIrkwDVRSGQLLGEYTGHQEPiLC 373
Cdd:TIGR03866  58 CASDSDTIQVIDPATGEVLHTLPSgpdpEQFALH----PNGKILYIANEDdalvTVI---DIETRKVLAQIDVGVEP-EG 129

                          90       100
                  ....*....|....*....|..
gi 19114724   374 MAITPDGKRVVTGSDDTELLVF 395
Cdd:TIGR03866 130 MAVSPDGKIVVNTSETTNMAHW 151
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-396 7.26e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 7.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  54 VQGFFEHKDSVFSVSINPVHSNLcASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKS 133
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 134 STGfEFITAFETVDEIVW-LSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGvgKRLATVDDSG 212
Cdd:COG2319 150 ATG-KLLRTLTGHSGAVTsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KLLASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 213 TLIVWNPATGAPECRMSSDDhrfdpgneetaAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIA 292
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHS-----------GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 293 LctaLP---ICACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQ 368
Cdd:COG2319 296 F---SPdgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372

                       330       340
                ....*....|....*....|....*...
gi 19114724 369 EPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:COG2319 373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-396 4.81e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.11  E-value: 4.81e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  60 HKDSVFSVSINPvHSNLCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEF 139
Cdd:cd00200   8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 140 ITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPgvGKRLATVDDSGTLIVWNP 219
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 220 ATGapECRMSSDDHrfdpgneetaagwtsfdcnaegnvlflggssgkvkvvninsshilasleaqTESVEAIALCTALPI 299
Cdd:cd00200 165 RTG--KCVATLTGH---------------------------------------------------TGEVNSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 300 CACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTpYLLTACA-DCVIRKWDVRSGQLLGEYTGHQEPILCMAIT 377
Cdd:cd00200 192 LLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                       330
                ....*....|....*....
gi 19114724 378 PDGKRVVTGSDDTELLVFD 396
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
78-396 4.38e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.05  E-value: 4.38e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  78 ASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPK 157
Cdd:COG2319  52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 158 GLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPgvGKRLATVDDSGTLIVWNPATGAPECRMSSDDHRFdp 237
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV-- 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 238 gneetaagwTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALctaLP---ICACASVDGTVALYDS 314
Cdd:COG2319 208 ---------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPdgrLLASGSADGTVRLWDL 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 315 ASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELL 393
Cdd:COG2319 276 ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355


                ...
gi 19114724 394 VFD 396
Cdd:COG2319 356 LWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
57-357 6.69e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.27  E-value: 6.69e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  57 FFEHKDSVFSVSINPVHSNLcASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTG 136
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 137 fEFITAFETVDEIVW-LSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPpgVGKRLATVDDSGTLI 215
Cdd:COG2319 195 -KLLRTLTGHTGAVRsVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 216 VWNPATGAPECRMSSDDHRFdpgneeTAAGWtSFDcnaeGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALCT 295
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGV------NSVAF-SPD----GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114724 296 ALPICACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRS 357
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
78-396 7.52e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 7.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  78 ASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPK 157
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 158 GLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPpgVGKRLATVDDSGTLIVWNPATGapECRMSSDDHRfdp 237
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DGKTLASGSADGTVRLWDLATG--KLLRTLTGHS--- 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 238 gneetaAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALCTALPICACASVDGTVALYDSASL 317
Cdd:COG2319 163 ------GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 318 KFRKSLP-HEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:COG2319 237 KLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
111-396 5.57e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 5.57e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 111 DWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAP 190
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 191 VNAGKFIPPgvGKRLATVDDSGTLIVWNPATGapECRMSSDDHRFDPgneetaagwTSFDCNAEGNVLFLGGSSGKVKVV 270
Cdd:COG2319  81 VLSVAFSPD--GRLLASASADGTVRLWDLATG--LLLRTLTGHTGAV---------RSVAFSPDGKTLASGSADGTVRLW 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 271 NINSSHILASLEAQTESVEAIA-------LctalpicACASVDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLL 342
Cdd:COG2319 148 DLATGKLLRTLTGHSGAVTSVAfspdgklL-------ASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLA 220

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19114724 343 TACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-269 3.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 3.02e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  57 FFEHKDSVFSVSINPvhSNLCASGGGDD--LGyIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSS 134
Cdd:cd00200  89 LTGHTSYVSSVAFSP--DGRILSSSSRDktIK-VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 135 TGfEFITAFET-VDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPgvGKRLATVDDSGT 213
Cdd:cd00200 166 TG-KCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD--GYLLASGSEDGT 242

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19114724 214 LIVWNPATGAPECRMSSDDHRFdpgneetaagwTSFDCNAEGNVLFLGGSSGKVKV 269
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSV-----------TSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-174 5.85e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 5.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  57 FFEHKDSVFSVSINPVHSNLCaSGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTG 136
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19114724 137 fEFITAFETVDEIVW-LSWHPKGLFLAAGCNDGSIWMWS 174
Cdd:cd00200 252 -ECVQTLSGHTNSVTsLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 93-132 1.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19114724     93 TGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWK 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
94-131 7.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 7.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19114724    94 GEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLW 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 60-165 5.64e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.49  E-value: 5.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   60 HKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQ--------ICQLTGHKDSIVAIDWSFDGTYI-ATGGMDSQVRL 130
Cdd:PTZ00420  73 HTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNI 152

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 19114724  131 WKSSTGFEfitAFETV--DEIVWLSWHPKGLFLAAGC 165
Cdd:PTZ00420 153 WDIENEKR---AFQINmpKKLSSLKWNIKGNLLSGTC 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-396 1.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19114724    357 SGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 78-218 4.52e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   78 ASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDW-SFDGTYIATGGMDSQVRLWKSSTGFEfITAFETVDEIVWLSW-H 155
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVS-IGTIKTKANICCVQFpS 627

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19114724  156 PKGLFLAAGCNDGSIWMWSLPSGKV-VQVMYGHTAPVNAGKFIPPGVgkrLATVDDSGTLIVWN 218
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST---LVSSSTDNTLKLWD 688
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 80-212 6.48e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 45.82  E-value: 6.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724  80 GGGDDLgYIWDITTGEQIcQLTGHKDSIVAIDWSFDGTYIA-TGGMDSQVRLWK---SSTGFEFITAFETVDeiVWLSWH 155
Cdd:COG0823   8 DGNSDI-YVVDLDGGEPR-RLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVvdaDGGEPRRLTFGGGYN--ASPSWS 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 156 PKGLFLA-AGCNDGS--IWMWSLPSGKVVQVMYGHTAPVnagkFIPPgvGKRLATVDDSG 212
Cdd:COG0823  84 PDGKRLAfVSRSDGRfdIYVLDLDGGAPRRLTDGPGSPS----WSPD--GRRIVFSSDRG 137
WD40 pfam00400
WD domain, G-beta repeat;
358-396 1.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19114724   358 GQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFD 396
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 37-130 2.41e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   37 AEQEQNDTMNNMVmdmSVQGffeHKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDG 116
Cdd:PTZ00421 107 EEGLTQNISDPIV---HLQG---HTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDG 180

                         90
                 ....*....|....
gi 19114724  117 TYIATGGMDSQVRL 130
Cdd:PTZ00421 181 SLLCTTSKDKKLNI 194
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
183-396 1.31e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 183 VMYGHTAPVNAGKFIPPGVGKRLATVDDSGTLIVWNPATGAPECRMSSDDHRFDPGNEETAAGWTSFDCNAEGNVLFLGG 262
Cdd:COG3391   7 LLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVAN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724 263 S-SGKVKVVNINSSHILASLEAQTESVEAIALCTALPICACASVDGTVALYDSASLKFRKSLPHEQAVIDCKFLPNTPYL 341
Cdd:COG3391  87 SgSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRL 166

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114724 342 LTACAD-----CVIRKWDVRSGQLLGEYTGHQEPiLCMAITPDGKRVV--------TGSDDTELLVFD 396
Cdd:COG3391 167 YVANSGsntvsVIVSVIDTATGKVVATIPVGGGP-VGVAVSPDGRRLYvanrgsntSNGGSNTVSVID 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 360-399 1.64e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.64e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 19114724 360 LLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFDCEH 399
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET 40
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 302-395 3.01e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 42.33  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114724   302 CASVDGTVALYDSASLKFRKSLPH----EQAVIDckflPNTPYLLTACAD----CVIrkwDVRSGQLLGEYTGHQEPiLC 373
Cdd:TIGR03866  58 CASDSDTIQVIDPATGEVLHTLPSgpdpEQFALH----PNGKILYIANEDdalvTVI---DIETRKVLAQIDVGVEP-EG 129

                          90       100
                  ....*....|....*....|..
gi 19114724   374 MAITPDGKRVVTGSDDTELLVF 395
Cdd:TIGR03866 130 MAVSPDGKIVVNTSETTNMAHW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-218 4.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.59e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 19114724    177 SGKVVQVMYGHTAPVNAGKFIPPgvGKRLATVDDSGTLIVWN 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
323-399 1.75e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.75e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19114724 323 LPHEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFDCEH 399
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 148-195 4.56e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 4.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 19114724   148 EIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVqvmygHTAPVNAGK 195
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-----HHFSAGSDL 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-174 5.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 19114724    147 DEIVWLSWHPKGLFLAAGCNDGSIWMWS 174
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
325-354 6.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 6.34e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 19114724   325 HEQAVIDCKFLPNTPYLLTACADCVIRKWD 354
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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