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Conserved domains on  [gi|19114733|ref|NP_593820|]
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protein Cwf21 [Schizosaccharomyces pombe]

Protein Classification

pre-mRNA-splicing factor CWC21( domain architecture ID 15347360)

pre-mRNA-splicing factor CWC21 is involved in pre-mRNA splicing

Gene Ontology:  GO:0008380|GO:0006397

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
cwf21_CWC21-like cd21372
cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This ...
51-139 7.46e-05

cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This subfamily includes complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. Both CWC21 and CWF21 are pre-mRNA-splicing factors that may function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome, together with ISY1. SRRM2 is required for pre-mRNA splicing as a component of the spliceosome. SRRM3 may play a role in regulating breast cancer cell invasiveness. It may be involved in RYBP-mediated breast cancer progression. Members of this family contain a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


:

Pssm-ID: 410599 [Multi-domain]  Cd Length: 49  Bit Score: 39.38  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733  51 DPSISEHECRRQIESKLLLYREQLLEEvssqhstdaaasdsntnfgtenpkppkaiikdeqsqsktkSLDEADVEILVQK 130
Cdd:cd21372   1 DKEILEHERKRQIELKCLELRDELEDE----------------------------------------GLSEEEIEEKVDE 40

                ....*....
gi 19114733 131 YREQLLKEL 139
Cdd:cd21372  41 LREKLLKEL 49
U2AF_lg super family cl36941
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
168-277 1.95e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


The actual alignment was detected with superfamily member TIGR01642:

Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733   168 SKNDDDGRLEERDDLRSSVDDDYYDYPRYSERKSLNSKRHVDNYNENRRRhYDSYSsydelerRRSSNESYSRRSELPRR 247
Cdd:TIGR01642   8 EREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRR-YDSRS-------PRSLRYSSVRRSRDRPR 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 19114733   248 dyNRHDERERYSYHRRRERSNSPSYTKNES 277
Cdd:TIGR01642  80 --RRSRSVRSIEQHRRRLRDRSPSNQWRKD 107
 
Name Accession Description Interval E-value
cwf21_CWC21-like cd21372
cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This ...
51-139 7.46e-05

cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This subfamily includes complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. Both CWC21 and CWF21 are pre-mRNA-splicing factors that may function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome, together with ISY1. SRRM2 is required for pre-mRNA splicing as a component of the spliceosome. SRRM3 may play a role in regulating breast cancer cell invasiveness. It may be involved in RYBP-mediated breast cancer progression. Members of this family contain a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410599 [Multi-domain]  Cd Length: 49  Bit Score: 39.38  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733  51 DPSISEHECRRQIESKLLLYREQLLEEvssqhstdaaasdsntnfgtenpkppkaiikdeqsqsktkSLDEADVEILVQK 130
Cdd:cd21372   1 DKEILEHERKRQIELKCLELRDELEDE----------------------------------------GLSEEEIEEKVDE 40

                ....*....
gi 19114733 131 YREQLLKEL 139
Cdd:cd21372  41 LREKLLKEL 49
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
168-277 1.95e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733   168 SKNDDDGRLEERDDLRSSVDDDYYDYPRYSERKSLNSKRHVDNYNENRRRhYDSYSsydelerRRSSNESYSRRSELPRR 247
Cdd:TIGR01642   8 EREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRR-YDSRS-------PRSLRYSSVRRSRDRPR 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 19114733   248 dyNRHDERERYSYHRRRERSNSPSYTKNES 277
Cdd:TIGR01642  80 --RRSRSVRSIEQHRRRLRDRSPSNQWRKD 107
 
Name Accession Description Interval E-value
cwf21_CWC21-like cd21372
cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This ...
51-139 7.46e-05

cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This subfamily includes complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. Both CWC21 and CWF21 are pre-mRNA-splicing factors that may function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome, together with ISY1. SRRM2 is required for pre-mRNA splicing as a component of the spliceosome. SRRM3 may play a role in regulating breast cancer cell invasiveness. It may be involved in RYBP-mediated breast cancer progression. Members of this family contain a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410599 [Multi-domain]  Cd Length: 49  Bit Score: 39.38  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733  51 DPSISEHECRRQIESKLLLYREQLLEEvssqhstdaaasdsntnfgtenpkppkaiikdeqsqsktkSLDEADVEILVQK 130
Cdd:cd21372   1 DKEILEHERKRQIELKCLELRDELEDE----------------------------------------GLSEEEIEEKVDE 40

                ....*....
gi 19114733 131 YREQLLKEL 139
Cdd:cd21372  41 LREKLLKEL 49
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
168-277 1.95e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114733   168 SKNDDDGRLEERDDLRSSVDDDYYDYPRYSERKSLNSKRHVDNYNENRRRhYDSYSsydelerRRSSNESYSRRSELPRR 247
Cdd:TIGR01642   8 EREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRR-YDSRS-------PRSLRYSSVRRSRDRPR 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 19114733   248 dyNRHDERERYSYHRRRERSNSPSYTKNES 277
Cdd:TIGR01642  80 --RRSRSVRSIEQHRRRLRDRSPSNQWRKD 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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