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Conserved domains on  [gi|19115038|ref|NP_594126|]
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BC10 family protein [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BC10 super family cl26952
Bladder cancer-related protein BC10; This family consists of a series of short proteins of ...
1-56 2.02e-10

Bladder cancer-related protein BC10; This family consists of a series of short proteins of around 90 residues in length. The human protein BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs). The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues. The function of this family is unknown.


The actual alignment was detected with superfamily member pfam06726:

Pssm-ID: 391639  Cd Length: 65  Bit Score: 52.04  E-value: 2.02e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115038     1 MLCLRYFIPMLLV--------ANAAPYFFYpIFMLSMIARKYPCPYCMIILGLLINT--RTLWSDS 56
Cdd:pfam06726   1 MFCLRWNIPVLLIpvpsnrslVNASPMFAV-LFLIGFYLELRPCVYCSITLGIFIFAicRPNWSDF 65
 
Name Accession Description Interval E-value
BC10 pfam06726
Bladder cancer-related protein BC10; This family consists of a series of short proteins of ...
1-56 2.02e-10

Bladder cancer-related protein BC10; This family consists of a series of short proteins of around 90 residues in length. The human protein BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs). The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues. The function of this family is unknown.


Pssm-ID: 369052  Cd Length: 65  Bit Score: 52.04  E-value: 2.02e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115038     1 MLCLRYFIPMLLV--------ANAAPYFFYpIFMLSMIARKYPCPYCMIILGLLINT--RTLWSDS 56
Cdd:pfam06726   1 MFCLRWNIPVLLIpvpsnrslVNASPMFAV-LFLIGFYLELRPCVYCSITLGIFIFAicRPNWSDF 65
 
Name Accession Description Interval E-value
BC10 pfam06726
Bladder cancer-related protein BC10; This family consists of a series of short proteins of ...
1-56 2.02e-10

Bladder cancer-related protein BC10; This family consists of a series of short proteins of around 90 residues in length. The human protein BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs). The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues. The function of this family is unknown.


Pssm-ID: 369052  Cd Length: 65  Bit Score: 52.04  E-value: 2.02e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115038     1 MLCLRYFIPMLLV--------ANAAPYFFYpIFMLSMIARKYPCPYCMIILGLLINT--RTLWSDS 56
Cdd:pfam06726   1 MFCLRWNIPVLLIpvpsnrslVNASPMFAV-LFLIGFYLELRPCVYCSITLGIFIFAicRPNWSDF 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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