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Conserved domains on  [gi|19114927|ref|NP_594015|]
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glycine decarboxylase T subunit gcv1 [Schizosaccharomyces pombe]

Protein Classification

aminomethyltransferase family protein( domain architecture ID 1562447)

aminomethyltransferase family protein similar to human mitochondrial aminomethyltransferase (glycine cleavage system T protein), which is part of the glycine cleavage system that catalyzes the degradation of glycine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
gcvT super family cl39066
glycine cleavage system aminomethyltransferase GcvT;
17-387 2.63e-164

glycine cleavage system aminomethyltransferase GcvT;


The actual alignment was detected with superfamily member PLN02319:

Pssm-ID: 476863 [Multi-domain]  Cd Length: 404  Bit Score: 466.12  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   17 AASSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSL 96
Cdd:PLN02319  27 ASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKD-SIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   97 KELKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWK---GVELERVQG-RALIAIQGP 172
Cdd:PLN02319 106 AGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKakgGDVSWHVHDeRSLLALQGP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  173 ETASVVQKLiPNVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADT--RVRPIGLGARDT 250
Cdd:PLN02319 186 LAAPVLQHL-TKEDLSKMYFGDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSegKVRLTGLGARDS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  251 LRLEAGMCLYGSDIDDTTSPVEGSLSWIIGKRRRKEGGFVGSSRILKELKDGPSRRRVGFIVEKVPAR-HGSAVEVDGVE 329
Cdd:PLN02319 265 LRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARsHSEILDESGEK 344
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114927  330 VGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:PLN02319 345 IGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYYK 402
 
Name Accession Description Interval E-value
PLN02319 PLN02319
aminomethyltransferase
17-387 2.63e-164

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 466.12  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   17 AASSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSL 96
Cdd:PLN02319  27 ASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKD-SIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   97 KELKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWK---GVELERVQG-RALIAIQGP 172
Cdd:PLN02319 106 AGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKakgGDVSWHVHDeRSLLALQGP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  173 ETASVVQKLiPNVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADT--RVRPIGLGARDT 250
Cdd:PLN02319 186 LAAPVLQHL-TKEDLSKMYFGDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSegKVRLTGLGARDS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  251 LRLEAGMCLYGSDIDDTTSPVEGSLSWIIGKRRRKEGGFVGSSRILKELKDGPSRRRVGFIVEKVPAR-HGSAVEVDGVE 329
Cdd:PLN02319 265 LRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARsHSEILDESGEK 344
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114927  330 VGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:PLN02319 345 IGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYYK 402
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
19-387 6.34e-153

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 436.05  E-value: 6.34e-153
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  19 SSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKE 98
Cdd:COG0404   1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYPG-GVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  99 LKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWKGVELERV-QGRALIAIQGPETASV 177
Cdd:COG0404  80 LKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDVTITDVtDDWALLAVQGPKAREV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927 178 VQKLIPnVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLA---DTRVRPIGLGARDTLRLE 254
Cdd:COG0404 160 LAKLTD-ADLSALPFMSFREGTVAGVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEageEFGVKPCGLGARDTLRLE 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927 255 AGMCLYGSDIDDTTSPVEGSLSWIIGKRRrkeGGFVGSSRILKELKDGPSRRRVGFIVE-KVPARHGSAVEVDGVEVGQV 333
Cdd:COG0404 239 AGYPLYGHELDETTTPLEAGLGWAVKLDK---GDFIGKEALLRQKEEGPRRKLVGLELDgRGVPRAGAPVLADGEVVGEV 315
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 19114927 334 TSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:COG0404 316 TSGTFSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGER 369
gcvT TIGR00528
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ...
22-383 2.65e-127

glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273121 [Multi-domain]  Cd Length: 362  Bit Score: 370.69  E-value: 2.65e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927    22 LKRTPLYDLHLKEGATIVPFAGFSMPVQYKGQTisASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELKP 101
Cdd:TIGR00528   1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYKGQI--EEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   102 FHSTLSAFTNETGGIIDDTIISKQDENT-YYIVTNAACSEKDEANLKKHIENwKGVELERVQGRALIAIQGPETASVVQK 180
Cdd:TIGR00528  79 GKAQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQN-GSTLDCQSDIISLLALQGPKAKTILEP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   181 LIpNVDFSVLK---FGQSAyvDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADTRVRPIGLGARDTLRLEAGM 257
Cdd:TIGR00528 158 LL-DQTVPGLKpffFGQEA--EFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPGVKPCGLGARDTLRLEAGM 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   258 CLYGSDIDDTTSPVEGSLSWIIgKRRRKEGGFVGSSRILKELKDGPSRRRVGF-IVEKVPARHGSAV-EVDGVE-VGQVT 334
Cdd:TIGR00528 235 CLYGQELDESITPLEAGLGWVI-SKSRQKYDFIGRAVLMEQKENGTEKKLVGLeMLEKGIARNGYPIfLPNGETeVGIVT 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 19114927   335 SGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVET 383
Cdd:TIGR00528 314 SGTASPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVRT 362
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
28-277 1.12e-113

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 331.86  E-value: 1.12e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927    28 YDLHLKEGATIVPFAGFSMPVQYKGQTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELKPFHSTLS 107
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   108 AFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWKGVELERVQGRALIAIQGPETASVVQKLIPNVDF 187
Cdd:pfam01571  81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   188 SVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLA---DTRVRPIGLGARDTLRLEAGMCLYGSDI 264
Cdd:pfam01571 161 EALPFFSFREIEIGGVPVRVSRTGYTGEDGFEIYVPAEDAVELWEALLEagaELGLRPAGLGARDSLRLEAGLPLYGHDL 240
                         250
                  ....*....|...
gi 19114927   265 DDTTSPVEGSLSW 277
Cdd:pfam01571 241 DEETTPLEAGLGW 253
 
Name Accession Description Interval E-value
PLN02319 PLN02319
aminomethyltransferase
17-387 2.63e-164

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 466.12  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   17 AASSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSL 96
Cdd:PLN02319  27 ASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKD-SIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   97 KELKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWK---GVELERVQG-RALIAIQGP 172
Cdd:PLN02319 106 AGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKakgGDVSWHVHDeRSLLALQGP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  173 ETASVVQKLiPNVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADT--RVRPIGLGARDT 250
Cdd:PLN02319 186 LAAPVLQHL-TKEDLSKMYFGDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSegKVRLTGLGARDS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  251 LRLEAGMCLYGSDIDDTTSPVEGSLSWIIGKRRRKEGGFVGSSRILKELKDGPSRRRVGFIVEKVPAR-HGSAVEVDGVE 329
Cdd:PLN02319 265 LRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARsHSEILDESGEK 344
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114927  330 VGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:PLN02319 345 IGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYYK 402
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
19-387 5.05e-162

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 459.03  E-value: 5.05e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   19 SSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKE 98
Cdd:PRK13579   6 TSPLKTLPLHALHLAAGARMVPFAGYDMPVQYPA-GVLKEHLHTRAHAGLFDVSHMGQIEVSGKDAAAALERLVPVDILA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   99 LKPFHSTLSAFTNETGGIIDDTIISKQDENtYYIVTNAACSEKDEANLKKHIENwkGVELERVQGRALIAIQGPETASVV 178
Cdd:PRK13579  85 LKEGRQRYTFFTNEQGGILDDLMVTNLGDH-LFLVVNAACKDADIAHLREHLSD--ECEVNPLDDRALLALQGPEAEAVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  179 QKLIPNVdfSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADTRVRPIGLGARDTLRLEAGMC 258
Cdd:PRK13579 162 ADLGPPV--AALRFMDGFEPRLHGVDCFVSRSGYTGEDGFEISVPADAAEALAEALLADPRVEPIGLGARDSLRLEAGLC 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  259 LYGSDIDDTTSPVEGSLSWIIGKRRRKEGGFVGSSRILKELKDGPSRRRVGFIVE-KVPARHGSAV-EVDGVEVGQVTSG 336
Cdd:PRK13579 240 LYGHDIDTTTTPVEAALEWAIQKARREAGGFPGAKAILAALAKGASRRRVGLKPEgRAPVREGAPLfDDAGTEIGTVTSG 319
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19114927  337 CPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:PRK13579 320 GFGPSVGGPVAMGYVPASLAAPGTAVFAEVRGKRLPVTVHALPFVPHRYKR 370
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
19-387 6.34e-153

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 436.05  E-value: 6.34e-153
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  19 SSSLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGqTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKE 98
Cdd:COG0404   1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYPG-GVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  99 LKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWKGVELERV-QGRALIAIQGPETASV 177
Cdd:COG0404  80 LKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDVTITDVtDDWALLAVQGPKAREV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927 178 VQKLIPnVDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLA---DTRVRPIGLGARDTLRLE 254
Cdd:COG0404 160 LAKLTD-ADLSALPFMSFREGTVAGVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEageEFGVKPCGLGARDTLRLE 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927 255 AGMCLYGSDIDDTTSPVEGSLSWIIGKRRrkeGGFVGSSRILKELKDGPSRRRVGFIVE-KVPARHGSAVEVDGVEVGQV 333
Cdd:COG0404 239 AGYPLYGHELDETTTPLEAGLGWAVKLDK---GDFIGKEALLRQKEEGPRRKLVGLELDgRGVPRAGAPVLADGEVVGEV 315
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 19114927 334 TSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVETHYYK 387
Cdd:COG0404 316 TSGTFSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGER 369
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
21-381 2.39e-142

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 408.74  E-value: 2.39e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   21 SLKRTPLYDLHLKEGATIVPFAGFSMPVQYKGQTisASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELK 100
Cdd:PRK00389   1 MLKRTPLYDLHVALGAKMVDFGGWEMPVQYGSII--EEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  101 PFHSTLSAFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENwKGVELE-RVQGRALIAIQGPETASVVQ 179
Cdd:PRK00389  79 PGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVVNAANREKDLAWIKSHAAG-FGVEVTdRSDDLAMIAVQGPKAREKLQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  180 KLIpNVDFSVLK-FGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLAdTRVRPIGLGARDTLRLEAGMC 258
Cdd:PRK00389 158 KLT-DADLSELKpFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLE-AGVKPCGLGARDTLRLEAGMP 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  259 LYGSDIDDTTSPVEGSLSWIIGKrrRKEGGFVGSSRILKELKDGPSRRRVGF-IVEKVPARHGSAVEVDGVEVGQVTSGC 337
Cdd:PRK00389 236 LYGQDMDETITPLEAGLGWTVKL--EEKRDFIGREALEAQKEAGVERKLVGLeLEERGIPRHGYPVLADGEEIGEVTSGT 313
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 19114927  338 PSPTLGKNIAMGYISTGlhqVGTPAHIKVRNKLHPAQVVRMPFV 381
Cdd:PRK00389 314 FSPTLGKSIALAYVPAG---VGDEVEVEIRGKQVPAKVVKPPFV 354
gcvT TIGR00528
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ...
22-383 2.65e-127

glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273121 [Multi-domain]  Cd Length: 362  Bit Score: 370.69  E-value: 2.65e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927    22 LKRTPLYDLHLKEGATIVPFAGFSMPVQYKGQTisASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELKP 101
Cdd:TIGR00528   1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYKGQI--EEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   102 FHSTLSAFTNETGGIIDDTIISKQDENT-YYIVTNAACSEKDEANLKKHIENwKGVELERVQGRALIAIQGPETASVVQK 180
Cdd:TIGR00528  79 GKAQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQN-GSTLDCQSDIISLLALQGPKAKTILEP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   181 LIpNVDFSVLK---FGQSAyvDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLADTRVRPIGLGARDTLRLEAGM 257
Cdd:TIGR00528 158 LL-DQTVPGLKpffFGQEA--EFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPGVKPCGLGARDTLRLEAGM 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   258 CLYGSDIDDTTSPVEGSLSWIIgKRRRKEGGFVGSSRILKELKDGPSRRRVGF-IVEKVPARHGSAV-EVDGVE-VGQVT 334
Cdd:TIGR00528 235 CLYGQELDESITPLEAGLGWVI-SKSRQKYDFIGRAVLMEQKENGTEKKLVGLeMLEKGIARNGYPIfLPNGETeVGIVT 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 19114927   335 SGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFVET 383
Cdd:TIGR00528 314 SGTASPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVRT 362
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
28-277 1.12e-113

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 331.86  E-value: 1.12e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927    28 YDLHLKEGATIVPFAGFSMPVQYKGQTISASHKWTREHSGLFDVSHMVQWFVRGENATAYLESITPSSLKELKPFHSTLS 107
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   108 AFTNETGGIIDDTIISKQDENTYYIVTNAACSEKDEANLKKHIENWKGVELERVQGRALIAIQGPETASVVQKLIPNVDF 187
Cdd:pfam01571  81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   188 SVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIPEEVSVDFASTLLA---DTRVRPIGLGARDTLRLEAGMCLYGSDI 264
Cdd:pfam01571 161 EALPFFSFREIEIGGVPVRVSRTGYTGEDGFEIYVPAEDAVELWEALLEagaELGLRPAGLGARDSLRLEAGLPLYGHDL 240
                         250
                  ....*....|...
gi 19114927   265 DDTTSPVEGSLSW 277
Cdd:pfam01571 241 DEETTPLEAGLGW 253
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
13-381 1.34e-29

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 117.54  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   13 QSSTAASSSLKRTPLYDLHLKEGATivpfaGFS------MPVQYkgQTISASHKWTREHSGLFDVSHMVQWFVRGENATA 86
Cdd:PRK12486   2 MALISPSRRLRRTPFSDGVEAAGVK-----AYTvynhmlLPTVF--ESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAAR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927   87 YLESITPSSLKELKPFHSTLSAFTNETGGIIDDTIISKQDENTYYIvtnaACSEKDEANLKKHIENWKGVELERVQGR-A 165
Cdd:PRK12486  75 LVQMLTPRDLRGMKPGQCYYVPIVDETGGMLNDPVALKLAEDRWWI----SIADSDLLLWVKGLANGRKLDVLVVEPDvS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  166 LIAIQGPETASVVQKLIPNvDFSVLKFGQSAYVDFKGVKCLFSRSGYTGEDGFEVSIP-EEVSVDFASTLL---ADTRVR 241
Cdd:PRK12486 151 PLAVQGPKADALMARVFGE-AIRDLRFFRFGYFDFEGTDLVIARSGYSKQGGFEIYVEgSDLGMPLWDALFeagKDLNVR 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114927  242 PiglGARDTL-RLEAGMCLYGSDIDDTTSPVEGSLSWIIGKRrrKEGGFVGSSRILKELKDGPSR--RRVGFIVEKVPAr 318
Cdd:PRK12486 230 A---GCPNLIeRIEGGLLSYGNDMTRDNTPHECGLGRFCNTQ--TDIGCIGKDALLRVAKEGPQKqiRGIKIGGERIPP- 303
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19114927  319 HGSA--VEVDGVEVGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFV 381
Cdd:PRK12486 304 CDRAwpLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGLEVETPDGMRPATVREGFWI 368
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
305-381 1.42e-27

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 103.71  E-value: 1.42e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114927   305 RRRVGFIVEK--VPARHGSAVEVDGVEVGQVTSGCPSPTLGKNIAMGYISTGLHQVGTPAHIKVRNKLHPAQVVRMPFV 381
Cdd:pfam08669   1 RRLVGLELDDgdPLLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVDAELAKPGTEVEVEIRGKRVPATVVKLPFY 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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