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Conserved domains on  [gi|295443078|ref|NP_594825|]
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protein arginine N-methyltransferase Rmt1 [Schizosaccharomyces pombe]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
25-191 3.52e-44

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 151.34  E-value: 3.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  25 HWgiHEEMLKDDVRTLSYRDAIMQnpHLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHK-AVQIVEVNKLSD 103
Cdd:COG4076   10 RW--HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 104 RITLIQGKMEEIQLPvEKVDIIVSEWMGYFLLYESMLDTVLVARDRYLAPDGLLFPDRAQIQLAAIEdadYKSEKIGFWD 183
Cdd:COG4076   86 RITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVE---SPVDAEGFED 161


                 ....*....
gi 295443078 184 D-VYGFDFS 191
Cdd:COG4076  162 WqFDGFDFR 170
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
25-191 3.52e-44

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 151.34  E-value: 3.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  25 HWgiHEEMLKDDVRTLSYRDAIMQnpHLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHK-AVQIVEVNKLSD 103
Cdd:COG4076   10 RW--HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 104 RITLIQGKMEEIQLPvEKVDIIVSEWMGYFLLYESMLDTVLVARDRYLAPDGLLFPDRAQIQLAAIEdadYKSEKIGFWD 183
Cdd:COG4076   86 RITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVE---SPVDAEGFED 161


                 ....*....
gi 295443078 184 D-VYGFDFS 191
Cdd:COG4076  162 WqFDGFDFR 170
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-155 6.93e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 72.21  E-value: 6.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEI-IHKAVQIVEVNKLsdRITLIQGKMEEIQLPVEKVDIIVSeWMGYFLLY 136
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVS-SGVLHHLP 77

                          90       100
                  ....*....|....*....|.
gi 295443078  137 ESMLDTVL--VArdRYLAPDG 155
Cdd:pfam13649  78 DPDLEAALreIA--RVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 58-158 2.86e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.92  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHKAVQIVEVNKLSDRITLIQGKMEEIQL-PVEKVDIIVSeWMGYFLLY 136
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIIS-DPPLHHLV 80

                         90       100
                 ....*....|....*....|..
gi 295443078 137 ESMLDTVLVARdRYLAPDGLLF 158
Cdd:cd02440   81 EDLARFLEEAR-RLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
51-126 5.46e-12

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 64.79  E-value: 5.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  51 HLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIihkAVQI----VEVNKLSDRITLIQGKmeeiqlpvEKVDIIV 126
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQ---AVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 54-126 1.07e-08

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 55.61  E-value: 1.07e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078   54 RDKIVLDVGCGTGILSMFCARAGAKHVYGVDM-SEIIHKAVQIVEVNKLSDRITLIQGKMEeiQLPVEKVDIIV 126
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDIdPLAVESARKNAELNQVSDRLQVKLIYLE--QPIEGKADVIV 230
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
25-191 3.52e-44

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 151.34  E-value: 3.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  25 HWgiHEEMLKDDVRTLSYRDAIMQnpHLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHK-AVQIVEVNKLSD 103
Cdd:COG4076   10 RW--HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 104 RITLIQGKMEEIQLPvEKVDIIVSEWMGYFLLYESMLDTVLVARDRYLAPDGLLFPDRAQIQLAAIEdadYKSEKIGFWD 183
Cdd:COG4076   86 RITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVE---SPVDAEGFED 161


                 ....*....
gi 295443078 184 D-VYGFDFS 191
Cdd:COG4076  162 WqFDGFDFR 170
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-158 1.71e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 74.67  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  49 NPHLFRDKIVLDVGCGTGILSMFCARAGAkHVYGVDMSEiihKAVQIVEVNKLSDRITLIQGKMEEIQLPVEKVDIIVSe 128
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISP---EALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC- 93

                         90       100       110
                 ....*....|....*....|....*....|
gi 295443078 129 wMGYFLLYESMLDTVLVARdRYLAPDGLLF 158
Cdd:COG2227   94 -SEVLEHLPDPAALLRELA-RLLKPGGLLL 121
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
51-126 2.62e-16

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 77.91  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  51 HLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIihkAVQI----VEVNKLSDRITLIQGKmeeiQLPVEKVDIIV 126
Cdd:COG2264  145 LLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPV---AVEAarenAELNGVEDRIEVVLGD----LLEDGPYDLVV 217
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-155 6.93e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 72.21  E-value: 6.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEI-IHKAVQIVEVNKLsdRITLIQGKMEEIQLPVEKVDIIVSeWMGYFLLY 136
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVS-SGVLHHLP 77

                          90       100
                  ....*....|....*....|.
gi 295443078  137 ESMLDTVL--VArdRYLAPDG 155
Cdd:pfam13649  78 DPDLEAALreIA--RVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 58-158 2.86e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.92  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHKAVQIVEVNKLSDRITLIQGKMEEIQL-PVEKVDIIVSeWMGYFLLY 136
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIIS-DPPLHHLV 80

                         90       100
                 ....*....|....*....|..
gi 295443078 137 ESMLDTVLVARdRYLAPDGLLF 158
Cdd:cd02440   81 EDLARFLEEAR-RLLKPGGVLV 101
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 59-158 4.50e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 61.53  E-value: 4.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   59 LDVGCGTGILSMFCARAGAkHVYGVDMSEiihKAVQIVEVNKLSDRITLIQGKMEEIQLPVEKVDIIVSEWMgyfLLYES 138
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISP---EMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEV---LHHVE 73

                          90       100
                  ....*....|....*....|
gi 295443078  139 MLDTVLVARDRYLAPDGLLF 158
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 58-158 4.98e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 63.02  E-value: 4.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEI-IHKAVQIVEVNKLSDRITLIQGKMEEIQLPvEKVDIIVS----EWMGY 132
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEqLEYARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEHVGP 133

                         90       100
                 ....*....|....*....|....*.
gi 295443078 133 fLLYESMLDTVlvarDRYLAPDGLLF 158
Cdd:COG2230  134 -ENYPAYFAKV----ARLLKPGGRLL 154
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
51-126 5.46e-12

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 64.79  E-value: 5.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  51 HLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIihkAVQI----VEVNKLSDRITLIQGKmeeiqlpvEKVDIIV 126
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQ---AVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 46-183 5.81e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.78  E-value: 5.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  46 IMQNPHLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMS-EIIHKAVQIVEVNKLSdRITLIQGKMEEI-QLPVEKVD 123
Cdd:COG0500   18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGLG-NVEFLVADLAELdPLPAESFD 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078 124 IIVSewMGYF-LLYESMLDTVLVARDRYLAPDGLLF---PDRAQIQLAAIEDADYKSEKIGFWD 183
Cdd:COG0500   97 LVVA--FGVLhHLPPEEREALLRELARALKPGGVLLlsaSDAAAALSLARLLLLATASLLELLL 158
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 43-175 8.89e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.93  E-value: 8.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  43 RDAIMQNPHLFRDKIVLDVGCGTGILSMFCARAGAkHVYGVDMS-EIIHKAVQivEVNKLSDRITLIQGKMEEIQLPVEK 121
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPDGS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295443078 122 VDIIVSewmgyFLLYESMLDTVLVARD--RYLAPDGLLF------PDRAQIQlAAIEDADYK 175
Cdd:COG2226   88 FDLVIS-----SFVLHHLPDPERALAEiaRVLKPGGRLVvvdfspPDLAELE-ELLAEAGFE 143
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 55-126 9.28e-12

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 64.59  E-value: 9.28e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295443078   55 DKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIihkAVQI----VEVNKLSDRITLIQGKmeeiQLPVEKVDIIV 126
Cdd:pfam06325 162 GESVLDVGCGSGILAIAALKLGAKKVVGVDIDPV---AVRAakenAELNGVEARLEVYLPG----DLPKEKADVVV 230
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 58-127 2.23e-10

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 59.77  E-value: 2.23e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078  58 VLDVGCGTGILSMFCA-RAGAKHVYGVDMSEIIHK-AVQIVEVNKLSDRITLIQGKMEEI--QLPVEKVDIIVS 127
Cdd:COG4123   41 VLDLGTGTGVIALMLAqRSPGARITGVEIQPEAAElARRNVALNGLEDRITVIHGDLKEFaaELPPGSFDLVVS 114
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
13-157 2.04e-09

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 56.16  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  13 LTAKDY---YFDSYSHwgIHEEMLkddVRTLSYR------DAIMQNPHLFRDKIVLDVGCGTGILSMFCARAGaKHVYGV 83
Cdd:COG4976    1 MALDAYveaLFDQYAD--SYDAAL---VEDLGYEapallaEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGV 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078  84 DMSEiihKAVQIVEVNKLSDRitLIQGKMEEIQLPVEKVDIIVSewmGYFLLYESMLDTVLVARDRYLAPDGLL 157
Cdd:COG4976   75 DLSE---EMLAKAREKGVYDR--LLVADLADLAEPDGRFDLIVA---ADVLTYLGDLAAVFAGVARALKPGGLF 140
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
58-158 2.54e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  58 VLDVGCGTGILS-MFCARAGAKHVYGVDMS-EIIHKAvqivevNKLSDRITLIQGKMEEIQLPvEKVDIIVSEWMGYFLl 135
Cdd:COG4106    5 VLDLGCGTGRLTaLLAERFPGARVTGVDLSpEMLARA------RARLPNVRFVVADLRDLDPP-EPFDLVVSNAALHWL- 76

                         90       100
                 ....*....|....*....|....
gi 295443078 136 yeSMLDTVLvAR-DRYLAPDGLLF 158
Cdd:COG4106   77 --PDHAALL-ARlAAALAPGGVLA 97
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 44-162 6.09e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 55.28  E-value: 6.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  44 DAIMQNPHLfRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHKAVQI-VEVNKLSdrITLIQGKMEEIQlPVEKV 122
Cdd:COG3897   61 RYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLnAALNGVA--ITTRLGDWRDPP-AAGGF 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 295443078 123 DIIV-SEwmgyfLLYE-SMLDTVLVARDRYLAPDGLLF---PDRA 162
Cdd:COG3897  137 DLILgGD-----VLYErDLAEPLLPFLDRLAAPGGEVLigdPGRG 176
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 54-126 1.07e-08

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 55.61  E-value: 1.07e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078   54 RDKIVLDVGCGTGILSMFCARAGAKHVYGVDM-SEIIHKAVQIVEVNKLSDRITLIQGKMEeiQLPVEKVDIIV 126
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDIdPLAVESARKNAELNQVSDRLQVKLIYLE--QPIEGKADVIV 230
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 45-127 1.18e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 54.99  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   45 AIMQNPHLFRDKIVLDVGCGTGILSMFCARAGAK-HVYGVDMSEIIHKAVQivevNKLSDRITLIQGKMEEIQLPVEKVD 123
Cdd:TIGR02072  25 ALLKEKGIFIPASVLDIGCGTGYLTRALLKRFPQaEFIALDISAGMLAQAK----TKLSENVQFICGDAEKLPLEDSSFD 100


                  ....
gi 295443078  124 IIVS 127
Cdd:TIGR02072 101 LIVS 104
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
44-127 1.85e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 53.75  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  44 DAIMQNphLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEiihKAVQIVEVN--KLSDRITLIQGKMEEIQLpVEK 121
Cdd:COG2263   37 LAYLRG--DIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDP---EALEIARENaeRLGVRVDFIRADVTRIPL-GGS 110


                 ....*.
gi 295443078 122 VDIIVS 127
Cdd:COG2263  111 VDTVVM 116
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 52-157 7.70e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 50.88  E-value: 7.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   52 LFRDKIVLDVGCGTGILSMFCAR--AGAKHVYGVDMSEI-IHKAVQIVEVNKLsDRITLIQGKMEEIQLPVE--KVDIIV 126
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEaIEKARENAQKLGF-DNVEFEQGDIEELPELLEddKFDVVI 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 295443078  127 SEwmgYFLLYESMLDTVLVARDRYLAPDGLL 157
Cdd:pfam13847  80 SN---CVLNHIPDPDKVLQEILRVLKPGGRL 107
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 45-127 2.40e-07

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 51.59  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   45 AIMQNPHLFRdkiVLDVGCGTGILSMFCARAGA-KHVYGVDMSEiihKAVQIVEVN----KLSDRITLIQGKMEEiQLPV 119
Cdd:TIGR00536 108 SLISQPPILH---ILDLGTGSGCIALALAYEFPnAEVIAVDISP---DALAVAEENaeknQLEHRVEFIQSNLFE-PLAG 180


                  ....*...
gi 295443078  120 EKVDIIVS 127
Cdd:TIGR00536 181 QKIDIIVS 188
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 58-189 3.28e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 50.92  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  58 VLDVGCGTGI--LSMFCARAGAkHVYGVDMSEiihKAVQIVEVN----KLSDRITLIQGKMEEIQLPVEKVDIIVS---- 127
Cdd:COG2890  116 VLDLGTGSGAiaLALAKERPDA-RVTAVDISP---DALAVARRNaerlGLEDRVRFLQGDLFEPLPGDGRFDLIVSnppy 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 128 ----EW---MGYFLLYESM---------LDTV-LVARD--RYLAPDGLLF----PDRAQIQLAAIEDADYksEKIGFWDD 184
Cdd:COG2890  192 ipedEIallPPEVRDHEPRlaldggedgLDFYrRIIAQapRLLKPGGWLLleigEDQGEAVRALLEAAGF--ADVETHKD 269


                 ....*
gi 295443078 185 VYGFD 189
Cdd:COG2890  270 LAGRD 274
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 43-126 4.93e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 50.95  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  43 RDAIMQnphLFRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEiihKAVQI----VEVNKLSDRITLIQGK----MEE 114
Cdd:COG1092  208 RARVAE---LAKGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSA---TALEWakenAALNGLDDRHEFVQADafdwLRE 281

                         90
                 ....*....|..
gi 295443078 115 IQLPVEKVDIIV 126
Cdd:COG1092  282 LAREGERFDLII 293
PRK14968 PRK14968
putative methyltransferase; Provisional
 55-195 6.88e-07

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 49.13  E-value: 6.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  55 DKIVLDVGCGTGILSMFCARAGAKhVYGVDMSEI-IHKAVQIVEVNKLSDR-ITLIQGKM-EEIQ-------------LP 118
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKK-VVGVDINPYaVECAKCNAKLNNIRNNgVEVIRSDLfEPFRgdkfdvilfnppyLP 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 119 VEKVDIIvSEWMGYFL--------LYESMLDTVlvarDRYLAPDGllfpdRAQIQLAAIEDADYKSEKIgfwdDVYGFDF 190
Cdd:PRK14968 103 TEEEEEW-DDWLNYALsggkdgreVIDRFLDEV----GRYLKPGG-----RILLLQSSLTGEDEVLEYL----EKLGFEA 168


                 ....*
gi 295443078 191 SPIKK 195
Cdd:PRK14968 169 EVVAE 173
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 38-158 1.02e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.19  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   38 RTLSYRDAIMQN-PHLFRDKIVLDVGCGTGILSMFCARAGAkHVYGVDMSEIIHKAVQIVEVNKLSDRitliqgkmEEIQ 116
Cdd:pfam13489   5 RERLLADLLLRLlPKLPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFDE--------QEAA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 295443078  117 LPVEKVDIIVS-EWMGYFLLYESMLDTVLvardRYLAPDGLLF 158
Cdd:pfam13489  76 VPAGKFDVIVArEVLEHVPDPPALLRQIA----ALLKPGGLLL 114
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 44-127 2.09e-06

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 48.62  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  44 DAIMQNPHLFRDKIVLDVGCGTGI--LSMFCARAGAKhVYGVDMSEiihKAVQIVEVN---KLSDRITLIQGKMEEiQLP 118
Cdd:PRK09328  98 EWALEALLLKEPLRVLDLGTGSGAiaLALAKERPDAE-VTAVDISP---EALAVARRNakhGLGARVEFLQGDWFE-PLP 172


                 ....*....
gi 295443078 119 VEKVDIIVS 127
Cdd:PRK09328 173 GGRFDLIVS 181
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 51-157 3.56e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 46.61  E-value: 3.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  51 HLFRDKIVLDVGCGTGILSM-FCARaGAKHVYGVDMSeiiHKAVQIVEVN----KLSDRITLIQGKMEEI--QLPVEKVD 123
Cdd:COG0742   38 PDIEGARVLDLFAGSGALGLeALSR-GAASVVFVEKD---RKAAAVIRKNleklGLEDRARVIRGDALRFlkRLAGEPFD 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 295443078 124 IIvsewmgyFL-------LYESMLDtvLVARDRYLAPDGLL 157
Cdd:COG0742  114 LV-------FLdppyakgLLEKALE--LLAENGLLAPGGLI 145
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 59-157 6.31e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   59 LDVGCGTGILSMFCARAGA-KHVYGVDMSEI-IHKAVQIVEVNKLSDRITLIQGKMEEIQLPVEKVDIIVsewMGYFLLY 136
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPgLEYTGLDISPAaLEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVV---ASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 295443078  137 ESMLDTVLVARDRYLAPDGLL 157
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 54-127 9.40e-06

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 45.27  E-value: 9.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   54 RDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHkavqivEVNKLSDRITLIQG---KMEEIQLPVE----KVDIIV 126
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQL------WKPRNDPGVTFIQGdirDPETLDLLEEllgrKVDLVL 94


                  .
gi 295443078  127 S 127
Cdd:pfam01728  95 S 95
PRK14967 PRK14967
putative methyltransferase; Provisional
 58-127 1.65e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 45.43  E-value: 1.65e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295443078  58 VLDVGCGTGILSMFCARAGAKHVYGVDMSEiihKAVQIVEVNKLSD--RITLIQGKMEEiQLPVEKVDIIVS 127
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAAGAGSVTAVDISR---RAVRSARLNALLAgvDVDVRRGDWAR-AVEFRPFDVVVS 107
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 55-126 2.74e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.55  E-value: 2.74e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295443078  55 DKIVLDVGCGTGILSMFCARAgAKHVYGVDMS-EIIHKAVQIVEVNKLsDRITLIQGKMEEI---QLPVEKVDIIV 126
Cdd:COG2265  234 GERVLDLYCGVGTFALPLARR-AKKVIGVEIVpEAVEDARENARLNGL-KNVEFVAGDLEEVlpeLLWGGRPDVVV 307
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 29-116 3.55e-05

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 44.44  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  29 HEEMLkDDVrtLSYrdaiMQNPHLFRDKIVLDVGCGTGILSMFCARAGAKhVYGVDMSEiihkavQIVEVNK-------L 101
Cdd:PRK07580  45 HQRMR-DTV--LSW----LPADGDLTGLRILDAGCGVGSLSIPLARRGAK-VVASDISP------QMVEEARerapeagL 110

                         90
                 ....*....|....*
gi 295443078 102 SDRITLIQGKMEEIQ 116
Cdd:PRK07580 111 AGNITFEVGDLESLL 125
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 32-115 4.04e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 44.02  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  32 MLKDDVRTLSYRDAimqnpHLFRDKIVLDVGCGTGILSMFCAR-AGAK-HVYGVDMSEiihKAVQIVEVN----KLSDRI 105
Cdd:PRK00377  23 MTKEEIRALALSKL-----RLRKGDMILDIGCGTGSVTVEASLlVGETgKVYAVDKDE---KAINLTRRNaekfGVLNNI 94

                         90
                 ....*....|
gi 295443078 106 TLIQGKMEEI 115
Cdd:PRK00377  95 VLIKGEAPEI 104
arsM PRK11873
arsenite methyltransferase;
57-127 5.40e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.17  E-value: 5.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 295443078  57 IVLDVGCGTGILSMFCARA-GAK-HVYGVDMS-EIIHKAVQIVEvnKLS-DRITLIQGKMEEIQLPVEKVDIIVS 127
Cdd:PRK11873  80 TVLDLGSGGGFDCFLAARRvGPTgKVIGVDMTpEMLAKARANAR--KAGyTNVEFRLGEIEALPVADNSVDVIIS 152
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 56-171 8.02e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 42.48  E-value: 8.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  56 KIVLDVGCGTGILSMFCARAGAK--HVYGVDMS-EIIHKAVQIVEVNKLSDRITLIQGKMEEI--QLPVEKVDIIV---- 126
Cdd:COG4122   18 KRILEIGTGTGYSTLWLARALPDdgRLTTIEIDpERAAIARENFARAGLADRIRLILGDALEVlpRLADGPFDLVFidad 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 295443078 127 -SEWMGYFLLYESML--DTVLVArDRYLAPDGLLFPDRAQIQLAAIED 171
Cdd:COG4122   98 kSNYPDYLELALPLLrpGGLIVA-DNVLWHGRVADPARRDPSTRAIRE 144
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 58-127 1.31e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.81  E-value: 1.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078   58 VLDVGCGTGILSMFCARAGAKHVygVDMSEIIHKAVQI----VEVNKLsDRITLIQGKMEEiQLPVEKVDIIVS 127
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAE--LTMVDINARALESarenLAANGL-ENGEVVASDVYS-GVEDGKFDLIIS 104
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
54-126 1.79e-04

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 42.59  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  54 RDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHKavqIVEVN----KLSD-RITLIQGKMEEI--QLPVEKVDIIV 126
Cdd:COG2521  132 RGDRVLDTCTGLGYTAIEALKRGAREVITVEKDPNVLE---LAELNpwsrELANeRIKIILGDASEVikTFPDESFDAII 208
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 43-125 1.89e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.06  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  43 RDAIMQNPHLFRDKIVLDVGCGTGILSMFCARAGAK--HVYGVDMSE-IIHKAVQIVEVNKLSDRITLIQGKMEEIQLPV 119
Cdd:PRK00216  40 RRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKtgEVVGLDFSEgMLAVGREKLRDLGLSGNVEFVQGDAEALPFPD 119


                 ....*.
gi 295443078 120 EKVDII 125
Cdd:PRK00216 120 NSFDAV 125
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
 53-194 4.21e-04

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 41.20  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  53 FRDKIVLDVGCGTGilsMF--CA-RAGAKHVYGVDmseiihkaV---QIVEvnKL-SD-RITLIQG----KMEEIQLPvE 120
Cdd:COG1189   76 VAGKVCLDIGASTG---GFtdCLlQRGAAKVYAVD--------VgygQLAW--KLrQDpRVVVLERtnarYLTPEDLP-E 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078 121 KVDIIV------SewmgyfllyesmLDTVLVARDRYLAPDGLL-------F---PDR---------AQIQLAAIEDADYK 175
Cdd:COG1189  142 PPDLVVidvsfiS------------LTLVLPALLALLKPGGELvalvkpqFevgRERvgkggvvrdPALHAEVIEKVLAA 209

                        170
                 ....*....|....*....
gi 295443078 176 SEKIGFwdDVYGFDFSPIK 194
Cdd:COG1189  210 AAELGL--RVLGLTPSPIT 226
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 54-128 4.88e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 40.32  E-value: 4.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295443078  54 RDKIVLDVGCGTGILSMFCARAGAKhVYGVDMSEiihKAVQIVEVNkLS----DRITLIQGKMEEIQLPVEKVDIIVSE 128
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLGRR-VIGSDIDP---KMVEGAREN-LEhygyEDADVIRGDARDLPLADESVDAIVTD 99
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 50-157 5.01e-04

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 41.24  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   50 PHL--FRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEIIHkaVQIVEVNKLS---DRITLIQGKMEEIQlPVEKVDI 124
Cdd:pfam08003 109 PHLspLKGRTILDVGCGNGYHMWRMLGEGAAMVVGIDPSELFL--CQFEAVRKLLgndQRAHLLPLGIEQLP-ALAAFDT 185

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 295443078  125 IVSewMGyfLLY--ESMLDTVLVARDRyLAPDGLL 157
Cdd:pfam08003 186 VFS--MG--VLYhrRSPLDHLLQLKDQ-LVKGGEL 215
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 59-158 5.32e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 38.83  E-value: 5.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078   59 LDVGCGTGILSMFCARA----GAKHVYGVDMSEIIHKAVQIVEVNKLSDRITLIQGKMEEI--QLPVEKVDIIvsewmgy 132
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAAlrdnGLGRLTAVDPDPGAEEAGALLRKAGLDDRVRLIVGDSREAlpSLADGPIDLL------- 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 295443078  133 FL----LYESMLDTVLVARdRYLAPDGLLF 158
Cdd:pfam13578  74 FIdgdhTYEAVLNDLELWL-PRLAPGGVIL 102
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
50-150 1.30e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 40.23  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  50 PHLF--RDKIVLDVGCGTGilsMFCAR---AGAKHVYGVDMSEIIhkAVQIVEVNKLSD---RITLIQGKMEEIQlPVEK 121
Cdd:PRK15068 116 PHLSplKGRTVLDVGCGNG---YHMWRmlgAGAKLVVGIDPSQLF--LCQFEAVRKLLGndqRAHLLPLGIEQLP-ALKA 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295443078 122 VDIIVSewMGyfLLY--------------------ESMLDT---------VLVARDRY 150
Cdd:PRK15068 190 FDTVFS--MG--VLYhrrspldhlkqlkdqlvpggELVLETlvidgdentVLVPGDRY 243
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 26-118 1.92e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 39.76  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  26 WGIHEE--------MLKDDVRTLSyrdaiMQNPHLFRDKIVLDVGCGTGILSMFCARAGAK-HVYGVDMSEiihKAVQIV 96
Cdd:COG2242  216 PGLPDEaferdkgpITKREVRALT-----LAKLALRPGDVLWDIGAGSGSVSIEAARLAPGgRVYAIERDP---ERAALI 287

                         90       100
                 ....*....|....*....|....*..
gi 295443078  97 EVNKLS---DRITLIQGKMEEI--QLP 118
Cdd:COG2242  288 RANARRfgvPNVEVVEGEAPEAlaDLP 314
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 58-127 2.17e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 38.63  E-value: 2.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 295443078  58 VLDVGCGTGILSMFCARAGAK-HVYGVDMSEiihKAVQI----VEVNKLsDRITLIQGKMEEiQLPVEKVDIIVS 127
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEaRVTLVDVNA---RAVELaranAAANGL-ENVEVLWSDGLS-GVPDGSFDLILS 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 52-126 3.51e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 38.60  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  52 LFRDKIVLDVGCGTGILSMFCARA-GAK-HVYGV----DMSEIihkAVQIVEVNKLSDRITLIQGKMEEiQLPVEKVDII 125
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAvGPEgKVYSYerreDFAEI---ARKNLERFGLPDNVELKLGDIRE-GIDEGDVDAV 164


                 .
gi 295443078 126 V 126
Cdd:COG2519  165 F 165
PRK08317 PRK08317
hypothetical protein; Provisional
 41-128 3.56e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.38  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  41 SYRDAIMQNPHLFRDKIVLDVGCGTGILSMFCARA--GAKHVYGVDMSEIIHKAVQIVEVNKLSdRITLIQGKMEEIQLP 118
Cdd:PRK08317   6 RYRARTFELLAVQPGDRVLDVGCGPGNDARELARRvgPEGRVVGIDRSEAMLALAKERAAGLGP-NVEFVRGDADGLPFP 84

                         90
                 ....*....|
gi 295443078 119 VEKVDIIVSE 128
Cdd:PRK08317  85 DGSFDAVRSD 94
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 96-155 3.80e-03

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 37.57  E-value: 3.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295443078   96 VEVNKLSDRITLIQGKMEEIQLPvEKVDIIVSEWMGYF----LLYESmLDTVLvardRYLAPDG 155
Cdd:pfam05185 111 INFEKWGDKVTIISSDMREWQGP-EKADILVSELLGSFgdneLSPEC-LDGAQ----KFLKPDG 168
tly TIGR00478
TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA ...
 53-86 8.64e-03

TlyA family rRNA methyltransferase/putative hemolysin; Members of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis. [Unknown function, General]


Pssm-ID: 129570 [Multi-domain]  Cd Length: 228  Bit Score: 37.09  E-value: 8.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 295443078   53 FRDKIVLDVGCGTGILSMFCARAGAKHVYGVDMS 86
Cdd:TIGR00478  74 VKNKIVLDVGSSTGGFTDCALQKGAKEVYGVDVG 107
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 55-180 8.78e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 37.53  E-value: 8.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295443078  55 DKIVLDVGCGTGILSMFCARAGAKHVYGVDMSEI-IHKAVQIVEVNKLSDRITLIQGK-MEEIQLPVEKVDIIVsewMGY 132
Cdd:COG2520  181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDaVEYLKENIRLNKVEDRVTPILGDaREVAPELEGKADRII---MNL 257

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295443078 133 FLLYESMLDTVL-VARDR------YLAPDGLLFPDRAQIQLAAIEDADYKSEKIG 180
Cdd:COG2520  258 PHSADEFLDAALrALKPGgvihyyEIVPEEDPFERAEERIEEAAEEAGYEVEILE 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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