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Conserved domains on  [gi|19115714|ref|NP_594802|]
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SHREC complex subunit Clr2 [Schizosaccharomyces pombe]

Protein Classification

Clr2_transil and Clr2 domain-containing protein( domain architecture ID 11245480)

Clr2_transil and Clr2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Clr2_transil pfam16761
Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain ...
 131-198 1.03e-28

Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain carrying the first and second of three regions on Clr2 that are necessary for transcriptional silencing by the protein. Clr2 is a protein in the SHREC complex that is a crucial factor required for heterochromatin formation and it plays a major role in mating-type and rDNA silencing. The third region is family pfam10383.


:

Pssm-ID: 435567  Cd Length: 68  Bit Score: 108.49  E-value: 1.03e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115714   131 YYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLC 198
Cdd:pfam16761   1 YILDDLPAGYTLYEHPKGPDPKHPRTDRYLYGHPSGKRFRSPNEFFPHLLWLMTDPTGDPANCPCKLC 68
Clr2 super family cl11049
Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet ...
 367-486 5.36e-06

Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organization at the cnt domain, the site of kinetochore assembly.


The actual alignment was detected with superfamily member pfam10383:

Pssm-ID: 402139  Cd Length: 138  Bit Score: 46.22  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115714   367 HFYGIFRGAEKLWINDLCVI--STSSLPSVL-----QKTSFMYISDIYVN----------EDDIVCFQGSLWTQIDKNAL 429
Cdd:pfam10383   1 YYQGIYLGAELIWVGDTVRLkpSGSSVAELLagappDVTDVMVIDEIRVLlpncdpdqlaEPYTVRLAGKIYTPSPLRAY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115714   430 DYNDSADNIDEHKDDLK--ELPRRLQMVSkLSNTYFRCLHDKSVEYVCPFADVLGRWYE 486
Cdd:pfam10383  81 RPPSSNAVPPAAPKPLGpeEVPDGFNAVG-MSGYGDYYRHRPGREVEVSEDDVIGRCYE 138
 
Name Accession Description Interval E-value
Clr2_transil pfam16761
Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain ...
 131-198 1.03e-28

Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain carrying the first and second of three regions on Clr2 that are necessary for transcriptional silencing by the protein. Clr2 is a protein in the SHREC complex that is a crucial factor required for heterochromatin formation and it plays a major role in mating-type and rDNA silencing. The third region is family pfam10383.


Pssm-ID: 435567  Cd Length: 68  Bit Score: 108.49  E-value: 1.03e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115714   131 YYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLC 198
Cdd:pfam16761   1 YILDDLPAGYTLYEHPKGPDPKHPRTDRYLYGHPSGKRFRSPNEFFPHLLWLMTDPTGDPANCPCKLC 68
Clr2 pfam10383
Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet ...
 367-486 5.36e-06

Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organization at the cnt domain, the site of kinetochore assembly.


Pssm-ID: 402139  Cd Length: 138  Bit Score: 46.22  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115714   367 HFYGIFRGAEKLWINDLCVI--STSSLPSVL-----QKTSFMYISDIYVN----------EDDIVCFQGSLWTQIDKNAL 429
Cdd:pfam10383   1 YYQGIYLGAELIWVGDTVRLkpSGSSVAELLagappDVTDVMVIDEIRVLlpncdpdqlaEPYTVRLAGKIYTPSPLRAY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115714   430 DYNDSADNIDEHKDDLK--ELPRRLQMVSkLSNTYFRCLHDKSVEYVCPFADVLGRWYE 486
Cdd:pfam10383  81 RPPSSNAVPPAAPKPLGpeEVPDGFNAVG-MSGYGDYYRHRPGREVEVSEDDVIGRCYE 138
 
Name Accession Description Interval E-value
Clr2_transil pfam16761
Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain ...
 131-198 1.03e-28

Transcription-silencing protein, cryptic loci regulator Clr2; Clr2_transil is a domain carrying the first and second of three regions on Clr2 that are necessary for transcriptional silencing by the protein. Clr2 is a protein in the SHREC complex that is a crucial factor required for heterochromatin formation and it plays a major role in mating-type and rDNA silencing. The third region is family pfam10383.


Pssm-ID: 435567  Cd Length: 68  Bit Score: 108.49  E-value: 1.03e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115714   131 YYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLC 198
Cdd:pfam16761   1 YILDDLPAGYTLYEHPKGPDPKHPRTDRYLYGHPSGKRFRSPNEFFPHLLWLMTDPTGDPANCPCKLC 68
Clr2 pfam10383
Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet ...
 367-486 5.36e-06

Transcription-silencing protein Clr2; Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organization at the cnt domain, the site of kinetochore assembly.


Pssm-ID: 402139  Cd Length: 138  Bit Score: 46.22  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115714   367 HFYGIFRGAEKLWINDLCVI--STSSLPSVL-----QKTSFMYISDIYVN----------EDDIVCFQGSLWTQIDKNAL 429
Cdd:pfam10383   1 YYQGIYLGAELIWVGDTVRLkpSGSSVAELLagappDVTDVMVIDEIRVLlpncdpdqlaEPYTVRLAGKIYTPSPLRAY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115714   430 DYNDSADNIDEHKDDLK--ELPRRLQMVSkLSNTYFRCLHDKSVEYVCPFADVLGRWYE 486
Cdd:pfam10383  81 RPPSSNAVPPAAPKPLGpeEVPDGFNAVG-MSGYGDYYRHRPGREVEVSEDDVIGRCYE 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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