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Conserved domains on  [gi|19115121|ref|NP_594209|]
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heavy metal ion homeostasis protein [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDFIP-like cd22212
NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally ...
 85-260 2.13e-48

NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1/2 have been shown to be involved in neural development by regulating the expression of the Robo1 receptor.


:

Pssm-ID: 412068  Cd Length: 171  Bit Score: 158.21  E-value: 2.13e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121  85 PSTSSNHADGHHvdsvfsnlSAKPTVESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEI-------YIDGMSV 157
Cdd:cd22212   3 PPYSSVTASGDA--------EADLNPDVPEAEEEEAPPSYEVAAADPLPTYEEVQRTKPLEDEDEErnvadlvLIDGLPL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121 158 GTGFSFVWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMISESGMEnnddqyNYDELPHQKLIGSIL 237
Cdd:cd22212  75 GTDLTFLLSFFVAFLFNWIGFLLTYCLSTTHAGRYGALAGFGLSLVKWGLIVKHSTDDS------EKGYLDSQSWLWWLL 148

                       170       180
                ....*....|....*....|...
gi 19115121 238 IIIGWCLVLVDTFGFIRIRRMKN 260
Cdd:cd22212 149 MILGWLIFLRGIIQYIRVKRLER 171
 
Name Accession Description Interval E-value
NDFIP-like cd22212
NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally ...
 85-260 2.13e-48

NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1/2 have been shown to be involved in neural development by regulating the expression of the Robo1 receptor.


Pssm-ID: 412068  Cd Length: 171  Bit Score: 158.21  E-value: 2.13e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121  85 PSTSSNHADGHHvdsvfsnlSAKPTVESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEI-------YIDGMSV 157
Cdd:cd22212   3 PPYSSVTASGDA--------EADLNPDVPEAEEEEAPPSYEVAAADPLPTYEEVQRTKPLEDEDEErnvadlvLIDGLPL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121 158 GTGFSFVWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMISESGMEnnddqyNYDELPHQKLIGSIL 237
Cdd:cd22212  75 GTDLTFLLSFFVAFLFNWIGFLLTYCLSTTHAGRYGALAGFGLSLVKWGLIVKHSTDDS------EKGYLDSQSWLWWLL 148

                       170       180
                ....*....|....*....|...
gi 19115121 238 IIIGWCLVLVDTFGFIRIRRMKN 260
Cdd:cd22212 149 MILGWLIFLRGIIQYIRVKRLER 171
DUF2370 pfam10176
Protein of unknown function (DUF2370); This family is conserved from fungi to humans. The ...
 94-222 4.12e-48

Protein of unknown function (DUF2370); This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.


Pssm-ID: 401984  Cd Length: 215  Bit Score: 158.97  E-value: 4.12e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121    94 GHHVDSVFSNLSAKPTV-ESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEIYIDGMSVGTGFSFVWSACVAIL 172
Cdd:pfam10176   5 GAGNDGVFANLSAKPDRgESNREEQEDKPPTYEEAAADAAPPYWETTILAPGMYYDEVFIDGLPVGNIFNFVWNLLVSMS 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19115121   173 FPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMI-----SESGMENNDDQY 222
Cdd:pfam10176  85 FQFVGFLLTYLLHTTHAAKQGSRAGLGITLIQYGFYMRpsnveSKVGKDKGPGRV 139
 
Name Accession Description Interval E-value
NDFIP-like cd22212
NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally ...
 85-260 2.13e-48

NEDD4 family-interacting protein; The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1/2 have been shown to be involved in neural development by regulating the expression of the Robo1 receptor.


Pssm-ID: 412068  Cd Length: 171  Bit Score: 158.21  E-value: 2.13e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121  85 PSTSSNHADGHHvdsvfsnlSAKPTVESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEI-------YIDGMSV 157
Cdd:cd22212   3 PPYSSVTASGDA--------EADLNPDVPEAEEEEAPPSYEVAAADPLPTYEEVQRTKPLEDEDEErnvadlvLIDGLPL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121 158 GTGFSFVWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMISESGMEnnddqyNYDELPHQKLIGSIL 237
Cdd:cd22212  75 GTDLTFLLSFFVAFLFNWIGFLLTYCLSTTHAGRYGALAGFGLSLVKWGLIVKHSTDDS------EKGYLDSQSWLWWLL 148

                       170       180
                ....*....|....*....|...
gi 19115121 238 IIIGWCLVLVDTFGFIRIRRMKN 260
Cdd:cd22212 149 MILGWLIFLRGIIQYIRVKRLER 171
DUF2370 pfam10176
Protein of unknown function (DUF2370); This family is conserved from fungi to humans. The ...
 94-222 4.12e-48

Protein of unknown function (DUF2370); This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.


Pssm-ID: 401984  Cd Length: 215  Bit Score: 158.97  E-value: 4.12e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121    94 GHHVDSVFSNLSAKPTV-ESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEIYIDGMSVGTGFSFVWSACVAIL 172
Cdd:pfam10176   5 GAGNDGVFANLSAKPDRgESNREEQEDKPPTYEEAAADAAPPYWETTILAPGMYYDEVFIDGLPVGNIFNFVWNLLVSMS 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19115121   173 FPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMI-----SESGMENNDDQY 222
Cdd:pfam10176  85 FQFVGFLLTYLLHTTHAAKQGSRAGLGITLIQYGFYMRpsnveSKVGKDKGPGRV 139
NDFIP1 cd22305
NEDD4 family-interacting protein 1; The NEDD4 (neural precursor cell expressed, ...
 121-210 3.66e-04

NEDD4 family-interacting protein 1; The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1 has been shown to play a role in a variety of processes, including inflammation, immune signaling, and nuclear trafficking.


Pssm-ID: 412069  Cd Length: 206  Bit Score: 40.68  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115121 121 PPSYEQAAADTA-------------PPYWDTTMVIPDY----------------GSNEIYI--------DGMSVGTGFSF 163
Cdd:cd22305  24 PPPYSSIAAESAayfdykdesgfpkPPSYNVATSLPSYdeaertkaeatiplvpGRDDDFVarddfddaDQLRIGNDGIF 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 19115121 164 VWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQrgYIMI 210
Cdd:cd22305 104 MLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIK--WILI 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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