UBA domain found in Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (atDRM2) and similar proteins; atDRM2, also called protein domains rearranged methylase 2, is a homolog of the mammalian de novo methyltransferase DNMT3. It is the major de novo methyltransferase targeted to DNA by small interfering RNAs (siRNAs) in the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis thaliana. atDRM2 is a part of the RdDM effector complex and plays a catalytic role in RdDM. It contains an N-terminal UBA domains and a C-terminal methyltransferase domain, both of which are required for normal RdDM.

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                ....*....|....*....|....*....|....*..
gi 19114857   5 DTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIFS 41
Cdd:cd14330   1 EEKIKTLVSMGFSESDARRALERCGYDVAAAADFLFS 37

UBA domain found in Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (atDRM2) and similar proteins; atDRM2, also called protein domains rearranged methylase 2, is a homolog of the mammalian de novo methyltransferase DNMT3. It is the major de novo methyltransferase targeted to DNA by small interfering RNAs (siRNAs) in the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis thaliana. atDRM2 is a part of the RdDM effector complex and plays a catalytic role in RdDM. It contains an N-terminal UBA domains and a C-terminal methyltransferase domain, both of which are required for normal RdDM.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19114857   5 DTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIFS 41
Cdd:cd14330   1 EEKIKTLVSMGFSESDARRALERCGYDVAAAADFLFS 37

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.

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                  ....*....|....*....|....*....|..
gi 19114857     8 IKTLKNMGVSESDAKDSLERCGYDVESAAEFI 39
Cdd:pfam00627   6 IQRLVEMGFDREQVREALRATGNNVERAAEYL 37

UBA domain found in Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (atDRM2) and similar proteins; atDRM2, also called protein domains rearranged methylase 2, is a homolog of the mammalian de novo methyltransferase DNMT3. It is the major de novo methyltransferase targeted to DNA by small interfering RNAs (siRNAs) in the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis thaliana. atDRM2 is a part of the RdDM effector complex and plays a catalytic role in RdDM. It contains an N-terminal UBA domains and a C-terminal methyltransferase domain, both of which are required for normal RdDM.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19114857   5 DTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIFS 41
Cdd:cd14330   1 EEKIKTLVSMGFSESDARRALERCGYDVAAAADFLFS 37

UBA domain found in Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins; UbcD4, also called ubiquitin carrier protein or ubiquitin-protein ligase, is a class II E2 ubiquitin-conjugating enzyme encoded by Drosophila E2 gene which is only expressed in pole cells in embryos. It is a putative E2 enzyme homologous to the Huntingtin interacting protein-2 (HIP2) of human. UbcD4 specifically interacts with the polyubiquitin-binding subunit of the proteasome. It contains a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain.

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                ....*....|....*....|....*....|....*.
gi 19114857   5 DTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIF 40
Cdd:cd14391   1 DAKIRQLMDMGFDEHKARVALSSHNWDLEKATESLF 36

UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins; RUP1p is a ubiquitin-associated (UBA) domain-containing protein encoded by a nonessential yeast gene RUP1. It can mediate the association of Rsp5 and Ubp2. The N-terminal UBA domain is responsible for antagonizing Rsp5 function, as well as bridging the Rsp5-Ubp2 interaction. No other characterized functional domains or motifs are found in RUP1p.

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                ....*....|....*....|....*....|....*..
gi 19114857   6 TKIKTLKNMGVSESDAKDSLERCGYDVESAAEFIFSG 42
Cdd:cd14307   2 EAVASLLEMGIPREVAIEALRETNGDVEAAANYIFSN 38

UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ubiquitin-associated (UBA) domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only the bind UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains.

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                ....*....|....*....|....*....|
gi 19114857   8 IKTLKNMGVSESDAKDSLERCGYDVESAAE 37
Cdd:cd14270   1 LAQLVEMGFSREQARRALRATNGDVEAAVE 30

UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain.

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                ....*....|....*....|....*....|....*
gi 19114857   5 DTKIKTLKNMGVSESDAKDSLERCGYDVESAAEFI 39
Cdd:cd14291   2 EDKLQQLMEMGFSEAEARLALRACNGNVERAVDYI 36