AAR2 splicing factor family protein similar to Schizosaccharomyces pombe A1 cistron-splicing factor aar2, a component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
13-298
6.87e-38
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.
The actual alignment was detected with superfamily member pfam05282:
Pssm-ID: 461609 [Multi-domain] Cd Length: 356 Bit Score: 138.58 E-value: 6.87e-38
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
13-298
6.87e-38
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.
Pssm-ID: 461609 [Multi-domain] Cd Length: 356 Bit Score: 138.58 E-value: 6.87e-38
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
148-305
1.92e-31
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the C-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.
Pssm-ID: 260100 Cd Length: 155 Bit Score: 115.86 E-value: 1.92e-31
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein ...
13-298
6.87e-38
AAR2 protein; This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.
Pssm-ID: 461609 [Multi-domain] Cd Length: 356 Bit Score: 138.58 E-value: 6.87e-38
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
148-305
1.92e-31
C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the C-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.
Pssm-ID: 260100 Cd Length: 155 Bit Score: 115.86 E-value: 1.92e-31
N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This ...
1-111
8.14e-18
N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; This family consists of the N-terminal domain of eukaryotic Aar2 and Aar2-like proteins. Aar2 is a U5 small nuclear ribonucleoprotein (snRNP) particle assembly factor and part of Prp8, which forms a large complex containing U5 snRNA, Snu114, and seven Sm proteins (B, D1, D2, D3, E, F and G). Upon import of the complex into the nucleus, Aar2 phosphorylation leads to its release from Prp8 and replacement by Brr2p, thus playing an important role in Brr2p regulation and possibly safeguarding against non-specific RNA binding to Prp8. Aar2p binds directly with the RNaseH-like domain in the C-terminal region of Prp8p. In yeast, Aar2 protein is involved in splicing pre-mRNA of the a1 cistron and other genes important for cell growth.
Pssm-ID: 260099 Cd Length: 126 Bit Score: 78.49 E-value: 8.14e-18
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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